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In organosulfur chemistry, thiosulfinate is a functional group consisting of the linkage R-S(O)-S-R (R are organic substituents). Thiolsulfinates are also named as alkanethiosulfinic (or arenethiosulfinic) acid esters. They are the first member of a family of compounds containing an oxidized disulfide bond. Other members of this family include thiosulfonates (R-SO₂-S-R), α-disulfoxides (R-S(O)-S(O)-R), sulfinyl sulfones (R-S(O)-SO₂-R), and α-disulfones (R-SO₂-SO₂-R), all of which are known. The thiosulfinate group can occur in cyclic as well as acyclic structures.
Bayer Williger monooxygenase mutant and application thereof
The invention discloses a Bayer Williger monooxygenase mutant and an application of the Bayer Williger monooxygenase mutant. The invention provides a monooxygenase mutant, and compared with an amino acid sequence shown as SEQ ID NO: 1, an amino acid sequence of the monooxygenase mutant contains amino acid residue difference of one or more sites; the activity of the monooxygenase mutant is improved compared with that of Bayer-Williger monooxygenase with the amino acid sequence shown as SEQ ID NO: 1, wherein the amino acid sequence of the Bayer-Williger monooxygenase is shown as SEQ ID NO: 1. According to the monooxygenase mutant provided by the invention, the chiral thiosulfinate compound can be generated with relatively high yield and stereoselectivity, and the reaction condition is mild.
Owner:SHANGHAI SYNTHEALL PHARM CO LTD