375results about "Sulfuric acid esters preparation" patented technology

The invention discloses a berberine electrostatic composite and a preparation method of the berberine electrostatic composite, which are applied to medical and health industries. The berberine electrostatic composite is prepared from anionic surfactant and berberine or berberine salt by compositing; the molar ratio of the anionic surfactant to the berberine or berberine salt is 1 to 0.5-10; the molar ratio of anion to the berberine salt is 1 to 1; the anionic surfactant is one or more of alkyl sulfate or alkyl sulfonate or fatty acid salt; the alkyl sulfate is one or more of sodium cholesteryl sulfate, lauryl sodium sulfate and deoxysodium cholate; the alkyl sulfonate is one or more of sodium heptanesulfonate and sodium dodecyl sulfate; the fatty acid salt is one or more of sodium caprate and sodium enanthate, and the berberine and berberine salt are obtained by chemical synthesis or by extracting traditional Chinese medicine. The berberine is prepared into the berberine electrostatic composite to increase the biological membrane penetrating ability of the berberine and improve the oral bioavailability of the berberine, and the berberine electrostatic composite plays a significant treatment role on important chronic metabolic disorder diseases such as diabetes mellitus, complication of the diabetes mellitus, hyperlipidemia and the like.

A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics

wherein

X is chlorine or bromine; R is hydrogen, C_1-4 alkyl group, an easily removable hydroxyl protective group, —CH₂COOR₅, or —C(CH₃)₂COOR₅, wherein R₅ is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV¹),

wherein X, R and R₅ are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII)

in an organic solvent at a temperature ranging from −30° C. to −15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.

The invention discloses a Gemini surfactant and a preparation method thereof. The structure of the Gemini surfactant is as shown in formula (I), wherein R is a C8-C16 alkyl group, and n is a natural number ranging from 1 to 3. The preparation method of the cationic Gemini surfactant as shown in formula (I) comprises the following steps: 1) reacting C8-C16 fatty alcohol with epoxy chloropropane in the presence of a basic compound and a phase transfer catalyst to generate a compound as shown in formula (II), wherein R is as defined in formula (1); 2) reacting the compound as shown in formula (II) with polyethylene glycol in the presence of alkali metal, and acidifying to obtain a compound as shown in formula (III), wherein the polymerization degree of the polyethylene glycol is 1-3; and 3) reacting the compound as shown in formula (III) with chlorosulfonic acid, and alkalifying to obtain the Gemini surfactant as shown in formula (I). The surfactant provided by the invention has stronger temperature tolerance, salt resistance, foamability and emulsibility, and can achieve a favorable synergic effect when being used with surfactants of other types.

There is provided a process for producing an α-substituted ester by reaction of a fluorosulfuric acid ester of α-hydroxyester with a Grignard reagent in the presence of a zinc catalyst. It is newly found that the reaction for production of α-substituted esters, in which the raw reaction substrate is limited to expensive trifluoromethanesulfonic acid esters, can proceed favorably with the use of fluorosulfuric acid esters suitable for mass-production uses. By the use of the fluorosulfuric acid ester high in optical purity, it is possible to obtain the α-substituted ester with high optical purity upon inversion of the asymmetric carbon configuration. The process of the present invention can solve all of the prior art problems and can be applied for industrial uses.

A method is disclosed for the production of taurine in high yield by a cyclic process of reacting monoethanolamine, sulfuric acid, and ammonium sulfite in the presence of additives to inhibit the hydrolysis of 2-aminoethyl hydrogen sulfate intermediate. The cyclic process is economical and little waste is generated.

The invention provides cardanol polyoxyethylene ether ammonium sulfate and a preparation method thereof. The preparation method comprises the following steps of: adding cardanol polyoxyethylene ether into a reactor provided with a stirrer, fully stirring at constant temperature and adding sulfamic acid and a catalyst; and stirring, reacting at constant temperature for 7 to 9 hours, neutralizing excessive sulfamic acid in the reaction system to a pH value of 8 to 10 by using sodium hydroxide, cooling, and filtering to prepare the cardanol polyoxyethylene ether ammonium sulfate. The cardanol polyoxyethylene ether which is prepared from natural cardanol is taken as a raw material for production, the negative influence of petroleum-synthesized cardanol polyoxyethylene ether ammonium sulfate on environment is avoided, the defects of more waste acid, high product saltness, complex technical control operation and the like in the technical route that the alkylpheol polyoxyethylene ether and a sulfating agent are directly reacted are overcome, and sulfated products is not needed to be neutralized by ammonia water or liquid ammonia.

Aspects of the present invention relate to compositions and methods for the use of ionic liquids with dissolved metal compounds as catalysts for a variety of chemical reactions. Ionic liquids are salts that generally are liquids at room temperature, and are capable of dissolving a many types of compounds that are relatively insoluble in aqueous or organic solvent systems. Specifically, ionic liquids may dissolve metal compounds to produce homogeneous and heterogeneous organometallic catalysts. One industrially-important chemical reaction that may be catalyzed by metal-containing ionic liquid catalysts is the conversion of methane to methanol.

Fluorosulfuric acid esters can be produced by reacting alcohols with sulfuryl fluoride (SO₂F₂) in the presence of a base and water. As a substrate thereof, optically active secondary alcohols are preferable, and optically active α-hydroxyesters and optically active 4-hydroxyprolines are particularly preferable. By performing the reaction in a two-phase system in the presence of a reaction solvent immiscible with water, a desired reaction proceeds particularly well. The present invention is a production method solving all the problems involved in conventional techniques while being industrially practicable.

Production of particle lauryl sodium sulfate is carried out by delivering liquid or cream lauryl sodium sulfate feed liquid into atomizer in bottom of atomizing granulating fluidized bed by pressure pump, heating air by heat exchanger, entering into bottom of fluidized bed, contacting with material by distributing board on fluidized bed, fluidizing material, continuously atomizing feed liquid by atomizing nozzle of atomizer, coating onto fluidized particle surface, particle growing, contacting with hot air, drying, fluidizing, coating, drying, particle growing to required particle size, lowering temperature of discharging section, discharging from fluidized bed, screening, and packing. Its advantages include low cost, reasonable process, no environmental pollution, and good fluidity and dissolubility.

The invention provides a process for drying lauryl sodium sulfate, which belongs to the technical field of preparation of a surfactant in an organic compound. The method is carried out in a compound vacuum drier formed by a vacuum tube type spray drying part (A), an adapting tank (B) and a vacuum scraper drying part (C), and comprises the following steps: (1) preheating a lauryl sodium sulfate material in a preheater to the temperature of between 50 and 100 DEG C, and making the material be in a half atomized state and enter a vacuum drying tube with vapor in the vacuum tube type spray drying part (A) at a pressure of between 0.2 and 1.0MPa by a conveying pump, so that the moisture content of the material is reduced to 50 to 10 percent; (2) introducing the material into the vacuum scraper drying part (C) through the adapting tank (B) for secondary drying, so that the moisture content of the dried material is lower than 3 percent; and (3) according to the prior process, granulating the dried materials through a double screw extruder to manufacture an acicular product. The process has reasonable design, and can effectively improve the drying efficiency and product quality.

A method and a device for the sulfonation or the sulfation of organic liquid raw materials with an SO₃/air mixture and other reaction gases in order to perform rapid, highly exothermic gas-liquid reactions in conventional thin-layer falling-film reactors are disclosed. The introduction of the SO₃/air mixture occurs through several feed locations, which are located within (along) the reaction tube or reaction tubes or in the annular gap of annular-gap falling-film reactors. High peak temperatures, undesirable byproducts, worsening of the color and local oversulfation or oversulfonation, which leads to side reactions, are largely avoided.

A method for preparing α-sulfo fatty acid alkyl ester salts, the method comprising the following steps: in the presence of a coloring inhibitor, the fatty acid alkyl ester is brought into contact with sulfonated gas to carry out a sulfonation step; The esterification step of esterifying the product of the sulfonation step; the neutralization step after the esterification step to obtain a neutralized product; the bleaching step of bleaching the neutralized product to obtain a bleached product; and preferably the The bleached product is subjected to a deodorization step for deodorization. Thus, the preparation process of the α-sulfo fatty acid alkyl ester salt can be simplified, and the α-sulfo fatty acid alkyl ester salt in an ideal state such as light color close to white and less odor can be obtained.

The present invention relates to a surfactant for general use in agricultural compositions, including, but not limited to herbicidal, fungicidal and insecticidal formulations comprised of two components: an alkoxylated tristyrylphenol acid neutralized to the desired pH or properties with an appropriate amount of alkoxylated alkyl amine.

The invention discloses a fluorosulfuryl-containing compound, and an intermediate, preparation method and application thereof. The fluorosulfuryl-containing compound disclosed by the prevention includes cations and anions, and the cations are shown as a formula 1 (please see the specifications for the formula). The fluorosulfuryl-containing compound can react with a substrate to efficiently synthesize a fluorosulfuryl product, is low in toxicity, easy to prepare and convenient to use, and is in a stable solid state at the normal temperature; and in addition, the substrate of the compound has extremely high adaptability and can include a phenolic compound and an amine compound, and the fluorosulfuryl-containing compound is a unique solid form reagent capable of realizing chemical transformation at present and thus has important academic and application value.

The invention discloses a hybrid vaporizer and application thereof to preparation of a sulfonated or sulfated product from liquid sulfur trioxide. The hybrid vaporizer consists of a shell (7), a liquid sulfur trioxide inlet (2) and a mixed gas outlet (6), and is characterized in that a jacket (4) is arranged outside the shell (7); the top of the shell (7) is provided with an inert gas inlet (1) and the liquid sulfur trioxide inlet (2); one end of the jacket (4) on the top of the shell (7) is provided with a circulating water or steam outlet (3); one end of the jacket (4) on the bottom of the shell (7) is provided with a circulating water or steam inlet (5); and the bottom of the shell (7) is provided with the mixed gas outlet (6). The hybrid vaporizer has the advantages of being applied to preparing the sulfonated or sulfated product with low viscosity, medium viscosity and high viscosity at the reaction temperature, along with adjustable pressure.

The invention relates to an emulsification viscosity reduction agent for a deep high-asphaltene super-heavy oil shaft, and belongs to the technical field of oil field chemical agent design. The emulsification viscosity reduction agent is characterized by comprising the chemical structural formula as follows, wherein R represents C8H17, C9H19, C10H21, C11H23 and C12H25; Y represents -CH2CH2-, -CH2CH2CH2-, -CH2CH2CH2CH2- and -CH2CH2CH2CH2CH2-; M represents Na, K and Li. The emulsification viscosity reduction agent for the deep high-asphaltene super-heavy oil shaft can be dissolved in formation water with hypersalinity and high calcium and magnesium ion content or oily sewage, is mixed with deep super-heavy oil and is compatible and soluble with asphaltene, so that the oil-water interfacial tension is reduced, an O/W emulsion is formed, the lifting viscosity of the deep super-heavy oil in the shaft is effectively reduced, the conventional lifting and exploiting requirements of the shaft are met, and economy and effectiveness for development of the deep super-heavy oil are improved.

The invention discloses a synthetic method for an alcohol ether sulfate salt foaming agent. The synthetic method comprises the following steps: fatty alcohol polyoxyethylene ether and sulfamic acid in the mole ratio being 1: (1.15-1.25) are added, then a catalyst is added, the mixture reacts for 2-4 h under the condition of 105-125 DEG C to prepare alcohol ether sulfate salt. The sulfamic acid is adopted to serve as a sulfating agent in the synthetic method and does not contain inorganic salt, and inorganic salt is prevented from being introduced into a final product; the reaction is simple and finished by one step, process parameters in the synthetic process are optimized, better process conditions are screened out, and the foaming power, the foam stability and the liquid carrying capacity of the prepared alcohol ether sulfate salt are better obviously.

The invention belongs to the field of sodium dodecyl sulfate, and especially relates to a production method of sodium dodecyl sulfate. The sodium dodecyl sulfate production method is characterized in comprising the steps that: (1) sulfonation and neutralization are carried out, wherein a sulfonating agent is added into lauryl alcohol, such that a sulfate is produced through a sulfonation reaction; sulfate is subjected to a neutralization reaction with sodium hydroxide, such that liquid sodium dodecyl sulfate is produced; (2) concentration is carried out; (3) drying is carried out, wherein the concentrated solid material is dried, and a drying temperature is 40-100 DEG C; and (4) crushing, molding, and packaging are carried out, wherein the dried solid material is crushed, molded, and packaged, such that products are obtained. The method provided by the invention has the advantages that: with the method, a production process route of sodium dodecyl sulfate used in a conventional daily use material is broken through. The product purity is up to 97% or even higher than 99%. The product can be used in biological pharmacy and chemical reagent production.

The invention discloses a surface active agent containing a hexafluoropropylene tripolymer group and a preparation method thereof. The hexafluoropropylene tripolymer is a fluorine-containing precursor material, and the surface active agent is prepared by taking a benzene ring as a rigid connecting chain. The surface active agent comprises a cation series, an amine oxide series and an anion series which are respectively in the form of 4-perfluoro-(4-methyl-3-isopropyl-2-amylene-2-group) oxygen benzyl ammonium cation, 4-perfluoro-(4-methyl-3-isopropyl-2-amylene-2-group) oxygen benzyl amine oxide and 4-perfluoro-(4-methyl-3-isopropyl-2-amylene-2-group) oxygen benzyl sulphonate (sulfate). The surface active agent disclosed by the invention has the advantages of no harm characteristic of a lasting organic pollutant, high surface activity, low critical micelle concentration and high heat stability; the fluorine-containing surface active agent disclosed by the invention has potential application value in special application fields of tertiary oil extraction, fluorine-containing polymer polymerization, and the like, and the fields of common surface active agents and the like.

A synthesis method of fatty alcohol sulfate belongs to the synthesis technical field of sulfate-type anion surface activator of organic chemistry. The invention uses fatty alcohol as raw material, which is characterized in that the invention uses sulfamic acid as sulfation agent and uses urea as catalyst to process sulfation reaction on fatty alaochol and sulfamic in the catalytic presence of urea and nitrogen gas protection, neutralizes via alkali solution, vacuums to remove generated ammonia gas and dilutes via water to prepare fatty alcohol sulfate, wherein the mol ratio of fatty alcohol and sulfamic acid is 1:1.0-2.0 and the mol ratio of fatty alcohol and catalyst urea is 1:0.2-1.0. The invention reasonably utilizes sulfamic as sulfation agent and urea as catalyst to process sulfation modification on fatty alcohol to synthesize fatty alcohol sulfate, with simple process, less side reaction, mild reaction condition and simple device, which is suitable for intermittent production with less device investment.