226results about How to "The synthesis process is green and environmentally friendly" patented technology

The invention discloses a synthetic method of cyclosulphate. A peroxysulfate solution is pre-synthesized through sulfuric acid and hydrogen peroxide, then under existence of an organic solvent, a metal inorganic compound and a catalyst, the peroxysulfate solution is dropwise added to generate a catalytic oxidation reaction with cyclosulfite, after the reaction is completed, salt residue is filtered out, still standing for layering is conducted, an organic layer is taken to be distilled, concentrated and purified, and a cyclosulphate high-quality product is obtained. According to the syntheticmethod of the cyclosulphate, the cheap sulfuric acid and hydrogen peroxide are used as the raw materials, the peroxysulfate solution is prepared to conduct catalytic oxidation on the cyclosulfite, onthe one hand, the reaction is mild, control is easy, and the reaction conversion rate is high; on the other hand, the evaporation capacity of water is small, energy consumption is low, generated wastewater is less, and a synthetic process is more environmentally friendly; and the prepared cyclosulphate is few in impurity, high in purity and wide in market prospect.

The invention discloses a benzoxadiazole compound and a preparation method and medical use thereof. The benzoxadiazole compound has the general structure shown in formula (I). The compound or pharmaceutically acceptable salts, tautomers, mesomers, racemates, stereoisomers, metabolites, metabolic precursors, prodrugs or solvates of the benzoxadiazole compound have an obvious inhibiting effect on PD-1/PD-L1 protein-protein interaction, so that the benzoxadiazole compound shown in the description can be applied to the preparation of an inhibitor with a PD-1/ PD-L1 inhibitory activity and the immunotherapy of tumors as an immunocheckpoint inhibitor.

The invention discloses star-shaped hydroxyl polyester adopting polyhydric alcoho as a nucleus and a preparation method and an application of the star-shaped hydroxyl polyester. The preparation method comprises the following steps: enabling 1 to 8 molar caprolactone and 1 to 4 molar anhydride to react for 6 to 10 h at 80 to 140 DEG C by adopting 1 molar small molecular polylasic alcohol as a core molecule to obtain a matrix star-shaped polyester, then reacting with 1 to 4 molar monoglycidyl ether at 90 to 150 DEG C to obtain star-shaped hydroxyl polyester. The prepared star-shaped hydroxyl polyester has the advantages of simple synthesis process, high solid content and low viscosity, a hydroxyl value is 140 to 250 mg KOH/g (80 percent of solid content), the viscosity at 25 DEG C when the solid content is 80 percent is 300 to 3000cp, the star-shaped hydroxyl polyester can be cross-linked with a polyurethane curing agent containing an isocyanate group and can be used for preparing a coating with a high solid content, the VOC content at the construction viscosity is smaller than 380 g/L, and the film performance can satisfy the national standard of the solvent-type dual-component polyurethane wood coatings.

The invention provides a preparation method of starch graft copolymer coal-water slurry dispersants. After oxidation modification of starch, in a redox system, sodium p-styrene sulfonate and a large monomer are introduced to a starch chain through free radical polymerization reaction to compound a series of coal-water slurry dispersants with excellent performance and unique characteristics. Chief constituents of the starch graft copolymer coal-water slurry dispersants are as follows, by mass: 8-20% of starch, 2-8% of oxidants, 10-30% of monomers and 2-4% of initiators. The starch graft copolymer coal-water slurry dispersants prepared by the method are brown sticky emulsion, the solid content is 26-38%, the pH value is 7-9, and the viscosity is 40-130mPa.s. The preparation method of the starch graft copolymer coal-water slurry dispersants exploits the advantages of strong dispersity of the sodium p-styrene sulfonate and carboxylate to the full and combines effects of hydrogen bond in water molecules and polyhydroxy on a starch straight chain and the space steric hindrance effect of a long chain of the large monomer to enable coal-water slurry to have good dispersion perfoamance and good storage stability. The dispersants can achieve biodegradation and have low toxicity, and raw materials of the dispersants are easy to obtain and low in cost.

The invention relates to a preparation method of environment-friendly one-component moisture curing polyurethane waterproofing paint. The preparation method is mainly characterized by comprising the following steps: adding RDEA of poly-functionality polyether glycol and polyglycol, dehydrating, adding isocyanate for reaction for 1-4 h at 50-80 DEG C, reducing to room temperature, adding a plasticizer, an antifoaming agent, an antioxidant and an ultraviolet light absorber that are pre-dried, uniformly mixing to obtain the polyurethane waterproofing paint. The environment-friendly one-component moisture curing polyurethane waterproofing paint has the advantages as follows: 1), the raw materials are low in cost and easy to obtain, the synthetic method is simple, convenient, efficient and low in cost, the scale-up of the operation processes and the industrial production are facilitated; 2), water is taken as a curing agent for polyurethane resin, therefore the polyurethane resin after curing in air with certain humidity can form a compact polyurethane elastomer coating which is high in safety; besides, poly-functionality active group is introduced and can form a compact cross-linked network after curing, with an excellent mechanical property (the film tensile strength is greater than 6 MPa, and the breaking elongation is greater than 1000%), the polyurethane waterproofing paint can serve as an excellent waterproofing material and is broad in application prospect.

The invention provides a method for preparing hydroxylamine hydrochloride, and specifically relates to a method for preparing hydroxylamine hydrochloride from hydrogen peroxide and ammonium chloride. The method comprises the following steps: catalyzing hydrogen peroxide, free ammonia and acetone or butanone to synthesize ketoxime first, and then enabling the ketoxime to react with ammonium chloride under a negative pressure to generate hydroxylamine hydrochloride, free ammonia, acetone or butanone, wherein the acetone or butanone and the free ammonia are recycled for reuse. The invention solves the problems of high raw material cost and more byproducts for preparation of hydroxylamine hydrochloride in the prior art; meanwhile, low-value ammonium chloride is used for preparing hydroxylamine hydrochloride to ensure that the cost is low, and the sustainable development of the soda industry can be promoted.

The invention relates to an intumescent flame retardant, and a synthesis method and an application thereof, and concretely relates to a three-sources-integrated intumescent flame retardant, and a synthesis method and an application thereof. The problems to be solved are low flame retardation efficiency, poor thermal stability and difficulty in processing of existing intumescent flame retardants. The three-sources-integrated intumescent flame retardant is a methylphosphonic acid-piperazine-neopentyl glycol phosphate oligopolymer. The method comprises the following steps: 1, heating piperazine and distilled water, adding saturated methylphosphonic acid, and carrying out heating, reacting, concentrating and drying to obtain a white crystal intermediate di-methylphosphonopiperazine; and 2, adding neopentylene glycol and a solvent, carrying out heating, adding the white crystal intermediate di-methylphosphonopiperazine, heating the obtained solution to reflux the solution, cooing the refluxed solution, carrying out suction filtration and washing, and drying the obtained product to obtain the three-sources-integrated intumescent flame retardant. The flame retardant has the advantages ofgood char forming performance, high thermal stability, and high-efficiency flame retardation to polyethylene resin, and the preparation method has the advantages of mild reaction conditions, simplicity in operation, and safety. The flame retardant is used for realizing the flame retardation of the polyethylene resin.

The invention belongs to the technical field of coatings, and discloses a water-based epoxy curing agent based on castor oil triglycidyl ether and a preparation method of the curing agent. The preparation method comprises the following steps: performing a reaction on bisphenol epoxy resin, polyetherol diglycidyl ether and a polyamine to prepare an epoxy-polyamine addition product with -NH2 groupsat two ends, adding the castor oil triglycidyl ether, performing a branching reaction to obtain a prepolymer with -NH2 groups at three branched chain tail ends, adding a monoepoxy compound to block terminal primary amine hydrogen, and finally adding water for dispersion to obtain the water-based epoxy curing agent. The water-based epoxy curing agent obtained by the method has the advantages of a long pot life, low viscosity and easy construction when used with water-based epoxy resin, and the cured product has a large cross-linking degree, has good flexibility while having good corrosion resistance, and overcomes the defects of low toughness and high brittleness of an ordinary epoxy coating layer.

The invention relates to products which belong to the technical field of concrete admixture. The technology is characterized by the following steps of: preparing stock solution which comprises the following components: deionized water, calcium oxide, sulphur powder and catalyst, wherein the catalyst consists of mixed solution of methoxypolyethylene glycol, dimethyl 1,3-propanediol and alkylphenol polyoxyethylene ether sodium sulfate; and then preparing an inorganic waterproof shrinkage reducing compacting agent for inorganic concrete, wherein the inorganic waterproof shrinkage reducing compacting agent comprises the following components: the deionized water, the stock solution, triethanolamine, the methoxypolyethylene glycol, the dimethyl 1,3-propanediol, the alkylphenol polyoxyethylene ether sodium sulfate, silicate and a defoaming agent DF-642. The novel shrinkage reducing compacting agent special for the concrete can effectively reduce early shrinkage of the concrete, reduce crack risk, improve compactness of the concrete, improve porosity structure, realize waterproof function and seepage-proof function with low intermingled quantity (0.1 to 2 percent), and improve durability of the concrete to physical corrosion and chemical corrosion. The invention relates to an III type compacting agent used for increasing the compactness and improving the strength of the concrete. The novel shrinkage reducing compacting agent special for the concrete is most suitable for the engineering field requiring high concrete strength and high waterproofing quality.

The invention discloses an amphipathic chitosan quaternary ammonium salt derivative and preparation thereof and application thereof. The structural formula of the amphipathic chitosan quaternary ammonium salt derivative is shown as in the description, wherein R1 is a 2-hydroxypropyl trimethyl ammonium halide group, R2 is alkyl or aromatic alkyl, and all a, b and c are polymerization degrees. The amphipathic chitosan quaternary ammonium salt derivative has excellent water solubility, degradability and biocompatibility, can effectively restrain the growth of gram negative bacteria and gram positive bacteria and can directly serve as antibacterial materials or can be used for preparing antibacterial composites. A preparation method of the amphipathic chitosan quaternary ammonium salt derivative is green, environmentally friendly, mild in reaction condition, low in cost and easy to industrialize.

The invention relates to a urea synthetic method which comprises the following steps: compression of raw material ammonia and carbon dioxide; synthesizing and gas stripping; medium and low pressure decomposition and recovery process; evaporation and pelletizing of urine. The method disclosed by the invention is simple, is low in cost and has a high synthesizing speed; obtained urea particles are uniform, have low impurity content, are moderate to dissolve and can be sufficiently adsorbed by crops more easily; moreover, an adsorption tower is utilized to treat tail gas, so that the synthesizing process is more environmental-friendly.

The invention relates to a sterilization polymer containing a quaternary ammonium salt and halamine or a halamine precursor functional group as well as a preparation method and application of the sterilization polymer. The preparation method comprises the following steps of: generating a high-molecular polymer containing the quaternary ammonium salt and the halamine precursor functional group through the reaction among a halo-methylated high-molecular polymer serving as a carrier, tertiary amine and a halamine precursor; and generating the sterilization high-molecular polymer containing the quaternary ammonium salt and the halamine precursor functional group through halogenating reaction. The sterilization high-molecular polymer has a quick, efficient and broad-spectrum sterilization effect, can be extensively applied to sterilization treatment of various water bodies and air as well as the control of harmful smelly gas. The sterilization high-molecular polymer also can be mixed with other materials to obtain various sanitary and anti-bacterial products such as an anti-bacterial mattress cover, an anti-bacterial blanket, an anti-bacterial diaper.

The invention relates to a fluorescent molecularly imprinted polymer hollow microsphere, a preparation method and application thereof, and belongs to the technical field of molecularly imprinted polymers. The preparation method comprises the following steps: preparing silicon dioxide nano-particles SiO2, preparing a polymer of silicon dioxide surface grafted fluorescein isothiocyanate SiO2@FITC-APTES; and preparing fluorescent molecular imprinting polymer SiO2@FITC-APTES@MIP, and etching the polymer to obtain hollow fluorescent molecular imprinting polymer FITC-APTES@MIP. The invention has theadvantages that the hollow fluorescent molecularly imprinted polymer which can rapidly and specifically detect a target analyte with high efficiency, can be prepared, and the synthesis process is safe and environment-friendly, specifically, the polymer can specifically adsorb the target analyte and generate fluorescence quenching, and has a remarkable quenching effect within 20 minutes, thereby shortening the detection time.

The invention discloses a castor oil-based double-crosslinkable reactive resin monomer and a preparation method thereof. The preparation method comprises the following steps: reacting ricinoleic acidwith epichlorohydrin to obtain castor oil-based epoxy resin, carrying out an epoxy ring-opening reaction on the castor oil-based epoxy resin and unsaturated acid to produce castor oil-based acrylate,and finally reacting the castor oil-based acrylate with unsaturated acid anhydride to obtain the castor oil-based double-crosslinkable reactive resin monomer. The castor oil-based double-crosslinkablereactive resin monomer prepared in the invention is applied to the field of functional resins, and has wide application prospects in the fields of building, mechanical manufacturing, food packaging,medicines and the like.

The invention provides a method for preparing avobenzone. The method comprises the steps that p-tert-butylbenzaldehyde and p-methoxyacetophenone serve as raw materials, a condensation reaction is performed under the alkaline condition, and prepared condensation products are oxidized into the avobenzone under the action of an oxidizing agent. The preparation method is simple, convenient, easy to perform and few in reaction steps, the preparation condition is mild and easy to control, and the prepared avobenzone is light in color, good in quality, pure in smell, high in market competitiveness and capable of easily achieving industrialization popularization.

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.