34 results about "Methylphosphonic acid" patented technology

The present invention relates to an enzymatically catalyzed method for producing L-glufosinate or a phosphoester thereof. The method includes reacting an activated L-homoserine HA with a substrate S selected from methylphosphinic acid and esters thereof. Sulfhydrylase enzyme E1 is used for the enzymatic catalysis. The invention makes accessible new substrates for the enzymatic production of L-glufosinate and its phosphoesters.

The invention relates to the technical field of pesticide production, and particularly discloses a preparation process of glufosinate-ammonium intermediate 3-(methyl hydroxyl phosphonyl) propionaldehyde. The preparation method comprises the following steps: 1, carrying out addition reaction on diethyl methylphosphonite and acrylic acid in absolute ethyl alcohol to generate 3-[ethyoxyl (methyl) phosphonyl] propionate; in the second step, 3-[ethyoxyl (methyl) phosphonyl] propionate is subjected to a hydrosilylation reaction in an oriented mode, and 3-triethyl siloxy-3-ethyoxyl propyl methyl ethyl phosphonate is generated; and 3, carrying out a simple dilute acid hydrolysis reaction to obtain the 3-(methyl hydroxyl phosphonyl) propionaldehyde. According to the method, a three-step reaction route of addition-hydrosilylation-hydrolysis is adopted, and the acrylic acid is used for replacing the traditional high-toxicity raw material acrolein, so that the toxicity risk is avoided from the source, the yield of the target glufosinate-ammonium intermediate is remarkably improved, the total yield of the three-step reaction can reach 95% or above, and the method is suitable for industrial production. And an efficient and green brand-new technical scheme is provided for large-scale production of glufosinate-ammonium.

The invention discloses a high-safety lithium ion battery electrolyte and a lithium ion battery prepared from the high-safety lithium ion battery electrolyte, and belongs to the technical field of lithium ion batteries. An additive O, O-diethyl (3-ethoxythiophene-2-yl) methylphosphonate is added during preparation of the lithium ion battery electrolyte, so that the high-safety lithium ion battery electrolyte is prepared; a cross-linking reaction or a polymerization reaction can be carried out under a high-temperature condition to form a carbonaceous protective layer, cooling is realized through an endothermic reaction in the forming process of the carbonaceous protective layer, and active substances in the battery are isolated after the carbonaceous protective layer is formed; the battery safety problem caused by higher heat production and higher battery combustion risk when the lithium ion battery is used for a large-scale energy storage system is solved.

The invention discloses a hydroxymethyl phosphonate flame retardant and a preparation method and application thereof.The method comprises the steps that phosphorus trichloride and epoxide serve as starting raw materials and react in the presence of a catalyst to generate trichloro alkyl phosphite, the obtained triester structure is dropwise added into phosphorous acid, heat preservation reaction is conducted, and dichloro alkyl phosphite is obtained; and adding a catalyst 2 into the diester product, heating, slowly adding paraformaldehyde, and continuously reacting to obtain the hydroxymethyl phosphate flame retardant. The method is low in cost, mild in reaction condition, solvent-free, capable of being efficiently completed without extreme conditions, high in reaction speed and high in conversion efficiency, is compatible with existing chemical production equipment, and provides a solid foundation for large-scale industrial production.

The invention discloses a preparation method and application of a triazole phosphate type corrosion and scale inhibitor, and relates to the technical field of industrial water treatment chemicals. The compound is prepared by a three-step synthesis method which comprises the following steps: firstly, preparing an amino methylene phosphonic acid compound with one-NH reaction site from n ethylene (n + 1) amine, phosphorous acid and formaldehyde; secondly, preparing a triazole derivative from ethylene glycol glycidyl ether and triazole; and reacting the two products with sodium bicarbonate to obtain a target product. The target molecule contains a sodium phosphate group and a triazole group at the same time, through the synergistic effect of functional groups, intramolecular synergy of scale inhibition and corrosion inhibition functions is achieved, and the corrosion inhibition performance higher than that of a DETPMP scale and corrosion inhibitor used commercially is shown. The triazole phosphate type corrosion and scale inhibitor has good catalytic activity on photocatalytic carbon dioxide reduction under the conditions of room temperature and high temperature, the TON (carbon monoxide conversion number) can reach 1206, and the selectivity is 100%.

The application discloses an amplification preparation method of dimethylheptyl methylphosphonate, and belongs to the technical field of medical intermediates. The core point of the application is that 2-octanol and phosphorus trichloride are used as raw materials, and tri-2-octyl phosphite is generated in an organic solvent in the presence of a catalyst A, then the tri-2-octyl phosphite is reacted with a methylating agent in the presence of a catalyst B to generate dimethylheptyl methylphosphonate. The method avoids the use of dangerous reagents and expensive reagents, reduces the raw material cost, reduces the generation amount of isomers, improves the reaction yield, greatly reduces the amount of three wastes, and makes the whole preparation process more green and environment-friendly. The process is simple and reliable, easy to industrial production, and provides a new reaction path for the synthesis of dimethylheptyl methylphosphonate.

The invention discloses a pomegranate-shaped core-shell structure tin pyrophosphate negative electrode material as well as a preparation method and application thereof, and belongs to the technical field of electrochemical energy storage materials. The preparation method comprises the following steps: mixing tetravalent tin salt and a phosphonic acid organic ligand, and carrying out hydrothermal reaction to obtain a tin-based metal organic framework precursor; the phosphonic acid organic ligand is selected from one or two of phenylphosphonic acid or (pyridine-2-yl methyl) phosphonic acid; and carrying out heat treatment on the tin-based metal organic framework precursor at 550-700 DEG C to obtain the pomegranate-shaped core-shell structure tin pyrophosphate negative electrode material. The tetravalent tin salt and the specific phosphonic acid ligand are used for constructing the precursor, and the Kirkendall effect in the pyrolysis process is utilized to form a unique core-shell structure, so that the negative electrode material shows excellent cycling stability under high current density when being used for the potassium ion battery or the sodium ion battery.

The invention provides a herbicide composition, a herbicide as well as a preparation method and application of the herbicide, and belongs to the technical field of agricultural herbicides. The composition provided by the invention comprises (1-hydroxypropane-1, 3-diyl) bis (methylphosphonic acid) and glufosinate-ammonium, and the weight ratio of the (1-hydroxypropane-1, 3-diyl) bis (methylphosphonic acid) to the glufosinate-ammonium is 20: 1-50: 1. The composition can be used for controlling weeds, especially weeds which have resistance to glufosinate-ammonium. The (1-hydroxypropane-1, 3-diyl) bis (methylphosphonic acid) and glufosinate-ammonium are compounded, a remarkable synergistic effect is shown, the prevention and treatment effect of glufosinate-ammonium is improved, the increasingly prominent resistance problem in use of a single glufosinate-ammonium agent can be effectively solved, and the weeding composition can be widely applied to the technical field of agricultural weeding.

Disclosed are a pyrethroid compound containing a cyano group and a double bond, a synthesis method therefor and an application thereof. In the synthesis method, t-butyl 3-formyl-2,2-dimethyl-cyclopropanoate and cyanomethyl phosphonate are used as raw materials, undergo Witting-Horner reaction, undergo column chromatography to obtain t-butyl (Z)-3-(2-cyanovinyl)-2,2-dimethyl-cyclopropanoate ester, undergo deprotection to obtain (Z)-3-(2-cyanovinyl)-2,2-dimethyl-cyclopropanoic acid, undergo acyl chlorination reaction to produce (Z)-3-(2-cyanovinyl)-2,2-dimethyl-cyclopropanoyl chloride, and are esterified with corresponding alcohol to obtain the pyrethroid compound. The compound can be used as an insecticide against pests such as mosquitoes, flies, German cockroaches and the like.

This invention relates to the field of ceramic materials, specifically disclosing a high water-resistant magnesium phosphate cement-based foam ceramic and its preparation method. The foam ceramic comprises the following components: 100-150 parts magnesium phosphate cement, 1-5 parts retarder, 5-20 parts foaming agent, 1-5 parts foam stabilizer, 5-15 parts lutetium ion source, 1-8 parts methylene phosphonic acid component, and 30-60 parts water. The method includes: (1) mixing the lutetium ion source, methylene phosphonic acid component, and water to obtain a complex solution. (2) mixing the magnesium phosphate cement and foam stabilizer, then adding the complex solution to the mixture and mixing to obtain a slurry. (3) adding the foaming agent to the slurry and allowing it to stand for foaming, followed by curing to obtain the foam ceramic. This invention not only effectively reduces the solubility of magnesium phosphate cement hydration products, but also combines CO2 foaming to generate a low-solubility magnesium carbonate shell, significantly improving the long-term stability of the foam ceramic in an aquatic environment while maintaining high porosity.

Organometallic precursor solutions containing one or more phosphonate, such as methylphosphonic acid, tert-butylphosphonic acid, diethoxyalyllphosphonate, benzylphosphonic acid, and phenylphosphonic acid, are described. Corresponding methods for forming radiation patternable coatings as well as methods for forming a pattern using a solventless developing process are also described. The incorporation of a phosphonate into an organometallic photoresist composition, such as an organotin photoresist composition, is described as a way to increase stability of organometallic precursor solutions, to improve the homogeneity of organometallic photoresist films, and / or to improve the patterning performance of organometallic photoresist coatings.

The invention relates to the technical field of high-value utilization of solid wastes, in particular to a method for preparing II-type anhydrous gypsum by utilizing phosphogypsum and application of the II-type anhydrous gypsum. The preparation method comprises the following steps: adding a crystal modifier 1, 3, 5-triazine-2, 4, 6-triamine hexaacetic acid or 1, 3, 5-triazine-2, 4, 6-triamine hexamethyl phosphonic acid, an alkaline regulator, a surfactant and water into phosphogypsum, reacting under a hydrothermal condition, filtering, and carrying out vacuum drying on the obtained solid to obtain the type II anhydrous gypsum. Then the type II anhydrous gypsum is added into the polypropylene, and the doping amount can be increased to 40%, so that the tensile property, bending property and impact property of the prepared composite material are improved compared with those of a pure polypropylene material, the mechanical property is improved, the use cost of a polymer is greatly reduced, and the application prospect is wide. A diversified application scene is provided for high-value utilization of the ardealite, and a new path is opened up for solving the current ardealite problem.

Compounds of the Formula (I), pharmaceutical compositions comprising compounds of the Formula (I), and their use for treating or preventing cancer: (I)

The application provides a preparation method of 4-(hydroxymethyl phosphono)-2-carbonyl butyric acid, comprising the following steps: a) mixing methyl phosphonate diester, carboxylic acid and acryloyl cyanide to perform an addition reaction, and obtaining (3-cyano-3-carbonyl propyl) methyl phosphonate liquor after reduced pressure distillation; b) uniformly mixing the (3-cyano-3-carbonyl propyl) methyl phosphonate liquor obtained in step a) with water, cooling to 10-40 DEG C, then adding hydrochloric acid dropwise to perform acidification, continuing to stir for 0.1-1 h after the dropwise addition is completed, then performing a hydrolysis reaction, and finally performing purification treatment to obtain 4-(hydroxymethyl phosphono)-2-carbonyl butyric acid. Compared with the prior art, the preparation method provided by the application does not need to perform a cyanation reaction, avoids the use of high-cost, hard-to-obtain cyclic phosphonic anhydride and the highly toxic sodium cyanide; and the preparation method has short process steps, the raw materials are widely sourced and low in cost, the reaction conditions are mild, and the element comprehensive utilization rate is high.

The invention discloses a synthetic method of bis (1-methylheptyl) methylphosphonate, and belongs to the technical field of organic phosphorus compound preparation, and the synthetic method comprises the following specific steps: S1, adding phosphorus trichloride and a solvent into a reaction container, putting a reaction system into an ice-water bath, and dropwise adding sec-octanol into a phosphorus trichloride solution; after the reaction is finished, removing the solvent and unreacted sec-octanol through reduced pressure distillation to obtain an intermediate di (1-methylheptyl) phosphonite; s2, adding the di (1-methylheptyl) phosphonite obtained in the step S1 into an alkali solution, and putting a reaction system into an ice-water bath; after the reaction is completed, adding a methylation reagent into the system; and after the reaction is finished, washing the reaction liquid with water until the reaction liquid is neutral, and removing volatile components through reduced pressure distillation to obtain the target product methyl phosphonic acid di (1-methylheptyl) ester. The method provided by the invention has the advantages of high safety and strong process controllability, and is suitable for an alternative synthesis route of industrial production.

The invention relates to the technical field of high polymer materials, in particular to a high-temperature-resistant polymer material composition and application thereof. The composition comprises monomers such as polyethylene glycol (200) dimethacrylate, isobornyl acrylate and the like, Sadama UV (Ultraviolet) resin, a photoinitiator TPO (Thermoplastic Polyolefin) and a core functional molecule ((2-(5, 5, 5-trifluoro-1-methacrylamidopent-2-yl)-1H-benzo [d] imidazole-1-yl) methyl) phosphonic acid. The core functional molecules are prepared step by step through condensation cyclization, Michael addition, Mannich reaction, catalytic hydrogenation acylation and acidic hydrolysis, the composition and a main matrix material are mixed, a polymer microcrystalline layer with the thickness of 20 microns is formed through UV curing, and then the 3MDT dimming film is prepared. The film has excellent high-temperature-resistant stability, strong interface adhesion, rapid dimming response and good mechanical properties, can keep a stable dimming effect in a high-temperature environment, and is suitable for high-end scenes such as buildings and automobiles.

The application provides a kind of F-free one-dose low IGZO damage metal etching solution and preparation method thereof, and relates to the technical field of semiconductor display panel manufacturing.The F-free one-dose low IGZO damage metal etching solution is composed of the following raw materials: hydrogen peroxide, complexing agent, 2,4-dichlorophenoxyacetic acid, ethylenediaminetetraacetic acid, corrosion inhibitor compound, and ultra-pure water is added to make up the volume;the corrosion inhibitor compound is obtained by mixing 2-mercapto-5-methylbenzimidazole and aminotrimethyl phosphonic acid in a mass ratio of 1:2-3, and the ratio of the addition amount of ethylenediaminetetraacetic acid to the corrosion inhibitor compound is ≤1.2.The application uses a complexing agent-corrosion inhibitor compound synergistic system, the IGZO layer damage rate is <5%, which significantly improves the device yield, and the Cu etching rate is 500-800 Å / min, the MoTi etching rate is 300-500 Å / min, and the rate matching is good.

A method of preparing an aluminum methyl methylphosphonate (AMMP) flame retardant by reacting at a reaction temperature of about 110 °C or higher for an amount of time sufficient to produce the AMMP, a reaction mixture containing an aqueous aluminum- containing methylphosphonic acid solution; and dimethyl methylphosphonate. The resulting product is intumescent.

The present application relates to wastewater treatment technical field, specifically to a kind of PVDF separation membrane and integrated process for treating printing and dyeing wastewater.The method adopts six-step process:1) PVDF microporous membrane pretreatment and pore adjustment;2) polydopamine primer preparation;3) alternatively depositing sodium polystyrene sulfonate and zirconium oxychloride octahydrate;4) aminomethyl phosphonic acid graft modification;5) UiO-66-NH2 type MOF epitaxial growth, and insert repair treatment strengthen interlayer coordination anchoring;6) stabilization treatment, enhance structural compactness.The membrane shows excellent removal performance to multi-sulfonic acid group anionic dyes, still maintains higher removal rate and flux recovery rate under high salt, complex working condition, effectively solves the problem of structural relaxation and selective removal of traditional PVDF membrane in high salt environment, and has good industrial application prospect.

The invention relates to the technical field of acrylic plates, and discloses a flame-retardant heat-insulating acrylic plate and a preparation method thereof.The flame-retardant heat-insulating acrylic plate comprises methyl methacrylate, an initiator and a specific composite additive system, and the composite additive system comprises four key functional components, the preparation method comprises the following steps of: taking tri (2-hydroxyethyl) boric acid ester as a precursor of a glass phase network, octa (aminophenyl) polyhedral oligomeric silsesquioxane as a network framework, diethyl diethanol amino methyl phosphonate as a precursor of a catalyst and a foaming agent, and pentaerythritol tetra [beta-(3, 3, 4-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5 The invention relates to 2, 5-di-tert-butyl-4-hydroxyphenyl) propionic acid] ester. Through the synergistic effect of the components, a compact ceramic foam thermal insulation layer can be generated in situ during combustion, the unification of excellent flame-retardant thermal insulation property and inherent high optical and mechanical properties of the material is realized, and the problem that comprehensive properties are difficult to consider in a traditional modification technology is solved.

This invention provides a method for preparing 4-(hydroxymethylphosphono)-2-carbonylbutyric acid, comprising the following steps: a) mixing methylphosphonite diester, carboxylic acid, and acryloyl chloride, performing an addition reaction, and distilling under reduced pressure to obtain a (3-chloro-3-carbonylpropyl)methylphosphonate solution; b) mixing the (3-chloro-3-carbonylpropyl)methylphosphonate solution obtained in step a) with sodium cyanide, solvent, and catalyst, performing a substitution reaction, and purifying to obtain a (3-cyano-3-carbonylpropyl)methylphosphonate solution; c) mixing the (3-cyano-3-carbonylpropyl)methylphosphonate solution obtained in step b) with water, cooling to 10℃~40℃, adding hydrochloric acid dropwise for acidification, stirring for 0.1h~1h after the addition is complete, then performing a hydrolysis reaction, and finally purifying to obtain 4-(hydroxymethylphosphono)-2-carbonylbutyric acid. Compared with existing technologies, the preparation method provided by this invention has simple process steps, mild reaction conditions, and high comprehensive utilization rate of elements.

This invention relates to an aminomethylphosphonic acid aminoguanidine nonlinear optical crystal, its preparation method, and its uses. The crystal has the molecular formula (CN4OH7)(CH2NH3PO3), a molecular weight of 203.15, belongs to the orthorhombic crystal system, and has a space group of [missing information]. P 212121, cell parameters are a =6.276(2)Å, b =10.239(4)Å, c =13.868(4)Å, α =90.00° β =90.00° c =90.00° Z =4, V =891.2(5)Å 3 Centimeter-sized crystals were grown using evaporation, aqueous solution cooling, or hydrothermal methods. The ultraviolet absorption edge of these crystals is shorter than 200 nm, and the experimental birefringence is approximately 0.15 at 546 nm. This crystal preparation method is simple and low-cost, exhibiting significant nonlinear optical effects, a large birefringence, a wide transmission range, and ease of growth and processing. It can be used as an ultraviolet nonlinear optical crystal and a birefringent crystal.

The invention relates to the technical field of solid waste treatment, in particular to a method for recycling metal lithium from a waste lithium battery material. The method comprises three core steps of leaching, adsorption and desorption precipitation: firstly, leaching LFP positive electrode powder by adopting a mixed leaching agent of dilute sulphuric acid and hydrogen peroxide; li < + > in the leachate is directionally adsorbed in a fixed bed through a specific modified resin adsorbent; and finally, analyzing, depositing lithium and the like to obtain the battery-grade lithium carbonate. Wherein the modified resin adsorbent is prepared from acrylonitrile and dimethylaminoethyl methacrylate through crosslinking copolymerization, nitrile group conversion and methylphosphonic acid group grafting modification, and PO4 < 3-> interference can be efficiently resisted. The method solves the problems of high acid consumption, poor adsorption selectivity, low lithium recovery rate and the like in the prior art, and has remarkable economic and environment-friendly values.

The application relates to the technical field of iron phosphate preparation, in particular to a high-purity iron phosphate material and a preparation method thereof. The preparation method of the high-purity iron phosphate material provided by the application comprises the following steps: mixing polystyrene microspheres, chloromethyl methyl ether, a first catalyst and an organic solvent to obtain primary modified polystyrene microspheres; mixing the primary modified polystyrene microspheres, aminomethyl phosphonic acid, a second catalyst, a cocatalyst and an organic solvent to obtain secondary modified polystyrene microspheres; mixing an iron source solution and a phosphorus source solution, then adding the secondary modified polystyrene microspheres to carry out reaction, and baking to obtain the high-purity iron phosphate material. The iron phosphate material obtained by the method has low impurity content and high tap density, and the preparation method is relatively simple, low in energy consumption and convenient to operate.

The invention discloses a method for separating Gd-160, Tb-161 and Dy-161 on the basis of phosphate levextrel resin. Dissolving the irradiated Gd-160 target material with an acid solution to obtain a raw material solution R1; filling a separation column with levextrel resin loaded with dimethyl heptyl methylphosphonate, and injecting the raw material solution R1 onto the separation column; acid liquor H1, acid liquor H2 and acid liquor H3 are sequentially adopted to conduct leaching and elution on the separation column at the flow velocity F1, the flow velocity F2 and the flow velocity F3 respectively, and effluent liquor P1, effluent liquor P2 and effluent liquor P3 obtained through separation are solutions containing Gd-160, Tb-161 and Dy-161 respectively; according to the present invention, the step-by-step elution process is adopted, and the carrier-free Tb-161 preparation can be achieved only through the single-column operation, such that the complex multi-column switching system is avoided, and the high-selectivity separation of the target nuclide Tb-161 and the impurity isotopes Gd-160 and Dy-161 is achieved.

The presently claimed invention relates to dielectric polishing composition comprising (A) surface - modified colloidal silica particles comprising a negatively - charged group on the surface of the particles, wherein the surface-modified colloidal silica particles have a negative charge, a particle size of from 5 nm to 200 nm, and a zeta potential < -35 mV at a pH in the range of from ≥ 2.0 to ≤ 4.5; (B) at least one buffering agent selected from L-arginine, lysine, or histidine; (C) at least one iron (III) oxidizer; (D) at least one pH adjusting agent selected from 2-amino-2-methyl- propan-1-ol or phosphoric acid and salts thereof; (E) at least one stabilizer; (F) at least one first corrosion inhibitor selected from tetrabutyl ammonium nitrate (TAN), tetrabutyl ammonium hydroxide, tetrabutyl ammonium acetate, tetrabutyl ammonium bromide, tetrabutyl ammonium sulfate, tetrapropyl ammonium hydroxide, amino tris(methylphosphonic acid), ethylenediaminetetra(methylenephosphonic acid), triethylenetetramine hexakis(methylphosphonic acid), phosphonobutane tricarboxylic acid, or diethylenetriaminepentakis (methylphosphonic acid) (DTPMP); (G) at least one second corrosion inhibitor selected from buformin, phenformin, guanine, proguanil hydrochloride, 2- guanidinobenzimidazole, polyhexamethylene biguanide hydrochloride, polyaminopropyl biguanide, chlorhexidine, or chlorhexidine salts; and (H) aqueous medium, wherein the pH of the composition is in the range of from ≥ 2.0 to ≤ 5.0.

Organometallic precursor solutions containing one or more phosphonate, such as methylphosphonic acid, tert-butylphosphonic acid, diethoxyalyllphosphonate, benzylphosphonic acid, and phenylphosphonic acid, are described. Corresponding methods for forming radiation patternable coatings as well as methods for forming a pattern using a solventless developing process are also described. The incorporation of a phosphonate into an organometallic photoresist composition, such as an organotin photoresist composition, is described as a way to increase stability of organometallic precursor solutions, to improve the homogeneity of organometallic photoresist films, and / or to improve the patterning performance of organometallic photoresist coatings.

This invention discloses a biodegradable packaging material and its preparation method, relating to the field of packaging materials. In preparing the biodegradable packaging material, vermiculite powder is grafted with chloromethyltrimethoxysilane and then reacted with piperazine, bis(2-chloroethyl)methylphosphonate, and ethylenediamine to obtain modified vermiculite powder; corn starch is oxidized with sodium periodate to obtain modified corn starch; polyvinyl alcohol, allyltrimethylammonium chloride, and 5-allylmercapto-[1,3,4]thiadiazole-2-amine are reacted to obtain modified polyvinyl alcohol; and modified corn starch, glycerol, modified polyvinyl alcohol, modified vermiculite powder, and zinc chloride are mixed to obtain the biodegradable packaging material. The biodegradable packaging material prepared by this invention exhibits excellent flame retardancy, antibacterial properties, mechanical properties, and rapid degradation.

A method for preventing corrosion of a metal member in which cooling water and steam are alternately brought into contact with each other, said method being characterized in that a phosphorus compound and / or a zinc compound are added to the cooling water, and an anti-corrosion film-forming substance is added to the steam. The phosphorus compound is at least one of hexametaphosphoric acid, triphosphoric acid, orthophosphoric acid, phosphono butane tricarboxylic acid, HEDP (1-hydroxyethylidene-1, 1-diphosphonic acid) and amino trimethylphosphonic acid.

The invention discloses a solar-blind ultraviolet region high-transmittance guanidine methylphosphonate nonlinear optical crystal and a preparation method and application thereof, the chemical formula of the crystal is [C (NH2) 3] 2 (CH3PO3), the crystal belongs to a monoclinic system, and the space group of the crystal is Cm (No.8). The guanidine methylphosphonate nonlinear optical material has excellent nonlinear optical performance, the powder frequency doubling intensity of the guanidine methylphosphonate nonlinear optical material is about 1.0 time of KDP, the light transmission range is wide, the ultraviolet cut-off edge is 207 nm, and frequency doubling laser output of an Nd: YAG (1064 nm) laser can be achieved. The growth method of the [C (NH2) 3] 2 (CH3PO3) crystal is simple, and the prepared crystal is high in quality, large in size and high in laser damage threshold (326.8 MW / cm < 2 >), is suitable for manufacturing a laser frequency conversion device, and can be applied to equipment such as an all-solid-state laser and an optical parametric oscillator.