31 results about "Aminomethylphosphonic acid" patented technology

The invention provides a preparation method of diethyl N,N-bis(2- hydroxyethyl) aminomethylphosphonate, comprising the following steps: (1) carrying out depolymerization on paraformaldehyde; (2) carrying out ring formation on formaldehyde and diethanol amine to prepare 3-(2- hydroxyethyl)-1,3-oxazolidine; (3) reacting 3-(2- hydroxyethyl)-1,3-oxazolidine with diethyl phosphite in the presence of anhydrous Lewis acid catalysts; and (4) filtering and recovering the catalysts to obtain a yellow transparent liquid product. The overall yield of the whole process reaches more than 99 %, and the content of diethyl N,N-bis(2- hydroxyethyl) aminomethylphosphonate in the product is 94 %-96 %. The preparation method disclosed in the invention is simple and efficient, has the advantages of high product yield, high content of effective components in the product, reduction of temperature in dehydration process, shortening of time, and low energy consumption, reduces the water content of the final product to 0.1-0.2 %, and reduces the dosage of the catalysts by 20-50%. The preparation method is suitable for large-scale industrial production.

The cross-linked polyphosphonate composition for the removal of metal ions from wastewater is a cross-linked anionic polyelectrolyte polymer having the formula:

The cross-linked anionic polyelectrolyte is made by cyclocopolymerizing diallylaminomethylphosphonic acid and 1,1,4,4-tetraallylpiperazinium dichloride (a cross-linker) to form a cross-linked polyzwitterionic acid (CPZA). The CPZA is then treated with a base, such as sodium hydroxide, to form a cross-linked anionic polyelectrolyte polymer having the above formula. The composition may be used to remove heavy metal ions, such as Cu²⁺ and Pb²⁺, from wastewater.

The invention relates to preparation of an immobilized metal ion affinity chromatographic material, and particularly relates to a method for preparing an immobilized metal affinity ion chromatographic monolithic column. In the method, a monolithic column material is prepared by using an organic-inorganic hybrid silica gel monolithic material of which the surface carries aldehyde groups as a vector; a phosphate buffer solution containing aminomethylphosphonic acid and sodium cyanotrihydroborate NaCNBH3 flows through the monolithic column material continuously to prepare a monolithic material vector of which the surface carries aldehyde chelation groups; and an aqueous solution of transition metal ions flows through the material vector to prepare the immobilized metal ion affinity chromatographic monolithic column. High-selectivity enrichment of phosphorylated peptide in a hybrid peptide section can be realized by utilizing the immobilized metal ion affinity chromatographic monolithic column. The invention has the advantages that the monolithic column has good selectivity to the phosphorylated peptide, can be recycled, and has the characteristics of large enrichment capability and high recovery rate; and the preparation method has the characteristics of simplicity, convenience, good permeability and small back pressure, and the prepared immobilized metal ion affinity chromatographic monolithic column has good mechanical strength and strong acid and alkali resistance.

The present invention relates to a method for improved removal of cations, preferably alkaline earth metals, in particular calcium and barium, from aqueous solutions using chelating resins having aminomethylphosphonic acid groups and iminodimethylphosphonic acid groups having high dynamic absorption capacity for cations at a low residual content of the cations and high regeneration efficiency, and a markedly lengthened loading duration of the chelating resin, to the chelating exchangers themselves, and also to uses thereof.

The cross-linked polyphosphonate-sulfone composition for removal of metal ions from wastewater relates to a cross-linked anionic polyelectrolyte polymer for the removal of metal ions, such as lead (Pb²⁺) and copper (Cu²⁺) ions, from wastewater and the like. The cross-linked anionic polyelectrolyte polymer has the formula:

The cross-linked anionic polyelectrolyte polymer is made by cyclopolymerization of diallylaminomethylphosphonic acid, 1,1,4,4-tetraallylpiperazinium dichloride (a cross-linker), and sulfur dioxide in the presence of AIBN (an initiator) in DMSO at 65° C. to form a cross-linked polyzwitterionic acid (CPZA). The CPZA is then treated with base (such as sodium hydroxide) to form the cross-linked anionic polyelectrolyte polymer having the formula shown above.

An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxidizing gas in the presence of a catalyst to form a reaction product mixture containing a formylphosphonic acid derivative and the conditions under which said contacting is carried out are controlled so that no more than 50% of the formylphosphonic acid derivative formed in the reaction product mixture is consumed by reaction with the reagent.

The invention relates to a trace toxicant analysis and detection method, and particularly relates to a gas chromatography method of measuring trace glufosinate ammonium, glyphosate and aminomethylphosphonic acid (metabolite thereof) in drinking water. The method comprises the steps of: enriching a trace target chemical-compound in the drinking water by novel methane sulfinate-magnesium-aluminum hydrotalcite calcined-product adsorbent stones, eluting the target material by a saturated sodium chloride solution, adjusting a pH value by sodium hydroxide, and derivatizing the target material step by step by Isopropyl chloroformate and trimethylsilylated diazomethane as a derivative agent, and using the gas chromatography method for fast analysis measurement. The novel adsorbent used by the method realizes fast and highly efficient adsorption on the target material by using a manner of dispersive solid-phase extraction, and the method can save a large amount of adsorption and elution time ascompared with a manner of solid-phase extraction; and the method only applies small-amount organic-solvent extraction, and has the remarkable advantages of safety, environmental protection and economy as compared with a liquid-liquid extraction method requiring use of a large amount of organic solvent.

The invention provides a method for determining residual quantity of glyphosate, glufosinate-ammonium and metabolite aminomethylphosphonic acid thereof in agricultural products. The method comprises the following steps: firstly, extracting and purifying glufosinate-ammonium, glyphosate and metabolite aminomethylphosphonic acid in a sample by adopting a solid-phase microextraction method, and then qualitatively and quantitatively detecting the glufosinate-ammonium, the glyphosate and the metabolite aminomethylphosphonic acid by adopting high performance liquid chromatography-tandem mass spectrometry and an internal standard method. According to the method disclosed by the invention, the lowest detection limits of glyphosate, glufosinate-ammonium and metabolite aminomethylphosphonic acid of the glyphosate, the glufosinate-ammonium and the metabolite aminomethylphosphonic acid are 0.03 mu g/kg, 0.29 mu g/kg and 0.39 mu g/kg. Compared with other detection methods, the method does not need a complex derivatization process, is high in detection efficiency, is simple and convenient, and is short in time consumption. By using the isotope internal standard, the interference caused by a series of reasons such as matrix effect can be avoided, and the quantitative result is more accurate. The method can also be used for simultaneously detecting three target objects including glyphosate, glufosinate-ammonium and aminomethylphosphonic acid in a complex sample, and is more efficient.

This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.

The invention discloses a method for determinating glyphosate, aminomethylphosphonic acid and glufosinate pesticide residues in tea leaves. By a liquid chromatography tandem mass spectrometry, the method is characterized by comprising the following steps: 1), weighing a test sample, adding 5-20mL of methanol water, whirling thoroughly, adding 5-20mL of dichloromethane, whirling, uniformly mixing,performing ultrasonic treatment, taking out, centrifuging, and taking a supernatant for purification; 2), taking 2mL of the supernatant, eluting with a CAX eluent in an activated CAX purifying small column, collecting by using 10ml of a round-bottom plastic tube, performing nitrogen blowing till a nearly dry state, adding 1mL of a boric acid buffer solution with the concentration of 1-5% for lateruse; 3), taking the stock solution, uniformly mixing, adding 200[mu]L of an FMOC-Cl derivatization reagent, uniformly mixing by whirling for 1min, derivatizing overnight at normal temperature, centrifuging at the speed of 4500r/min for 5min, then filtering by using a 0.22[mu]m organic filtration membrane, and applying to a machine for detection. By the method, the detection limit is 0.010mg/kg.

The invention relates to a rapid detection method for glyphosate, glufosinate-ammonium and aminomethylphosphonic acid in beer. The rapid detection method sequentially comprises the following steps: S1, a pretreatment step and S2, a computer test step. According to the method, an SPE column is not used for purification, so that the pretreatment time is greatly shortened; according to the invention,glyphosate, glufosinate-ammonium and aminomethylphosphonic acid are simultaneously detected; according to the method, the derivation operation conditions are simplified, and the derivation efficiencyis improved; according to the method, LC-MS/MS detection is adopted, the limit of quantitation can reach 0.010 mg/Kg, and the method is superior to a detection method in the prior art.