Aggregation-induced emission (AIE) illuminant?Cbased urine protein detection device for monitoring health of people

An aggregation-induced luminescence and detection device technology is applied in the field of portable urine protein detection devices, which can solve problems such as limiting the effective range of biological probes.

Inactive Publication Date: 2013-07-10
NANO & ADVANCED MATERIALS INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When they are dispersed in aqueous media or bound to proteins in buffered solutions, these molecules tend to aggregate, which quenches their fluorescence and thus greatly limits their effective range as biological probes

Method used

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  • Aggregation-induced emission (AIE) illuminant?Cbased urine protein detection device for monitoring health of people
  • Aggregation-induced emission (AIE) illuminant?Cbased urine protein detection device for monitoring health of people
  • Aggregation-induced emission (AIE) illuminant?Cbased urine protein detection device for monitoring health of people

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0050] Synthesis of Water-Soluble AIE Compound 1

[0051] In a 250 mL two-neck round bottom flask, 4-hydroxybenzophenone and 3 equivalents of Zn powder were dissolved in 80 mL of anhydrous THF, and the resulting suspension was cooled to -78 °C under N2 protection. Then TiCl 4 Add dropwise to the solution mixture. After warming to room temperature, the mixture was refluxed for 12 h. The reaction mixture was cooled to room temperature, then filtered. After evaporation of the filtrate, the crude product was purified by recrystallization from THF / methanol to give 1,2-bis(4-hydroxyphenyl)-1,2-diphenylethylene as a white solid.

[0052] in N 2 Add 0.5 g (1.37 mmol) of 1,2-bis(4-hydroxyphenyl)-1,2-diphenylethylene and 20 mL of absolute ethanol into a 100 mL round bottom flask under protection. Stir the mixture until all solids are dissolved. A mixture of NaOEt (0.20 g, 3.0 mmol) in 20 mL of ethanol was then added dropwise, which turned from a colorless solution to orange-red af...

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Abstract

The invention relates to a portable urine protein detection device which uses an aggregation-induced emission (AIE) illuminant to detect one or more urine proteins and quantitate total urine protein in a urine sample so as to monitor health of people. The invention particularly relates to a device, the device uses a water-soluble AIE illuminant to detect one or more urine proteins so as to determine the content of target protein and total urine protein in a tested object. The device can be used in household or clinical environment, and is used for monitoring health of people at regular intervals.

Description

[0001] Cross References to Related Applications [0002] This application is a non-provisional application under 35 U.S.C. §119(e), which claims the benefit of U.S. Provisional Application 61 / 631,661, filed January 9, 2012, the disclosure of which is incorporated by reference into this article. technical field [0003] The invention relates to a portable urine protein detection device, which uses aggregation-induced luminescence (AIE) luminescent substance to detect urine protein and quantify total urine protein in a urine sample, so as to monitor human health. In particular, it relates to a device for detecting one or more urinary proteins by using a water-soluble AIE luminescent material so as to determine the content of both target protein and total urinary protein in a subject. The device can be used in a home or clinical setting for regular monitoring of a person's health. Background technique [0004] Many human diseases are not easily diagnosed except at a very adv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64C09K11/06C07C309/11C07C303/24C07D249/04C07F7/10
Inventor 唐本忠林荣业郭子健
Owner NANO & ADVANCED MATERIALS INST
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