5 results about "Asymmetric carbon" patented technology

The invention provides a method for preparing a chiral helicene compound through cyclization reaction of an iridium-catalyzed 3-aryl indazole biaryl compound and disubstituted alkyne. The method comprises the following steps: under the action of an iridium catalyst, a chiral cyano phosphorus-oxygen ligand and an additive, carrying out an intermolecular asymmetric carbon-hydrogen bond activation reaction on a 3-aryl indazole biaryl compound and disubstituted alkyne, and after the reaction is finished, separating to obtain the chiral diazaspirene-containing compound, according to the invention, synthesis of the chiral helicene compound is realized through a transition metal catalysis asymmetric carbon-hydrogen bond activation method, the research technology of Cp metal catalysis asymmetric carbon-hydrogen bond activation is further developed, and the synthesis strategy of the chiral helicene compound is expanded at the same time; reaction substrates are wide in universality, and chiral control in the reaction process is realized through the chiral cyano phosphine oxide, so that the product has very high enantioselectivity; various chiral helicene compounds are synthesized, the synthesis method is simple and convenient, and the atom economy is high.

The application discloses a kind of photocontrol chiral ligand based on diarylethene, structural general formula is as shown in following formula:After the photocontrol chiral ligand based on diarylethene synthesized in the application and rhodium catalyst coordination, when catalyzing asymmetric carbon hydrogen amidation at room temperature, higher reaction yield and higher ee value can be obtained by using ligand in open loop state to catalyze, and lower reaction yield and lower ee value can be obtained by using ligand in light stable state to catalyze.The application makes up the deficiency that there is currently lack of photo-thermal bistable photocontrol catalyst in the field of photocontrol asymmetric catalysis, and widens the application of diarylethene in photocontrol asymmetric catalysis.

The present invention provides industrially suitable processes for preparing intermediates in the production of substituted polycyclic pyridone derivatives having a cap-dependent endonuclease inhibitory activity. In the process as shown below, wherein each symbol is as defined in the specification, an optically active substituted tricyclic pyridone derivative of the formula (VII) is obtained in high yield and high enantioselectivity by subjecting a compound of the formula (III) or (VI) to intramolecular cyclization with controlling stereochemistry to obtain a compound of the formula (IV) having a removable functional group on an asymmetric carbon, and then removing the functional group thereof;

The application belongs to the technical field of asymmetric catalytic synthesis, and particularly relates to a preparation method of a planar chiral indene metal complex with a benzazulene skeleton, a synthesis intermediate and catalytic application. The application provides a key intermediate for preparing the planar chiral indene metal complex, i.e. a chiral indenone in (R) configuration and (S) configuration, and a chiral indene ligand without a coordinating side arm prepared based on the chiral indenone. The chiral indene ligand of the application is strong in modification, easy to complex with a transition metal compound to obtain a single planar chiral indene metal complex. The planar chiral indene metal complex can be applied to various asymmetric carbon hydrogen activation reactions as a catalyst, and the chiral indene metal complex does not need to be separated into stereoisomers in a synthesis process, so that the synthesis difficulty and costs in various aspects are greatly reduced.

This invention provides a receptor, a sensor, a synthesis system, a measurement method, and a method for manufacturing the receptor. The receptor comprises: a substrate; and a molecularly imprinted polymer membrane formed on the substrate, having spaces for capturing at least a portion of a compound having asymmetric carbon atoms. The receptor may include a metal layer formed between the substrate and the molecularly imprinted polymer membrane, having a nanostructure on the surface in contact with the membrane. In any of the above-described receptors, the molecularly imprinted polymer membrane may have non-covalently bound functional groups on the surface forming the spaces.