16 results about "Asymmetric carbon" patented technology

The invention provides a method for preparing a chiral helicene compound through cyclization reaction of an iridium-catalyzed 3-aryl indazole biaryl compound and disubstituted alkyne. The method comprises the following steps: under the action of an iridium catalyst, a chiral cyano phosphorus-oxygen ligand and an additive, carrying out an intermolecular asymmetric carbon-hydrogen bond activation reaction on a 3-aryl indazole biaryl compound and disubstituted alkyne, and after the reaction is finished, separating to obtain the chiral diazaspirene-containing compound, according to the invention, synthesis of the chiral helicene compound is realized through a transition metal catalysis asymmetric carbon-hydrogen bond activation method, the research technology of Cp metal catalysis asymmetric carbon-hydrogen bond activation is further developed, and the synthesis strategy of the chiral helicene compound is expanded at the same time; reaction substrates are wide in universality, and chiral control in the reaction process is realized through the chiral cyano phosphine oxide, so that the product has very high enantioselectivity; various chiral helicene compounds are synthesized, the synthesis method is simple and convenient, and the atom economy is high.

The application discloses a kind of photocontrol chiral ligand based on diarylethene, structural general formula is as shown in following formula:After the photocontrol chiral ligand based on diarylethene synthesized in the application and rhodium catalyst coordination, when catalyzing asymmetric carbon hydrogen amidation at room temperature, higher reaction yield and higher ee value can be obtained by using ligand in open loop state to catalyze, and lower reaction yield and lower ee value can be obtained by using ligand in light stable state to catalyze.The application makes up the deficiency that there is currently lack of photo-thermal bistable photocontrol catalyst in the field of photocontrol asymmetric catalysis, and widens the application of diarylethene in photocontrol asymmetric catalysis.

The present invention provides industrially suitable processes for preparing intermediates in the production of substituted polycyclic pyridone derivatives having a cap-dependent endonuclease inhibitory activity. In the process as shown below, wherein each symbol is as defined in the specification, an optically active substituted tricyclic pyridone derivative of the formula (VII) is obtained in high yield and high enantioselectivity by subjecting a compound of the formula (III) or (VI) to intramolecular cyclization with controlling stereochemistry to obtain a compound of the formula (IV) having a removable functional group on an asymmetric carbon, and then removing the functional group thereof;

The application provides a method for constructing a planar chiral [2,2] paracyclophane by cobalt-catalyzed asymmetric carbon-hydrogen bond activation-kinetic resolution, which comprises the following steps: under the condition of direct current electrolysis, using a cobalt catalyst, a chiral ligand and an additive, taking a graphite felt electrode as an anode and a platinum electrode as a cathode, and allowing a racemic [2,2] paracyclophane formamide to undergo asymmetric carbon-hydrogen bond dehydrogenation coupling / kinetic resolution with an aryl acid, and after the reaction is completed, corresponding post-treatment is performed to obtain a planar chiral [2,2] paracyclophane formamide and a planar chiral oxo para-[2,2] paracyclophane. The application realizes electrochemical synthesis of the planar chiral oxo para-[2,2] paracyclophane by the method of crust-abundant transition metal catalyzed asymmetric carbon-hydrogen bond activation, the reaction substrate has wide universality, the stereoselectivity is excellent, and the product and the split-recovered raw material have excellent ee value (up to >99% ee) and a split factor (up to 1057).

The invention provides a method for constructing a chiral axis-containing planar chiral cyclophane compound by activating intramolecular asymmetric carbon-hydrogen bonds under the catalysis of cobalt, which comprises the following steps of: under the action of a cobalt catalyst, a chiral auxiliary agent and an additive, carrying out intramolecular asymmetric C-H activation reaction on alkynyl benzamide, and after the reaction is finished, separating the chiral axis-containing planar chiral cyclophane compound from the alkynyl benzamide to obtain the chiral axis-containing planar chiral cyclophane compound. Separating to obtain a planar chiral cyclophane compound containing a chiral axis; the synthesis of the planar chiral cyclophane compound containing the chiral axis is realized by a transition metal catalyzed asymmetric C-H activation method, the research technology of cheap transition metal catalyzed C-H activation is further developed, and meanwhile, the synthesis strategy of the planar chiral cyclophane compound containing the chiral axis is expanded; according to the present invention, the reaction substrate has characteristics of wide adaptability and strong product stereoselectivity, and the chiral control is achieved through the salicyl oxazoline so as to provide the high enantioselectivity and the high diastereoselectivity of the product; various planar chiral cyclophane compounds containing chiral axes are synthesized, the synthesis method is simple and convenient, the atom economy is good, and the synthesis efficiency is high.

A method of treating or preventing peripheral neuropathies includes administering a therapeutically effective amount of a cyclic amine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof to a patient who needs treatmentwherein, carbon marked with * is asymmetric carbon; and A represents a group represented by general formulae (IIa), (IIb) or (IIc):wherein R1 represents a methyl group or an ethyl group optionally substituted with a halogen atom, R2 represents a hydrogen atom or an alkylcarbonyl group having 2 to 5 carbon atoms, each R3 independently represents a methyl group or an ethyl group, and n represents 1 or 2.

This thin film includes a plurality of inorganic chains comprising a perovskite substance and constituting a chain-like structure, and a chiral molecule. At a boundary section between the inorganic chains that are adjacent, the chiral molecule is bonded to the inorganic chains via a functional group covalently bonded to one asymmetric carbon atom constituting the chiral molecule, thereby forming a helical structure formed as a result of the chiral molecule surrounding the periphery of the inorganic chain. Said asymmetric carbon atom covalently bonded to the functional group is an asymmetric carbon atom, from among a plurality of asymmetric carbon atoms of the chiral molecule, that is at a position where the helical angle of the helical structure is not at a minimum value.

Provided is a method for the photoisomerization of an optically active amino acid, the method comprising irradiating an optically active amino acid represented by formula (1) with light in a solvent containing a basic compound. In the formula, R1 represents a protecting group, R2 represents an organic group, R3 and R4 each independently represent a hydrogen atom or an organic group, R5 represents a hydrogen atom or a protecting group, n represents an integer of 0-3, and * represents an asymmetric carbon atom.

The present invention discloses a method for preparing a lipid-chain-substituted biphenyl-type or phenylpyrrole-type chiral monophosphine ligand. The method comprises: using the biphenyl-type or phenylpyrrole-type monophosphine ligand as a raw material, controlling the reaction temperature at 70-150°C in an organic solution under the protection of an inert gas, and subjecting the raw material to an asymmetric carbon-hydrogen activation reaction with an aliphatic olefin, aliphatic alkyne, or a derivative thereof, catalyzed by a monovalent iridium catalyst and in the presence of the chiral ligand. This synthetic route has not been reported in the literature, and the raw materials are inexpensive and readily available. The unit operations are simple, the equipment requirements are low, and it is suitable for rapidly constructing a new chiral monophosphine ligand library.

The invention relates to the technical field of organic synthesis, and provides an asymmetric carbon-hydrogen bond boronation reaction catalyst and a preparation method of chiral dicyclobutane. A catalyst composed of a chiral boron-based ligand and an iridium salt is adopted to catalyze an asymmetric carbon-hydrogen bond boronation reaction of prochiral dicyclobutane, in a reaction system, the iridium salt and the chiral boron-based ligand are combined to form a complex, the complex reacts with B2pin2 to form an active intermediate, and the active intermediate is separated from the chiral boron-based ligand to form the chiral dicyclobutane. Then the iridium center and a carbon-hydrogen bond of a 3-substituted dicyclobutane-1-formamide compound are subjected to an asymmetric oxidative addition reaction to form an iridium-carbon bond, then reduction elimination is carried out, and the target product chiral dicyclobutane is generated. The reaction condition for constructing the chiral dicyclobutane is mild, the selectivity is high, the enantioselectivity is 95% or above, the substrate universality is wide, and chiral dicyclobutane compounds of different structures can be synthesized.

The application belongs to the technical field of asymmetric catalytic synthesis, and particularly relates to a preparation method of a planar chiral indene metal complex with a benzazulene skeleton, a synthesis intermediate and catalytic application. The application provides a key intermediate for preparing the planar chiral indene metal complex, i.e. a chiral indenone in (R) configuration and (S) configuration, and a chiral indene ligand without a coordinating side arm prepared based on the chiral indenone. The chiral indene ligand of the application is strong in modification, easy to complex with a transition metal compound to obtain a single planar chiral indene metal complex. The planar chiral indene metal complex can be applied to various asymmetric carbon hydrogen activation reactions as a catalyst, and the chiral indene metal complex does not need to be separated into stereoisomers in a synthesis process, so that the synthesis difficulty and costs in various aspects are greatly reduced.

The invention discloses a surface-asymmetric carbon-based hydrogel photothermal conversion material as well as a preparation method and application thereof, and belongs to the technical field of photothermal conversion materials. The method comprises the following steps: dissolving a carbon-based compound and a polyvinyl alcohol monomer in deionized water to obtain a corresponding suspension, and carrying out freezing and thawing cycles for a certain number of times to obtain carbon-based polyvinyl alcohol hydrogel; and uniformly coating the surface of the carbon-based-polyvinyl alcohol hydrogel material with a cellulose solution with a temperature phase transition characteristic to obtain the surface-asymmetric carbon-based hydrogel photo-thermal conversion material. The photothermal conversion material disclosed by the invention can be converted from a hydrophilic surface to a hydrophobic surface after absorbing heat and raising temperature under illumination, so that an asymmetric Janus structure is formed, and the photothermal conversion material has efficient photothermal conversion capability, high water transmission rate and excellent long-term stability.

This invention provides a receptor, a sensor, a synthesis system, a measurement method, and a method for manufacturing the receptor. The receptor comprises: a substrate; and a molecularly imprinted polymer membrane formed on the substrate, having spaces for capturing at least a portion of a compound having asymmetric carbon atoms. The receptor may include a metal layer formed between the substrate and the molecularly imprinted polymer membrane, having a nanostructure on the surface in contact with the membrane. In any of the above-described receptors, the molecularly imprinted polymer membrane may have non-covalently bound functional groups on the surface forming the spaces.

The present invention relates to a thin film in which a plurality of inorganic layers comprising a perovskite substance and forming a layered structure are alternately stacked with organic layers, the organic layers being formed at the boundaries between the adjacent inorganic layers by bonding chiral molecules to the inorganic layers via functional groups covalently bonded to asymmetric carbon atoms of the chiral molecules, the perovskite substance comprising two or more types of halide ions.

A composition in which a fullerene derivative is used, the composition having a partial structure represented by general formula (1), containing stereoisomers in mirror-image relationship caused by asymmetric carbon atoms represented by C * in general formula (1), and "1" # imgabs0 # (in formula (1), each CF represents a carbon atom that forms a fullerene skeleton and is adjacent to each other, and C * represents an asymmetric carbon atom).

The present invention addresses the problem of providing: a composition having a large refractive index anisotropy with respect to a radio wave, excellent melting point lowering properties, and a low melting point; and a radio wave control element.　This composition contains two or more liquid crystal compounds. The two or more liquid crystal compounds include a first liquid crystal compound and a second liquid crystal compound that satisfy a relationship in which the Tanimoto similarity is 0.75 or less. At least one of the first liquid crystal compound and the second liquid crystal compound has an asymmetric carbon atom, satisfies the relationship represented by formula (X), and satisfies the relationship represented by formula (Y).