64results about How to "Good for persistence" patented technology

The invention provides a drug-oligomer conjugate having the following general formula:wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently selected from the group consisting of straight or branched PEG polymers having from 2 to 130 PEG subunits, and sugars; L is a lipophilic moiety selected from the group consisting of alkyl groups having 2-26 carbon atoms, cholesterol, adamantane and fatty acids; o is a number from 1 to the maximum number of covalent bonding sites on H; m+n+p together have a value of at least one and not exceeding the total number of covalent bonding sites on D for the -H', -L and -H-L substituents; the H-L bond(s) are hydrolyzable and the D-L' bond(s), when present, are hydrolyzable; the conjugate being further characterized by one of the following: (i) m is 0 and p is at least 1; (ii) n is 0 and p is at least 1; (iii) m and n are each 0 and p is at least 1; (iv) p is 0 and m and n are each at least 1. The therapeutic drug moiety is preferably a therapeutic protein or peptide, preferably insulin or a functional equivalent thereof.

The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two independent levels by: (1) removing sole dependence on balanced lethal maintenance functions; and (2) incorporating at least one plasmid partition function to prevent random segregation of expression plasmids, thereby enhancing their inheritance and stability. The Plasmid Maintenance System may be employed within a plasmid which has been recombinantly engineered to express a variety of expression products.

The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.

The present invention provides microcapsules with favorable speed, intensity and persistence of the release of foreign substances encapsulated inside microorganism cells. The present invention also provides a manufacturing method of a microcapsule and an oral composition containing the microcapsule. The microcapsules having at least one foreign substance enclosed in microorganism cells onto whose surfaces are adhered at least one member selected from the group consisting of saccharides, high-intensity sweeteners, proteins and polyhydric alcohols.

The invention relates to a medical waste management weight verification method. The method performs weight management on medical wastes from a generation point to a final disposal point through relay nodes at various levels, weighs the medical wastes at the generation point, pastes a waste information Label, uploads initial weight information to a cloud management platform, reweighs the medical wastes during in-warehouse and out-warehouse processes at the relay points and the disposal points, and enables the cloud management platform match and verify the weight and the initial weight of the medical wastes. The method controls the entire life cycle of the medical wastes from generation to disposal, performs weight control and repeated verification in the whole process of production, storage, transportation and disposal so as to prevent leaks, enhance the safety of a closed-loop system, and eliminates opportunities for criminals to take advantage.

Disclosed herein is a method for preparing a liquid chemical for forming a water-repellent protective film, the liquid chemical being for forming the water-repellent protective film at the time of cleaning a wafer having at its surface an uneven pattern and containing silicon element at least at a part of the uneven pattern at least on surfaces of recessed portions of the uneven pattern, the liquid chemical containing a nonaqueous organic solvent, a silylation agent, and an acid or a base. The method includes (i) adjusting a water content of the nonaqueous organic solvent to 200 mass ppm or less by dehydration; and (ii) mixing the nonaqueous organic solvent, the silylation agent, and the acid or the base after the adjusting step.

A granular slow-release nitrogenous fertilizer which is less in the release velocity of a nitrogen component than a conventional granular slow-release nitrogenous fertilizer and which is excellent in long-term persistence and the sustained releasability of the nitrogen component. The granular slow-release nitrogenous fertilizer is prepared by granulating a mixture of a urea-aldehyde condensate and an oxidized wax. The content of the oxidized wax is preferably three to 25 weight percent and more preferably five to 15 weight percent. The oxidized wax contains polar groups and therefore has extremely excellent compatibility with the urea-aldehyde condensate. Therefore, the urea-aldehyde condensate, which is sparingly soluble, is extremely uniformly dispersed in the granular slow-release nitrogenous fertilizer according to the present invention; hence, the release velocity of the urea-aldehyde condensate into soil is low.

The present disclosure provides a safety tire having a puncture-resistant, bulletproof, and leakproof capability between about −45° C. to about 120° C. without any damaging process to the inside wall of the tire, but just by spray coating a layer of leakproof and hermetically-repairing macromolecular material with a thickness of about 2 mm to about 8 mm to the inside wall of the tire that does not have an inner tube. The present disclosure also provides the components of the leakproof and hermetically-repairing macromolecular material and the method to prepare the puncture-resistant bulletproof and leakproof safety tires.

Provided are a Gemini-type alkyl-polyoxyalkylene-modified silicone suitable for use in preparing a silicone emulsion; a production method of thereof; and a defoaming agent composition containing such Gemini-type alkyl-polyoxyalkylene-modified silicone.The Gemini-type alkyl-polyoxyalkylene-modified silicone is expressed by the following general formula (A):wherein each of R1, R2, R3, R4, R5 and R6 represents an alkyl group or the like; n represents an integer of 0 to 300; and (B) represents a group expressed by the following general formula (1) or general formula (2):wherein each of R7 and X represents a hydrocarbon group; R8 represents a hydrogen atom, a hydrocarbon group, a formyl group or an acyl group; and a and b represent numbers satisfying 2≦a≦200 and 0≦b≦200, provided that a+b=2 to 200.

An antifogging article having a high antifogging property and being excellent in persistence of the antifogging property is provided. The antifogging article having a substrate and a water absorbing layer on a surface of at least a part of the substrate, wherein the water absorbing layer comprises a cured epoxy resin as a main body, obtained by reacting a polyepoxide and a curing agent, and a surfactant having an HLB within a range of 6 to 18, the HLB being calculated by a Griffin method.

[Problem] To provide a method for preparing a protective film-forming liquid chemical, in a method for producing a wafer having at its surface an uneven pattern and containing silicon element at least at a part of the uneven pattern. The liquid chemical forms a water-repellent protective film on the uneven pattern of the wafer and improves a cleaning step which tends to induce a pattern collapse, and particularly provides a good persistence (pot life) of the improving effect.[Solution] A method for preparing a liquid chemical for forming a water-repellent protective film, the liquid chemical being for forming a water-repellent protective film at the time of cleaning the wafer at least on surfaces of recessed portions of the uneven pattern, the liquid chemical containing a nonaqueous organic solvent, a silylation agent, and an acid or base. The method for preparing a liquid chemical for forming a water-repellent protective film is characterized by including:a dehydrating step for adjusting a water content of the nonaqueous organic solvent to 200 mass ppm or less; anda mixing step for mixing the nonaqueous organic solvent, the silylation agent, and the acid or base after the dehydrating step.

An object of the present invention is to provide a method of fixing an antibacterial agent, by which method it is possible to impart articles of a wide range of materials with excellent antibacterial property and good persistence of antibacterial activity. Specifically, the method of fixing an antibacterial agent, comprises the steps of:subjecting a surface of an article to a surface treatment of providing the surface with oxygen-containing functional groups; and thensubjecting the article to a treatment using an antibacterial agent composition including a silicon-containing compound (a) represented by general formula (1) below.wherein R1 represents a hydrocarbon group having 6 or more carbon atoms, R2 and R3 represent lower hydrocarbon groups, respectively, which hydrocarbon groups may be the same or different from each other, R4 represents a divalent lower hydrocarbon group, R5, R6 and R7 represent lower alkyl groups or lower alkoxy groups, respectively, which may be the same or different from each other, and X represents a halogen ion or an organic carbonyloxy ion, or alternatively, first treating the article by using the antibacterial agent composition; and then subjecting the article to a 1-10 GHz microwave irradiation treatment in a state where the antibacterial agent composition remains on the surface of the article.

The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two independent levels by: (1) removing sole dependence on balanced lethal maintenance functions; and (2) incorporating at least one plasmid partition function to prevent random segregation of expression plasmids, thereby enhancing their inheritance and stability. The Plasmid Maintenance System may be employed within a plasmid which has been recombinantly engineered to express a variety of expression products.

The present invention relates to the use, as active ingredient, of a 1-N-(halo-3-pyridylmethyl)-N-methylamino-1-alkylamino-2-nitroethylene derivative for preparing a veterinary pharmaceutical composition for topical use in the treatment of external parasites, in particular fleas, in domestic animals, in particular in dogs and cats, intended to be applied at least every 2 weeks.

Provided is a dentifrice composition containing erythritol, which is excellent in storage stability and the persistence of a cool feeling and gives a higher refreshing feeling. The dentifrice composition comprises: (A) 15 to 50 weight % of erythritol having a particle size of less than 355 μm; (B) 10 to 40 weight % of water; and (C) 0.6 to 3 weight % of a binder.

The invention provides novel (2S)-2-ethylphenylpropanoic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor (PPAR) α to activate and exhibit lipid-lowering effect, inhibitory effect on the arteriosclerosis, antiobesity effect, blood glucose-lowering effect, etc., their addition salts, and their medicinal compositions. (2S)-2-Ethylphenylpropanoic acid derivatives represented by a general formula (1) [wherein R1 denotes a halogen atom or trifluoromethyl group, R2 denotes a hydrogen atom, halogen atom or trifluoromethyl group, and, when R2 denotes a hydrogen atom, R3 denotes a halogen atom or trifluoromethyl group and, when R2 denotes a halogen atom or trifluoromethyl group, R3 denotes a hydrogen atom, halogen atom or trifluoromethyl group], and their addition salts.

The present invention relates to a defoamer oil compound that contains an organopolysiloxane (A), a fine silica powder (B), and a group (C) that is represented by the organopolysiloxanes of formulas (I) and / or (II)(in the formulas, c, d, and e are each an integer of 0 or more, and at least one of X1 to X3 is the group represented by formula (i)). The component (C) is used as a surface treatment agent for the component (B). The present invention makes it possible to obtain a silicone-based defoamer composition that imparts good initial defoaming properties even in an alkaline foaming liquid, that exhibits very little loss in performance over time, and that has excellent defoaming performance.

A cooling agent composition includes a methyl menthol derivative represented by the following general formula (1). In the formula (1), a symbol * indicates an asymmetric carbon atom, X represents a hydrogen atom or a substituent, and Y represents an aryl group having 6 to 20 carbon atoms which may have a substituent.

Embodiments of the disclosure include methods and compositions for producing NKT cells effective for immunotherapy and also methods and compositions for providing an effective amount of NKT cells to an individual in need of immunotherapy. In specific embodiments, the NKT cells are CD62L+ and have been exposed to one or more costimulatory agents to maintain CD62L expression. The NKT cells may be modified to incorporate a chimeric antigen receptor, in some cases.

The present invention provides a transfer member containing a polyimide resin and carbon black. The carbon black has a pH value of no more than 5 and a volatile component of at least 3.5%, and the content of carbon black is 22 to 30 parts by weight relative to 100 parts by weight of the polyimide resin. The invention also provides a method for manufacturing a transfer member comprising the steps of: dividing a poly(amic acid) resin solution containing carbon black into plural portions, and mixing the divided solutions by allowed the solutions to collide with each other at a pressure of at least 150 MPa; and forming a transfer member containing the polyimide resin using the poly(amic acid) resin solution, which has the carbon black mixed therein. The invention further provides an image forming apparatus using the transfer member above.

The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.

Disclosed is a pest repellent that has excellent heat resistance and solvent resistance, that can be kneaded into a resin molded article or a synthetic fiber, and that has excellent durability and persistence for which a pest repellent effect is sustained for a long period even when it is used for a long period or washed. A durable pest repellent that has both high heat resistance and persistence has been accomplished by supporting on a specific layered silicate a pest repellent chemical containing as an essential component at least one selected from N,N-diethyl-m-toluamide, 1-piperidinecarboxylic acid-2-(2-hydroxyethyl)-1-methylpropyl ester, and N,N-diethyl-m-toluamide and 1-piperidinecarboxylic acid-2-(2-hydroxyethyl)-1-methylpropyl ester.

UV-photoprotective, topically applicable cosmetic / dermatological compositions contain:(a) at least one silicon-containing s-triazine substituted with two aminobenzoate or aminobenzamide groups of specific formula (I),and (b) at least one non-silicon-containing lipophilic 1,3,5-triazine compound UV-screening agent, such compositions having improved photoprotective effectiveness in the UV-B range and the 1,3,5-triazine compound(s) being improvedly soluble therein.

A dip-forming composition of the present invention comprises a dip-forming latex containing a copolymer obtained by copolymerizing 100 parts by weight of a monomer mixture containing 70 to 85 parts by weight of a conjugated diene monomer, 10 to 28 parts by weight of an aromatic vinyl monomer, 2 to 5 parts by weight of an ethylenically unsaturated acid monomer and 0 to 18 parts by weight of other monomer copolymerizable with these monomers, said copolymer having a toluene insoluble content of 30% by weight or more and a toluene swelling degree of 70 times or less; and a vulcanizing agent, a vulcanization accelerator and zinc oxide which are blended in said latex in amounts of 0.5 to 2 parts by weight, 0.25 to 1 part by weight and 0.5 to 1 part by weight, respectively, on the basis of 100 parts by weight of a solid content of the latex. There can be provided a dip-formed article exhibiting an excellent touch and feel, sufficient tensile strength and elongation at break and an excellent persistence of close fitting, as well as a dip-forming composition capable of providing such a dip-formed article.

Disclosed is a high-solid antifouling paint composition characterized by including:(A) a carboxyl group-containing copolymer that has a structural unit derived from an unsaturated carboxylic acid monomer (a1) and a structural unit derived from an other unsaturated compound monomer (a2) copolymerizable with the unsaturated carboxylic acid monomer (a1), and has a weight average molecular weight of 1,000 to 6,000 as measured with GPC,(B) a polyvalent metal compound capable of reacting with the carboxyl group of the carboxyl group-containing copolymer (A), and(C) an antifouling agent.The high-solid antifouling paint composition of the present invention provides an antifouling coating film that imposes less environmental burden, affects human bodies less, and has excellent antifouling performance, excellent persistence thereof and excellent mechanical strength.

American ryegrass varieties and seed used to produce the grass are provided. The grass is useful as a short lived, improved turfgrass on golf courses, athletic fields and other areas using seeded turfgrasses. The grass is useful in overseeding of dormant warm season grasses since its lack of heat tolerance allows for a smooth transition for the warm-season grass. The grass will provide a green cover during the winter months but will die out when the temperatures increases to the point which allow the warm-season grass to grow. In more temperate climates American ryegrass will provide a permanent turf more cold tolerance, with good winter color, and better drought tolerance and persistence than perennial ryegrass.

Provided is an immersion oil for microscope including a liquid olefin polymer (A), a liquid diene polymer (B), a diaryl alkane (C), and an alkyl benzene (D), the immersion oil for microscope being capable of maintaining low fluorescence of its own over a long period of time, having good characteristics required for an immersion oil for microscope, such as good refractive index, Abbe number, viscosity, and resolution, and being particularly suitable as an immersion oil for a fluorescence microscope.