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Method of fixing antibacterial agent and article obtained by the method

a technology of antibacterial agent and antibacterial composition, which is applied in the direction of cationic surface active compounds, metallic material coating processes, medical preparations, etc., can solve the problems of reducing cleaning performance, unable to disclose the composition itself containing the aforementioned antibacterial components, and the antibacterial agent cannot prevent the formation of denture plaque at the surface of artificial teeth. , to achieve the effect of excellent antibacterial property and good antibacterial activity

Active Publication Date: 2014-10-14
HIROSHIMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention allows for a compound with silicon to be fixed onto a wide range of materials, including synthetic resin-based articles. This results in the article having effective antibacterial properties that persist over a long period of time. The technical effect is that a variety of materials can now be provided with long-lasting antibacterial activity.

Problems solved by technology

Further, there is a problem in the prior art that, although an acidic denture (artificial tooth) cleaner is preferable for removal of denture plaque, most of denture cleaners are adjusted to exhibit neutral pH, thereby inevitably decreasing cleaning performance thereof, because an acidic denture cleaner causes a gum material to be deformed and / or discolored and a metal material to be blackened.
However, JP 2004-209241 fails to disclose an antibacterial agent composition itself containing the aforementioned antibacterial components.
However, in the case of the conventional antibacterial agent, there is a problem that, although dental materials such as artificial tooth, implant, crown, bridge, orthodontic bracket, and dental wire can be cleaned by using the antibacterial agent, the antibacterial agent cannot prevent denture plaque from being formed again at a surface of an artificial tooth during use of the artificial tooth fixed inside a mouth cavity.

Method used

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  • Method of fixing antibacterial agent and article obtained by the method
  • Method of fixing antibacterial agent and article obtained by the method
  • Method of fixing antibacterial agent and article obtained by the method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0086]In the present Example, it was investigated how antibacterial property and persistence of antibacterial activity of an article having an antibacterial agent fixed thereon is affected by conducting a pretreatment with ozone water or microwave irradiation (a microwave oven) prior to carrying out the antibacterial agent fixing treatment using an antibacterial agent composition.

[0087](Material)

[0088]A test piece of 10×10×0.2 mm acryl plate was used as an article on which an antibacterial agent was fixed. A strain GDH18 of Candida Albicans was used as the bacteria for the antibacterial property test. The bacteria was incubated on Sabouraud agar for 18 hours and then a bacteria solution having bacteria concentration of 1×106 cells / mL was prepared using ultra pure water (MQ water).

[0089](Ozone Water Treatment)

[0090]Test pieces as 1×1 cm acryl plates were immersed for 5, 10, 15 minutes, respectively, in approximately 30 mL of ozone water (0.4 to 0.6 ppm) produced by “Ozone Dash” manuf...

example 2

In the present Example, the relationship between duration of the ozone water pretreatment and antibacterial performance and persistence of antibacterial activity in an article having an antibacterial agent fixed thereon was analyzed.

[0100](Material)

[0101]Test pieces each having a dimension of 10×10×0.2 mm were prepared using acrylic resin for denture base (the product name “Acron MC”, manufactured by GC Corporation), which acrylic resin was polymerized according to the conventional manner. A surface firmly attached on glass, of the test piece, was used as a test surface. A strain GDH18 of Candida Albicans was used as the bacteria for use in the antibacterial property test. The bacteria was incubated on Sabouraud agar for 18 hours and a bacteria solution having bacteria concentration of 1×106 cells / mL was prepared using ultra pure water (MQ water).

[0102](Ozone Water Treatment)

[0103]The test pieces were immersed for 0, 1, 3, 5, 10 minutes, respectively, in approximately 30 mL of ozone...

example 3

[0109]In the present Example, it was investigated how the ozone water treatment and use of the antibacterial agent composition containing cationic surfactant or amphoteric surfactant affect antibacterial property and persistence of antibacterial activity of an article.

[0110](Material)

[0111]A hemocytometer cover glass was used as a test piece of an article on which an antibacterial agent is fixed. A strain GDH18 of Candida Albicans was used as the bacteria for use in the antibacterial-property test. The bacteria was incubated on Sabouraud agar for 18 hours and a bacteria solution having bacteria concentration of 1×106 cells / mL was prepared using ultra pure water (MQ water).

[0112](Ozone Water Treatment)

[0113]The test pieces were immersed for 1 minute in approximately 30 mL of ozone water (0.4 to 0.6 ppm) produced by using ultra pure water and “Ozone Dash” manufactured by Ozone Total System Co., Ltd. The test pieces were then drained on a filtering paper and immersed for 5 minutes in f...

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Abstract

An object of the present invention is to provide a method of fixing an antibacterial agent, by which method it is possible to impart articles of a wide range of materials with excellent antibacterial property and good persistence of antibacterial activity. Specifically, the method of fixing an antibacterial agent, comprises the steps of:subjecting a surface of an article to a surface treatment of providing the surface with oxygen-containing functional groups; and thensubjecting the article to a treatment using an antibacterial agent composition including a silicon-containing compound (a) represented by general formula (1) below.wherein R1 represents a hydrocarbon group having 6 or more carbon atoms, R2 and R3 represent lower hydrocarbon groups, respectively, which hydrocarbon groups may be the same or different from each other, R4 represents a divalent lower hydrocarbon group, R5, R6 and R7 represent lower alkyl groups or lower alkoxy groups, respectively, which may be the same or different from each other, and X represents a halogen ion or an organic carbonyloxy ion, or alternatively, first treating the article by using the antibacterial agent composition; and then subjecting the article to a 1-10 GHz microwave irradiation treatment in a state where the antibacterial agent composition remains on the surface of the article.

Description

[0001]This application is a National Stage Application of PCT / JP2009 / 058229, filed 21 Apr. 2009, which claims benefit of Serial No. 2008-123450, filed 9 May 2008 in Japan and which applications are incorporated herein by reference. To the extent appropriate, a claim of priority is made to each of the above disclosed applications.TECHNICAL FIELD[0002]The present invention relates to a method of fixing an antibacterial agent, by which not only excellent antibacterial properties and good persistence of antibacterial effect but also excellent cleaning properties can be imparted to an article. The present invention also relates to an article obtained by the method of fixing an antibacterial agent.PRIOR ART[0003]As population of our society is aging, the number of people using dental materials, in particular, dentures is increasing and an amount of use of denture cleaners is increasing accordingly. Currently, denture cleaners of various compositions are being used. Further, as people's co...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K33/40
CPCC11D3/48A01N55/00C11D1/62C11D3/162A01N25/24A01N25/30A01N25/34A01N33/12A01N2300/00A61K8/41
Inventor NIKAWA, HIROKI
Owner HIROSHIMA UNIVERSITY
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