626results about How to "Increased persistence" patented technology

Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first nucleic acid molecule and at least one second nucleic acid molecule. The second nucleic acid molecule encodes a transcription factor or a translation factor or a transcription factor and a translation factor. The contemporaneous expression can be from operably linking the first and second nucleic molecules to a single promoter, or from operably linking the first nucleic acid molecule to a first promoter and the second nucleic molecule to a second promoter wherein the first and second promoters function substantially contemporaneously. Thus, the first and second nucleic acid molecules can be at the same locus in the vector, or at different loci. The second nucleic acid molecule can encode: one transcription factor or more than one transcription factor; or one translation factor or more than one translation factor; or at least one transcription factor and at least one translation factor. The transcription factor can be from vaccinia H4L, D6, A7, G8R, A1L, A2L, H5R, or combinations thereof. The translation factor can be from a K3L open reading frame, an E3L open reading frame, a VAI RNA, an EBER RNA, a sigma 3 open reading frame, a TRBP open reading frame, or combinations thereof. The vector can be a poxvirus such as an attenuated poxvirus, e.g., NYVAC, or ALVAC.

The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.

The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.

This disclosure provides, for instance subset-optimized CART cells and related methods. For instance, the disclosure describes methods and compositions of CD4′ and CD8′ T cells that express CARs containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused CAR-expressing T cells for treating a subject having a disease, e.g., a cancer.

The invention relates to a plant flower culture medium. The plant flower culture medium is prepared from organic medium composition particles, inorganic medium composition particles, slow release fertilizer efficiency control particles and botanicals. The botanicals are compositions of photoactive toxins and pyrethrin. Compositions formed by evenly mixing air-dried cow dung, tea leaves, pinus massoniana needle decomposed materials, chitosan, plant ash and humus are adopted in the organic medium composition particles. Compositions of perlite, kieselguhr, rare earth and citricacide-titatnium chelate are adopted in the inorganic medium composition particles. Copolymers of medium trace element compounds in chelation of potassium acrylate or poly glutamic acid potassium and amino acid and a plant regulator are adopted in the slow release fertilizer efficiency control particles. The plant flower culture medium has the advantages that environment friendliness, insect prevention and slow release fertilizer efficiency control are achieved, the requirements for nutrient elements for plant flower growth are met, photosynthesis is promoted, the remarkable promotion effect is achieved for the root taking and survival rate of plants, the flowering phase is prolonged, the yield is increased, and very important significance is provided for developing water-saving planting and improving the ecological environment.

A primary alkaline battery includes a cathode including a nickel oxyhydroxide and an anode including zinc or zinc alloy particles. Performance of the nickel oxyhydroxide alkaline cell is improved by adding zinc fines to the anode.

The invention discloses a workpiece stamping intelligent control process. The workpiece stamping intelligent control process controls automatically and satisfies all actions to be operated coherently to effectively improve working efficiency, no manual work is needed, safety is improved and cost is effectively saved. Product quality is guaranteed to enable products to meet market demands. The invention further provides an intelligent control manipulator implementing the process. Through an efficient, accurate, flexible, safe operation mode flexible in design, the intelligent control manipulator is convenient to operate, production efficiency is greatly improved, structural design is reasonable, design mode is flexible, effects are obvious, process persistence is high, raw materials are saved and energy consumption is quite low; a regulation and control type industrial control process satisfies different demands, the structural design enhances smoothness, swing precision is guaranteed, and machining process is guaranteed to be completed automatically, continuously and effectively; and conventional manual or semi-automatic machining modes are replaced, and resources are saved.

An electric marketing metering mobile application system and a work method thereof relate to a metering system. Traditional managing software which can only be used in a local area network of an electric power company greatly restrains site communication and improvement of the service quality. The electric marketing metering mobile application system comprises an upper computer and a portable handheld set. The handheld set is provided with a wireless communication module, a task receiving module, a route planning module, a metering module and a site data uploading module. The upper computer is provided with a BOSS professional system. The BOSS professional system is provided with a mobile operation platform module, a wireless communication module, a task arranging module, a metering data receiving module and an abnormal reason processing module. The technical scheme of the electric marketing metering mobile application system brings convenience to assert managers to quickly process assert managing practice, achieves mobile operation of assert management and removes limit of the site hardware environment.

The invention relates to a solar low-temperature thermal power generation and combined heat and cold supply system, which solves the problems that the lower-temperature solar thermal power generation has lower efficiency, is unsuitable for small-scale application and can not supply electric energy, cold energy, warm air and hot water simultaneously. The system consists of a composite paraboloid heat collector system, a phase-change heat storage system, an organic Rankine cyclic power generating system, an absorption and refrigeration system, a hot water supply system and a warm air supply system which are connected in parallel. An inlet of a steam turbine of the power generating system is communicated with an organic working substance outlet of an evaporator; an outlet of the steam turbine is communicated with a mixer through a heat regenerator; an air suction port of the middle part of the steam turbine is communicated with another end port of the mixer through a pipeline; the other side of the heat regenerator is connected in series with a condenser; a third port of the mixer is communicated with an organic working substance inlet of the evaporator through a pump; and the output end of the steam turbine is connected with a power generator. The system has high operating efficiency and three combined supplies of heat, power and cold, is suitable for small-scale application, is easy to build and low in cost, does not need to consume one-off energy and is favorable for environmental protection.

The invention discloses a human-computer interaction guiding method and device based on artificial intelligence. The method comprises the following steps that S1, interaction information input by a user is received, and a current topic is determined according to the interaction information; S2, multiple to-be-chosen guiding topics which are related to the current topic are obtained on the basis of a topic graph; S3, user image data of the user are obtained; S4, the guiding topic is chosen from the multiple to-be-chosen guiding topics which are related to the current topic according to the user image data and fed back to the user. According to the human-computer interaction guiding method and device based on the artificial intelligence, the current topic is determined by receiving the interaction information input by the user, the multiple to-be-chosen guiding topics which are related to the current topic are obtained on the basis of the topic graph, and then the guiding topic is chosen from the multiple to-be-chosen guiding topics which are related to the current topic by combining the user image data and fed back to the user, so that the sustainability of human-computer interaction is improved, and the human-computer interaction is more fluent and natural.

The invention discloses an SIP (Session Initiation Protocol)-based regional ground-to-air radio station voice networking system which comprises a plurality of ground-to-air radio stations and also comprises a tandem scheduling server, an SIP (Session Initiation Protocol) radio station voice communication terminal and a networking node network element device, wherein the networking node network element device is connected between the tandem scheduling server and the SIP (Session Initiation Protocol) radio station voice communication terminal and connected with the ground-to-air radio stations.The SIP (Session Initiation Protocol)-based regional ground-to-air radio station voice networking system can realizes integration with a ground-to-air data link system and can realize goal-oriented ground-to-air voice command which is compatible and coordinated with ground-to-air data link system; and a commander can synchronously obtain the voice command control capacity when seeing a target. Moreover, a communication link for directly implementing the voice command control on first-line task aircrafts is provided for a remote high-level command center within shorter setup time and in more flexible setup mode so that commands of chief executives can reach the first-line aircrafts immediately and the effect that a link can be uses as long as set up is achieved.

The present invention provides microcapsules with favorable speed, intensity and persistence of the release of foreign substances encapsulated inside microorganism cells. The present invention also provides a manufacturing method of a microcapsule and an oral composition containing the microcapsule. The microcapsules having at least one foreign substance enclosed in microorganism cells onto whose surfaces are adhered at least one member selected from the group consisting of saccharides, high-intensity sweeteners, proteins and polyhydric alcohols.

The invention provides a method for displaying a virtual keyboard, the virtual keyboard and a touch screen terminal. The method comprises the following steps of: receiving sliding information of a user for the virtual keyboard, wherein the virtual keyboard comprises a plurality of parts, and a part of the plurality of parts are displayed in a keyboard display area of a screen; and moving and / or loading the corresponding part in the virtual keyboard according to the sliding information, and displaying the changed part in the keyboard display area of the screen. The application of a panoramic keyboard is provided, unlimited sliding of the user can be accepted, keyboards with different input functions are prevented from being frequently opened and closed by the user in the input process, the problem of interruption when the user switches the keyboards can be solved, the using efficiency of various keyboards is improved, and using smoothness and continuity are improved.

The invention relates to a phase-changed heat insulation polyolefin foam material and a preparation method thereof. The phase-changed heat insulation polyolefin foam material is prepared by carrying out the operations including mixing, melt extrusion, preheating and foaming on raw materials including phase-changed microcapsules, polyolefin resin, a foaming agent, a cross-linking agent, a blowing promoter, a color masterbatch, an antiager and a processing aid. When the temperature is reduced, the phase of the phase-changed material can be changed, heat is released, and thus, the environment temperature is regulated. Meanwhile, a microcapsule technology is adopted, the phase-changed material is used as a capsule core material to be wrapped inside a capsule wall, and thus, the loss of the phase-changed capsule core material from a porous foam material is reduced, and the continuity of a heat insulation effect is improved.

A novel pharmacy messaging system, method and computer program product that leverages healthcare by providing functionality enabling the generation of targeted messages for enhancing the patient's experience while waiting for their prescription to be filled. The invention addresses directly the issue of leveraging healthcare by optimizing the customer time spent waiting to have their prescriptions filled, and particularly, by driving “foot-traffic” to the local pharmacy and successfully transforming patient wait time into a potential revenue generating opportunity for companion products. The pharmacy messaging system delivers targeted messages to patients based on their prescription information and one or more of their demographic, healthcare payor, claims, and past purchase history.

The invention provides a pixel driving circuit and a driving method thereof, a display panel and a display device, is applied to the technical field of display, solves the problem that the voltage retention rate of a capacitor in a conventional pixel driving circuit is insufficient. The pixel driving circuit comprises an energy storage sub-circuit, a reset sub-circuit, a compensation sub-circuit,a driving sub-circuit and an electric leakage suppression sub-circuit, wherein the energy storage sub-circuit is coupled with a first node and a second node; the reset sub-circuit is coupled with thesecond node, a first scanning time sequence signal end and an initialization signal end; the compensation sub-circuit is coupled with the second node, a third node and a second scanning time sequencesignal end; the driving sub-circuit is coupled with the second node, the third node and the first voltage signal end; and the electric leakage suppression sub-circuit is coupled with the energy storage sub-circuit, the reset sub-circuit and the compensation sub-circuit. The electric leakage suppression sub-circuit is configured to suppress electric leakage of the energy storage sub-circuit in theprocess of generating and transmitting the driving signal by the driving sub-circuit. The pixel driving circuit is used in the display device.

Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

The invention discloses an online analysis system for monitoring harmful gases in a livestock and poultry farm. The online analysis system comprises a sampling unit, a purifying unit and an analytic unit connected in turn. Steam with a constant pressure is introduced into the sampling unit, is sent into the purifying unit by an injection pump and then is passed into the gas analytic unit. Through multiple times of filtration and dehumidification treatments, the gasses exhausted by a ventilation opening of the livestock and poultry farm can be stably sampled under various working conditions, and the sampled gasses automatically undergo dust removal, dehumidification drying, pressure and flow stabilization, fine filtration, flow measurement and quantitative analysis. Besides, measurement range calibration and zero point calibration are performed on a gas analyzer through a standard gas connected with the analytic unit to realize online calibration of the analysis system. The invention also discloses an online analysis method for monitoring the harmful gasses in the livestock and poultry farm. Through the online analysis system and the online analysis method, hydrogen sulfide, ammonia gas, carbon dioxide, carbon monoxide and methane exhausted by the ventilation opening of the livestock and poultry farm can be accurately and reliably detected and analyzed online.

Atrial arrhythmias, a major contributor to cardiovascular morbidity, are believed to be influenced by autonomic nervous system tone. The main purpose of this invention was to highlight new findings that have emerged in the study of effects of autonomic nervous system tone on atrial arrhythmias, and its interaction with class III antiarrhythmic drug effects. This invention evaluates the significance of sympathetic and parasympathetic activation by determining the effects of autonomic nervous system using a vagal and stellar ganglions stimulation, and by using autonomic nervous system neurotransmitters infusion (norepinephrine, acetylcholine). This invention evaluates the autonomic nervous system effects on the atrial effective refractory period duration and dispersion, atrial conduction velocity, atrial wavelength duration, excitable gap duration during a stable circuit (such atrial flutter circuit around an anatomical obstacle), and on the susceptibility of occurrence (initiation, maintenance and termination) of atrial re-entrant arrhythmias in canine. This invention also evaluates whether autonomic nervous system activation effects via a local neurotransimitters infusion into the right atria can alter those of class III antiarrhythmic drug, sotalol, during a sustained right atrial flutter. This invention represents an emergent need to set-up and develop a new class of anti-cholinergic drug therapy for the treatment of atrial arrhythmias and to combine this new anti-cholinergic class to antiarrhythmic drugs. Furthermore, this invention also highlights the importance of a local application of parasympathetic neurotransmitters / blockers and a catheter ablation of the area of right atrium with the highest density of parasympathetic fibers innervation. This may significantly reduce the occurrence of atrial arrhythmias and may preserve the antiarrhythmic effects of any drugs used for the treatment of atrial re-entrant arrhythmias.

The present invention is a method of improving the persistence of electrical neural stimulation, and specifically a method of improving the persistence of an image supplied to a retina, or visual cortex, through a visual prosthesis. A continuously stimulated retina, or other neural tissue, will desensitize after a time period in the range of 20 to 150 seconds. However, an interruption of the stimulation on the order of a few milliseconds will restore the retinal sensitivity without the user perceiving the interruption, or with the user barely perceiving the interruption.

Provided are an electric marketing service expansion mobile application system and a work method thereof. . Traditional managing software which can only be used in a local area network of an electric power company greatly restrains site communication and improvement of the service quality. The electric marketing service expansion mobile application system comprises an upper computer and a portable handheld set. The handheld set is provided with a wireless communication module, a task receiving module, a route planning module, a customer information inquiring module, a power grid information inquiring module, a service expansion processing module and a site data uploading module. The upper computer is provided with a BOSS professional system. The BOSS professional system is provided with a mobile operation platform module, a service expansion data receiving module and a work order processing module. The technical scheme of the electric marketing service expansion mobile application system changes an interactive traditional operation method of going back and forth between a site and the BOSS system for many times, achieves space extension and time expansion of marketing service expansion work and improves the work efficiency and the service level again.

The invention discloses a method and system for supporting an urban land utilization and traffic integrated planning policy. The method comprises the following steps of: S1, constructing a land utilization model; S2, constructing a traffic planning demand predicting model; S3, judging a convergence property of a traffic accessibility value according to a traffic accessibility value result and an accessibility convergence index obtained according to the traffic planning demand predicting model, if a result indicates no convergence, executing an S4, and if the result indicates convergence, executing an S5; S4, feeding a result of the traffic planning demand predicting model back to the land utilization model, and returning to the S1 to restart a model computing process; and S5, stopping a cyclic feedback process, meanwhile, evaluating results of each land utilization scheme and each traffic planning scheme in real time when the cyclic feedback process is stopped, and selecting a preferential land utilization and traffic planning scheme. According to the invention, the urban land utilization and traffic planning can be realized automatically according to basic data, and the planning efficiency and the reasonableness, the scientificity and the continuity for planning can be improved.

Provided are chimeric antigen receptors (CARs) having antigen specificity for B-cell Maturation Antigen (BCMA). Also provided are related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs. Methods of treating or preventing cancer in a mammal are also provided.

The invention relates to a synchronous display device and a synchronous display method. The device comprises a synchronous control circuit, more than one mainboards and more than two display cards. Any one of mainboards is inserted with at least one display card. The synchronous control circuit comprises a frame synchronous control circuit and a reference clock generating circuit. A signal output end of the frame synchronous control circuit is connected with a signal input end of each mainboard. A signal output end of the reference clock generating circuit is connected with a clock signal input end of each display card. The frame synchronous control circuit generates a reference frame synchronous signal or uses a frame synchronous signal of a display channel of a preset display card as the reference frame synchronous signal. Each mainboard adjusts the frame synchronous signal of the display channel of the corresponding display card according to the reference frame synchronous signal. The invention adopts the same reference frame synchronous signal and reference clock signal to together complete synchronous display, cannot generate the clock error and also cannot generate the accumulated error among the frame synchronous signals so as to improve accuracy and continuity of synchronization among the display signals.

The invention discloses a minitype intelligent bidirectional self-adaptation grid-connected photovoltaic power generation system, which comprises a photovoltaic battery board matrix and a confluence box, wherein the output end of the output end of the confluence box is connected with a storage battery controller, an inversion / rectification integrated converter and a direct-current load control switch; the storage battery controller and the direct-current load control switch are connected with a storage battery set and a local direct-current load; the output end of a converter is connected with an alternating-current load control switch and an grid-connected controller; the output end of the alternating-current load control switch is connected with a local alternating-current load; each output end is connected with a conversion module; a voltage and current sampling conversion module is connected with a signal modulation circuit; the output end of a signal modulation circuit is connected with a DSP (digital signal processor); and each control end is connected with a PWM (pulse width modulation) interface. A control method of the minitype intelligent bidirectional self-adaptation grid-connected photovoltaic power generation system comprises parameter preparation control, power generation and power supply control. The system and the method have the advantages of good reliability, convenience in installation, operation and maintenance, high stability, strong adaptivity and high solar energy utilization ratio.

The invention discloses an indoor air disinfectant and a preparation method thereof, and relates to the technical field of disinfectants, and the indoor air disinfectant comprises the following raw materials: 45-55 parts of Chinese herbal medicine extract, 35-36 parts of a fungicide, 32-33 parts of plant essential oil, 20-25 parts of an activation particle, 17-19 parts of an assistant and 75-80 parts of deionized water. The indoor air disinfectant is non-toxic and nonirritant, fresh in smell, good in disinfection effect and long lasting in effect.

Transaction handling apparatus for effecting a transaction between a group of purchasers and a vendor. The transaction handling apparatus includes vendor apparatus running a vendor process which displays at least one user operable component associated with a product or service on offer. The transaction handling apparatus also includes server apparatus which stores purchase data comprising identification data identifying each of plural purchasers. The transaction handling apparatus also includes plural client processes and payment processing apparatus which receives payment in respect of each of the client processes and conveys the payments to the vendor in dependence on operation of the client processes. A payment received in respect of a client process forms a part of the price of the product or service. Operation by a user of the user operable component stores product data relating to the product or service, the stored product data being comprised in the purchase data.

The invention discloses a high-performance wickerwork coating which is prepared from the following components: waterborne polyurethane, silicon-acrylate emulsion, dioctyl phthalate, shellac resin, mung bean starch, polyvinyl alcohol, a filler, an antibacterial additive and water. Compared with the existing wickerwork coating, the wickerwork coating disclosed by the invention is high in storage stability and long in coating film service life; compared with the coating film service life of the common wickerwork coating, the coating film service life of the high-performance wickerwork coating is prolonged by twice or triple; a paint layer formed by the coating is touch, high in brightness, high in adhesive force, anti-acid, anti-sulfur, high in salt resistance, stable in performance, and not liable to corrode and discolor; the coating disclosed by the invention is extremely high in high-temperature resistance, high in adhesive force, and not liable to fall off; furthermore, during use, the coating can be quickly dried and is high in leveling property; moreover, the coating is harmless to the environment and a human body, and is environment-friendly.

The invention relates to a drilling and exploiting technology, in particular to a method for exploiting coal bed gas, and aims to solve the problem that stable yield and high yield of coal bed gas cannot be realized by using the conventional coal bed gas exploiting technology. The method for exploiting coal bed gas comprises the following steps: a, drilling a vertical well from the ground to the bottom of a coal bed, drilling a plurality of horizontal holes in a plurality of layers by taking the inner wall of the vertical well in the thickness of the coal bed as a starting point, wherein all the horizontal holes distributed in the plurality of layers are formed radially by taking the vertical well as the center after being staggered in an axial space; the vertical well and the horizontal holes are fully filled with water; b, crack making: putting a combustion device filled with a solid propellant into the vertical well, generating a large amount of high-temperature and high-pressure gas by using rapid combustion of the solid propellant, transmitting pressure and impacting the coal bed through water, and forming three-dimensional netlike irregular cracks on the coal bed; c, injecting a chlorine dioxide blocking remover into the horizontal holes; d, exploiting the coal bed gas from the well mouth of the vertical well on the ground. The method is reasonable in design, and the exploitation quantity of the coal bed gas is increased.