314results about How to "Easy to functionalize" patented technology

Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non-specific interaction, adsorption or attachment of molecular or ionic components present in an analyte solution. Chemical, biochemical or biological groups that are able to recognize, interact with and bind specifically to target molecules in the material containing the analyte to be detected can be coupled to, integrated into, or absorbed to the multifunctional copolymers. These multifunctional copolymer coatings are compatible with a variety of different established methods to detect, sense and quantify the target molecule in an analyte. The multifunctional copolymer coatings typically include brush copolymers based on a polycationic or polyanionic (jointly referred to herein as ‘polyionic’) backbone with side chains that control interaction with the environment, such as poly(ethylene glycol) or poly(ethylene oxide)-based side chains that decrease cellular adhesion, and analyte-specific side chains. They can be used to pattern the surfaces into non-adhesive and specifically adhesive areas by applications of known techniques such as microfluidic or contact printing techniques.

The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.

The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material.

The present invention is generally directed to methods of functionalizing carbon nanotubes (CNTs) in acidic media. By first dispersing CNTs in an acidic medium, bundled CNTs can be separated as individual CNTs, affording exposure of the CNT sidewalls, and thereby facilitating the functionalization of such CNTs, wherein functional groups are attached to the subsequently exposed sidewalls of these individualized CNTs. Once dispersed in this substantially unhundled state, the CNTs are functionalized according to one or more of a variety of functionalization processes. Typically, ultrasonication or non-covalent wrapping is not needed to afford such dispersion and subsequent functionalization. Additionally, such methods are easily scalable and can provide for sidewall-functionalized CNTs in large, industrial-scale quantities.

The invention discloses a preparation method for a graphene fiber and belongs to the field of graphene fiber preparation. The preparation method comprises the following steps: firstly, preparing 2-20 mg.mL<-1> purified graphene oxide solution by using an oxidation stripping graphite method; secondly, injecting the graphene oxide solution in the first step in a pipeline reactor with the inside diameter of 0.1-10 mm and sealing; thirdly, heating the pipeline reactor at the temperature of 100-300 DEG C for 1-6 hours and reducing and assembling the graphene oxide into a water-containing graphene oxide fiber; and fourthly, drying the water-containing graphene fiber obtained in the third step at the temperature of 20-60 DEG C and dehydrating and contracting the water-containing graphene fiber to obtain dry graphene fiber. The preparation method is simple in operation process and low in raw material cost; and the graphene fiber obtained by the method disclosed by the invention has the advantages of uniform structure, excellent mechanical property and easiness in functionalization.

The invention relates to a preparation method of an aramid fiber nanofiber aerogel, in particular to a preparation method of the aerogel. The invention aims to solve the problems of poor mechanical strength and poor heat resistance of an existing aerogel. The preparation method comprises the steps of (1) extracting; (2) preparing a dark red aramid fiber nanofiber solution; (3) preparing an aramid fiber nanofiber hydrogel; (4) carrying out vacuum filtration and cleaning; (5) freeze drying to obtain the aramid fiber nanofiber aerogel. According to the aramid fiber nanofiber aerogel prepared through the preparation method provided by the invention, the temperature of primary thermal decomposition is 500 DEG C, so that the aramid fiber nanofiber aerogel can be used in a temperature interval ranging from 200 DEG C to 500 DEG C for a long time; the tensile strength of the aramid fiber nanofiber aerogel prepared through the preparation method provided by the invention reaches to 230 MPa. The invention discloses the preparation method of the aramid fiber nanofiber aerogel.

The present invention relates to a photoresist composition comprising a photoacid generator and at least one novel polymer comprising at least one unit as described by structure 1, where, either (i) R1 is an aliphatic cyclic unit of a polymer, R2 is selected from H, F, (C1-C8)alkyl, (C1-C8)fluoroalkyl, cycloalkyl, cyclofluoroalkyl, and (CR3R4)p(CO)OR5, and Rf is selected from F, H, (C1-C8)alkyl, or a fully or partially fluorinated alkyl, and cyclofluoroalkyl, or (ii) R1 and R2 combine to form an aliphatic cyclic unit of a polymer, and Rf is selected from F, H, (C1-C8)alkyl and a fully or partially fluorinated alkyl, and cyclofluoroalkyl, or (ii) R1 and Rf combine to form an aliphatic cyclic unit of a polymer, and R2 is selected from H, F, (C1-C8)alkyl, (C1-C8)fluoroalkyl, cycloalkyl, cyclofluoroalkyl, and (CR3R4)p(CO)OR5; and, R3 and R4 are independently H, F, (C1-C8)alkyl, (C1-C8)fluoroalkyl, cycloalkyl, cyclofluoroalkyl, (CR3R4)p(CO)OR5, R3 and R4 may combine to form an alkylspirocyclic or a fluoroalkylspirocyclic group, X is selected from (C1-C8)alkylene, (C1-C8)fluoroalkylene, O(C1-C8)alkylene, O(C1-C8)fluoroalkylene, cycloalkyl and fluorinatedcycloalkyl, R5 is H or an acid labile group, m=0-1, and p=1-4. The invention also relates to a process for imaging the photoresist composition of the present invention.

This invention is based upon the discovery that rubbery polymers having a high vinyl content and a low degree of branching can be synthesized with an initiator system that is comprised of (a) a lithium initiator selected from the group consisting of allylic lithium compounds and benzylic lithium compounds, (b) a Group I metal alkoxide, and (c) a polar modifier; wherein the molar ratio of the Group I metal alkoxide to the polar modifier is within the range of about 0.1:1 to about 10:1; and wherein the molar ratio of the Group I metal alkoxide to the lithium initiator is within the range of about 0.01:1 to about 20:1. These high vinyl polymers offer reduced levels of hysteresis and better functionalization efficiency.

A method of making a facile, surface-independent, polyphenol coating is disclosed. In general, the method includes contacting at least a portion of the substrate to be coated with an aqueous solution containing one or more salts and one or more nitrogen-free phenolic compounds. Substrates of all kinds may be used, and compounds used to make the coating may include epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC) and epicatechin-3-gallate (ECG), tannic acid, gallic acid, pyrogallol, and/or other nitrogen-free phenolic compounds. The coating made using the method, methods of using the coating, and kits comprising the coating precursors are also disclosed.

The invention discloses a capture sieve and a device for capturing cells or biomolecules in solutions. The capture sieve comprises a net-shaped base body and a capture layer formed on the net-shaped base body, wherein the capture layer comprises capture matter which can be in specific binding with target cells or biomolecules. The capture sieve and the device provided by the invention have high specificity and high flux, are suitable for capturing the cells or capturing the biomolecules in the solutions by adopting the molecules expressed by the cells, and are particularly suitable for capturing and sorting circulating tumor cells.

The invention relates to a method of forming a polyphenylene ether resin containing residual aliphatic unsaturation. A polyphenylene ether is reacted with a capping agent in a solvent to form the polyphenylene ether resin containing residual aliphatic unsaturation, which is precipitated from solution by combining the solution with an antisolvent. The precipitated polyphenylene ether resin containing residual aliphatic unsaturation has lower levels of residual impurities than the same compound isolated by devolatilization.

The invention discloses a preparation method and application of a three-dimensional graphene electrode for an electrochemical biosensor. The preparation method comprises the following steps of: fixing spongy graphene in which industrially produced foam nickel is taken as a substrate and which has a three-dimensional structure and is synthesized through chemical vapor deposition on a glass or quartz sheet; connecting the spongy graphene with the three-dimensional structure and a wire by using a silver conductive adhesive; and coating organic silica gel on a connection point of the metal wire and the graphene for insulation to obtain a spongy graphene electrochemical electrode with the three-dimensional structure. The three-dimensional spongy graphene electrode has the outstanding characteristics of high conductivity, high specific surface area, high electrochemical stability and the like, is easily subjected to surface functional modification, and has high detection sensitivity to dopamine and nicotinamide adenine dinucleotide; and a highly sensitive electrochemical biosensor for non-enzymatically and selectively detecting glucose can be obtained after the surface of the electrode is modified by Co3O4.

The present invention relates to a photoresist composition comprising a photoacid generator and at least one polymer comprising at least one unit as described by structure 1, The invention also relates to a process for imaging the photoresist composition of the present invention, and to a process of making the polymer in the presence of an organic base.

The invention discloses a fluorine-containing alkoxy ring triphosphonitrile derivative and a preparing method thereof, belonging to the technical field of macromolecule synthesis and textile finishing, and the derivative is used for a multifunctional finishing agent of textile. The method takes fluorine-containing alcohol as a material for reacting with hexachlor ring triphosphonitrile for substitution to synthesize the fluorine-containing alkoxy ring triphosphonitrile derivative; and the fluorine-containing alkoxy ring triphosphonitrile derivative is emulsified by choosing a suitable emulsifier and optimizing emulsion formula, thus obtaining the multifunctional finishing agent of textile with good stability. By adopting the finishing process of rolling-baking-toasting, the textile after finishing has not only good flame-retardant finishing effect but also certain water proof and oil proof effect owning to the introduction of fluoride in the phosphonitrile flame retardant.

The invention discloses light-cured 3D (three-dimensional) printing photosensitive resin which is prepared from, by weight, 2-10 parts of functional monomer, 5-10 parts of photo-initiators, 40-50 parts of low polymer, 20-50 parts of activated diluents and 1-30 parts of additives. The invention further discloses a preparation method and an application of the light-cured 3D printing photosensitive resin. The light-cured 3D printing photosensitive resin can simply realize surface functional modification of a light-cured 3D printing component. The light-cured 3D printing photosensitive resin is prepared by the aid of a light-cured 3D printing component manufacturing method based on easy modifiability of poly-pyrocatechol amine compounds. The surface of the obtained light-cured 3D printing photosensitive resin is provided with an easily modified polymer layer, various surface functional modification can be realized without destroying functionality of original materials, and a modified layer and a body are good in bondability.

The invention discloses a two-component PU (polyurethane) coating. Firstly, castor oil is used for cross-linking prepolymers: a multifunctional group structure in the castor oil can cross-link the polymers to a certain extent, the cross-linking degree of the polymers is increased, so that the interaction force among molecular chains is increased, motion of the molecular chains is hindered, water molecules can hardly enter the molecular chains to enable the polymers to swell, and the water absorption of a film is reduced; meanwhile, the castor oil is a triglyceride of fatty acid, the film has the good hydrophobicity due to long nonpolar fatty acid chains in molecules of the castor oil, and the water absorption is further reduced; besides, ester groups in the castor oil have higher cohesive energy, so that the tensile strength of the film can be enhanced; ethyl cellulose has better heat resistance and thermoplasticity, has good compatibility with PU and can improve the comprehensive performance of the prepolymers; then blending modification is performed on the PU prepolymers and polysilsesquioxane.

The invention discloses a preparation method of phenolphthalein polyether sulfone containing a tertiary amine side group, which comprises the following steps of: (a) adding a halogenated organic matter monomer or a nitrified organic matter monomer, a catalyst and a solvent into a prepared phenolphthalein bisphenol monomer containing the tertiary amine side group to form a mixed solution; and (b) leading the mixed solution to react at 80-220 DEG C. The invention also discloses a phenolphthalein polyether sulfone homopolymer containing the tertiary amine side group and a phenolphthalein polyether sulfone copolymer containing the tertiary amine side group. The phenolphthalein or the phenolphthalein polyether sulfone is adopted as a raw material to generate substitution reaction with asymmetric amine to obtain the phenolphthalein polyether sulfone containing the tertiary amine side group. Because a tertiary amine group is a polar group and has higher hydrophily, the application limitation of the phenolphthalein polyether sulfone is overcome, and particularly, the adverse effect of the phenolphthalein polyether sulfone used as an ultrafiltration membrane or a reverse osmosis support base membrane applied to water treatment is eliminated. Meanwhile, the tertiary amine group has higher activity, is easy to convert into other groups, such as a quaternary amine group, and the like, and is beneficial to the further functionalization of the phenolphthalein polyether sulfone and the modification of a polyether sulfone product.

The invention discloses an easy-to-wash PVDF (polyvinylidene fluoride) ultrafiltration membrane and a preparation method thereof. The preparation method comprises the following steps: with triethyl phosphate as a solvent, ultrasonically dispersing a certain amount of poly N-isopropylacrylamide modified attapulgite in the solvent, adding PVDF powder and stirring violently till the PVDF powder is dissolved, adding a pore-foaming agent, namely polyethylene glycol, and uniformly stirring, and finally standing for defoaming to obtain a membrane casting solution; with water as a coagulating bath, preparing the ultrafiltration membrane by using an immersion precipitation phase conversion method. By introducing the poly N-isopropylacrylamide modified attapulgite into the PVDF ultrafiltration membrane, the unique nano-fiber structure of the attapulgite and the three-dimensional net structure formed by PVDF can be used to effectively improve the structure and strength of a pure PVDF ultrafiltration membrane, and the high hydrophilicity of the attapulgite is used to improve the permeability and hydrophilicity of the membrane; meanwhile, the ultrafiltration membrane also has the temperature sensitivity of poly N-isopropylacrylamide, and anti-pollution and easy-to-wash properties are realized.

The invention relates to a chip of a surface plasmon resonance instrument which is based on polyethylene glycol and a preparation method. The chip comprises a glass film base and a gold plating film on the glass film base; wherein the gold plating film is provided with an initiator layer which is introduced in the way of self-assembly and a functionalized polyethylene glycol layer which is combined with the initiator layer. The invention uses a quartz crystal microbalance to monitor the growth of the film at the surface of the chip at real time and the chip of the invention effectively solves the problem of non-specific absorption of protein. As the surface ornament of the chip is not limited to traditional carboxylic dextran, the density and types of the functional groups at the chip surface are no longer strictly restricted. Furthermore, the chip of the invention also has good performance in terms of the specificity maintenance and quality control of biological signaling molecule and so on. The preparation method of the chip of the invention has few steps and the low manufacturing cost and is more suitable for industrial production. The chip has more potential of deep development and more superior generality.

The invention discloses a method for capturing cells or biomolecules. The method comprises the following steps: (I) enabling a medium containing target cells or biomolecules to enter a device comprising a capturing mechanism for capturing the target cells or biomolecules; (II) enabling the medium to flow through the capturing mechanism so that the target cells or biomolecules are bound to the capturing structure; (III) removing the needless impurities, cells or molecules which are not specifically bound to the capturing mechanism; (IV) enabling the target cells or biomolecules to be separated from the capturing mechanism; and (V) collecting the target cells or biomolecules. The capturing mechanism comprises one or more stacked capturing sieves, wherein each capturing sieve comprises a net-shaped base body and a capturing layer formed on the net-shaped base body, and the capturing layer contains capturing matter which can be in specific binding with the target cells or biomolecules. The method disclosed by the invention has high specificity and high flux, is suitable for capturing the cells or capturing the biomolecules in the solutions by adopting molecules expressed by cells, and is particularly suitable for capturing and sorting circulating tumor cells.