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Multifunctional polymeric surface coatings in analytic and sensor devices

InactiveUS6884628B2Low expenseOptical clarityImmobilised enzymesBioreactor/fermenter combinationsIonNon specific
Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non-specific interaction, adsorption or attachment of molecular or ionic components present in an analyte solution. Chemical, biochemical or biological groups that are able to recognize, interact with and bind specifically to target molecules in the material containing the analyte to be detected can be coupled to, integrated into, or absorbed to the multifunctional copolymers. These multifunctional copolymer coatings are compatible with a variety of different established methods to detect, sense and quantify the target molecule in an analyte. The multifunctional copolymer coatings typically include brush copolymers based on a polycationic or polyanionic (jointly referred to herein as ‘polyionic’) backbone with side chains that control interaction with the environment, such as poly(ethylene glycol) or poly(ethylene oxide)-based side chains that decrease cellular adhesion, and analyte-specific side chains. They can be used to pattern the surfaces into non-adhesive and specifically adhesive areas by applications of known techniques such as microfluidic or contact printing techniques.
Owner:UNIV ZURICH +1

Method for assessing improvement in hand hygiene practices

A method for assessing improvement in hand hygiene practices using sanitation solution dispensers deployed within particular areas of interest in a healthcare facility or the like. Each of the dispensers has a counter associated therewith, with the counter producing a count indicative of actual events of a healthcare worker sanitizing his / her hands. Other data is acquired that impacts the number of anticipated hand sanitation events in this particular area of interest. From this data, a number of anticipated hand sanitation events is determined. Finally, a determination is made, from information obtained through actual observation, of the number of opportunities that healthcare workers will have for hand sanitation in the area of interest over a particular period of time. A performance index, indicative of compliance with hand hygiene protocol, is then obtained by dividing the difference between the actual number of hand sanitizing events and the number of anticipated hand hygiene events by the number of opportunities for such hand hygiene events. This index may then be used to gauge improvement or regression in hand hygiene practices in an area of interest, or to measure the effectiveness of intervention programs, or to compare performance between various areas of interest.
Owner:GOJO IND INC

Method for selectively combining multiple membranes for assembly into test strips

A method for selectively combining multiple membranes for assembly into test strips (such as visual blood glucose test strips with side-by-side membranes). The method includes first measuring a plurality of color parameters (e.g., L*, a* and b*color parameters) associated with membrane samples from at least two membrane lots. Next, response characteristics (e.g., blood glucose response levels) are simulated for a speculative test strip that includes, for purposes of the simulation, combined multiple membranes tentatively selected from the at least two membrane lots. The simulated response characteristics are based on the measured plurality of color parameters of the tentative selection of combined multiple membranes. Optionally, the simulated response characteristics can also be based on simulated color parameters of the tentative selection of combined multiple membranes. Subsequently, assembly of the at least two membrane lots into a test strip with combined membranes is contingent on acceptable simulated response characteristics. Any suitable color parameters can be employed. The method can be used to selectively combine two or more membranes based on any number of color parameters. The assembled test strips can be used to measure glucose, cholesterol, proteins, ketones, phenylalanine or enzymes in blood, urine, saliva or other biological fluid, as well as sample fluid characteristics (e.g., pH and alkalinity).
Owner:LIFESCAN IP HLDG LLC

Optical resonator type organic electroluminescent element

An optical resonator type organic electroluminescent element has a multilayered film mirror 30, a transparent electrode 12, an electron hole transportation layer 14 and a luminescent layer 16 configuring an organic layer, and a metallic electrode mirror 20, formed on a glass substrate 10. The optical resonator type organic electroluminescent element amplifies a specific wavelength (especially, in a range of about 30 nm toward a shorter wavelength side from a luminescence peak wavelength of the organic layer) in luminescence light by a minute optical resonator, which comprises the multilayered film mirror 30 and the metallic electrode mirror 20. It is determined that the minute optical resonator has an optical length L which is twice as long as a resonance wavelength, the organic layer has a thickness of 100 nm or more, and the transparent electrode has a thickness of 50 nm or more or a thickness so to have a sheet resistance of 30 OMEGA/square or less. Thus, the transparent electrode can be prevented from generating heat even when a large current is caused to flow into it, and the element characteristics can be reliably prevented from being deteriorated. Moreover, the reliability of this element can be improved because the organic layer containing the luminescent layer has a sufficient thickness.
Owner:TOYOTA CENT RES & DEV LAB INC

Connectors, tracks and system for smooth-faced metal framing

A novel system for constructing smooth-faced metal framing and novel connectors therefore. The system and connectors of the present invention utilize known metal framing or wall studs that demonstrate a U-channel configuration having a base, sidewalls and marginal lips that extend inward from the sidewalls. A variety structurally related connectors, comprising at least a connector body, base flange, and two lip receiving grooves, are described. These connectors are capable of interconnecting metal framing performing all framing functions including, without limitation, floor and ceiling joists, top and bottom plates, roof rafters, roof rims, window sills, trusses, headers and wall studs. The connectors lock into place within the stud and are secured from the inside using fasteners applied into the non-surface aspects of the stud. The stud connectors demonstrate three dimensional rigidity and a box-like fit within the metal framing studs to form joints that are strong, durable and precise. The framing system using the stud connectors of the present invention leaves the outside surfaces of the framing members and studs smooth and continuous, without protruding fastener heads or interruptions of any sort. The resulting smooth outside surfaces can be covered much more easily and inexpensively than the uneven and generally awkward outside surfaces presently encountered in metal framed structures. The manner in which the connectors lock within the studs promote their safe and efficient installation. The system and connectors of the present invention enables an entire structure to be framed using one type and size of metal framing studs cut to appropriate lengths on site.
Owner:SALDANA ELUTERIO
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