174 results about "Jet injection" patented technology

The invention relates to a method for minimizing mean blood glucose levels in an insulin dependent patient by administering insulin to the patient in a sufficiently fast manner to provide a difference of 50% or less between high and low blood glucose levels. Advantageously, the insulin is administered to the patient by jet injection and the high and low blood glucose levels differ by an amount that is less than that which would be obtained after injection of insulin by a conventional needle syringe. The invention also relates to a method for reducing mean blood glucose levels in an insulin dependent patient that is receiving insulin through a conventional syringe and needle arrangement. This method provides for administration of the insulin to the patient by jet injection rather than by the syringe by substituting a jet injector for the syringe.

The invention relates to an RNA comprising at least one open reading frame (ORF) and comprising at least one modification, which increases the expression of the encoded peptide or protein. Furthermore, the invention relates to the medical use of such a modified RNA administered to a subject by jet injection. The invention relates further to a pharmaceutical composition and to a kit of parts comprising said modified RNA for administration by jet injection, preferably for use in the field of gene therapy and/or genetic vaccination. Additionally, the invention relates to a method for enhancing the (localized) expression of RNA-encoded peptides or proteins in the dermis or muscle (of a mammal) comprising administering the modified RNA by jet injection. And finally, the invention relates to a method of treatment comprising administering the modified RNA by jet injection to a subject in need thereof.

A device (10) and method for tranporting fluids across biological barriers enhances penetration of a biological barrier by the use of directional insertion, preferably with asymmetric microneedles (18) and/or microneedles (18) with sharp edges. Additionally, or alternatively, adhesion followed by alteration of contact geometry is employed to stretch the biological barrier across the microneedles (18), thereby also enhancing penetration. Also disclosed is a device (10) and method which combine shallow penetration by hollow microneedles (18) with jet injection via the microneedles (18) to achieve a total liquid penetration depth greater than the mechanical penetration depth of the microneedles (18).

A method of preparing and ablating heart tissue includes a pre-treatment step of delivering a jet of conductive fluid to a portion of heart tissue. The conductive fluid is delivered using an injection device such as a hand-held jet injector, probe, or catheter. After injecting the heart tissue with the conductive fluid, RF energy is delivered to the site of the injection to form a lesion. The method enables a physician to produce large and accurately placed lesions within the treated tissue.

In the present invention, the impedance between patient's body and the jet injection drug delivery device is measured through the liquid jet during the drug delivery process. The liquid jet completes the electrical circuit formed by impedance monitor, drug delivery device, and the patient's body. When the jet pierces stratum corneum, the impedance in the circuit immediately decreases, thus an indicating the successful drug delivery. The impedance monitor then provides a signal, visible, audible, or electronic, indicating that the process of the drug delivery through skin was successful.

A device for delivering a drug includes a housing; at least one nozzle at a portion of the housing; a source of drug in the housing; and an energy source for providing a pressure of up to about 2,000 psi for driving the drug through the at least one nozzle and out of the housing. The drug is delivered to tissue under microjet propulsion. The device is particularly useful for drug delivery applications such as transdermal and ocular by way of example.

An apparatus and methods for forming a diamond film, are provided. An example of an apparatus for forming a diamond film includes an electrodeless microwave plasma reactor having a microwave plasma chamber configured to contain a substrate and to contain a reactant gas excited by microwaves to generate a microwave plasma discharge. Gas injection ports extend through an outer wall of the plasma chamber at a location upstream of the plasma discharge and above the substrate. Gas jet injection nozzles interface with the gas injection ports and are configured to form a directed gas stream of reactant gas having sufficient kinetic energy to disturb a boundary layer above an operational surface of the substrate to establish a convective transfer of the film material to the operational surface of the substrate.

The invention provides a method and device for processing revolving parts by high-speed jet injection electroforming. The method is characterized in that an electroforming core mould is partially buried in an electroforming groove which is filled with hard particles or is in direct contact with a plated negative pole surface through a friction piece, so that the defects of accumulated tumors, burrs and the like on a deposition surface can be effectively removed by the friction of the hard particles or the friction piece on an electroforming layer; and a computer is used for controlling a jet nozzle to scan along with a certain track and cooperates with the rotary motion of the electroforming core mould at the same time, so that the exposed electroforming core mould surface is subjected to selective scanning electroforming so as to pile up the required parts layer by layer. The device of the invention mainly comprises a table movement mechanism, a negative pole rotation drive device, a control system, a temperature control device, an electroforming liquid circulating filter system and the like. The method and device for processing the revolving parts by high-speed jet injection electroforming of the invention are adopted, thus not only effectively removing the defects of hard spots, air holes, accumulated tumors and the like on the electroforming layer surface and manufacturing the electroforming layer with compact and even texture at higher deposition speed, but also abandoning the complicated negative pole female die of the traditional electroforming and rapidly and efficiently forming the revolving parts with different shapes and wall thicknesses by one step.

The invention relates to a nozzle device adapted for placement against a skin surface of a subject, the nozzle device providing a means for stretching the skin, the nozzle device being suitable for use in jet injection. More specifically, the skin stretching means is arranged circumferentially relative to a nozzle, the skin stretching means having an initial first configuration corresponding to an initial state in which the skin stretching means is adapted to be placed against a skin surface of the subject, the skin stretching means being moveable to a second configuration, wherein movement of the skin stretching means to the second configuration after the skin stretching means has been placed against the skin of the subject results in the skin being stretched relative to the outlet nozzle.

An injector includes a trigger mechanism including: a trigger member disposed about an axis having an aperture and a protrusion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a trigger engagement member configured to engage the aperture of the trigger member when the trigger member is in a pre-firing condition; an energy source associated with the ram for powering the ram to expel the medicament; and a user-operable firing-initiation member having an aperture engaged with the protrusion of the trigger member and operable for causing an axial translation of the trigger member in a proximal direction from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.

The invention provides a construction method of a long spiral high-pressure spraying cement-soil continuous wall, which comprises the following steps: 1) making a guide wall or digging a guide ditch along the center line of the pile, and determining the pile position of the spraying pile; 2) injecting the long spiral high-pressure spraying The slurry stirring pile-forming device is aligned with the pile position as the drilling center, and drilled into the hole; 3) Start the grouting pump, and use the long spiral high-pressure jet grouting to stir the pile-forming device during the lifting or lowering process of high-pressure rotary spraying until it is formed. 4) insert section steel into the spigot pile; 5) repeat the steps 2), 3) and 4) until the continuous cement-soil continuous wall is formed; 6) construct the joint beam; 7) backfill the foundation pit, Pull out the section steel after finishing. Compared with the general slope protection pile support system, firstly, the section steel can be recycled, and secondly, cement soil is used instead of concrete, so it is relatively more economical and more efficient, and can achieve the two walls of the supporting wall and the curtain wall. The water stop effect is also better than the system composed of general slope protection piles + rotary grouting piles.

An exemplary embodiment of an injector includes a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger mechanism can include a floating trigger member having a retaining portion, a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a floating trigger engagement member configured to engage the retaining portion of the floating trigger member when the floating trigger member is in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation of the floating trigger member from the pre-firing condition to a firing condition in which the floating trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.

The invention relates to a microscale pulse electrolysis jet processing system and a processing method thereof, which belongs to the technical field of electrolysis processing. The microscale pulse electrolysis jet processing system comprises a pulse direct-current power supply, an electrolyte jet injection device, an electrolyte circulating and filtering system, a workpiece installing and fixing system and a worktable motion control system, wherein a filter core body and a nozzle are arranged in the electrolyte jet injection device, are made of metal materials, thereby not only increasing filter effect and eliminating an electrolyte pulsation phenomenon, but also leading the electrolyte to be sufficiently polarized negatively under the function of a high-voltage pulse direct-current electric field and then to transmitted to a position to be processed of a processing workpiece in a high-speed flowing mode, electrochemical anode dissolution is generated at the injection point, the high-quality and efficient processing of microstructures such as small holes, narrow grooves, dimpling pits, and the like are realized by using the numerical control motion of a machine tool worktable.

An in ovo jet injection apparatus and related methods for treating live eggs. The jet injection apparatus includes one or more jet injection delivery devices configured to deliver one or more treatment substances to predetermined areas of eggs using a high pressure stream of the treatment substance(s). Multiple treatment substances can be delivered so that they are spatially and/or temporally separate. The devices and methods of the invention enable the effective use of a plurality of treatment substances, including those that are effective when used alone but can be noxious if mixed. The methods and apparatus for the jet injection of substances into embryonic chicks reduce the risk of mechanical injury to the developing birds that would be caused by injection needles. The methods and apparatus of the invention can also reduce the introduction of an infection into the chicks.

The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

A method for making a jet injection drug delivery device wherein the drug delivery device has at least one drug reservoir and at least one injection nozzle includes the steps of: identifying a drug desired to be delivered; identifying a volume of the drug desired to be delivered; establishing a reservoir diameter for the at least one drug reservoir; establishing a nozzle diameter for the at least one injection nozzle; identifying a tissue model for delivery of the drug; identifying a penetration depth in the tissue model for the delivery of the drug; and injecting the drug into the tissue model under variable pressure until the desired penetration depth is achieved. The method also includes identifying an optimal pressure range for the drug delivery device that achieves the desired penetration depth.

The invention provides a flame stabilizer for an after-combustion chamber of a gas turbine engine. In the device, which is characterized in that turbine rear frames are integrated, a radial flame stabilizer and a center cone in the prior art are omitted, and the an upstream concave structure and the a jet injection gas flow are used for forming a vortex system to form a necessary backflow region for flame stabilization, thereby reducing the amount of parts, shortening the total length of the combustion chamber, lightening the structural weight, reducing the resistance loss, and enabling the thrust-weight ratio of the engine to have great expansion lifting space.

Ablation apparatus including an active electrode in electrical communication with an energy source, and a jet injector capable of propelling an electrically conducting fluid to a skin surface, the jet injector being positioned relative to the active electrode such that the electrically conducting fluid is in electrical communication with the active electrode.

The invention provides an abrasive jet injection multiple fracturing device. The device comprises multiple stages of spray guns which are connected in series, wherein each spray gun is a hollow cylinder, and at least two nozzles are formed on the side wall of each spray gun; the spray guns comprise a primary bottom spray gun which is arranged on the lower part of the abrasive jet injection device and multiple stages of upper spray guns which are positioned on the upper part of the bottom spray gun; a slide bushing capable of sealing the nozzle of the spray gun in the stage is arranged in each upper spray gun; an accommodating hole for accommodating the nozzle is formed on the side wall of each spray gun; a nozzle cap is sleeved outside the nozzle, and an inner hole of the nozzle cap is matched with the outer wall of the nozzle; the nozzle cap is in threaded connection with the accommodating hole, so that the nozzle is fixed on the side wall of each spray gun; and a splash-proof block is arranged on the outer wall of each spray gun close to the nozzles. The abrasive jet injection multiple fracturing device can effectively prevent splash-return jet from eroding and destroying a spray gun body, prolongs the service life of the spray guns, and simultaneously, reduces the manufacturing cost of the spray guns.

The invention relates to an abrasive material jet injection device which is provided with a spray gun for injecting abrasive material jet, wherein the spray gun is provided with at least two nozzles, and the spray gun is connected with an oil tube. The abrasive material jet injection device has simple structure and is easy to assemble and maintain. The key part (nozzle) in the device has longer service life so as to satisfy the requirements of two operations of perforating and fracturing. Because a check valve and a sieve tube are arranged, the phenomenon that the nozzle of the injection device is subjected to sand jamming can be greatly lowered; meanwhile, when the device is subjected to sand jamming faults, base fluid is pumped into the annulus of an annular tube, the base fluid enters the injection device via the check valve by the sieve tube, which is convenient to flush the device, and therefore the well can be subjected to backflushing to ensure that the operation is successfully carried out. Because a packer is omitted, construction equipment is simplified. According to the abrasive material jet injection device, the defect of the known technology is overcome, abrasive material jet pore forming and fracturing are combined, and therefore layering can be precisely carried out in a vertical well or sectional fracturing can be precisely carried out in a horizontal well section.