46 results about "Optical resolution" patented technology

The invention provides a wafer defect detection method and device, and the method comprises the steps: obtaining a macroscopic image comprising the global or regional defect information of the surface of a wafer, and generating a rechecking task set based on the abnormal features in the macroscopic image; under the condition that the re-checking task set is not empty, driving the imaging unit and the wafer to generate relative displacement so as to obtain a microscopic feature image of the target area in the re-checking task set; determining the native defect attribute of the wafer according to the microscopic feature image; wherein the optical resolution of the microscopic feature image is higher than that of the macroscopic image.

The invention relates to a light and miniature big-target-surface low-light lens, and the lens comprises a front lens group A, a diaphragm B and a rear lens group C, wherein the front lens group A, the diaphragm B and the rear lens group C are sequentially arranged in an incident direction of an optical path. The front lens group A includes a positive meniscus lens A1, a negative meniscus lens A2,a biconcave lens A3 and a biconvex lens A4, wherein the positive meniscus lens A1, the negative meniscus lens A2, the biconcave lens A3 and the biconvex lens A4 are sequentially arranged in an incident direction of the optical path. The biconcave lens A3 and the biconvex lens A4 are in close connection with each other as a first bonding group. The rear lens group C includes a biconcave lens C1, abiconvex lens C2, a biconvex lens C3, a plano-convex lens C4 and a negative meniscus lens C5, wherein the biconcave lens C1, the biconvex lens C2, the biconvex lens C3, the plano-convex lens C4 and the negative meniscus lens C5 are sequentially arranged in an incident direction of the optical path. The biconcave lens C1 and the biconvex lens C2 are in close connection with each other as a secondbonding group. The invention also relates to an imaging method of the lens. The lens is reasonable in design, effectively improves the imaging quality under the requirement of the large target surfaceof the lens, reduces the number of optical lenses, and realizes light and miniature lens. The lens has strong light collecting and light transmitting ability, and the target surface of the lens is large. The lens is high in optical resolution, is large in angle of view, and is large in observable range.

The invention discloses a preparation method of L-5 methyltetrahydrofolic acid based on an MOFs catalyst, and high-selectivity hydrogenation and methylation of folic acid are realized under mild conditions by designing MOFs material loaded noble metal nanoparticles with a chiral confinement effect. The method does not need an optical resolution step, and the ee value of the product is gt; and the catalyst can be recycled, so that the method is suitable for industrial production.

To provide a simple method for optically resolving a chiral compound, which is expected to be industrially applicable.SOLUTION: A method for optical resolution of a chiral compound includes dissolving a mixture of both enantiomers of the chiral compound in a first solvent to prepare a first solution, stirring the prepared first solution, precipitating a first gel in the stirred first solution, and separating the first solution into the first gel and a first supernatant.SELECTED DRAWING: Figure 1

Provided herein are methods, devices, and systems that may improve optical resolution when imaging through a thickness of samples. A method for generating a depth profile of a tissue of a subject may comprise using an optical probe to transmit an excitation light beam from a light source towards a surface of the tissue; using one or more focusing units in the optical probe to simultaneously adjust a depth and a position of a focal point of the excitation light beam along a scanning path; detecting at least a subset of the signals generated upon contacting the tissue with the excitation light beam; and using one or more computer processors programmed to process the at least the subset of the signals to generate the depth profile of the tissue.

The invention discloses a spectrum super-resolution method and system based on an FP cavity and deep learning, and the method comprises the steps: S1, carrying out the initialization of spectrum collection, and selecting light with a specific wavelength after the light is acted with a target detection object; s2, performing photoelectric conversion and digitization to generate low-resolution original discrete spectrum data of corresponding wavelengths; s3, continuous spectrum scanning is carried out, and original discrete spectrum data collection of the whole target wave band is completed; and S4, performing super-resolution spectrum reconstruction, and judging whether cyclic reconstruction is performed or not based on a reconstruction data quality evaluation result until the quality is qualified. According to the method, an accurate mapping model from a low-resolution spectrum to a high-resolution spectrum is established through a pre-trained deep neural network, and an original spectrum which is collected by an FP cavity and is limited by the theoretical limit optical resolution of the FP cavity can be reconstructed into a super-resolution spectrum of which the resolution remarkably exceeds the theoretical limit. The problem that the resolution of an FP cavity in a long-wave region is sharply reduced is effectively solved, and the full-wave-band uniform high resolution is realized.

Techniques for optical resolution determination from barcode chart images are described herein. In an example, a computer system receives an image captured by an image acquisition system having a camera with a lens. The image is of a chart including barcode sets arranged in one or more orientations with respect to an optical axis of the camera, and individual barcodes of a barcode set have a barcode attribute. The computer system decodes the barcode sets in the image using a barcode decoder. The computer system determines, for individual barcode attributes and for individual orientations, a number of decoded barcodes in the barcode sets that match encoded information stored in a barcode manifest. The computer system determines a resolution metric of the image acquisition system for a target barcode decode rate based on a distribution of a decode rate associated with the barcode attribute for the decoded barcodes.

The present invention provides a method for chiral resolution of Trolox. The present disclosure relates to a method for producing a solid salt of a compound of formula I, wherein an amide-based solvent is added to a sample, which contains a compound of formula I, while being assumed to contain a compound of formula II, in the presence of an optical resolution agent:Formula I: (R)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to R Trolox)Formula II: (S)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to S Trolox).

This invention discloses a super-resolution photoacoustic microscopy imaging method based on a deep neural network, comprising: acquiring two sets of photoacoustic signal data at high and low resolution using an optical resolution photoacoustic microscopy imaging system; reconstructing images from the two sets of acquired photoacoustic signal data; preprocessing the two sets of reconstructed original photoacoustic images to form an input sample set; building and training a deep neural network model, specifically a DenseRes-SRGAN adversarial neural network architecture optimized based on photoacoustic images; and inputting the acquired high and low resolution images into the trained deep neural network to obtain super-resolution results. The high and low resolution sampling of this invention does not skip information within the field of view. Compared with sparse data, the representative pixels are a weighted representation of each small pixel in a large step scan mode, thereby reproducing low-scale information that cannot be resolved by low resolution and large focal diameter. Compared with high-resolution reconstruction of sparse data, it has improved reconstruction generalization ability and realism.

The invention discloses a photoacoustic calculation mesoscopic imaging device and method based on linear light scanning. According to the invention, NIR (near infrared) focusing line light scanning, low-frequency annular array detection and composite image calculation and reconstruction are fused. The near-infrared light which is subjected to multi-angle scanning and highly focused in the whole imaging area keeps the fine optical resolution capability in the direction perpendicular to the length direction of the linear light, and efficient photoacoustic signal excitation is achieved. By adopting the low-frequency annular ultrasonic transducer array, high-sensitivity full-view detection of low-attenuation photoacoustic signals is ensured, and the defect of insufficient near-infrared optical absorption is remarkably compensated. Through composite image calculation and reconstruction, the acoustic diffraction limit of the low-frequency photoacoustic signal in the line light length direction is broken through, and background noise with artifacts is suppressed. The technology provides a new visual angle with high spatial resolution for non-invasive and label-free deep small animal brain imaging.

The invention provides a device and method for detecting drill-borne video imaging resolution, and relates to the technical field of optical measurement, and the device comprises a transparent pressure-resistant window with a composite target inside, a coaxial programmable illumination assembly, an IMU, an environment sensor, an imaging assembly and a control processing unit. Synchronously acquiring composite target image data, IMU data and environment sensing data, and performing time alignment on the data; calculating and measuring an MTF curve, a motion MTF, a medium MTF and a pixel aperture MTF based on a composite target image, IMU data, environment sensing data and an image obtained by an imaging assembly; stripping the moving MTF, the medium MTF and the pixel aperture MTF from the measured MTF curve to obtain an optical intrinsic MTF; and detecting the drill-borne video imaging resolution according to the measured MTF and the optical intrinsic MTF. According to the invention, the measurement of the effective resolution and the intrinsic optical resolution of while-drilling video imaging under complex working conditions is realized.

The present invention belongs to the field of fundus imaging technology and discloses an ultra-wide-angle ellipsoidal confocal laser scanning fundus imaging system, comprising: a spectroscopic module, a focusing module, a scanning module, a transmission lens group, an ellipsoidal reflector, and a detection module; wherein the center of the scanning module and the center of the transmission lens group are on the same optical axis A, the human eye pupil is located at the first focus of the ellipsoidal reflector, and the transmission lens group entrance pupil is located at the second focus of the ellipsoidal reflector; the transmission lens group includes a movable focusing lens for changing the position of the first image plane of light reflected from the human eye retina when moving along the optical axis A, thereby achieving clear images of the retinas of human eyes with different diopters. Without introducing a free-form surface, the present invention achieves ultra-wide-angle multi-wavelength confocal laser scanning fundus imaging with a single intraocular field of view angle of 200°, and a full-field optical resolution of 15μm. By moving the focusing lens, imaging compensation can be performed for human eyes with a diopters ranging from -15D to +15D.

The utility model relates to the technical field of optical imaging, in particular to a series lens group optical coupling system for an image intensifier. Comprising a series lens group, and the series lens group comprises a first lens and a second lens which are sequentially arranged between a phosphorescent screen of an image intensifier and a CCD or CMOS camera in parallel from front to back; the first lens is a collimating lens and is used for converting light rays from an object into parallel light beams; and the second lens is an imaging lens and is used for focusing the parallel light beams on a camera photosensitive device to form a clear image. According to the series-connection lens group, through combination of the two lenses, effective focusing and imaging of light rays are achieved, and the series-connection lens group has a high aperture ratio, high light transmission efficiency and excellent optical resolution; compared with traditional optical fiber taper coupling, the series lens group reduces image artifacts and improves image quality. And meanwhile, maintenance and upgrading are facilitated, and a complex re-alignment process is not needed.

The invention relates to the technical field of objective lens imaging, in particular to an imaging method adopting a phase-change material to immerse an objective lens, which comprises the following steps: step 1, placing a wafer into an imaging cavity and positioning the wafer under the objective lens, and pressurizing the imaging cavity to preset pressure; step 2, pumping protective gas into the imaging cavity, heating the imaging cavity to a set temperature capable of liquefying a phase-change material of gas, and filling the liquid phase-change material between the wafer and the objective lens through a sample adding pipeline; step 3, translating the wafer to complete scanning imaging of the wafer, and synchronously supplementing the phase change material of the liquid to keep the space between the objective lens and the wafer to be filled all the time; and 4, pumping out the protective gas and the phase change material which is changed into gas under a preset condition. According to the invention, the space between the mirror and the wafer is filled with the liquid phase change material, so that a very good optical resolution is maintained on the premise that the wafer is not damaged.

The invention is applied to the technical field of optical microscopic imaging, and discloses a two-dimensional multi-focus optical resolution photoacoustic microscopic imaging system and an imaging method. The system comprises a laser, a lens assembly, a filtering pinhole, a reflector assembly, an optical diffraction element, a focusing lens, a self-made 3D scanner, an acoustic coding mask, a plane focusing ultrasonic transducer, an amplifier, a data acquisition card, a signal generator and an imaging processing terminal. According to the two-dimensional multi-focus optical resolution photoacoustic microscopic imaging system, a laser device outputs a laser beam, and the laser beam is projected to a subsequent optical diffraction element after being subjected to beam expanding by a beam expanding unit composed of a pair of plano-convex lenses and spatial filtering processing of a pinhole in sequence; and the imaging processing terminal obtains the digital photoacoustic signal and processes the digital photoacoustic signal to obtain an imaging image of the sample, so that the purpose of providing a solution for rapid OR-PAM in an economical and efficient manner is achieved, and the speed limitation caused by the laser repetition rate is broken.

The application relates to the technical field of fundus imaging, in particular to a rotating parabolic fundus imaging system and an imaging method, the imaging system comprising a light detection module, a light source module, a light splitting module, a scanning module, an amplification module and a parabolic reflection module; the parabolic reflection module comprises at least one group of parabolic mirrors; each group of parabolic mirrors comprises a pair of parabolic concave mirrors, the focal points of each parabolic concave mirror fall on the optical axis of the amplification module, the focal points of any two adjacent groups of parabolic mirrors coincide, and the conjugate planes where the focal points at the two ends are located are the real entrance pupil of the amplification module and the pupil of the human eye respectively; the parabolic mirrors and the scanning module are rotatably arranged at 360 degrees with the optical axis of the amplification module as the rotation axis. The application has the effects of realizing ultra-wide-angle fundus imaging under a long working distance, the system giving consideration to high resolution and free pupil dilation, the full field of view being free of field of view loss, and the full field of view optical resolution reaching 15 um.

High-resolution microscopy method for the three-dimensional position determination of objects, in particular individual fluorophores, preferably for spatially high-resolution luminescence microscopy of a sample (7) which is labelled with labeling molecules (1) which can be activated or switched with a signal such that they can only be excited to emit certain luminescence radiation in the activated state, wherein the method comprises the following steps: a) Introducing the signal onto the sample (7) such that only a subset of the labeling molecules (1) present in the sample (7) are activated, wherein the sample (7) contains subregions in which activated labeling molecules (1) are at least as far apart from the nearest neighboring activated labeling molecules (1) as is greater than or equal to a length which results from a predetermined optical resolution, b) Excitation of the activated molecules (1) to emit luminescence radiation, c) Detection of the luminescence radiation with the predetermined optical resolution, and d) Generating a single image from the luminescence radiation recorded in step c), wherein the geometric locations of the luminescence-emitting labeling molecules are determined with a spatial resolution increased above the predetermined optical resolution, where the steps are repeated several times and the resulting individual images are combined to form a complete image, characterized by the fact that an object is imaged via an imaging system (OB, TL) with a microscope objective (15, OB) onto an area detector (5, CCD) consisting of individual detector elements, wherein at least one microlens arrangement (ML, ZL), which is partially located in front of the detector elements, images a different object plane (OE1) onto the detector elements in the direction of light behind the microlenses than onto detector elements in front of which there are no microlenses.

Random arrays of single molecules are provided for carrying out large scale analyzes, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm2 and have nearest neighbor distances that permit optical resolution of on the order of 109 single molecules per cm2. Many analytical chemistries can be applied to random arrays of the invention, including sequencing by hybridization chemistries, sequencing by synthesis chemistries, SNP detection chemistries, and the like, to greatly expand the scale and potential applications of such techniques.

Example embodiments relate to foveated imagers for automotive applications. An example embodiment includes a device. The device includes a rotationally symmetric foveated lens. The rotationally symmetric foveated lens is configured to receive light from an environment. The rotationally symmetric foveated lens is also configured to produce an image at an image plane based on the received light. The device also includes an image sensor having an associated image sensor resolution. The image sensor is positioned at the image plane and configured to capture an image having an associated field of view of the environment. Based on a distortion profile of the rotationally symmetric foveated lens and the image sensor resolution, the captured image exhibits a first angular optical resolution in a central region of the field of view and a second angular optical resolution in a peripheral region of the field of view.

The invention provides a portable spectrum analyzer based on a grating diffraction principle, and relates to the field of spectrum analyzers. The portable spectrum analyzer based on the grating diffraction principle comprises a supporting structure, a handle is fixedly connected to the position, close to the rear side, of the center of the lower end face of a main body, a control button is arranged at the position, close to the upper end, of the center of the front side wall of the handle, and the supporting structure is arranged at the position, close to the front side edge, of the center of the lower end face of the main body. All optical, mechanical and electronic components are highly integrated in a compact sealed shell by adopting an integrated optical machine design and an image plane diffraction optical path, a complicated movable adjusting mechanism of a traditional spectrometer is abandoned, the size is small, the weight is light, handheld or portable handheld operation is truly realized, and the cost is low. Through the blazed grating, the aspherical lens and the high-sensitivity image sensor which are optimally designed, the wide spectral range, the high optical resolution and the low stray light level which are comparable with those of a traditional table type spectrograph are achieved in a compact structure.

This invention relates to a tube lens compatible with high-NA objectives, a rapid automated optical inspection system and method. The tube lens includes a lens assembly comprising a first cemented lens with positive optical power, a second cemented lens with negative optical power, and a third cemented lens with positive optical power, arranged sequentially along the principal optical axis. The first cemented lens is disposed on one side of the object being tested. The first cemented lens comprises a first lens and a second lens cemented together; the second cemented lens comprises a third lens and a fourth lens cemented together; and the third cemented lens comprises a fifth lens and a sixth lens cemented together. The design of this invention enables a 1.4X tube lens, compatible with high-NA objectives. Its lens assembly includes multiple cemented lenses forming a positive-negative-positive structure, which improves the pixel resolution, optical resolution, and minimum defect size detection capability. It also has a long front working distance, adaptable to both vertical and horizontal inspection optical paths.

An optical-resolution photoacoustic microscopy (OR-PAM) system for visualizing water content deep in biological tissue uses an all-fiber 1930-nm hybrid optical parametrically-oscillating emitter. The emitter includes a tunable laser source whose output is amplified by a first erbium-doped fiber amplifier (EDFA). The output of the first amplifier is modulated with a Mach-Zehnder amplitude modulator that receives an RF signal with a nanosecond pulse width and a multiple kilohertz repetition rate. A second EDFA further amplifies the signal and passes it to a fiber circulator that in turn delivers it to a 1950 / 1550 mm fiber wavelength-division-multiplexing coupler WDM. The coupler introduces the signal to a cavity that includes a spool of highly nonlinear fiber and a Thulium-doped fiber amplifier TDFA. From the TDFA the signal reaches a 50 / 50 fiber coupler that sends part to a second output TDFA and guides part back to the cavity through a port of the WDM.

This invention discloses a non-contact device and method for inspecting the appearance of the inner surface of a hole. The device can be functionally divided into a motion control section and an image acquisition section. The motion control section includes a single-axis displacement stage, a single-axis rotary stage, a two-dimensional alignment stage, and a motion controller. The image acquisition section includes an industrial microscope head, an industrial camera, a video tube, and an LED lighting source. The measurement process includes the following steps: 1) calibrating the measuring device using a high-precision optical resolution plate; 2) calibrating the two-dimensional alignment stage using circular markers; 3) calibrating the rotation center position using a laser; 4) aligning the hole to be measured with the probe based on the calibration results; 5) initiating automatic image acquisition and stitching; and 6) calculating the actual size of the defect and its position within the hole. This invention can achieve panoramic defect inspection of the inner wall of blind holes or countersunk holes with diameters of 4mm-8mm and depths <45mm.

The invention discloses a cell sorting device and method and a computer readable storage medium, and belongs to the technical field of cell sorting. The cell sorting device comprises a flow chamber which is provided with a contraction section flow channel with a non-circular cross section and is used for guiding cells to flow through the flow channel in a preset orientation; the optical detection unit is arranged around the flow chamber and is used for detecting the cells in the preset orientation state; the liquid droplet forming unit is used for enabling the sample flow to be ejected in a liquid droplet form; a charging unit selectively applying a charge to the droplet; and a deflection means for sorting the charged droplets by applying a deflection force to the charged droplets. By arranging the at least one contraction section with the non-circular cross section, the cells are stably arranged in the flowing direction of the sample flow in the preset orientation, and the signal-to-noise ratio, the resolution ratio and the sorting accuracy of optical detection are improved. The optical detection unit detects the cells subjected to predetermined orientation in a flow chamber excitation mode, the effective numerical aperture is increased, the optical resolution and the signal acquisition efficiency are improved, and the sorting precision and efficiency are improved.

This invention relates to the field of driving circuit system technology, and more particularly to a CCD driving circuit system with adaptive integration time. The technical solution includes a CCD, an FPGA main controller, operational amplifiers and an AD converter, a USB 3.0 main controller, a power converter, and a CCD clock driver. The CCD is used to receive solar radiation and generate analog signals. This invention achieves rapid, accurate, and reliable adaptive adjustment of the integration time. It not only fundamentally overcomes the inherent defects of existing technologies, such as low adjustment efficiency, susceptibility to interference, and unreasonable target settings, but also reduces the burden on the host computer through a hardware integration scheme. This ensures that the optical resolution rate analyzer can stably acquire high signal-to-noise ratio and high-precision spectral data over a long period under various complex lighting conditions, significantly improving the overall performance and automation level of the instrument.

The application relates to the field of microscopes, in particular to a laser scanning confocal microscope which comprises a light splitting mechanism, multiple filter systems and multiple detection systems, the light splitting mechanism is used for transmitting fluorescent beams with different wavelengths to different filter systems, the filter systems correspond to the detection systems one by one, each filter system is matched with a different wavelength range, is used for filtering stray light emitted by a non-focal plane doped in the fluorescent beam, and the detection system is used for receiving the fluorescent beam leaving the filter system and converting to obtain an electric signal. Different wavelengths of fluorescent light are transferred to different filter systems for processing through the light splitting mechanism, at this time, the wavelength range matched by the filter system is small, and the optical resolution of all wavelength bands is ensured to reach the best state.

Random arrays of single molecules are provided for carrying out large scale analyzes, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm2 and have nearest neighbor distances that permit optical resolution of on the order of 109 single molecules per cm2. Many analytical chemistries can be applied to random arrays of the invention, including sequencing by hybridization chemistries, sequencing by synthesis chemistries, SNP detection chemistries, and the like, to greatly expand the scale and potential applications of such techniques.

The invention relates to a photoacoustic imaging system and a photoacoustic imaging method. The photoacoustic imaging system comprises a laser source module used for providing excitation laser; the light transmission module is connected with the laser source module and is used for combining and / or splitting the excitation laser to form a first laser beam and a second laser beam; the imaging module comprises an optical resolution module used for focusing and irradiating a first laser beam on a to-be-measured object; the acoustic resolution module is used for diverging and irradiating the second laser beam on the to-be-detected object; the ultrasonic transducer is used for detecting a photoacoustic signal generated after the to-be-detected object is excited by the first laser beam and / or the second laser beam, and converting the photoacoustic signal into an imaging signal; wherein the focus of the optical resolution module, the central point of the irradiation area of the acoustic resolution module and the detection axis of the ultrasonic transducer are arranged in an overlapping manner; the driving module is used for driving the imaging module and the to-be-detected object to move relatively; and the data processing and control module is used for performing image reconstruction based on the imaging signal.

Example embodiments relate to foveated imagers for automotive applications. An example embodiment includes a device. The device includes a rotationally symmetric foveated lens. The rotationally symmetric foveated lens is configured to receive light from an environment. The rotationally symmetric foveated lens is also configured to produce an image at an image plane based on the received light. The device also includes an image sensor having an associated image sensor resolution. The image sensor is positioned at the image plane and configured to capture an image having an associated field of view of the environment. Based on a distortion profile of the rotationally symmetric foveated lens and the image sensor resolution, the captured image exhibits a first angular optical resolution in a central region of the field of view and a second angular optical resolution in a peripheral region of the field of view.

An endoscope imaging module, an endoscope having same, and a surgical instrument. The imaging module comprises a first optical assembly (100). The first optical assembly (100) comprises: an objective lens (101) having a first f-number, a beam splitting element (102), a relay lens (103) having a second f-number, a reflective element (104), a first image collector (105), and a second image collector (106). The objective lens (101), the beam splitting element (102), and the first image collector (105) form a first imaging light path, and the objective lens (101), the beam splitting element (102), the relay lens (103), the reflective element (104), and the second image collector (106) form a second imaging light path. The first f-number is greater than the second f-number, and a wavelength of a first imaging light beam in the first imaging light path is greater than a wavelength of a second imaging light beam in the second imaging light path. The f-numbers of the two imaging light paths are relatively independent and do not interfere with each other, thereby improving the optical resolution limit corresponding to the first imaging light beam to achieve higher resolution during imaging, while enabling the resolutions of the first imaging light beam and the second imaging light beam during final imaging to be relatively close.