33 results about "Optical resolution" patented technology

The invention provides a wafer defect detection method and device, and the method comprises the steps: obtaining a macroscopic image comprising the global or regional defect information of the surface of a wafer, and generating a rechecking task set based on the abnormal features in the macroscopic image; under the condition that the re-checking task set is not empty, driving the imaging unit and the wafer to generate relative displacement so as to obtain a microscopic feature image of the target area in the re-checking task set; determining the native defect attribute of the wafer according to the microscopic feature image; wherein the optical resolution of the microscopic feature image is higher than that of the macroscopic image.

The invention relates to a light and miniature big-target-surface low-light lens, and the lens comprises a front lens group A, a diaphragm B and a rear lens group C, wherein the front lens group A, the diaphragm B and the rear lens group C are sequentially arranged in an incident direction of an optical path. The front lens group A includes a positive meniscus lens A1, a negative meniscus lens A2,a biconcave lens A3 and a biconvex lens A4, wherein the positive meniscus lens A1, the negative meniscus lens A2, the biconcave lens A3 and the biconvex lens A4 are sequentially arranged in an incident direction of the optical path. The biconcave lens A3 and the biconvex lens A4 are in close connection with each other as a first bonding group. The rear lens group C includes a biconcave lens C1, abiconvex lens C2, a biconvex lens C3, a plano-convex lens C4 and a negative meniscus lens C5, wherein the biconcave lens C1, the biconvex lens C2, the biconvex lens C3, the plano-convex lens C4 and the negative meniscus lens C5 are sequentially arranged in an incident direction of the optical path. The biconcave lens C1 and the biconvex lens C2 are in close connection with each other as a secondbonding group. The invention also relates to an imaging method of the lens. The lens is reasonable in design, effectively improves the imaging quality under the requirement of the large target surfaceof the lens, reduces the number of optical lenses, and realizes light and miniature lens. The lens has strong light collecting and light transmitting ability, and the target surface of the lens is large. The lens is high in optical resolution, is large in angle of view, and is large in observable range.

To provide a simple method for optically resolving a chiral compound, which is expected to be industrially applicable.SOLUTION: A method for optical resolution of a chiral compound includes dissolving a mixture of both enantiomers of the chiral compound in a first solvent to prepare a first solution, stirring the prepared first solution, precipitating a first gel in the stirred first solution, and separating the first solution into the first gel and a first supernatant.SELECTED DRAWING: Figure 1

Provided herein are methods, devices, and systems that may improve optical resolution when imaging through a thickness of samples. A method for generating a depth profile of a tissue of a subject may comprise using an optical probe to transmit an excitation light beam from a light source towards a surface of the tissue; using one or more focusing units in the optical probe to simultaneously adjust a depth and a position of a focal point of the excitation light beam along a scanning path; detecting at least a subset of the signals generated upon contacting the tissue with the excitation light beam; and using one or more computer processors programmed to process the at least the subset of the signals to generate the depth profile of the tissue.

The invention discloses a spectrum super-resolution method and system based on an FP cavity and deep learning, and the method comprises the steps: S1, carrying out the initialization of spectrum collection, and selecting light with a specific wavelength after the light is acted with a target detection object; s2, performing photoelectric conversion and digitization to generate low-resolution original discrete spectrum data of corresponding wavelengths; s3, continuous spectrum scanning is carried out, and original discrete spectrum data collection of the whole target wave band is completed; and S4, performing super-resolution spectrum reconstruction, and judging whether cyclic reconstruction is performed or not based on a reconstruction data quality evaluation result until the quality is qualified. According to the method, an accurate mapping model from a low-resolution spectrum to a high-resolution spectrum is established through a pre-trained deep neural network, and an original spectrum which is collected by an FP cavity and is limited by the theoretical limit optical resolution of the FP cavity can be reconstructed into a super-resolution spectrum of which the resolution remarkably exceeds the theoretical limit. The problem that the resolution of an FP cavity in a long-wave region is sharply reduced is effectively solved, and the full-wave-band uniform high resolution is realized.

The present invention provides a method for chiral resolution of Trolox. The present disclosure relates to a method for producing a solid salt of a compound of formula I, wherein an amide-based solvent is added to a sample, which contains a compound of formula I, while being assumed to contain a compound of formula II, in the presence of an optical resolution agent:Formula I: (R)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to R Trolox)Formula II: (S)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to S Trolox).

This invention discloses a super-resolution photoacoustic microscopy imaging method based on a deep neural network, comprising: acquiring two sets of photoacoustic signal data at high and low resolution using an optical resolution photoacoustic microscopy imaging system; reconstructing images from the two sets of acquired photoacoustic signal data; preprocessing the two sets of reconstructed original photoacoustic images to form an input sample set; building and training a deep neural network model, specifically a DenseRes-SRGAN adversarial neural network architecture optimized based on photoacoustic images; and inputting the acquired high and low resolution images into the trained deep neural network to obtain super-resolution results. The high and low resolution sampling of this invention does not skip information within the field of view. Compared with sparse data, the representative pixels are a weighted representation of each small pixel in a large step scan mode, thereby reproducing low-scale information that cannot be resolved by low resolution and large focal diameter. Compared with high-resolution reconstruction of sparse data, it has improved reconstruction generalization ability and realism.

The invention discloses a photoacoustic calculation mesoscopic imaging device and method based on linear light scanning. According to the invention, NIR (near infrared) focusing line light scanning, low-frequency annular array detection and composite image calculation and reconstruction are fused. The near-infrared light which is subjected to multi-angle scanning and highly focused in the whole imaging area keeps the fine optical resolution capability in the direction perpendicular to the length direction of the linear light, and efficient photoacoustic signal excitation is achieved. By adopting the low-frequency annular ultrasonic transducer array, high-sensitivity full-view detection of low-attenuation photoacoustic signals is ensured, and the defect of insufficient near-infrared optical absorption is remarkably compensated. Through composite image calculation and reconstruction, the acoustic diffraction limit of the low-frequency photoacoustic signal in the line light length direction is broken through, and background noise with artifacts is suppressed. The technology provides a new visual angle with high spatial resolution for non-invasive and label-free deep small animal brain imaging.

The invention provides a device and method for detecting drill-borne video imaging resolution, and relates to the technical field of optical measurement, and the device comprises a transparent pressure-resistant window with a composite target inside, a coaxial programmable illumination assembly, an IMU, an environment sensor, an imaging assembly and a control processing unit. Synchronously acquiring composite target image data, IMU data and environment sensing data, and performing time alignment on the data; calculating and measuring an MTF curve, a motion MTF, a medium MTF and a pixel aperture MTF based on a composite target image, IMU data, environment sensing data and an image obtained by an imaging assembly; stripping the moving MTF, the medium MTF and the pixel aperture MTF from the measured MTF curve to obtain an optical intrinsic MTF; and detecting the drill-borne video imaging resolution according to the measured MTF and the optical intrinsic MTF. According to the invention, the measurement of the effective resolution and the intrinsic optical resolution of while-drilling video imaging under complex working conditions is realized.

The utility model relates to the technical field of optical imaging, in particular to a series lens group optical coupling system for an image intensifier. Comprising a series lens group, and the series lens group comprises a first lens and a second lens which are sequentially arranged between a phosphorescent screen of an image intensifier and a CCD or CMOS camera in parallel from front to back; the first lens is a collimating lens and is used for converting light rays from an object into parallel light beams; and the second lens is an imaging lens and is used for focusing the parallel light beams on a camera photosensitive device to form a clear image. According to the series-connection lens group, through combination of the two lenses, effective focusing and imaging of light rays are achieved, and the series-connection lens group has a high aperture ratio, high light transmission efficiency and excellent optical resolution; compared with traditional optical fiber taper coupling, the series lens group reduces image artifacts and improves image quality. And meanwhile, maintenance and upgrading are facilitated, and a complex re-alignment process is not needed.

The invention is applied to the technical field of optical microscopic imaging, and discloses a two-dimensional multi-focus optical resolution photoacoustic microscopic imaging system and an imaging method. The system comprises a laser, a lens assembly, a filtering pinhole, a reflector assembly, an optical diffraction element, a focusing lens, a self-made 3D scanner, an acoustic coding mask, a plane focusing ultrasonic transducer, an amplifier, a data acquisition card, a signal generator and an imaging processing terminal. According to the two-dimensional multi-focus optical resolution photoacoustic microscopic imaging system, a laser device outputs a laser beam, and the laser beam is projected to a subsequent optical diffraction element after being subjected to beam expanding by a beam expanding unit composed of a pair of plano-convex lenses and spatial filtering processing of a pinhole in sequence; and the imaging processing terminal obtains the digital photoacoustic signal and processes the digital photoacoustic signal to obtain an imaging image of the sample, so that the purpose of providing a solution for rapid OR-PAM in an economical and efficient manner is achieved, and the speed limitation caused by the laser repetition rate is broken.

The application relates to the technical field of fundus imaging, in particular to a rotating parabolic fundus imaging system and an imaging method, the imaging system comprising a light detection module, a light source module, a light splitting module, a scanning module, an amplification module and a parabolic reflection module; the parabolic reflection module comprises at least one group of parabolic mirrors; each group of parabolic mirrors comprises a pair of parabolic concave mirrors, the focal points of each parabolic concave mirror fall on the optical axis of the amplification module, the focal points of any two adjacent groups of parabolic mirrors coincide, and the conjugate planes where the focal points at the two ends are located are the real entrance pupil of the amplification module and the pupil of the human eye respectively; the parabolic mirrors and the scanning module are rotatably arranged at 360 degrees with the optical axis of the amplification module as the rotation axis. The application has the effects of realizing ultra-wide-angle fundus imaging under a long working distance, the system giving consideration to high resolution and free pupil dilation, the full field of view being free of field of view loss, and the full field of view optical resolution reaching 15 um.

High-resolution microscopy method for the three-dimensional position determination of objects, in particular individual fluorophores, preferably for spatially high-resolution luminescence microscopy of a sample (7) which is labelled with labeling molecules (1) which can be activated or switched with a signal such that they can only be excited to emit certain luminescence radiation in the activated state, wherein the method comprises the following steps: a) Introducing the signal onto the sample (7) such that only a subset of the labeling molecules (1) present in the sample (7) are activated, wherein the sample (7) contains subregions in which activated labeling molecules (1) are at least as far apart from the nearest neighboring activated labeling molecules (1) as is greater than or equal to a length which results from a predetermined optical resolution, b) Excitation of the activated molecules (1) to emit luminescence radiation, c) Detection of the luminescence radiation with the predetermined optical resolution, and d) Generating a single image from the luminescence radiation recorded in step c), wherein the geometric locations of the luminescence-emitting labeling molecules are determined with a spatial resolution increased above the predetermined optical resolution, where the steps are repeated several times and the resulting individual images are combined to form a complete image, characterized by the fact that an object is imaged via an imaging system (OB, TL) with a microscope objective (15, OB) onto an area detector (5, CCD) consisting of individual detector elements, wherein at least one microlens arrangement (ML, ZL), which is partially located in front of the detector elements, images a different object plane (OE1) onto the detector elements in the direction of light behind the microlenses than onto detector elements in front of which there are no microlenses.

Example embodiments relate to foveated imagers for automotive applications. An example embodiment includes a device. The device includes a rotationally symmetric foveated lens. The rotationally symmetric foveated lens is configured to receive light from an environment. The rotationally symmetric foveated lens is also configured to produce an image at an image plane based on the received light. The device also includes an image sensor having an associated image sensor resolution. The image sensor is positioned at the image plane and configured to capture an image having an associated field of view of the environment. Based on a distortion profile of the rotationally symmetric foveated lens and the image sensor resolution, the captured image exhibits a first angular optical resolution in a central region of the field of view and a second angular optical resolution in a peripheral region of the field of view.

The invention provides a portable spectrum analyzer based on a grating diffraction principle, and relates to the field of spectrum analyzers. The portable spectrum analyzer based on the grating diffraction principle comprises a supporting structure, a handle is fixedly connected to the position, close to the rear side, of the center of the lower end face of a main body, a control button is arranged at the position, close to the upper end, of the center of the front side wall of the handle, and the supporting structure is arranged at the position, close to the front side edge, of the center of the lower end face of the main body. All optical, mechanical and electronic components are highly integrated in a compact sealed shell by adopting an integrated optical machine design and an image plane diffraction optical path, a complicated movable adjusting mechanism of a traditional spectrometer is abandoned, the size is small, the weight is light, handheld or portable handheld operation is truly realized, and the cost is low. Through the blazed grating, the aspherical lens and the high-sensitivity image sensor which are optimally designed, the wide spectral range, the high optical resolution and the low stray light level which are comparable with those of a traditional table type spectrograph are achieved in a compact structure.

This invention relates to a tube lens compatible with high-NA objectives, a rapid automated optical inspection system and method. The tube lens includes a lens assembly comprising a first cemented lens with positive optical power, a second cemented lens with negative optical power, and a third cemented lens with positive optical power, arranged sequentially along the principal optical axis. The first cemented lens is disposed on one side of the object being tested. The first cemented lens comprises a first lens and a second lens cemented together; the second cemented lens comprises a third lens and a fourth lens cemented together; and the third cemented lens comprises a fifth lens and a sixth lens cemented together. The design of this invention enables a 1.4X tube lens, compatible with high-NA objectives. Its lens assembly includes multiple cemented lenses forming a positive-negative-positive structure, which improves the pixel resolution, optical resolution, and minimum defect size detection capability. It also has a long front working distance, adaptable to both vertical and horizontal inspection optical paths.

An optical-resolution photoacoustic microscopy (OR-PAM) system for visualizing water content deep in biological tissue uses an all-fiber 1930-nm hybrid optical parametrically-oscillating emitter. The emitter includes a tunable laser source whose output is amplified by a first erbium-doped fiber amplifier (EDFA). The output of the first amplifier is modulated with a Mach-Zehnder amplitude modulator that receives an RF signal with a nanosecond pulse width and a multiple kilohertz repetition rate. A second EDFA further amplifies the signal and passes it to a fiber circulator that in turn delivers it to a 1950 / 1550 mm fiber wavelength-division-multiplexing coupler WDM. The coupler introduces the signal to a cavity that includes a spool of highly nonlinear fiber and a Thulium-doped fiber amplifier TDFA. From the TDFA the signal reaches a 50 / 50 fiber coupler that sends part to a second output TDFA and guides part back to the cavity through a port of the WDM.

This invention discloses a non-contact device and method for inspecting the appearance of the inner surface of a hole. The device can be functionally divided into a motion control section and an image acquisition section. The motion control section includes a single-axis displacement stage, a single-axis rotary stage, a two-dimensional alignment stage, and a motion controller. The image acquisition section includes an industrial microscope head, an industrial camera, a video tube, and an LED lighting source. The measurement process includes the following steps: 1) calibrating the measuring device using a high-precision optical resolution plate; 2) calibrating the two-dimensional alignment stage using circular markers; 3) calibrating the rotation center position using a laser; 4) aligning the hole to be measured with the probe based on the calibration results; 5) initiating automatic image acquisition and stitching; and 6) calculating the actual size of the defect and its position within the hole. This invention can achieve panoramic defect inspection of the inner wall of blind holes or countersunk holes with diameters of 4mm-8mm and depths <45mm.

The invention discloses a cell sorting device and method and a computer readable storage medium, and belongs to the technical field of cell sorting. The cell sorting device comprises a flow chamber which is provided with a contraction section flow channel with a non-circular cross section and is used for guiding cells to flow through the flow channel in a preset orientation; the optical detection unit is arranged around the flow chamber and is used for detecting the cells in the preset orientation state; the liquid droplet forming unit is used for enabling the sample flow to be ejected in a liquid droplet form; a charging unit selectively applying a charge to the droplet; and a deflection means for sorting the charged droplets by applying a deflection force to the charged droplets. By arranging the at least one contraction section with the non-circular cross section, the cells are stably arranged in the flowing direction of the sample flow in the preset orientation, and the signal-to-noise ratio, the resolution ratio and the sorting accuracy of optical detection are improved. The optical detection unit detects the cells subjected to predetermined orientation in a flow chamber excitation mode, the effective numerical aperture is increased, the optical resolution and the signal acquisition efficiency are improved, and the sorting precision and efficiency are improved.

This invention relates to the field of driving circuit system technology, and more particularly to a CCD driving circuit system with adaptive integration time. The technical solution includes a CCD, an FPGA main controller, operational amplifiers and an AD converter, a USB 3.0 main controller, a power converter, and a CCD clock driver. The CCD is used to receive solar radiation and generate analog signals. This invention achieves rapid, accurate, and reliable adaptive adjustment of the integration time. It not only fundamentally overcomes the inherent defects of existing technologies, such as low adjustment efficiency, susceptibility to interference, and unreasonable target settings, but also reduces the burden on the host computer through a hardware integration scheme. This ensures that the optical resolution rate analyzer can stably acquire high signal-to-noise ratio and high-precision spectral data over a long period under various complex lighting conditions, significantly improving the overall performance and automation level of the instrument.

The application relates to the field of microscopes, in particular to a laser scanning confocal microscope which comprises a light splitting mechanism, multiple filter systems and multiple detection systems, the light splitting mechanism is used for transmitting fluorescent beams with different wavelengths to different filter systems, the filter systems correspond to the detection systems one by one, each filter system is matched with a different wavelength range, is used for filtering stray light emitted by a non-focal plane doped in the fluorescent beam, and the detection system is used for receiving the fluorescent beam leaving the filter system and converting to obtain an electric signal. Different wavelengths of fluorescent light are transferred to different filter systems for processing through the light splitting mechanism, at this time, the wavelength range matched by the filter system is small, and the optical resolution of all wavelength bands is ensured to reach the best state.

The invention relates to a photoacoustic imaging system and a photoacoustic imaging method. The photoacoustic imaging system comprises a laser source module used for providing excitation laser; the light transmission module is connected with the laser source module and is used for combining and / or splitting the excitation laser to form a first laser beam and a second laser beam; the imaging module comprises an optical resolution module used for focusing and irradiating a first laser beam on a to-be-measured object; the acoustic resolution module is used for diverging and irradiating the second laser beam on the to-be-detected object; the ultrasonic transducer is used for detecting a photoacoustic signal generated after the to-be-detected object is excited by the first laser beam and / or the second laser beam, and converting the photoacoustic signal into an imaging signal; wherein the focus of the optical resolution module, the central point of the irradiation area of the acoustic resolution module and the detection axis of the ultrasonic transducer are arranged in an overlapping manner; the driving module is used for driving the imaging module and the to-be-detected object to move relatively; and the data processing and control module is used for performing image reconstruction based on the imaging signal.

Example embodiments relate to foveated imagers for automotive applications. An example embodiment includes a device. The device includes a rotationally symmetric foveated lens. The rotationally symmetric foveated lens is configured to receive light from an environment. The rotationally symmetric foveated lens is also configured to produce an image at an image plane based on the received light. The device also includes an image sensor having an associated image sensor resolution. The image sensor is positioned at the image plane and configured to capture an image having an associated field of view of the environment. Based on a distortion profile of the rotationally symmetric foveated lens and the image sensor resolution, the captured image exhibits a first angular optical resolution in a central region of the field of view and a second angular optical resolution in a peripheral region of the field of view.

This invention relates to the field of optical imaging technology and discloses a dual-band co-aperture fusion imaging optoelectronic payload optical system, comprising: a shared sapphire optical window, a shared dichroic mirror, a visible light straight-tube optical path, and a mid-wave infrared U-shaped optical path arranged sequentially from the object side to the image side; the visible light straight-tube optical path and the mid-wave infrared U-shaped optical path have the same optical field of view, the same optical resolution, and the same optical distortion. In this invention, the object-side beam passes through the same front sapphire optical window, causing the two optical axes to coincide. The dichroic mirror then simultaneously separates the incident beam into the visible light path and the mid-wave infrared optical path, achieving co-aperture and real-time acquisition of dual-band signals, enabling parallax-free fusion imaging of targets at any distance. This invention possesses excellent anti-interference capabilities, multi-dimensional information fusion enhancement effects, and dual-band anti-interference capabilities, and can be mounted on various unmanned intelligent devices, optoelectronic turrets, and optoelectronic pods.

The application discloses a wafer defect detection method based on phase shift interference and movement difference, collects phase shift interference pictures of a measured wafer under single visual field, and completes three-dimensional topography data recovery of the wafer surface; the sample is microscopically scanned by a horizontal displacement table according to a certain step size, the sample is repeatedly measured for multiple times, second-order difference is made by using adjacent two measurement results, then the multiple second-order difference results are sequentially cropped and superimposed, so that the wafer surface defects form a specific mode of three-pole pattern; the defect three-pole pattern is detected and marked by using frequency domain high-pass filtering and image morphological operation and other image processing methods. Compared with other wafer defect detection methods, the application has high detection sensitivity, can accurately identify defects smaller than the optical resolution scale, and can classify and judge the concave-convex state of the defects, the method is suitable for surface defect detection of wafers and transparent or opaque optical elements, and is especially suitable for defect detection of patterned wafers.

The present invention relates to a process for the preparation of a compound of formula (I) based on optical resolution of an enantiomer mixture of 1, 4-dichloro-5-(methyl-d3)-6, 7-dihydro-5H-cyclopenta [d] pyridazine; the method comprises the following steps: reacting the enantiomer mixture with an optically active compound to form a compound of isomers, and separating the obtained compound through crystallization to obtain the compound shown in the formula (I), the method has the advantages of low price of the reaction initiator, simple post-treatment operation, high yield, high chemical and chiral purity of the product, and suitableness for large-scale industrial production. The compounds of formula (I) are useful for the preparation of a thyroxine [beta] receptor agonist (R)-2-(3, 5-dichloro-4-((7-(methyl-d3)-1-oxo-2, 5, 6, 7-tetrahydro-1H-cyclopenta [d] pyridazine-4-yl) oxy) phenyl)-3, 5-dioxo-2, 3, 4, 5 + tetrahydro-1, 2, 4-triazine-6-formonitrile, which agonist is useful for the treatment of primary hypercholesteremia in adults.

The present invention relates to large-scale CubeSat chassis and methods of making and using same. The disclosed CubeSat comprises specific structural features that can yield up to at least a 27 U CubeSat that has comparable or even better performance and benefits than that of smaller CubeSats. Such volume increase coupled with the structural integrity of Applicants' CubeSats opens up a wide range of CubeSat performance increases including, but not limited to, larger payloads, more diverse payloads and larger CubeSat fuel capacities. Such increased payload capabilities includes, for example, increased focal length capabilities and such improved maneuverability results in, for example, decreased ground sample distance, increased optical resolution, increased ability to change orbits, increased structural stability. In addition, the judicious selection of such specific structural features can result increased payload capabilities and improved maneuverability.

Example embodiments relate to foveated imagers for automotive applications. An example embodiment includes a device. The device includes a rotationally symmetric foveated lens. The rotationally symmetric foveated lens is configured to receive light from an environment. The rotationally symmetric foveated lens is also configured to produce an image at an image plane based on the received light. The device also includes an image sensor having an associated image sensor resolution. The image sensor is positioned at the image plane and configured to capture an image having an associated field of view of the environment. Based on a distortion profile of the rotationally symmetric foveated lens and the image sensor resolution, the captured image exhibits a first angular optical resolution in a central region of the field of view and a second angular optical resolution in a peripheral region of the field of view.

Methods and systems for generating bright-field ellipsometric images indicative of structural defects sized below the optical resolution limit are presented herein. In some examples, bright-field ellipsometric images offer a higher signal to noise ratio of small defect signals to nuisance pattern noise signals compared to dark-field imaging at the null condition. Various ellipsometric imaging techniques are employed to generate images of a wafer or reticle under inspection. The images provide intensity contrast that is indicative of phase differences induced by the scattering response of different structures in the imaging field of the ellipsometric imaging system. In one aspect, an ellipsometric imaging system employs a polarizer in the illumination path and an analyzer and at least one waveplate in the imaging path. The ellipsometric imaging system generates images having intensity differences that differentiate defects of interest from nuisance pattern noise with relatively high signal to noise ratio.

Methods and systems for performing multi-resolution in situ decoding are described. The method may comprise, for example, acquiring at least one first image of a biological sample at a first optical resolution; identifying locations for a plurality of target analytes based on the at least one first image; acquiring at least one second image of the biological sample at a second optical resolution in at least one decoding cycle of a plurality of decoding cycles used for in situ decoding of the target analytes; and extracting signal intensity data for signals associated with all or a portion of the target analytes from the at least one second image based on the locations for the target analytes identified in the at least one first image. In some instances, the method may further comprise using the signal intensity data extracted from the at least one second image to decode the target analytes.