412 results about "Picoline" patented technology

Production of anti-fiberization medicine pyphenitone is carried out by taking 2-amino-5-picoline as initial materials, diazotizing, hydrolyzing to obtain 5-methyl-amino-2(1H)pyridone, nucleophilic substituting benzene halide with under existence of catalyst and purifying to obtain final product. It is cheap, has short reactive time and more yield. It can be used for industrial production.

The N-arylsulfilimine-catalyzed coupling of aromatic sulfonyl chlorides with N-([1,2,4]triazolopyrimidin-2-yl)amines to form N-([1,2,4]triazolo-pyrimidin-2-yl)aryl sulfonamides is improved by the selection of 3-picoline or 3,5-lutidine as the base.

Provided is a pharmaceutical preparation for treatment or prevention of glaucoma or ocular hypertension, comprising 0.0003 to 0.01% (w/v) of isopropyl(6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate, or a salt thereof.

The invention discloses synthesis methods of 2-chloro-5-trichloromethylpyridine and 2-chloro-5-trifluoromethylpyridine, namely a novel method, which comprises the steps of carrying out photocatalytic chlorination on trimethylpyridine as a raw material so as to obtain 3-trichloromethylpyridine, and then, carrying out gas-phase thermocatalytic chlorination so as to obtain 2-chloro-5-trichloromethylpyridine, and a method, which comprises the step of carrying out gas-phase thermal chlorination on 3-trifluoromethylpyridine as a raw material so as to obtain 2-chloro-5-trifluoromethylpyridine. The synthesis methods disclosed by the invention have the advantages that the process is simple and easy, the raw materials are cheap and are easily obtained, the yield is relatively high, the purity of products is high, and the like.

The invention relates to luminescent novel material synthesis technologies and particularly relates to blue-green materials with novel tri/tetra-coordination dual-core copper [I] coordination compounds and a preparation method thereof. According to the preparation method, the novel dual-core copper [I] coordination compound blue-green materials, namely [Cu2[bmptzH][[mu]-dppm]2][ClO4]2 and [Cu2[fptz][[mu]-dppm]2][ClO4], which simultaneously have two coordination bonding manners, namely tri-coordination and tetra-coordination, and have special structures, are synthesized from functionalized pyridine triazole bidentate chelating ligands (5-tert-butyl-3-[6-methyl-pyridine-2-yl]-1,2,4-triazole and 5-trifluoromethyl-3-[pyridine-2-yl]-1,2,4-triazole) and an organic diphosphine auxiliary ligand (bis[diphenylphosphino]methane). The blue-green materials show very good photoluminescence properties in a solid state, and the photoinduced quantum efficiency is 66% and 77% respectively.

The invention relates to the field of organic nonlinear optical materials and relates to methyl pyridinium with an organic two-photon absorption material, and a preparation method and the application of the methyl pyridinium. The structural formula of the product is described in structural formula (I); the preparation method comprises the steps of taking 2,6-dimethyl pyridine as a raw material and finally obtaining a compound (I) by conducting oxidizing reaction, esterification reaction, methylolation reaction, halogenation reaction, nucleophilic addition reaction, Wittig reaction and the final methylation reaction. The raw materials are easy to access, and the synthesis steps are simple. The compound (I) has excellent two-photon absorption performance and good water solubility and is an ideal biological fluorescence probe; an obvious solvatochromism phenomenon easily occurs, the compound can be used for detecting water content in a common organic solvent, can also be used as a fluorescent probe for detecting the PH value in a solution system, has a series of advantages of high sensibility, quick response, identification by naked eyes and the like, and has an excellent application prospect.

The invention provides a metallic complex taking pyridine as parent body. It comprises following steps: taking picoline as raw material, placing trimethyl silicon base on substituent group after modification, carrying out addition reaction with benzenenitrile and getting a kind of metallic organic compound complexed witheta3-aza and pyridine. The method is characterized by temperate reaction condition, simple process, fast reaction speed and high productivity. The complex can be used as catalyst for alkene polymerization, and is characterized by long endurance, low cost, stable performance for oxygen atom and other foreign atoms in functional group, high activity and adjustable selectivity.

The invention belongs to the technical field of chemical synthetic medicines and particularly relates to water soluble salts of an organic acid of 5-(2-fluorophenyl)-N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methylamine and an injection thereof for treating gastric acid related diseases and a preparation method thereof. The invention discloses the salts of the organic acid of 5-(2-fluorophenyl)-N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methylamine shown as the following general formula in the specification, wherein n is 1 or 1/2 and HA is an organic acid. According to the salts of the organic acid, which are disclosed by the invention, the solubility of the salts in water or an artificial gastric and intestinal juice is far greater than TAK438, and the solubility of pyroglutamate and lactate in water is greater than 1g/mL.

The invention discloses a preparing method of 2-chlorine-3-trifluoro metyl group pyridine as new type pesticide intermediate, which comprises the following steps: refluxing organic solvent; chlorinating 2-chlorine-3-metyl group pyridine; stripping organic solvent; crystallizing; centrifuging; hot-dissolving chlorinated material; fluoriding; distilling steam; separating; rectifying. This invention possesses simple craft and easy to operate, which can get high purity product with purity not less than 98% and receiving ratio at about 85%.

The invention relates to a novel synthetic method for preparing 2-chlorine-3-amino-4-picoline, and belongs to a production process and corresponding various process conditions for preparing the 2-chlorine-3-amino-4-picoline by using 4-picoline as raw materials sequentially through four-step reaction: concentrated nitric acid nitration, sodium pyrosulfite nitro migration, catalyst catalytic hydrogenation and hydrogen peroxide and concentrated hydrochloric acid chlorination. The method has the beneficial effects that industrial products of 4-picoline are used as raw materials, the raw materials are easily obtained, the price is proper, the reaction condition is mild, and a novel and efficient new path is provided for the industrial production of the 2-chlorine-3-amino-4-picoline.

The preparation process of Ru(II)-polypyridine complex includes the following steps: preparing 1,10-phenanthroline-5,6-diquinone, pyridine [3, 2-a:2', 3'-c] phenazine as ligand I, and 7,8-dimethyl pyridine [3, 2-a: 2', 3'-c] phenazine as ligand II, Ru(bipy)2Cl2.2H2O (bipy=2, 2'-dipyridyl) as precursor I and Ru(phen)2Cl2.2H2O as precursor II; adding certain amount of Ru(bipy)2Cl2.2H2O/Ru(phen)2Cl2.2H2O, ligand I/ligand II, and mixture liquid of methanol and water, heating reflux for certain time, heating to concentrate, adding water and boiling, freezing, adding sodium tetrafluoborate, filtering and separating out precipitate, re-crystallization in alcohol, and stoving under infrared lamp to obtain the Ru(II)-polypyridine complex. The Ru(II)-polypyridine complex is used as nucleic acid recognizing probe for the analysis and detection of nucleic acid, and has high stability, high sensitivity, high selectivity and other advantages.

The invention discloses a preparation method of esomeprazole and a magnesium salt thereof. The preparation method comprises the steps: with 4-methoxy-2-hydroxymethyl-3,5-dimethyl pyridine as raw material, carrying out a reaction with hydrobromic acid to obtain 4-methoxy-2-bromomethyl-3,5-dimethyl pyridine, namely a compound II; dripping a methanol solution of the compound II into a methanol solution of a compound III, and carrying out a reaction to obtain 5-methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl thio-1H-benzimidazole, namely a compound IV; dissolving the compound IV in dichloromethane, adding D-diethyl tartrate, tetrabutyl titanate and water for reaction, and thus obtaining esomeprazole; and carrying out a reaction of esomeprazole with magnesium methoxide to obtain magnesium esomeprazole. The method is utilized to prepare esomeprazole and the magnesium salt thereof, and can effectively reduce the production cost.

The invention relates to a preparation method of 2-chloro-5-picoline. According to the method, benzyl chloride is taken as a raw material, benzaldehyde is taken as an inhibitor, ammonia is taken as an aminating agent, a product has a condensation reaction with propionaldehyde under the catalysis of an organic base, then a product has acetylation with an acetylation reagent, finally, a product performs cyclization under actions of N,N-dimethylformamide and triphosgene, and the target product 2-chloro-5-picoline is obtained through purification. The product purity is higher than or equal to 99.5%, and the total molar yield higher than 80% is realized. The preparation method of 2-chloro-5-picoline has good reaction selectivity, high yield and few three wastes, is simple to operate and facilitates industrialized production.

The invention discloses a 2-(2'-hydroxyl styryl) naphthyridine probe reagent and preparation and application thereof. The probe reagent is mainly prepared by concentrated sulfuric acid, sodium 3-nitrobenzene sulfonate, boric acid, FeSO4.7H2O, 2-amino-6-picoline, salicylide, glycerol and acetic anhydride. The 2-(2'-hydroxyl styryl) naphthyridine probe reagent has the advantages that the probe reagent can selectively detect various target ions, single-probe, multi-target and multi-mode identification and detection are achieved, and the probe reagent can be used for detecting Hg<2+>, Ag<+> and F<-> ions; a probe is simple in structure, low in preparation cost, diversified in detection and identification manners, high in detection sensitivity, good in selectivity, excellent in performance, easy in operation condition control and promising in application prospect.

The invention provides a preparation method of 2-chloro-6-trichloromethyl pyridine. The method comprises the following steps: carrying out water gasification by taking 2-trichlormethyl as initial material, then taking activated carbon with metal ion oxides, such as Fe, Zn and the like as catalyst, taking nitrogen as carrier gas, reacting with chlorine and then generating 2-chloro-6-trichloromethylpyridine, and rectifying to obtain the finished product with the overall yield being more than 75 percent. In the preparation method, continuous reactions are adopted, and the operation is very safeand convenient; and meanwhile, hydrogen chloride generated by reaction is prepared into hydrochloric acid by water absorption as the used materials are less, excess chlorine and sodium hydroxide reactto prepare sodium hypochlorite, therefore, the emission amount of three wastes is less, which is environmental-friendly; and the production cost of the product is greatly reduced.

The invention discloses a preparing method of 2, 3-dichloro-5-trifluoro metyl group pyridine as new type pesticide intermediate, which comprises the following steps: refluxing organic solvent; chlorinating 2, 3-dichloro-5-metyl group pyridine; stripping organic solvent; crystallizing; centrifuging; hot-dissolving chlorinated material; fluoriding; distilling steam; separating; rectifying. This invention possesses simple craft and easy to operate, which can get high purity product with purity not less than 98% and receiving ratio at about 85%.

The process of preparing 2-chloro-6-trifluoromethylpyridine as one new type of pesticide intermediate includes the following steps: chloridizing 2-chloro-6-tetramethyl pyridine in refluxing organic solvent, eliminating organic solvent, heating to dissolving chloridizing material, fluorinating, steam distilling, separating and rectifying. The process of the present invention is simple, easy to operate and favorable to industrial production, and the obtained product has purity not lower than 98 %, yield of 85 % and low production cost.

The invention provides an industrial production method for preparing 2-chloro-5-picoline, and relates to the technical field of production of pesticide intermediates. According to the method, 2-chloro-5-picoline is synthesized by taking 5-methyl-3, 4-dihydro-2 (1H) pyridine as a raw material and triphosgene or phosgene as a chlorinating agent in the presence of a basic catalyst. The method has the characteristics of high reaction yield and good product quality; and the reaction yield is 94%; and the content detected by liquid chromatography is more than 94%.