49 results about "Picoline" patented technology

The invention provides a preparation method of fluoride ether bacteria amide, which comprises the following steps: dissolving pentafluorobenzonitrile in a solvent, dropwise adding a sodium methoxide solution at-10-30 DEG C for 2-15 hours, continuing to carry out heat preservation reaction for 0.5-2 hours after dropwise adding, and carrying out post-treatment to obtain 2, 3, 5, 6-tetrafluoro-4-methoxybenzonitrile; the preparation method comprises the following steps: jointly dissolving 2, 3, 5, 6-tetrafluoro-4-methoxybenzonitrile, 3-chloro-5-(trifluoromethyl) pyridine-2-yl) methanol and a catalyst acid in a solvent, reacting at 50-110 DEG C for 5-32 hours, and performing post-treatment on the obtained reaction liquid to obtain fluoride ether bacteria amide, according to the method, sodium methoxide and pentafluorobenzonitrile which are low in price and easy to obtain are subjected to etherification reaction, thionyl chloride and bis (trichloromethyl) carbonate are not used, the green chemical principle is met, and the method has the advantages of being short in step, safe and easy to operate and the like, so that the method has high implementation value and practical production applicability.

The invention discloses a near-infrared absorption zwitter-ion ethylene-linked covalent organic framework photocatalyst as well as a preparation method and application thereof, and the preparation method comprises the following steps: carrying out hydrothermal reaction on a mixture of an N-(3-sulfopropyl)-2, 4, 6-(trimethyl) pyridine monomer, an aldehyde monomer containing a thiophene unit, organic alkali and water to obtain the near-infrared absorption zwitter-ion ethylene-linked covalent organic framework photocatalyst. The zwitterionic ethylene-linked covalent organic framework photocatalyst ZVCOFs with near-infrared absorption is obtained. According to the method, a one-step green hydrothermal method is adopted, water is used as a solvent, pollution to the environment is reduced, traditional tedious freezing-pumping-unfreezing operation is omitted, high-yield COFs are obtained, and the method has the potential of industrial amplification. The ZVCOFs show excellent hydrophilicity due to rich zwitterionic groups and thiophene units, the light absorption range can be expanded to a near-infrared light region, the light absorption band edge reaches up to 852-1230 nm, and the ZVCOFs have excellent hydrogen evolution performance of photocatalytic water decomposition.

An improved process for the production of 4-amino-5-methyl-(1H)-pyridin-2-one and derivatives. In the process, 4-hydroxy-5-methyl-(1H)-pyridin-2-one is reacted under pressure with an ammonium salt without adding aqueous ammonia or feeding in gaseous ammonia to provide the target compounds in high yield and high purity. The reaction mixture is not or much less corrosive to enamel coatings of a reaction container surface, since gaseous ammonia as reagent is not used.

The invention belongs to the field of fluorine-containing pesticide synthesis, and particularly relates to synthesis of fluopyram. The fluopyram is innovatively synthesized by adopting a one-pot catalytic system, and the reaction process is as shown in the formula 1: 2-acetonitrile-3-chloro-5-trifluoromethylpyridine (1) and o-trifluoromethyl benzoyl chloride (2) are used as initial raw materials, a catalyst with a specific structure and an alkali-binding acid agent are added into an ionic liquid, and a reaction is performed at the temperature of 60-80 DEG C for 1-2 hours to obtain the fluopyram. And preparing the target product fluopyram (3) by a high-efficiency one-pot method under the catalytic action of a supported metal catalyst in a hydrogen atmosphere. According to the one-pot synthesis process of fluopyram, the reaction is clean and pollution-free, the operation is simple and convenient, the utilization rate of raw materials is high, and the application frequency of Raney nickel can be increased under the condition that the yield is not influenced through a reaction system formed by combining water and an organic solvent. The o-trifluoromethyl benzoic acid recovered from the water phase can be further converted into o-trifluoromethyl benzoyl chloride, so that the utilization rate of the raw materials is improved. The synthesis process route is effectively shortened, and meanwhile, the use of expensive protection groups for protection in the hydrogenation reduction process is avoided, so that the process is more simplified.

The invention relates to a synthetic method of an indoloquinazolinone compound. The synthetic method comprises the following steps: reacting 2-aminoacetophenone with aryl isocyanate under the catalytic action of a palladium complex to obtain the indoloquinazolinone compound, wherein the palladium complex is an N, N-coordinated palladium complex containing a meta-carborane ligand. The preparation process of the palladium complex comprises the following steps: adding an n-BuLi solution into a meta-carborane solution to carry out a deprotonation reaction, then adding 3-chloromethylpyridine to carry out a nucleophilic substitution reaction, finally adding Pd (OAc) 2 to carry out a coordination reaction to obtain a palladium complex head product, and carrying out post-treatment to obtain the palladium complex product. Compared with the prior art, the method disclosed by the invention has the advantages of good adaptability, high catalytic efficiency, few byproducts, mild reaction conditions, lower cost, easiness in product separation, no generation of a large amount of waste residues and the like.

The present disclosure provides crystalline forms, solvates, and hydrates of (R)-5-fluoro-2-methyl-1-((R)-5-(pyridin-2-yl)-2,3-dihydro-1H-inden-2-carbonyl)indoline-6-sulfonamide and methods of preparation.

The application provides a supercapacitor electrolyte with low self-discharge, a preparation method and application thereof, raw materials of the supercapacitor electrolyte include organic solvents, ammonium salt and pyridine oxide; the organic solvents are one or more of acetonitrile, fluoroacetonitrile, propionitrile, butyronitrile and isobutyronitrile; the ammonium salt is tetraethylamine bistrifluoromethylsulfonylimide or tetraethylammonium bis(trifluoromethanesulfonyl)imide; and the pyridine oxide is pyridine-N-oxide, 4-methylpyridine oxide or 3-methylpyridine oxide. By selective use of specific additives and optimized configuration of electrolyte salt, the supercapacitor electrolyte of the application can effectively reduce the self-discharge rate of the supercapacitor and significantly improve the energy utilization efficiency of the capacitor.

The application relates to the technical field of catalytic materials, and relates to an organic photocatalytic material and a preparation method thereof.1, comprising the following steps: mixing modified N-hydroxy phthalimide phenylacetate, an aliphatic nitroalkane, 2,6-dimethylpyridine, a photocatalyst and a solvent, then irradiating under visible light, placing in an inert atmosphere, stirring for 2-8 hours, and obtaining a product through post-treatment to obtain a final product; the mass ratio of the modified N-hydroxy phthalimide phenylacetate, the nitro compound, the 2,6-dimethylpyridine, the photocatalyst and the solvent is 2-5:1-2:1-3:1:8-11. The visible light catalysis method can be used to synthesize the nitro compound under mild conditions, and further provides a green and efficient new path for the preparation of a nitrogen-containing drug intermediate.

The invention discloses a high-cycle-stability absorption liquid for capturing carbon dioxide and a preparation method and application thereof, and relates to the technical field of gas separation and purification, the absorption liquid comprises a main absorption component, an auxiliary absorption component, an active component, an additive and a solvent; the additive is 4, 4 '-dihydroxy diphenyl ether and 3-methyl-3H-imidazole methyl [4, 5-b] pyridine-6-carboxylate; the solvent is water. The absorption liquid provided by the invention can be used for capturing carbon dioxide in industrial waste gas, has excellent carbon dioxide absorption and desorption capacity and rapid absorption and desorption kinetics, improves the CO2 absorption load capacity, has excellent absorption and desorption rate and low-temperature capturing performance, and has better stability in long-period operation. In addition, the method solves the problems of cost, energy consumption, environment compatibility and the like, and has a good application prospect.

The application discloses an MXene aerogel diaphragm and a preparation process thereof, and belongs to the technical field of lithium battery diaphragms. The MXene aerogel diaphragm disclosed by the application contains the following components in parts by weight: 100 parts of modified carboxymethyl cellulose, 5-15 parts of MXene nanosheets, 20-30 parts of a crosslinking agent, 0.1-100 parts of a pH regulator, and 10000-20000 parts of a solvent. The modified carboxymethyl cellulose is prepared by first subjecting sodium carboxymethyl cellulose to a nucleophilic ring-opening reaction with glycidyl methacrylate to obtain GMA-CMC, and then subjecting the GMA-CMC to a Michael addition with 2-amino-4-(trifluoromethyl) pyridine hydrochloride. The MXene aerogel diaphragm disclosed by the application has excellent structural stability, high ionic conductivity and good thermal stability.

This invention relates to a method for synthesizing azoxystrobin, belonging to the field of organic synthesis technology. The method uses 2-(2-(chloromethyl)phenyl)-3-methoxyacrylonitrile and 2-hydroxy-6-trifluoromethylpyridine as raw materials, condensing them under alkaline conditions to obtain an etherified intermediate, which is then directly hydrolyzed and esterified with methanol under acidic conditions to obtain azoxystrobin. This method avoids the use of expensive 3-isochloroketone as a raw material, using inexpensive 2-(2-(chloromethyl)phenyl)-3-methoxyacrylonitrile prepared from o-methylphenylacetonitrile as the key fragment, further reducing the cost of azoxystrobin raw materials. Furthermore, the process route is simple, the yield is high, and it is suitable for industrial production.

The invention relates to a crystal form A of(S)-2-(3S,8S)-3-(4-(3,4-dichlorobenzyloxy)phenyl-7-((S)-1-phenylpropyl)-2,3,6,7,8,9-hexahydro-[1,4]-dioxino[2,3-g]isoquinolin-8-ylformylamino)-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propionic acid (“OAD2”), and methods of preparation thereof. Crystal form A may be useful in the treatment of various conditions and metabolic disorders including, but not limited to, type 2 diabetes.

The application discloses a preparation method of fluopyram, which comprises the following steps: step 1: in the presence of solvent 1 and a base, dimethyl malonate and 2,3-dichloro-5-trifluoromethyl pyridine are added to react, a salt reaction is carried out by adjusting pH, and 2-[3-chloro-5-(trifluoromethyl) pyridyl] dimethyl malonate potassium salt, namely intermediate 1, is obtained; step 2: o-trifluoromethyl benzoyl chloride, an organic base and chloromethylamine are added to react, and intermediate 2 is obtained; step 3: solvent 3, intermediate 1 and intermediate 2 are added to react, and intermediate 3 is obtained; step 4: water, a base, solvent 4 and intermediate 3 are added, pH is adjusted after reaction, and continuous reaction is carried out, and fluopyram is obtained. By adopting the preparation method, the yield of fluopyram is high, the purity is high, the reaction time is short, the reaction condition is mild, and the method is suitable for mass production.

Method for obtaining 2,3-diphenyl-6-{[5-(trifluoromethyl)pyridine-2-yl]oxy}-6,7-dihydro-5H-imidase[2,1-b][1,3]thiazine involves the reaction of starting material, 6-hydroxy-2,3-diphenyl-6,7-dihydro-5H-imidase[2,1-b][1,3]thiazine, with halogen-substituted pyridine in dimethylformamide. Previously obtained solution of 2,3-diphenyl-6,7-dihydro-5H-imidazo[2,1-b] [1,3]thiazine-6-ol and NaH in dimethylformamide is stirred for 0.5 hours at room temperature; only then is 5-(trifluoromethyl)-2-chloropyridine added in a 1:1 ratio, and mixture is subjected to intensive stirring for 24 hours. Then reaction mixture is poured onto ice; resulting precipitate is filtered off and identified as 2,3-diphenyl-6- {[5-(trifluoromethyl)pyridin-2-yl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]-thiazine. Thus, the synthesis is carried out by first preparing solution of starting compound with NaH using the method of prolonged stirring, followed by the main synthesis with a reaction time of 24 hours.

The invention discloses a continuous production and preparation method of 2-chloro-5-chloromethylpyridine, and belongs to the technical field of synthesis of pesticide intermediates. The method comprises the following steps: continuously introducing 2-chloro-2-chloromethyl-4-cyanobutyraldehyde, a solvent and triphosgene into a two-stage series cyclization reactor, carrying out a reaction at a specific temperature under a negative pressure condition, and timely removing hydrogen chloride generated by the reaction; and after the reaction is finished, extracting the separated tar with a solvent to recover effective components, washing and alkali-washing the obtained organic phase, and desolventizing and distilling the organic phase in a two-stage series film evaporator to obtain the high-purity 2-chloro-5-chloromethylpyridine product. Through full-process continuous operation, the polymerization side reaction is effectively inhibited, the retention time of the material in a severe environment is shortened, the problems of low yield, poor quality and tedious post-treatment in the prior art are solved, the process is efficient and environmentally friendly, the product yield is stabilized to be 90% or above, the product content reaches 96% or above, and the method is suitable for industrial large-scale production.

The invention relates to the technical field of chemical synthesis, in particular to a tetranuclear dysprosium-based metal-organic framework material and a preparation method and application thereof. A chemical formula of the tetranuclear dysprosium-based metal-organic framework material is [Dy4 (dbm) 2 (H2L1) 2 (HL2) 2 (CH3O) 2]. 6CH3OH, H4L1 is N '2, N' 6-bis ((E)-3, 5-di-tert-butyl-2-hydroxybenzylidene) pyridine-2, 6-dicarbohydrazide, H3L2 is (E)-N '-(3, 5-di-tert-butyl-2-hydroxybenzylidene)-6-(hydroxymethyl) pyridine hydrazide, and Hdbm is dibenzoylmethane; the tetranuclear dysprosium-based metal-organic framework material crystal belongs to a monoclinic system and a C2 / c space group. The preparation method of the chiral phosphine nickel (II) complex is simple and convenient to operate, high in purity and good in reproducibility. The tetranuclear dysprosium-based metal-organic framework material disclosed by the invention is good in thermal stability, shows good catalytic performance in a cycloaddition reaction for synthesizing cyclic carbonate through CO2 catalytic conversion, and has a good application prospect.

Disclosed in the present invention is a process for preparing a key intermediate of fluopyram. The key intermediate is dimethyl [3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[2-(trifluoromethyl)benzoyl]amino}methyl)malonate. The process comprises the following steps: in the presence of a solvent 1, reacting the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridyl]malonate with the compound 1-D in a reaction container, and recovering the solvent 1 by means of distillation, so as to obtain the intermediate compound, wherein the solvent 1 is selected from acetic ester solvents having a boiling point range of 40-110°C at a normal temperature and a normal pressure. The process of the present invention is simple and convenient, the total yield is high, the solvent is easy to recover, and the product purity is high; the intermediate does not require any post-purification treatment, and can be directly used for the synthesis of fluopyram; and the process can be amplified, and is beneficial for cost reduction, efficiency improvement and commercial mass production.

Crystalline and amorphous forms of N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl-5-fluoro-4-(3-iso-propyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-amine (Compound 1) and various salts thereof, preparation methods of these crystalline and amorphous forms, pharmaceutical compositions containing these crystalline or amorphous forms, and use of these crystalline and amorphous forms, or pharmaceutical compositions thereof, for treatment of diseases or disorders associated with cyclin-dependent kinase (CDK), especially CDK4 and CDK6, activities, such as various cancers, are disclosed.

The invention discloses a preparation method of fluopyram, which comprises the following steps: mixing 2, 3-dichloro-5-trifluoromethylpyridine, a solvent and alkali, dropwise adding cyanoacetate for reaction, adding an N-acetoxymethyl-2-trifluoromethyl benzamide solution for reaction, adding methanol, a sodium hydroxide solution and a hydrogen peroxide solution for catalytic hydrolysis, adding a sodium hydroxide solution and a hydrogen peroxide solution for reaction, and performing reduced pressure distillation to obtain the fluopyram. And performing hydrochloric acid acidification and decarboxylation on the catalytic hydrolysis product to obtain the fluopyram. According to the preparation method of the fluopyram, the 2, 3-dichloro-5-trifluoromethylpyridine, the cyanoacetate and the N-acetoxymethyl-2-trifluoromethyl benzamide are taken as raw materials, and under the action of the hydrogen peroxide, not only can the preparation efficiency be improved, but also the fluopyram with high yield and high purity can be prepared; the method has the advantages of simple process, low cost, high preparation efficiency, high product yield, high purity, environmental protection and the like, can improve the product competitiveness, and is convenient for realizing industrial application.

The purpose of the present invention is to provide a pharmaceutical composition that comprises a specific compound and exhibits a superior preservation efficacy, the specific compound being stable within the pharmaceutical composition, and to provide methods for improving the stability of the specific compound within the pharmaceutical composition and the preservation efficacy of the pharmaceutical composition. The pharmaceutical composition according to the present invention comprises isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate or a salt thereof, and further comprises edetic acid or a salt thereof.

To provide a pharmaceutical composition for use in the manufacture of a medicament for treating obesity.SOLUTION: A pharmaceutical composition comprising a crystalline hydrochloride form (Form B) of (S) -2 - (3S, 8S) - 3 - (4 - (3, 4-dichlorobenzyloxy) phenyl-7 - ((S) - 1-phenylpropyl) - 236789 - hexahydro - [1,4] - dioxino [2, 3-g] isoquinolin-8-ylformylamino) - 3 - (4 - (2, 3-dimethylpyridin-4-yl) phenyl) propionate ("OAD2") and a pharmaceutically acceptable carrier, the crystalline hydrochloride form is characterized as having an X-ray powder diffraction pattern (XRPD) comprising peaks at the following diffraction angles (2 θ) measured using Cu, K α radiation: 5.3 ± 0.2 °, 9.2 ± 0.2 °, 10.3 ± 0.2 °, 13.2 ± 0.2 °, and 14.8 ± 0.2 °.SELECTED DRAWING: Figure 1

To provide a stable crystalline form of (S) -2 - (3S, 8S) - 3 - (4 - (3, 4-dichlorobenzyloxy) phenyl-7 - ((S) - 1-phenylpropyl) - 236789 - hexahydro - [1,4] - dioxino [2, 3-g] isoquinolin-8-ylformylamino) - 3 - (4 - (2, 3-dimethylpyridin-4-yl) phenyl) propionate ("OAD2").SOLUTION: There is provided a crystalline form A of OAD2, characterized in that the X-ray powder diffractogram comprises peaks at 2-theta angles of 9.53 °, 12.32 °, 13.80 °, 17.84 °, 18.56 °, 19.40 °, 20.38 °, 20.99 °, 21.78 ° and 24.69 °.SELECTED DRAWING: Figure 1

The invention belongs to the field of fine chemical engineering and pesticides, and particularly relates to a preparation method of N-(pyrimidine-5-ylmethyl) pyridine-2-amine. The invention provides a novel preparation method of pyrimidine-5-formaldehyde, which is used for preparing pyrimidine-5-formaldehyde by taking phosphorus oxychloride and DMF (Dimethyl Formamide) as initial raw materials. Pyrimidine-5-formaldehyde and 2-aminopyridine are used as initial raw materials of the N-(pyrimidine-5-yl methyl) pyridine-2-amine, and a new synthesis path is provided for preparation of the N-(pyrimidine-5-yl methyl) pyridine-2-amine. The invention also provides a novel intermediate in the preparation process of the pyrimidine-5-formaldehyde and the N-(pyrimidine-5-yl methyl) pyridine-2-amine. The synthesis route provided by the invention has the advantages of easily available raw materials, simple operation, easily controllable conditions, high yield and few impurities.

The invention discloses a preparation method of 2-chloromethyl-4-methoxy-3, 5-dimethyl pyridine hydrochloride, which comprises the following steps: carrying out oxidation reaction on 3, 5-dimethyl pyridine to obtain 3, 5-dimethyl pyridine nitrogen oxide; the method comprises the following steps: in mixed acid of nitric acid and sulfuric acid, carrying out nitration reaction on 3, 5-dimethyl pyridine nitrogen oxide to obtain 4-nitro-3, 5-dimethyl pyridine nitrogen oxide; the method comprises the following steps: carrying out methoxy reaction on 4-nitro-3, 5-dimethyl pyridine nitrogen oxide to obtain 4-methoxy-3, 5-dimethyl pyridine nitrogen oxide, activating the 4-methoxy-3, 5-dimethyl pyridine nitrogen oxide by using an activating reagent, carrying out chlorination reaction on the 4-methoxy-3, 5-dimethyl pyridine nitrogen oxide and thionyl chloride to obtain free alkali of 2-chloromethyl-4-methoxy-3, 5-dimethyl pyridine, and carrying out reaction on the free alkali of 2-chloromethyl-4-methoxy-3, 5-dimethyl pyridine nitrogen oxide and the free alkali of 2-chloromethyl-4-methoxy-3, 5-dimethyl pyridine nitrogen oxide to obtain the 2-chloromethyl-4-methoxy-3, 5-dimethyl pyridine nitrogen oxide. And carrying out a salt forming reaction in an organic solvent of HCl to obtain the 2-chloromethyl-4-methoxy-3, 5-dimethyl pyridine hydrochloride. According to the invention, the'activation-chlorination 'yield is greater than 93.5%.

The invention belongs to the technical field of medicine analysis, and particularly relates to a method for analyzing a phosphodiesterase 4 inhibitor and impurities thereof. According to the analysis method for the phosphodiesterase 4 inhibitor and the impurities thereof, the dipotassium phosphate aqueous solution is used as a mobile phase A, acetonitrile is used as a mobile phase B, and gradient elution parameters and chromatographic parameters such as the flowing speed of the mobile phase, the column temperature, the sample size and the detection wavelength are improved, so that the purity of the phosphodiesterase 4 inhibitor is improved. The method can be used for simultaneously detecting and analyzing (E)-1-(3-(tetrahydrothiophene-3-yl) oxy-4-methoxystyryl)-2, 6-dimethyl pyridine-4-(1H)-ketone and seven impurities thereof, and solves the problem that in the prior art, the (E)-1-(3-(tetrahydrothiophene-3-yl) oxy-4-methoxystyryl)-2, 6-dimethyl pyridine-4-(1H)-ketone and seven impurities thereof are lacked. The invention aims to solve the technical problems in the prior art in a conventional method for detecting and analyzing 2, 6-dimethyl pyridine-4-(1H)-ketone and impurities thereof.

The present application relates to the field of catalyst preparation, in particular to a complex catalyst for synthesizing dimethyl carbonate, a preparation method and application thereof; the complex catalyst is prepared by complex coordination reaction of copper salt and multiple types of nitrogen-containing and oxygen-containing organic ligands; the copper salt is selected from one or more of cuprous chloride, cuprous bromide, cuprous iodide, copper chloride, copper sulfate, copper nitrate and copper acetate; the ligand is selected from two or more of nicotinamide, 3,4-dihydro-2(1H) quinolinone, 1-hydroxyisoquinoline, 2-pyridine carboxamide, o-phenanthroline, hexamethylphosphorus triamide, N-methyl-1-pyridine-2-methylamine, N-isopropylphthalimide, 3-cyanoisoquinoline, N-methylpyrrolidone, N-methylphthalimide, 2-hydroxyquinoline, phthalimide, trans-N-(2-pyridylmethylene) aniline and respective derivatives thereof, and is prepared by compounding in different proportions; under the synergistic effect of multiple ligands, the selectivity of dimethyl carbonate is ensured to be higher than 98%, and the selectivity of CO is greatly improved.

The invention relates to the technical field of organic synthetic chemistry, in particular to a method for synthesizing 7-dehydrocholesterol from cholesterol. Comprising the following steps: dissolving cholesterol in a first solvent, adding cyclohexanone and aluminum isopropoxide, and carrying out an Oppenauer oxidation reaction to obtain an intermediate 1; dissolving the intermediate 1 in a second solvent, sequentially adding isopropenyl acetate and p-toluenesulfonic acid, and carrying out first acetylation reaction to obtain an intermediate 2; dissolving the intermediate 2 in a third solvent, and carrying out an upper debromination reaction to obtain an intermediate 3; and dissolving the intermediate 3 in a fourth solvent, then adding 2, 4, 6-trimethylpyridine and acetyl chloride as reaction accelerators, carrying out a second acetylation reaction to obtain an intermediate 4, and carrying out a reduction reaction and purification on the intermediate 4 to obtain the 7-dehydrocholesterol. The 7-dehydrocholesterol is synthesized by the method, the total synthesis yield exceeds 60%, the product purity is 98% or above, and the method is easy to amplify for industrial synthesis.

The invention relates to the technical field of cigarette perfuming, in particular to an essence microcapsule, a preparation method thereof and a cigarette. The preparation method comprises the following steps: preparing mesoporous silica particles; loading polyethylene glycol into pore channels of the mesoporous silica particles to obtain functional particles; mixing essence, divinyl benzene, isophorone diisocyanate, a photoinitiator and the functional particles, and performing high-speed shearing to form Pickering emulsion; and carrying out polymerization reaction on the Pickering emulsion under an illumination condition to form the essence microcapsule. According to the preparation method, the thermal response characteristic of the functional particles is combined with a photopolymerization process of a Pickering emulsion template, and the problems that a traditional essence microcapsule is volatile at normal temperature and is non-uniform in high-temperature release are solved.

Nav1. 8 blockers, methods of modulating Nav1. 8 sodium ion channels, and methods of treating and / or alleviating the symptoms of conditions, diseases or disorders associated with increased Nav1. 8 activity or expression are provided.SOLUTION: Provided are pyridine carboxamide compounds for inhibiting Nav1. 8. Specific examples thereof include N - (1, 3-benzothiazol-6-yl) - 2 - (4-fluoro-2-methoxy-phenoxy) - 5 - (trifluoromethyl) pyridine-3-carboxamide. Also provided is a method of modulating a Nav1. 8 sodium ion channel, comprising administering to a subject in need thereof a modulating effective amount of the compound to the subject.SELECTED DRAWING: None