The invention discloses a method for decoloring and degrading soluble azo dyes through catalysis of chloroperoxidase and oxidation of H2O2, which comprises the following steps: preparing solution; decoloring and degrading; and computing the decoloring and degrading rate of the azo dyes. In the established method for decoloring and degrading soluble azo dyes orange II, bromophenol blue, methylene blue and soluble aniline blue wastewater through the catalysis of the chloroperoxidase and the oxidation of the H2O2, the H2O2 is used as an oxidant based on a bio-enzyme catalysis degradation system, a large conjugate system and azo structures and other chormophoric groups in the dyes are quickly damaged, irreversible decoloration and degradation of the dyes are realized, and the biochemical quality is improved. The method has the advantages of high speed of decoloring and degrading, high efficiency, simple operating steps, low consumption of the chloroperoxidase and the H2O2, and the like, and can be applied to treatment of industrial wastewater with soluble azo dyes.