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Concentration detection method for mixed solution of cephalosporin antibiotics based on Raman spectrum

A technology of Raman spectroscopy and mixed solutions, which is applied in Raman scattering, material excitation analysis, etc., to achieve the effects of easy monitoring, high measurement accuracy and high sensitivity

Inactive Publication Date: 2013-11-27
TIANJIN UNIV
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Problems solved by technology

Raman spectroscopic detection of mixed solutions of cephalosporin antibiotics is rarely reported

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  • Concentration detection method for mixed solution of cephalosporin antibiotics based on Raman spectrum
  • Concentration detection method for mixed solution of cephalosporin antibiotics based on Raman spectrum
  • Concentration detection method for mixed solution of cephalosporin antibiotics based on Raman spectrum

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Embodiment Construction

[0021] The present invention will be further described in detail below in combination with specific embodiments.

[0022] The cephalosporin antibiotics described in the present invention include ceftriaxone (CRO), cefazolin (CTX), and cefazolin sodium (COL), which have the advantages of strong antibacterial effect, resistance to penicillinase, high clinical curative effect, and low toxicity. It is widely used to treat bacterial infections in animals.

[0023] Such as figure 1 Shown, the present invention is based on the concentration detection method of the cephalosporin antibiotic mixed solution of Raman spectrum, comprises the following steps:

[0024] Step 1, measuring the Raman spectrum of the calibration set cephalosporin antibiotic mixed solution with known concentration. Using the method of orthogonal experimental design, 25 groups of samples of three antibiotic mixed solutions were prepared as analysis samples. First, accurately weigh the three kinds of antibiotics,...

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Abstract

The invention discloses a concentration detection method for a mixed solution of cephalosporin antibiotics based on Raman spectra. The concentration detection method comprises the following steps: (1) measuring a Raman spectrum of a mixed solution of cephalosporin antibiotics with known concentration; (2) preprocessing the Raman spectrum of the mixed solution of the cephalosporin antibiotics with the known concentration in the step (1); (3) processing the preprocessed Raman spectrum of the mixed solution of the cephalosporin antibiotics in the step (2) by a partial least square method so as to obtain a corrected prediction model; (4) acquiring a Raman spectrum of a mixed solution of to-be-measured cephalosporin antibiotics, and carrying out preprocessing; (5) inputting the Raman spectrum preprocessed in the step (4) into the prediction model so as to obtain the concentration of the mixed solution of the cephalosporin antibiotics. According to the concentration detection method, the concentration of the mixed solution of the multivariable cephalosporin antibiotics is detected by virtue of the Raman spectra. The method is quick and accurate, overcomes the limitations of the prior art effectively, and has important significances on fast food safety inspection and real-time monitoring.

Description

technical field [0001] The invention relates to the field of Raman spectrum detection, in particular to a Raman spectrum detection method for the concentration of cephalosporin antibiotic solution. Background technique [0002] Raman scattering, also known as the Raman effect, is the scattering of frequency changes caused by the interaction of incident light and molecular motion when light passes through a medium. Raman spectroscopy can provide qualitative and quantitative information about the composition and molecular structure of chemical substances. The number of bands, frequency shift, band intensity and shape of the Raman spectrum of a substance are directly related to the vibration and rotation of the molecule. Raman scattering is ubiquitous in all molecules, whether it is gas, liquid or solid, organic or inorganic things. This makes Raman spectroscopy have the function of qualitative analysis and distinguishing similar substances. The peak intensity of the Raman s...

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 林旺李重阳冯远明
Owner TIANJIN UNIV
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