Compound inhalation preparation containing antifungal drug

An antifungal drug and antifungal technology, applied in the field of compound inhalation preparations, can solve problems such as the use of antifungal drugs that have not been found

Inactive Publication Date: 2014-12-17
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no antifungal drugs have been found to be used in the treatment of asthma and chronic obstructive pneumonia caused by non-microbial infections

Method used

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  • Compound inhalation preparation containing antifungal drug
  • Compound inhalation preparation containing antifungal drug
  • Compound inhalation preparation containing antifungal drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] According to the table below, micronize active ingredient 1 with a flow energy mill and mix it with active ingredient 2. Micronize 10 g of anhydrous lactose with a flow energy mill to an average particle size of 42 μm. Packed in 1000 size 3 capsules, the active ingredients in each capsule are shown in the table below.

[0051]

Embodiment 2

[0053] According to the table below, micronize active ingredient 1 with a flow energy mill and mix it with active ingredient 2. Micronize 10 g of anhydrous lactose with a flow energy mill to an average particle size of 42 μm. Packed in 1000 size 3 capsules, the active ingredients in each capsule are shown in the table below.

[0054] Example number

[0055] The preparation of aerosol, the active ingredient used is the weight of 1000 dosage units, HFA-134a is 1,1,1,2-tetrafluoroethane, HFA-227 is 1,1,1,2,3,3, 3-Heptafluoropropane.

Embodiment 3

[0057] active ingredient

[0058] Ethanol 10g

[0059] HFA-134a 490g

[0060] Preparation process: add 1000 times the unit weight of the active ingredients 1 and 2 in the table below to the prescribed amount of ethanol, stir, fill in divided doses, seal the dose valve system, and then pressurize and inject HFA-134a respectively to obtain the product.

[0061]

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Abstract

The invention relates to the components and applications of a compound inhalation preparation containing an antifungal drug. When a trace amount of an antifungal drug is compounded with a drug for treating asthma and chronic obstructive pneumonia, a good curative effect will be generated; and the curative effect is more prominent, when the antifungal drug is compounded with glucocorticoid and an anti-cholinergic agent.

Description

Technical field: [0001] The present invention relates to the composition and application of compound inhalation preparation containing antifungal drugs. Background technique: [0002] Antifungal drugs are a general term for substances that inhibit and kill fungi, and are mainly used to treat fungal infections in mammals. The main route of administration of antifungal drugs is oral or injection, and can also be used to treat diseases caused by fungal infections in the lungs through aerosol inhalation, but this aerosol inhalation has obvious disadvantages. First, the mist produced is mainly water. Steam, after diluting the air, reduces the oxygen partial pressure. After continuous ultrasonic atomization inhalation, the water vapor occupies the entire respiratory tract, and oxygen cannot reach the alveoli, resulting in hypoxia in the patient. Secondly, the sprayed mist has a certain pressure, preventing the air around the mouth from entering the respiratory tract. , so that th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P11/00A61P11/06
Inventor 孙亮姚民芳赵琳
Owner TIANJIN JINYAO GRP
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