8 results about "PDE4 Inhibitors" patented technology

A class of PDE4 inhibitor compounds, isomers, solvates, deuterated derivatives or pharmaceutically acceptable salts thereof. Medicaments comprising the compounds, isomers, solvates, deuterated derivatives and pharmaceutically acceptable salts thereof, and their use in the preparation of a medicament for the treatment of diseases associated with PDE4 inhibition, such as autoimmune diseases, cancer.

Provided is the use of a PDE4 inhibitor for treating and / or preventing chronic obstructive pulmonary diseases or related diseases thereof.

Disclosed are methods for treating Jordan's syndrome in a subject in need thereof and methods of reducing at least one sign or symptom of Jordan's syndrome in a subject in need thereof. The methods comprise administering a therapeutically effective amount of a phosphodiesterase 4 (PDE4) inhibitor to the subject. The PDE4 inhibitor may be BPN14770 and may be administered daily.

This invention discloses a PDE4 inhibitor, its preparation method, and its applications, belonging to the field of pharmaceutical technology. Targeting PDE4, this invention designed and synthesized 36 novel PDE4 inhibitors. The synthesized PDE4 inhibitors exhibit significant inhibitory effects on PDE4, and most compounds possess anti-inflammatory activity. Compound 11b has been shown to have therapeutic effects on pulmonary fibrosis.

This invention relates to natural extracts, specifically to the use of a *Selaginella uncinata* extract in the preparation of medicaments for the treatment and / or prevention of phosphodiesterase type 4 (PDE4)-related diseases. The extract of this invention and the biflavonoids therein possess significant PDE4 inhibitory activity and can be used to prepare PDE4 inhibitors for the treatment and / or prevention of PDE4-related diseases.