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Application of edetate in properly changing surface tension of tiotropium bromide olodaterol spray

A technology of edetate and tiotropium bromide, which is applied in the direction of aerosol delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of easy explosion, propellant toxicity, and discomfort issues such as stimulation

Pending Publication Date: 2020-03-13
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the disadvantages of the latter relative to the former are: 1. Higher cost (due to internal pressure vessels, valve systems and special production equipment)
2 The propellant has a cooling effect, and repeated use on the injured skin wound can cause unsuitable irritation.
3 The propellant has certain toxicity, so it is not suitable for patients with heart disease to use as an inhalation aerosol
4 prone to explosion

Method used

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  • Application of edetate in properly changing surface tension of tiotropium bromide olodaterol spray
  • Application of edetate in properly changing surface tension of tiotropium bromide olodaterol spray
  • Application of edetate in properly changing surface tension of tiotropium bromide olodaterol spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation method: mix tiotropium bromide or tiotropium bromide monohydrate with water whose pH value is adjusted with hydrochloric acid, and adjust the surface tension of the solution with disodium edetate.

[0026] Pharmaceutical preparation of 100ml:

[0027]

Embodiment 2

[0029] Preparation method: mix tiotropium bromide or tiotropium bromide monohydrate with water whose pH value is adjusted with hydrochloric acid, and adjust the surface tension of the aqueous solution with calcium sodium edetate.

[0030] Pharmaceutical preparation of 100ml:

[0031]

[0032]

Embodiment 1

[0035] Preparation method: Mix tiotropium bromide or tiotropium bromide monohydrate with water whose pH value is adjusted with hydrochloric acid, and use Tween or Span to adjust the surface tension of the aqueous solution.

[0036]

[0037] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a medicinal tiotropium bromide olodaterol spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like, wherein edetate isused for changing the surface tension of a medicinal composition which does not contain propellants and consists of tiotropium bromide or a hydrate thereof, olodaterol medicinal salt and water.

Description

Technical field: [0001] The present invention relates to the drug tiotropium bromide olodaterol spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis, etc., wherein edetate is changed from tiotropium bromide or its Hydrate, olodaterol pharmaceutical salts, and the application of the surface tension of the pharmaceutical composition composed of water. Background technique: [0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperrespons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/18A61K31/46A61K31/538A61P11/06A61P11/00
CPCA61K9/0078A61K9/12A61K47/183A61K31/46A61K31/538A61P11/06A61P11/00
Inventor 张杰孙亮
Owner TIANJIN JINYAO GRP
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