Application of edetate in properly changing surface tension of tiotropium bromide olodaterol spray

A technology of edetate and tiotropium bromide, which is applied in the direction of aerosol delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of easy explosion, propellant toxicity, and discomfort issues such as stimulation
CN110876724APending Publication Date: 2020-03-13TIANJIN JINYAO GRP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN JINYAO GRP
Publication Date
2020-03-13

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Abstract

The invention relates to a medicinal tiotropium bromide olodaterol spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like, wherein edetate isused for changing the surface tension of a medicinal composition which does not contain propellants and consists of tiotropium bromide or a hydrate thereof, olodaterol medicinal salt and water.
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Description

Technical field:

[0001] The present invention relates to the drug tiotropium bromide olodaterol spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis, etc., wherein edetate is changed from tiotropium bromide or its Hydrate, olodaterol pharmaceutical salts, and the application of the surface tension of the pharmaceutical composition composed of water. Background technique:

[0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperrespons...

Claims

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