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Tiotropium bromide aerosol composition and preparation method thereof

A technology of tiotropium bromide and composition, applied in the field of preparation of the medicine

Active Publication Date: 2019-10-08
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Lysine is a common drug, especially amino acid can be used as a carrier in dry powder inhalation (powder aerosol), which has not been reported in aerosol

Method used

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  • Tiotropium bromide aerosol composition and preparation method thereof
  • Tiotropium bromide aerosol composition and preparation method thereof
  • Tiotropium bromide aerosol composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription of pharmaceutical preparation of 100ml:

[0025]

[0026] Preparation method: mix tiotropium bromide or tiotropium bromide monohydrate, bacteriostatic agent, lysine and water to dissolve completely, and adjust the pH value with hydrochloric acid.

Embodiment 2

[0028] Prescription of pharmaceutical preparation of 100ml:

[0029]

[0030]

Embodiment 1

[0033] Prescription of pharmaceutical preparation of 100ml:

[0034]

[0035] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention relates to a drug tiotropium bromide for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis and the like, the drug is an inhalable aerosol, and the invention also relates to a preparation method of the drug.

Description

Technical field: [0001] The invention relates to tiotropium bromide, a medicine for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis, etc. The medicine is an inhalable aerosol, and also relates to a preparation method of the medicine. Background technique: [0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and relieving asthma symptoms be achieved. At present, the drugs for the treatment of asthma and other lung disease...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/46A61K47/18A61P11/06A61P11/00
CPCA61K9/12A61K9/0078A61K31/46A61K47/183
Inventor 张杰孙亮
Owner TIANJIN JINYAO GRP
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