Dogskin plaster and technique of preparing the same

Abstract

The invention provides a dog-skin plaster and a preparation technique thereof. The dog-skin plaster is made from a substrate and raw herbal materials of black-plaster dog-skin plasters. The mass ratio of the raw herbal materials is the same as the mass ratio in the prescription of the black-plaster dog-skin plaster. A processed radix aconiti replaces an unprocessed radix aconiti, and a processed kusnezoff monkshood root replaces an unprocessed kusnezoff monkshood root, wherein no lead is contained. The preparation uses an ethanol extracting technology and a volatile-oil extracting technique to replace the extracting technology of frying vegetable oil in the original preparation, which can completely extract drug ingredients, without such disadvantages as drug ingredients being easily destroyed by high temperature and air pollution which are generated by the extracting technique of frying vegetable in the original preparation; the new substrate replaces the original black-plaster substrate, which has the advantages of larger drug quantity, easy putting up and off, good compatibility, release property and skin penetration property, without toxic lead content. The unprocessed radix aconiti and the unprocessed kusnezoff monkshood root in the original prescription are replaced respectively by the processed radix aconiti and the processed kusnezoff monkshood root, thus ensuring the effectiveness and safety of the preparation and eliminating the skin sensitization caused by the original dog-skin plaster.

Description

technical field [0001] The invention relates to a novel externally-used traditional Chinese medicinal preparation Goupi Tie Plaster and a preparation process thereof. Goupi paste is a new preparation developed by the research institute for the secondary development of the original black plaster preparation Goupi plaster. In the original prescription, Aconitum aconitum and Aconitum aconitum are replaced by Aconitum aconitum and Aconitum aconitum, and ethanol extraction process and volatile oil extraction process are used. The vegetable oil frying extraction process that replaces the original preparation, Background technique [0002] Goupi ointment is a traditional black plaster preparation, which was included in the 1995 edition, 2000 edition, and 2005 edition of "Chinese Pharmacopoeia". "Goupi Gao" has the effects of expelling wind and cold, promoting blood circulation and relieving pain. It is used to treat numbness of extremities caused by wind-cold-dampness, stagnation...

AI Technical Summary

Problems solved by technology

Although Goupi Ointment was included in the 2005 edition of "Chinese Pharmacopoeia", some shortcomings of the black ointment dosage form have seriously limited the production and use of Goupi Ointment

For example: 1. Red lead is added to the matrix, which contains lead elements that are poisonous to the human body, and will penetrate into the body through the skin during use; 2. During the preparation of black plaster, the medicinal materials are extracted with vegetable oil at high temperature and refined , when the oil temperature reaches 320°C, many active ingredients are easy to decompose and destroy; 3. The polarity of vegetable oil is very small, and many active ingredients of traditional Chinese medicine with high polarity such as alkaloids, various glycosides, polysaccharides, etc. are difficult to dissolve In vegetable oils, due to these reasons, there is no standard for thin-layer identification and content determination of dog skin ointment; if the medicinal material powder is added to the refined matrix for use, the active ingredients will be released slowly from the medicinal material cells, and the skin absorption will also be corresponding 4. The small molecule aldehyde compounds produced by vegetable oil during the long-term refining process are prone to allergies to the skin

5. Black plaster produces a large amount of harmful gas during the production process, seriously polluting the air

These deficiencies largely limit the use of dog skin ointment, and now the "dog skin ointment" on the market has its name, but there is nothing like it

[0006] In addition, in the prescription of Goupi Gao, the monarch drug Shengchuan Aconitum and Shengcaowu are poisonous medicinal materials. The secondary development and research of Goupi Gao may be an important obstacle that cannot be overcome. During the research process, it is likely to be blocked due to the toxicity of the drug. Forced to dismount, this situation often occurs in the research of external use of traditional Chinese medicine