32 results about "Concentration Response" patented technology

The invention relates to the extraction and/or presentation of glucose concentrations estimated as a function of time into a format that facilitates conveyance of the underlying information. More particularly, short term actions, such as exercise, diabetes drug treatment, and/or food intake, are correlated to glucose response profiles. Optionally, glucose concentration responses are back correlated to parameters, such as time, exercise, diabetes drug treatment and/or food intake. The resulting correlated data are output to the user in a time compressed format, in video format, and/or as a cluster allowing diagnosis and treatment information to be more readily determined and used. These information presentations are useful for both the medical professional and the end user. The information presentation is preferably used with a noninvasive, implantable, semi-continuous, and/or continuous analyte analyzer, such as a glucose concentration analyzer.

An inverse analysis method for characterizing diffusion of vapor from an underground source of volatile contaminant using data taken by an in-situ sensor. The method uses one-dimensional solutions to the diffusion equation in Cartesian, cylindrical, or spherical coordinates for isotropic and homogenous media. If the effective vapor diffusion coefficient is known, then the distance from the source to the in-situ sensor can be estimated by comparing the shape of the predicted time-dependent vapor concentration response curve to the measured response curve. Alternatively, if the source distance is known, then the effective vapor diffusion coefficient can be estimated using the same inverse analysis method. A triangulation technique can be used with multiple sensors to locate the source in two or three dimensions. The in-situ sensor can contain one or more chemiresistor elements housed in a waterproof enclosure with a gas permeable membrane.

The invention provides methods for analyzing and predicting the in vivo respiratory toxicity of a compound (e.g., pharmaceutical, biological, cosmetic, or chemical compounds) or composition comprising a combination of an in vitro mammalian cell model with multiple endpoint analysis, and time and concentration response curves. The methods allow the determination of a predicted in vivo respiratory toxicity value of a compound without the use of animals, with a high degree of accuracy. The methods comprise detecting any combination of cell viability markers and expression levels of genes implicated in respiratory toxicity and/or sensitization, such as pro-inflammatory response genes, combining the viability and gene expression level data with concentration response and time response data, conducting a computational analysis, and comparing test compound data to a database of known respiratory toxicants/sensitizers to predict and/or analyze the respiratory toxicity. An indication of organ specificity is provided by a toxicity index, which is determined by comparing mean IC₅₀ values in lung cells to mean IC₅₀ values in liver cells.

The present invention provides methods for predicting the in vivo skin sensitizing activity of chemical compounds using a combination of mammalian cell models with multiple endpoint analysis, time and concentration response curves. The methods allow the determination of a predicted in vivo sensitization value of a compound—for example, a EC3 LLNA value, a GPMT value or a IVTI value—without the use of animals, with a high degree of accuracy. The methods involve detecting expression levels of genes implicated in skin sensitization, combining expression level data with concentration response data, conducting a computational analysis, and comparing test compound data to a database of known skin sensitizers.

The invention discloses a probe molecule based on a 1,8-naphthalimide derivative, a preparation method and an application. The schiff base modified 4-naphthalimide derivative is prepared as the probemolecule by allowing 4-bromine-1,8-naphthalic anhydride and ethanolamine to give a condensation reaction to form 4-bromine-N-2-aminoethyl alcohol-1,8-naphthalimide to react with hydrazine hydrate to form 4-hydrazino-N-2-aminoethyl alcohol-1,8-naphthalimide and allowing pyrrole-2-methanal and primary amine of 4-hydrazino-N-2-aminoethyl alcohol-1,8-naphthalimide to give a condensation reaction; andthe probe molecule takes a pyrrole heterocyclic ring as a receptor and naphthalimide as fluorescent chromophore and achieves specific identification and concentration response of Cu<2+> via changes inabsorbance, fluorescence and a color. The probe molecule has the advantages of simple synthesis method, low cost, easiness and simplicity in operation, good selectivity, high sensitivity, low detection limit and the like, and can be used for real-time and quick detection of a complicated sample.

The invention discloses a high-throughput cytotoxicity assessment method. A used system comprises a PC (personal computer)/notebook computer, a cell incubator, a high-throughput 384 x microelectrode plate, a target cell, to-be-measured compounds and a cable resisting signal transmission, wherein the PC/notebook computer is used for monitoring cell growth and controlling parameters of a growth environment. According to the method, firstly, a target cell is exposed in to-be-measured compounds with different concentrations, and corresponding curves of the target cell in the whole target cell exposure process are recorded by real-time cell monitoring software; a cytotoxicity index is calculated according to the cell number change represented by the corresponding curves, and the index is the number change of the target cell in the whole index increase period, namely, the target cell response area; a concentration-response curve based on the target cell response area is obtained with a multiple concentration test method; and on that basis, a new cytotoxicity index is calculated and obtained. With the adoption of a non-intrusive detection method, high-throughput cytotoxicity assessment can be realized without bio-labeling.

The invention relates to a DNA structural element of ion concentration response, and a preparation and application thereof. The preparation method comprises the following steps: synthesizing a DNA triangular paper folding structure; synthesizing a DNA quadrilateral folding paper structure, changing an ion concentration, and observing the DNA structure variation by utilizing an atomic force microscope. The invention particularly relates to the DNA triangular folding paper structure and the DNA quadrilateral folding paper structure serving as elements, and the two DNA structures have reversible ion response functions. The invention provides two DNA two-dimensional folding paper structure of the ion concentration response. When the ion concentration of a solution is changed, the DNA structural element can have the reversible structural variation; the DNA structural element is precise and controllable in structure, easy in decoration and good in biological compatibility; and the preparation method is simple, high in operability, and capable of further meeting the production requirement of a biological chip and a nano device.

The invention relates to an electrochemical sensor based on magnetic nano-particle modified electrodes and a preparation method thereof. The method comprises preparing ferroferric oxide/paratoluene sulfonic acid sodium salt spolypyrrole (NaTSA-PPy) with NaTSA-PPy and magnetic nano-particles, coating the ferroferric oxide/NaTSA-PPy onto the surfaces of glass carbon electrodes to obtain the magnetic nano-particle modified electrodes (Fe3O4/NaTSA-PPy/GC, and structuring the electrochemical sensor through the Fe3O4/NaTSA-PPy/GC for detection of ascorbic acid. The Fe3O4/NaTSA-PPy/GC electrochemical sensor is sensitive in concentration response and can accurately measure out the content of the ascorbic acid inside medium; meanwhile, the modified layers of the electrodes are not easy to fall off, high in detecting stability and wide in detecting range.

The invention discloses a CMAQ model-based rapid atmospheric environment capacity measurement and calculation method, a storage medium and a terminal. The method comprises the following steps of establishing an emission sequence; simulating air quality; establishing an emissions-concentration response function; calculating the up-to-standard concentration; establishing an emission reduction hypothesis and solving the environmental capacity, sorting the simulation result and the corresponding emission ratio to obtain contribution values of different emission sources to the environmental concentration; according to different pollution source contribution conditions, designing corresponding reduction schemes, and combining the emission-emission of corresponding emission sources; solving a concentration response function, and solving a corresponding pollutant concentration contribution; and combining according to the actual management and control requirements to obtain the standard environment concentration, and calculating to obtain the corresponding pollutant discharge amount, namely the atmospheric environment capacity. According to the present invention, the calculation time and resources are effectively saved, clear physical significance is achieved, calculation is flexible in different pollution control modes, and the method can be used for solving the problem of atmosphericenvironment capacity balance calculation of different scales such as provincial level, urban level and district and county level.

The invention discloses a method for rapidly detecting lead serving as a heavy metal element in a tobacco based on X-ray fluorescence. The method comprises the steps of sample pretreatment, sample preparation, quick detection on a peak area of the lead serving as the heavy metal element in tobacco through a handheld X-ray fluorescence spectrometer, and calculation of the concentration of the lead serving as the heavy metal element according to a provided concentration-response standard curve of the lead in the tobacco. Compared with the prior art, the method disclosed by the invention has the advantages of high detection sensitivity, high specificity, simplicity, quickness, safety, reliability and the like; a test process is very simple and quick, and is obviously better than the conventional standard method.

The invention discloses a concentration response type biochemical multi-component online analyzer. The concentration response type biochemical multi-component online analyzer comprises a multi-component concentration detection module, a precise sampling mechanical arm, a multi-channel data acquisition module, an automatic sampling module and a multi-channel flow path structure; the multi-componentconcentration detection module is composed of a detection pool, a sample pool, a sampling pool, a cleaning pool and a waste liquid pool, and can realize online detection on multi-component concentration; the sampling mechanical arm is composed of a two-freedom-degree mechanism arm, a precision syringe and a sample injection needle, and realizes precise locating sampling control on the detection pool; the multi-channel data acquisition module is composed of an embedded development board and a touch screen, and realizes online detection, display and storage on the multi-component concentration;the automatic sampling module is composed of a precision membrane sampler, a miniature vacuum diaphragm pump and a stop valve; and the four parts are linked and assembled through a multi-channel flowpath integrated structure. According to the concentration response type biochemical multi-component online analyzer disclosed by the invention, online real-time detection on multiple substrates, keyintermediate metabolites and product concentrations in a microbial fermentation process can be realized; the structure is compact; and batch production is conveniently carried out.

The present invention provides a fluorescent sensor for detecting respiratory ammonia. A curcumin derivative (BFCUR) having a large steric hindrance and electrospun nanofibers (ENF) having a high porosity and a high specific surface area are compounded. The BFCUR with large steric hindrance is used as a sensing fluorophore, so that aggregation caused by pi-pi accumulation is effectively avoided; and the ENF with high porosity and high specific surface area can improve the sensitivity of the sensor. The sensor provided by the invention shows excellent performance in detection of respiratory ammonia, has ultralow detection limit, wider ammonia gas concentration response range and short response time, is slightly interfered by carbon dioxide and water vapor, and is high in cycling stability and light stability and good in recoverability. The sensor disclosed by the invention is successfully applied to respiratory ammonia detection of patients with chronic kidney diseases and helicobacter pylori infection, is high in sensitivity and reliable in detection result, and has important significance in clinical practice.

The embodiments of the invention provide a mixed gas component concentration identification method and system, and belongs to the technical field of multi-component gas sensing. The mixed gas component concentration identification method includes the following steps: obtaining a detection response value of a gas sensor for a target gas component in mixed gas and determining a guess concentration value based on the detection response value; executing Newton iterative calculation based on the guess concentration value and a Newton iterative calculation method and determining corresponding iterative concentration values in order for iterative calculation; determining change amount in the concentration values before and after each iterative calculation and stopping the iterative calculation when the change amount is less than a preset concentration threshold; and determining the concentration of the target gas component according to the iterative concentration value determined by the lastiterative calculation. Combined the Newton iterative calculation method and detection response prediction technology, the mixed gas component concentration identification method and system reduce thelimitation of linear concentration response of the gas sensor to the detection of the component concentration of the actual mixed gas and ensure the high accuracy of gas component concentration detection.

The invention discloses responding type gold nano-cluster particles for blood glucose regulation and a preparation method of the responding type gold nano-cluster particles, and belongs to the field of biomedicine. The responding type gold nano-cluster particles comprise a carrier material, a glucose responding sensitive switch factor and pharmaceutical molecules. The preparation method comprisesfollowing steps: firstly, preparing BSA-coated gold nano-cluster particles BSA-GNCs to serve as the carrier material of the pharmaceutical molecules; removing amino on BSA molecules by glutaraldehyde,converting tail ends of the molecules into carboxyl by glycine, activating carboxyl, and grafting and modifying carboxyl with 4-aminophenylboronic acid to serve as the glucose responding sensitive switch factor; grafting the glucose responding sensitive switch factor with glycosylated insulin to obtain the responding type gold nano-cluster particles for blood glucose regulation. The gold nano-cluster particles can release insulin according to glucose concentration response; functions of responding to glucose concentration in real time, rapidly and intelligently transmitting and releasing insulin and regulating blood glucose of a human body are achieved.

The present invention discloses a method for rapidly generating a dense silver chloride plating layer, and belongs to the technical field of reinforced concrete structure material corrosion and protection. The method comprises that: 1) one end of a silver wire and one end of a copper electric cable are welded, the welding position is sealed with an epoxy resin, the sliver wire at the exposed end is pre-treated, and the pre-treated sliver wire is soaked in a AgCl plating liquid; and 2) after the silver wire is soaked in the AgCl plating liquid for 10-60 min, a layer of the black and dense silver chloride plating layer is generated on the surface. According to the method of the present invention, the strong oxidizing property of the hypochlorite is used to manufacture the chlorine ion selective electrodes in the large-batch manner within the short time, such that the manufacturing time is significantly shortened, and the electrode manufacturing efficiency is improved; and the electrode manufactured through the method has the excellent electric potential reproducibility, and the chloride ion concentration-response curve of the electric potential is good.

The invention provides a composite polyamide film with salt concentration responsiveness, a preparation method and use of the composite polyamide film, and belongs to the technical filed of compositefilm preparation. The preparation method of the composite film comprises the following steps that (1), a support layer is fixed in a glass plate and a Teflon frame, aqueous phase monomer solution is poured into the Teflon frame, the support layer is soaked for 1-10 minutes; (2), the aqueous phase monomer solution is outwelled, surface moisture of the support layer is removed, then oil phase monomer solution is poured into the surface of the support layer, interface polymerization reaction is conducted for 30-600s; and (3), the oil phase monomer solution is outwelled, the prepared composite polyamide film is placed in distilled water at 4 DEG C to be saved. According to the composite polyamide film, the peculiar salt concentration response characteristics is provided, water flux of the composite polyamide film can increase with increase of salt concentration in raw material solution. Small organic molecules such as salt and dye in the raw material solution can be effectively separated,and very high separation efficiency is provided.

The invention relates to a particle immunodetection method which is characterized in that a sample is diluted into different concentration (the method can be used to dilute the sample in a reaction hole), and then respectively added into the reaction hole, so that the reaction result of each concentration can be superimposed; the supernatant liquid or the diluted supernatant liquid after reaction is inhaled into the other hole for comparable reaction and display, or in the same hole for step-by-step reaction and display, and then the displayed value of the sediment is calculated, and the concentration of the object to be tested can be identified. The method can reduce the hook effect and avoid washing.

The invention discloses a lake division eutrophication nutrition footprint index evaluation method which mainly comprises the following steps: a phase space track line establishment step: utilizing lake division data to carry out filtering processing according to a time sequence, and establishing a filtering phase space track line of a consequence index and a reason index; A confinement nutrient identification step of identifying a confinement nutrient using the filtered phase-space trajectory; and a filtering track line segmentation step: carrying out time period division on the filtering phase space track line according to the inflection point of the track line, and establishing a multi-time period curve of an algae density and nutrient concentration response relation and a non-linear multi-time period nutrition index (TFI) relation. The method is mainly applied to lake eutrophication evaluation with algae control requirements and lakes with historical data of more than 10 years.

The invention discloses a variable-volume bellow device, a use method of the bellow device and an anesthesia machine breathing loop. The variable-volume bellow device comprises a bellow cover, a folding bag and a separation plate, wherein the bellow cover is connected onto the anesthesia machine breathing loop; the folding bag is arranged in the bellow cover; the separation plate can vertically move for regulating the volume of the bellow cover; the separation plate is arranged in the bellow cover above the folding bag; the outer peripheral edge of the separation plate is tightly pasted with the inner wall of the bellow cover. The variable-volume bellow device is used for the anesthesia machine breathing loop; the separation plate can be movably installed in the bellow cover for regulating the volume of the bellow cover; the dead cavity in the bellow device in the breathing loop is reduced or eliminated; the use quantity of anesthesia medicine and medical gas is reduced; the surgery cost is reduced; in addition, the response speed of the anesthesia effect is higher; unnecessary time caused by slow anesthetic gas concentration response in the anesthesia surgery process is reduced; wasted time caused by slow anesthesia response in the anesthesia surgery process is reduced.

The invention discloses a composition and an adiponectin detection kit. The composition contains organic acid salt. By adding the organic acid salt into the detection reagent, the low-concentration reaction signal value is effectively increased, and the adiponectin detection sensitivity is further improved.

The invention discloses a printing consumable self-adaptive control method and a printing consumable control device, wherein the method includes: receiving a pairing instruction from a printer; searching for pairing information corresponding to the pairing instruction; judging whether the pairing information is used; if not, then call the response data in the response data set and send them to the printer until the pairing is successful; if so, call the response data in the response data set corresponding to the pairing information and send the response The data is sent to the printer, and when the pairing with the printer is unsuccessful, the remaining response data in the response data set is sequentially retrieved and sent to the printer until the pairing is successful. Through the present invention, the printing consumables using the method or device can automatically identify the printer model, which is suitable for multiple types of printers, without any manual intervention, and does not need to be modified on the printing consumables for different types of printers, reducing the cost.