32 results about "Concentration Response" patented technology

The invention provides methods for analyzing and predicting the in vivo respiratory toxicity of a compound (e.g., pharmaceutical, biological, cosmetic, or chemical compounds) or composition comprising a combination of an in vitro mammalian cell model with multiple endpoint analysis, and time and concentration response curves. The methods allow the determination of a predicted in vivo respiratory toxicity value of a compound without the use of animals, with a high degree of accuracy. The methods comprise detecting any combination of cell viability markers and expression levels of genes implicated in respiratory toxicity and / or sensitization, such as pro-inflammatory response genes, combining the viability and gene expression level data with concentration response and time response data, conducting a computational analysis, and comparing test compound data to a database of known respiratory toxicants / sensitizers to predict and / or analyze the respiratory toxicity. An indication of organ specificity is provided by a toxicity index, which is determined by comparing mean 1050 values in lung cells to mean 1050 values in liver cells.

A method and a device for measuring concentration with reference to a time-gated optical path, the method comprising: determining a measurement point and a reference position required for measurement according to the rate of change of the light intensity values ​​at different positions of the object to be measured from a light source with the concentration of the object to be measured; The measured value is obtained at the measurement point; the reference value is obtained at the reference position. First, the light intensity values ​​of photons with different transmission optical paths are measured at the reference position, and then the photons with a sensitivity of 0 to the concentration change of the measured object are extracted by the time gate method, as Reference value; data processing is performed on the measured value and the reference value to obtain the concentration of the analyte. The method and device for measuring concentration by reference to time-gated determination of optical path of the present invention propose that the time-gated detection method is applied to in-body reference measurement, and the photons that are not sensitive to glucose concentration response and the most sensitive photons are respectively picked up by the time-gated method as the reference value of the measurement. And the detected value, and the reference value is used to correct the measured value to make the measured value closer to the real value, thereby reducing the system error.

The invention discloses a method for rapidly detecting lead serving as a heavy metal element in a tobacco based on X-ray fluorescence. The method comprises the steps of sample pretreatment, sample preparation, quick detection on a peak area of the lead serving as the heavy metal element in tobacco through a handheld X-ray fluorescence spectrometer, and calculation of the concentration of the lead serving as the heavy metal element according to a provided concentration-response standard curve of the lead in the tobacco. Compared with the prior art, the method disclosed by the invention has the advantages of high detection sensitivity, high specificity, simplicity, quickness, safety, reliability and the like; a test process is very simple and quick, and is obviously better than the conventional standard method.

The invention discloses a wide-range and high-precision automatic detection method for glucose. Based on the fact that the self-made Prussian blue bio-enzyme electrode has a wide range of linearization characteristics for glucose concentration detection, the automatic adjustment of the injection volume according to the self-identified detection area is proposed to achieve a wide range of high-precision detection under an unknown glucose concentration range. The invention adopts the Prussian blue biological enzyme electrode to react with the microbial fermentation liquid in a special detection pool to generate a microampere-level current. By designing a microampere current detection circuit and filtering processing, a response signal and a glucose concentration response equation are established to calculate the measured value of the glucose concentration. , the system independently identifies the detection concentration interval according to the measured value, adjusts the set value V of the injection volume according to the deviation, and automatically injects the sample V through the high-precision intelligent sampling device, so that the concentration of the analyte in the detection pool is at the optimum value of the sensing electrode Response range, to achieve a wide range of glucose, high-precision automatic detection.