Nanoparticle-
fibrous membrane composites are provided as tunable interfacial scaffolds for flexible chemical sensors and biosensors by assembling gold nanoparticles (Au NPs) in a
fibrous membrane. The gold nanoparticles are functionalized with organic, polymeric and / or biological molecules. The fibrous membranes may include different filter papers, with one example featuring a multilayered
fibrous membrane consisting of a
cellulose nanofiber (CN) top layer, an electrospun
polyacrylonitrile (PAN) nanofibrous midlayer (or alternate material), and a non-woven
polyethylene terephthalate (PET) fibrous support layer, with the nanoparticles provided on the fibrous membranes through interparticle molecular / polymeric linkages and
nanoparticle-nanofibrous interactions. Molecular linkers may be employed to tune
hydrogen bonding and electrostatic and / or hydrophobic /
hydrophilic interactions to provide sensor specificity to gases or liquids. The sensors act as
chemiresistor-type sensors. A preferred implementation is a sweat sensor.