18 results about "Naphthalic anhydride" patented technology

The invention relates to the technical field of naphthalimide preparation, in particular to a synthetic method of naphthalimide derivatives. Comprising the following steps: dissolving a mixture of 1, 8-naphthalic anhydride and 4-aminoacetophenone in acetic acid containing sodium acetate, carrying out a reflux reaction, after the reaction is completed, cooling the mixture to room temperature, filtering to obtain a crude product, and washing to obtain a pure compound 1; the method comprises the following steps: dissolving a mixture of a compound 1, a hydrazine derivative and an acid catalyst in an organic solvent, carrying out a reflux reaction, after the reaction is completed, cooling the mixture to room temperature, filtering to obtain a crude product, and washing to obtain the naphthalimide compound. The synthesis reaction is safe and reliable, the process is simple and easy to control, and the reaction yield is high; the combination of the synthesized drug and DNA has spontaneity, and the drug has good anti-proliferative activity.

This invention discloses a method for preparing a single-component room-temperature phosphorescent / fluorescent dual-emission polymer film, comprising: reacting a terminal amino-substituted alkane with halogen-modified naphthalenecarboxylic anhydride to synthesize an organic light-emitting small molecule with phosphorescent / fluorescent dual-emission function; and mixing the obtained organic light-emitting small molecule into a dynamically cross-linked supramolecular polymer to obtain a single-component room-temperature phosphorescent / fluorescent dual-emission polymer film. This invention also discloses the single-component room-temperature phosphorescent / fluorescent dual-emission polymer film prepared by the above method and its applications. The preparation method of this invention is simple and low-cost. The polymer film prepared with only a single component can generate a phosphorescent / fluorescent dual-emission ratio light signal with stable emission. The film color changes with changes in ambient humidity, and the film can sense ambient humidity in the range of 1–100%, showing broad application prospects in sensing, anti-counterfeiting, and bioimaging fields.

The invention relates to the technical field of organic synthesis, in particular to a small-molecule electron transport material containing a naphthalimide terminal group and preparation and application thereof.4-bromo-1, 8-naphthalic anhydride is used as a raw material, brominated naphthalimide terminal groups are obtained through imidization, then different conjugated fused ring core units are used as raw materials, and the small-molecule electron transport material containing the naphthalimide terminal group is prepared through a one-step method. And coupling the conjugated fused ring core unit with naphthalimide through a coupling reaction to obtain the small-molecule electron transport material containing the naphthalimide terminal group. By virtue of high electron affinity, strong electron withdrawing property, good thermal stability and morphological stability and relatively strong designability of structure and function of naphthalimide, the micromolecule electron transport material shows excellent electron mobility, tight intermolecular accumulation and good three-dimensional charge transport characteristic; surface / interface defects can be effectively passivated, trap-assisted recombination is inhibited, and the photoelectric conversion efficiency and the stability of the perovskite solar cell are synergistically improved.

The invention relates to the technical field of carbon steel corrosion inhibitors, and discloses a 1, 8-naphthalimide derivative-based carbon steel corrosion inhibitor and application thereof.The novel 1, 8-naphthalimide derivative corrosion inhibitor is synthesized by taking 1, 8-naphthalene anhydride as a parent molecule and introducing ethidene diamine as a modification group, and the 1, 8-naphthalimide derivative corrosion inhibitor is used for preparing the carbon steel corrosion inhibitor based on the 1, 8-naphthalimide derivative and the carbon steel corrosion inhibitor based on the 1, 8-naphthalimide derivative. A novel primary amine-naphthalimide derivative corrosion inhibitor is developed by directionally introducing a double-end primary amine group structure, and a primary amine group can provide stronger electron donating ability than hydroxyl, so that the adsorption performance of the corrosion inhibitor on the surface of steel and the quality of a formed passive film are improved. Molecules of the corrosion inhibitor simultaneously have a rigid pi-conjugated skeleton and a nitrogen-containing electron donating center, so that multi-site synergistic adsorption on the surface of the steel bar is realized, a thicker and more compact protective film is formed, the inhibition efficiency of the corrosion inhibitor on chlorine salt corrosion is improved, and the long-term protection effect of the corrosion inhibitor is prolonged.

The invention belongs to the technical field of protein aggregation detection fluorescent probes, and particularly relates to a protein aggregation detection fluorescent probe containing quaternary ammonium salt and an aggregation-induced emission skeleton as well as a preparation method and application of the protein aggregation detection fluorescent probe. The probe takes a reaction product of 4-bromo-1, 8-naphthalic anhydride and 4-(diphenylamino) phenylboronic acid as the aggregation-induced emission skeleton, and the reaction product is reacted with N, N-dimethylformamide to obtain the protein aggregation detection fluorescent probe containing quaternary ammonium salt and the aggregation-induced emission skeleton. The quaternary ammonium salt group is introduced by sequentially reacting N, N-dimethyl ethylenediamine and diethyleneglycol-2-bromoethyl methyl ether, the quaternary ammonium salt group has the characteristics of water solubility and aggregation-induced emission, and the chemical structure of the quaternary ammonium salt group comprises a naphthalimide mother nucleus, a diphenylamino substituent group and a quaternized side chain.

The invention provides a preparation method of N-hydroxyl-1, 8-naphthalimide perfluorobutyl sulfonate, which comprises the following steps: step 1, adding absolute ethyl alcohol, continuing to add 1, 8-naphthalic anhydride and hydroxylamine hydrochloride, dropwise adding triethylamine, and heating to reflux reaction after dropwise adding to obtain white solid N-hydroxyl-1, 8-naphthalimide; and step 2, adding tetrahydrofuran, continuing to add N-hydroxy-1, 8-naphthalimide and DMAP, controlling the temperature to be 20-25 DEG C, dropwise adding perfluorobutyl sulfonyl chloride, and after the reaction is completed, obtaining a solid product N-hydroxy-1, 8-naphthalimide perfluorobutyl sulfonate. Under the condition that the yield is not reduced, a green and clean solvent is used in the preparation method and is easy to recycle, the reaction temperature is reduced, the reaction time is greatly shortened, absolute ethyl alcohol is used as the solvent, the disadvantage of water as the solvent on the ring-closing dehydration reaction is avoided, and compared with dioxane, the method has the advantages of being environmentally friendly, simple and convenient in synthesis step and the like.

The application discloses an enamine N-oxide containing a naphthalimide fluorescent group, a preparation method of the enamine N-oxide and application of the enamine N-oxide in a fluorescent probe. 2+ The application also provides a general synthesis method of the compound, wherein an amino functional group containing structural fragment is reacted with 4-bromo-1,8-naphthalic anhydride, and then the enamine N-oxide is generated through steps of hydroxyl substitution, bromine substitution and alkyne addition. 2+ When the compound is applied as the fluorescent probe, the compound has high sensitivity, excellent space-time resolution and light stability, is suitable for dynamically monitoring changes of Fe 2+ content in the iron death process and related protein marker research, and provides a new generation of molecular tools for iron death mechanism research, and has important application prospects in the fields of disease model construction and drug screening.

The invention discloses a cellulose acetate based 1, 8-naphthalimide fluorescent probe for detecting hydrogen sulfite (HSO3 <->) as well as a preparation method and application of the cellulose acetate based 1, 8-naphthalimide fluorescent probe. The preparation method comprises the following steps: by taking 4-bromo-1, 8-naphthalic anhydride as a raw material, carrying out condensation reaction on the 4-bromo-1, 8-naphthalic anhydride and 4-aminobutyric acid to prepare 4-(4-bromo-1, 8-naphthalic diimide) butyric acid, namely BNA-B; the preparation method comprises the following steps: carrying out coupling reaction on BNA-B and 4-formyl phenylboronic acid to prepare 4-(4-(4-formyl phenyl)-1, 8-naphthalimidoyl) butyric acid, namely FNA-B; the preparation method comprises the following steps: carrying out aldol condensation reaction on FNA-B and 1, 2, 3, 3-tetramethyl-3H-indole iodide to prepare a compound INA-B; and the compound INA-B and cellulose acetate (CA) are subjected to an esterification reaction, such that the cellulose acetate-based 1, 8-naphthalimide fluorescent probe INA-B-CA is prepared. The compound INA-B-CA can specifically recognize HSO3 <->, under the irradiation of 365nm ultraviolet light, after HSO3 <-> is added into a DMSO / PBS solution of INA-B-CA, the fluorescence color of the solution is changed from yellow to blue, and the probe has a good application prospect.

The invention discloses a fluorescent probe capable of responding to various cytochrome P450 enzymes and a preparation method and application thereof.According to the method, a traditional dye 4-bromo-1, 8-naphthalic anhydride serves as a parent nucleus, an aminoethyl side chain is introduced through a reaction with N-methylethylenediamine or ethanediamine, and then the fluorescent probe is obtained; and further performing coupling modification with 4-substituted phenylboronic acid to obtain a molecular structure with excellent fluorescence performance. In the prepared fluorescent probe, response groups such as substituted phenyl can be catalytically oxidized by CYPs, fluorescence on-off change is excited without coenzyme, and selective response to CYPs of various subtypes such as CYP 1A1, CYP 1A2, CYP 2B6, CYP 2D6 and the like is realized. Meanwhile, the prepared fluorescent probe has good water solubility, light stability and pH adaptability, shows high signal-to-noise ratio and low toxicity in a complex biological system, and has application potentials of later CYPs activity imaging, biomarker screening, disease diagnosis and the like.

The invention belongs to the technical field of biomedical materials, and relates to I-type and II-type naphthalimide photosensitizers and a preparation method and application thereof, and the naphthalimide photosensitizers have the following structural formula. The preparation method comprises the following steps: S1, carrying out a heating reaction on 4-bromo-1, 8-naphthalic anhydride and n-butylamine to obtain NI-1; s2, NI-1 and [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid are subjected to a reaction under the action of an XPhos Pd G2 catalyst and a K3PO4 alkali, and NI-OCH3-2O is obtained; and S3, the NI-OCH3-2O and a Lawson reagent are subjected to a heating reaction, and XX is obtained. Compared with the prior art, the preparation method has the advantages that naphthalimide is used as a mother nucleus, a photosensitizer precursor NI-OCH3-2O is obtained through Suzuki coupling reaction and [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid, and finally the photosensitizer NI-OCH3-2S is obtained through carbonyl thiolation. The naphthalimide photosensitizer has relatively strong absorption in a range of 400-700 nm, generates O2 <-> and < 1 > O2 under excitation of red light, can overcome limitation of tumor hypoxia, and has a good photodynamic therapy effect.

The present application relates to a kind of colorimetric-fluorescent dual-mode detection reagent for detecting color amine substance on site, which is composed of 4-mercapto-1,8 naphthalene dicarboxylic anhydride and organic solvent, and the reagent produces orange complex and quenches blue fluorescence by reacting 4-mercapto-1,8 naphthalene dicarboxylic anhydride with the substance to be measured, with a response time of less than 1 s, and the colorimetric-fluorescent detection limit can reach nM level.The method described in the present application can be used for on-site drug detection and analysis of color amine drugs in drug-related cases, with the characteristics of simple operation, strong anti-interference, fast response, sensitive reaction, easy visual observation, etc.The reagent provides an effective visual on-site detection technique for the detection of new and precise amine drugs, and has a broad application prospect, and provides a good research foundation for the field of drug detection, which can provide an effective technical means for the police department to quickly detect drugs on site.

The invention relates to the technical field of preparation of ammonia-free deproteinized latex medical surgical gloves, in particular to ammonia-free deproteinized latex medical surgical gloves and a preparation method thereof, and the ammonia-free deproteinized latex medical surgical gloves comprise the following raw materials in parts by weight: 1000 parts of 60wt% ammonia-free natural concentrated latex, 8-12 parts of a compound enzyme preparation, 0.1-0.3 part of p-hydroxyacetophenone-1, 2, 4-triazole-1, 2, 4-triazole-1, 2, 4-triazole-1, 2, the anti-corrosion coating is prepared from the following components in parts by weight: 0.8 to 1.2 parts of a 1, 2-hexanediol compound anti-corrosion system, 0.8 to 1.2 parts of composite filler, 1.5 to 2.5 parts of o-naphthalic anhydride, 0.5 to 1.5 parts of stearic acid, 10 to 14 parts of tert-butyl peroxybenzoate, 1.3 to 1.7 parts of an accelerant TMTM and 0.2 to 0.4 part of an antioxidant 1010. Through a self-made compound enzyme preparation, a compound filler and p-hydroxyacetophenone-1, 2-hexanediol compound preservative system, the preservative stability and mechanical strength of the medical surgical gloves are remarkably improved, and meanwhile, the sensitization of the medical surgical gloves is reduced.

The invention belongs to the field of high polymer materials, and relates to a preparation method of naphthyl polyester-polycarbonate-polyether glycol and a method for synthesizing novel polyester by using the naphthyl polyester-polycarbonate-polyether glycol. The naphthyl polyester-polycarbonate-polyether glycol is prepared by catalyzing ring-opening copolymerization of epoxypropane, 1, 8-naphthalic anhydride and carbon dioxide by using a non-metal catalytic system. And introducing naphthyl polyester-polycarbonate-polyether glycol into a PBAT chain in a copolycondensation manner to generate the novel polyester with excellent performance. The content of chain segments of polyester, polycarbonate and polyether in naphthyl polyester-polycarbonate-polyether glycol is regulated and controlled, and the content of four chain segments of polybutylene terephthalate, poly (butylene adipate), poly (naphthyl terephthalate) glycol ester and poly (naphthyl adipate) glycol ester in the novel polyester is regulated and controlled; the thermal property, the mechanical property and the degradation property of the novel polyester can be adjusted. Compared with pure PBAT, the PBAT is obviously improved.

The invention discloses an anti-phenolic yellowing polypropylene staple fiber and a preparation method thereof, and belongs to the technical field of high-performance polypropylene, the preparation method comprises the following steps: reacting 2, 3-naphthalic anhydride with 1-methyl-1-phenylhydrazine to generate a ring-opening intermediate containing a naphthalene ring and hydrazide structure, and esterifying the ring-opening intermediate with compound fatty alcohol of hexadecanol and 2-octyldodecanol to obtain an anti-phenolic yellowing agent; the phenolic yellowing resistant agent is compounded with low-viscosity mineral white oil, caprylic capric triglyceride, polyethylene glycol fatty acid ester, polyisobutylene succinimide and lauryl phosphate monoester potassium salt to form an oil-based phenolic yellowing resistant functional agent, and the oil-based phenolic yellowing resistant functional agent is coated on the surface of a polypropylene fiber through a bundling oiling process. Compared with the prior art, the method has the advantages that double synergy of compact barrier and uniform covering is achieved, the anchoring capacity of the functional film is enhanced, the yellowing grade of the obtained polypropylene staple fiber phenol reaches 4.5 grade, the polypropylene staple fiber phenol is free of attenuation after being soaked in water, the breaking strength is larger than or equal to 4.5 cN / dtex, and the elongation at break is larger than or equal to 40%.

The application belongs to the technical field of ion detection, and particularly relates to a preparation method of a ratio type fluorescent probe for detecting ions, which comprises the following steps: dissolving ethylenediamine and di-tert-butyl dicarbonate in chloroform to obtain product 1; dissolving the product 1 in anhydrous ethanol, adding 4-nitro-1,8-naphthalic anhydride to obtain product 2; dissolving the product 2 in dimethylformamide, and adding N-phthaloylglycine to obtain product 3; dissolving the product 3 in dichloromethane, and adding phenylthiochloroformate to obtain a fluorescent probe NAP; dissolving the fluorescent probe NAP in DMSO to prepare mother liquor A, dissolving methoxyl chitosan CS-MeO in water to prepare mother liquor B; and mixing the mother liquor A and the mother liquor B to prepare a Nano-NAP solution. The ratio fluorescent probe is used for detecting ions, and has the advantages of high selectivity, small interference, low detection limit, good pH stability and the like, and has high use value and wide application prospect.

The invention relates to a naphthalimide photoinitiator as well as a synthesis method and application thereof. The method takes 4-bromo-1, 8-naphthenic anhydride as a starting raw material, and is efficiently synthesized through three steps of reaction: 1, under the catalysis of cuprous iodide and bis (triphenylphosphine) palladium dichloride, carrying out Sonogashira coupling on the compound and 1-octyne in tetrahydrofuran, and introducing an eight-carbon alkyne long chain to obtain a compound 3; secondly, the compound 3 and ethanolamine (0.37 g, 6 mmol) are subjected to aminolysis in ethyl alcohol, an intermediate compound 4 containing hydroxyl is generated, and the yield is as high as 92%; and 3, reacting the compound 4 with 2-chloroethyl isocyanate under the catalysis of dibutyltin dilaurate to generate a final product compound 1, and the yield reaches 95%. The process route is simple, the condition is mild, the total yield is high, and the obtained photoinitiator has excellent solubility, reaction activity and compatibility with high polymer materials and is suitable for a photocuring system.

The invention discloses a fluorescent probe for detecting copper (I) in forage grass and a preparation method and application thereof, and relates to the field of forage grass detection and fluorescent probes, the preparation method of the fluorescent probe comprises the following steps: (1) preparation of an intermediate a: preparing the intermediate a by using 2-bromo-1, 8-naphthalic anhydride; (2) preparing a probe Nap1: preparing the Nap1 by using the intermediate a; according to the probe Nap1 provided by the invention, a DPA group is introduced to the site 2 of naphthalimide, the specificity of the spatial position enables the probe Nap1 to have very high specificity to copper (I), almost no reaction is generated to other metal ions, the response to copper (I) is obviously higher than that of copper (II), the probe Nap1 is not easily interfered by other substances in the detection process, and copper (I) in pasture can be selectively detected.

The invention discloses a preparation method of a near-infrared fluorescent probe for detecting cysteine and a detection method of the near-infrared fluorescent probe, and belongs to the technical field of biomedical imaging. The preparation method comprises the following steps: preparing NA-1 from 4-bromo-1, 8-naphthalic anhydride, preparing NA-2 from NA-1 and potassium carbonate, and dissolving NA-2 in hydriodic acid to obtain NA-3; mixing the NA-3 with hexamethylenetetramine to obtain NA-4; the preparation method comprises the following steps: mixing NA-4 with 2-(3, 5, 5-trimethylcyclohex-2-ene-1-subunit) malononitrile to obtain NA-OH; and dissolving the NA-OH in anhydrous dichloromethane to react to obtain NA-BH, namely the near-infrared fluorescent probe for detecting cysteine. The fluorescent probe provided by the invention is designed and synthesized based on a photoinduced electron transfer (PeT) mechanism, and through a specific nucleophilic substitution reaction between 2, 4-dinitrobenzenesulfonyl chloride (DNBS) and cysteine, the probe realizes'off-on 'response of fluorescence.