Ratiometric fluorescent probe for detection of hydrogen sulfide and preparation method of ratio-dependent fluorescent probe

A fluorescent probe and ratiometric technology, applied in the field of analysis and detection, can solve problems such as being susceptible to interference and difficult to guarantee detection accuracy, and achieve the effect of easy aggregation
CN104263353AActive Publication Date: 2015-01-07SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2015-01-07

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Abstract

The invention discloses a ratiometric fluorescent probe for detection of hydrogen sulfide and a preparation method of the ratiometric fluorescent probe. A compound of the probe is 2-(6-azido-1,3-dioxo-benzoisoquinolinyl)ethyl 2-(4-((4-(1,2,2-triphenylvinyl)phenoxy)methyl)-1,2,3-triazolyl)ethyl)succinate. During the preparation, 4-bromo-1,8-naphthalic anhydride is reacted with 2-aminoethanol to obtain a solid, namely, 6-bromo-2-(2-hydroxyethyl)-benzoisoquinoline-dione, the product is reacted with sodium azide to obtain a solid, namely, 6-azido-2-(2-hydroxyethyl)-benzoisoquinoline-dione; and then 6-azido-2-(2-hydroxyethyl)-benzoisoquinoline-dione is subjected to a series of reaction to obtain the solid probe compound. The probe compound is composed of hydrophobic tetraphenylvinyl and hydrophilic receptor units containing azide group and can be used for quantitative analysis of hydrogen sulfide in chemical, biological, environmental and other samples.
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Description

technical field

[0001] The invention relates to a fluorescent probe compound, in particular to a fluorescent probe for hydrogen sulfide detection and a preparation method thereof, belonging to the technical field of analysis and detection. Background technique

[0002] Hydrogen sulfide is a flammable acidic gas, easily soluble in water. When the concentration is low, it has a foul smell like rotten eggs; when the concentration is high, it has no smell, because high concentration hydrogen sulfide can paralyze the olfactory nerve; it is an acute Highly toxic substance, inhalation of a small amount of high-concentration hydrogen sulfide can be fatal in a short period of time, and long-term exposure to hydrogen sulfide gas can anesthetize the human olfactory nervous system. Hydrogen sulfide occurs naturally in crude oil, natural gas, volcanic gas and hot springs, and it can also be produced during the breakdown of organic matter by bacteria. Hydrogen sulfide also exists in a va...

Claims

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