The invention relates to the technical field of pesticides, specifically to a herbicide composition containing 4-(2-chloro-(methylsulfonyl)-3-((2,2,2-trifluoroethoxyl)methyl)benzoyl)-1-ethyl-1H-pyrazole-5-yl-1,3-dimethyl-1H-pyrazole-4-formate and saflufenacil, and an application thereof. The composition comprises an effective component A namely 4-(2-chloro-(methylsulfonyl)-3-((2,2,2-trifluoroethoxyl)methyl)benzoyl)-1-ethyl-1H-pyrazole-5-yl-1,3-dimethyl-1H-pyrazole-4-formate, an effective component B namely saflufenacil and a safener compound C, wherein the safener compound C is one or more selected from the group consisting of isoxadifen-ethyl, cyprosulfamide, mefenpyr-diethyl and furilazole; and the mass percentage content of A, B and C in the herbicide composition accounts for 1% to 95%, preferably 10% to 80% of the total content of the herbicide composition. The herbicide composition can effectively prevent and control common weeds in a corn field, improves prevention and control effects on noxious broadleaf weeds, and specifically has significant prevention and control effects on Gramineae weeds like crabgrass, eleusine indica and setaria viridis and broadleaf weeds like amaranthus retroflexus and conyza canadensis which can generate resistance to ALS inhibitor herbicides. The herbicide composition provided by the invention can expand weed control spectrum, reduce usage amount and retard generation and development of drug tolerance and drug resistance to weeds, and has important economic value and social significance.