The invention belongs to the technical field of pharmaceutical preparations, and provides a weeding composition containing isoxaflutole, pyroxasulfone and
terbuthylazine as well as a herbicide and application thereof. The weeding composition is prepared from isoxaflutole, pyroxasulfone and
terbuthylazine according to the
mass ratio of (1-10): (1-20): (1-50), has a remarkable synergistic effect, and can effectively reduce the use dosage of
pesticide, reduce the
pesticide use frequency, reduce the
pesticide use cost and reduce the
adverse effect of the pesticide on the
ecological environment. The weeding composition provided by the invention can expand the weeding spectrum, solves various
weed problems through one-time medication, and makes up for the defects and limitations during use of a
single agent; the service life of the herbicide is prolonged, and the herbicide has important significance on comprehensive treatment of
weed resistance; the weeding composition is rapid in pesticide effect, long in lasting period and low in use cost, and can be used for controlling
annual weeds in corn fields; the weeding composition is safe to crops.