Method and device for measuring concentration with reference to time-gated optical path
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A technology of reference measurement and time gate, applied in the field of spectral detection, can solve the problems of many components and physiological factors, difficult real-time monitoring or quantitative measurement, etc., to achieve the effect of improving specificity, reducing system error and improving applicability
Active Publication Date: 2022-07-22
TIANJIN UNIV +1
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Since most components in blood, such as water, fat, protein, etc., have absorption in the near-infrared, and the spectral peaks overlap with each other, factors such as biological activities, mood swings, and environmental influences will directly or indirectly affect the information of blood components. Effective extraction, and due to the many and complex components and physiological factors in the blood, it is difficult to monitor them in real time or quantitatively measure them at the current level of scientific research
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Embodiment 1
[0094] Example 1 Simulation experiment of single-point fixed optical path reference measurement method
[0095] Simulation parameters: MCMLGO is used to simulate, with 2% Intralipid-glucose solution as the medium, the glucose concentration is 0mg / dL, 500mg / dL, 1000mg / dL and 1500mg / dL respectively, under the condition of 1200nm light source, the number of photons emitted by the light source is 10 9 indivual.
[0096] Variation parameters: light source energy fluctuation ±5% and ±10%.
[0097] Measured value: At the floating reference point, the sum of all photons with long optical path transmission is selected as the detection value.
[0098] Reference value: The number of photons emitted from the detection point and the transmission optical path length is the reference transmission optical path length as the reference value. According to theoretical analysis, for 2% Intralipid-glucose solution, the reference transmission optical path length of photons emitted at the spatial ...
Embodiment 2
[0102] Embodiment 2 The simulation experiment result of multi-point fixed optical path reference measurement method
[0103] Simulation parameters: MCMLGO was used to simulate the propagation of photons in the tissue and the distribution of the emission on the surface of the medium. 2% Intralipid-glucose solution was used as the medium, and the glucose concentrations were 0mg / dL, 500mg / dL, 1000mg / dL and 1500mg / dL, respectively. , in the case of a 1200nm light source, the number of photons emitted by the light source is 10 9 indivual.
[0104] Variation parameters: light source energy fluctuation ±5% and ±10%.
[0105] Measured value: Select the 1.25mm transmission optical path length as the center, and the total number of photons with the transmission optical path length range of 1.25±0.25mm as the measured value.
[0106] Reference value: The sum of the number of photons emitted from the detection radius and the transmission optical path length is the reference transmission...
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Abstract
A method and a device for measuring concentration with reference to a time-gated optical path, the method comprising: determining a measurement point and a reference position required for measurement according to the rate of change of the light intensity values at different positions of the object to be measured from a light source with the concentration of the object to be measured; The measured value is obtained at the measurement point; the reference value is obtained at the reference position. First, the light intensity values of photons with different transmission optical paths are measured at the reference position, and then the photons with a sensitivity of 0 to the concentration change of the measured object are extracted by the time gate method, as Reference value; data processing is performed on the measured value and the reference value to obtain the concentration of the analyte. The method and device for measuring concentration by reference to time-gated determination of optical path of the present invention propose that the time-gated detection method is applied to in-body reference measurement, and the photons that are not sensitive to glucose concentration response and the most sensitive photons are respectively picked up by the time-gated method as the reference value of the measurement. And the detected value, and the reference value is used to correct the measured value to make the measured value closer to the real value, thereby reducing the system error.
Description
technical field [0001] The invention belongs to the technical field of spectrum detection, and in particular relates to a method and a device for measuring concentration by reference to a time-gated optical path. Background technique [0002] The use of near-infrared spectroscopy to detect the concentration of substance components has been widely used in food, drug testing, air pollution testing, water quality monitoring and many other fields. The clinical application of near-infrared spectroscopy is also one of the current research hotspots, especially near-infrared non-invasive blood glucose detection, which can not only achieve timely, safe, and painless self-monitoring of blood glucose concentration, but also does not require consumables, which can greatly reduce testing costs. , has a very high clinical application value. [0003] Based on the achievements and experience of various research groups at home and abroad, the most critical bottleneck restricting the precisi...
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