High-concentration hydrogen peroxide emulsion for treating senile plaques and application of high-concentration hydrogen peroxide emulsion

Abstract

The invention provides a high-concentration hydrogen peroxide emulsion for treating senile plaques and application thereof, and in the high-concentration hydrogen peroxide emulsion, hydrogen peroxide is used as an active component, can oxidize and decompose melanin in skin, and has a freckle removing effect; the hydrogenated polydecene is used as an emollient, so that the skin can be moistened and the texture of the skin is improved; hydrogenated castor oil (PEG-40) is used as an emulsifier, so that an emulsion system is stable; the bisabolol has anti-inflammatory and soothing effects, and can relieve the irritation of hydrogen peroxide to the skin; citric acid can adjust the pH value of the emulsion, so that the emulsion is more suitable for the physiological environment of skin; sodium hyaluronate has a moisturizing effect and can enhance the barrier function of skin. All the components have a synergistic effect, so that the emulsion has a good senile plaque treatment effect, and meanwhile, irritation to skin is reduced.

Description

Technical Field

[0001] This invention relates to the field of skin care products and topical medicines, and in particular to a high-concentration hydrogen peroxide emulsion for treating age spots and its application. Background Technology

[0002] Age spots, medically known as seborrheic keratosis, are a common benign skin tumor, most often seen in middle-aged and elderly people. The incidence of age spots gradually increases with age, not only affecting the patient's appearance but also potentially causing psychological stress.

[0003] Currently, the main methods for treating age spots include laser therapy, cryotherapy, surgical excision, and topical medication. While laser and cryotherapy are highly effective, they may cause adverse reactions such as pain and swelling during the treatment process, and are also relatively expensive. Surgical excision is suitable for larger age spots, but it has the disadvantages of being more invasive and having a slower recovery time.

[0004] Topical medications have gained widespread attention due to their convenience and minimal side effects. Hydrogen peroxide, as a strong oxidizing agent, has a certain effect on removing blemishes. Its mechanism of action is to oxidize and decompose melanin in the skin, thereby reducing pigmentation. However, high concentrations of hydrogen peroxide are irritating to the skin, and direct application can damage the skin barrier, causing adverse reactions such as redness, swelling, and pain.

[0005] Therefore, developing a high-concentration hydrogen peroxide preparation that not only has a good therapeutic effect on age spots but also reduces skin irritation is of great clinical significance and application value. Summary of the Invention

[0006] In view of the above problems, embodiments of the present invention are proposed to provide a high-concentration hydrogen peroxide emulsion for treating age spots and its application therein, which overcomes or at least partially solves the above problems.

[0007] To address the aforementioned problems, embodiments of the present invention disclose a high-concentration hydrogen peroxide emulsion for treating age spots, the components of which, by mass percentage, comprise:

[0008] The 30% hydrogen peroxide solution contains 33.3% hydrogen peroxide.

[0009] Hydrogenated polydecene content 20%;

[0010] Hydrogenated castor oil (PEG-40) content 10%;

[0011] Bisabolol content: 0.2%;

[0012] Citric acid content: 0.05%;

[0013] Sodium hyaluronate content: 0.1-0.3%;

[0014] The remainder is purified water.

[0015] Optionally, the content of sodium hyaluronate is 0.2%.

[0016] Optionally, it also includes 0.01-0.05% vitamin E.

[0017] Optionally, it also includes 0.1-0.5% dipotassium glycyrrhizate.

[0018] Optionally, the pH value of the emulsion is 3.5-4.5.

[0019] Alternatively, high-concentration hydrogen peroxide emulsions for treating age spots may be used in the treatment of age spots.

[0020] An application of a high-concentration hydrogen peroxide emulsion for treating age spots involves applying the emulsion to the affected area of ​​age spots 1-2 times daily for 2-8 weeks.

[0021] This invention offers the following advantages: In the high-concentration hydrogen peroxide emulsion of this invention, hydrogen peroxide, as the active ingredient, can oxidize and decompose melanin in the skin, thus achieving a spot-removing effect; hydrogenated polydecene, as a skin moisturizer, can moisturize the skin and improve its texture; hydrogenated castor oil (PEG-40), as an emulsifier, can stabilize the emulsion system; bisabolol has anti-inflammatory and soothing effects, which can reduce the irritation of hydrogen peroxide to the skin; citric acid can adjust the pH value of the emulsion, making it more suitable for the skin's physiological environment; sodium hyaluronate has a moisturizing effect and can enhance the skin's barrier function. The synergistic effect of these components gives the emulsion a good therapeutic effect on age spots while reducing skin irritation. Detailed Implementation

[0022] To make the objectives, features, and advantages of this application more apparent and understandable, the application will be further described in detail below through specific embodiments. Obviously, the described embodiments are only some, not all, of the embodiments of this application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0023] Some embodiments of the present invention provide a high-concentration hydrogen peroxide emulsion for treating age spots, the components of which, by mass percentage, include:

[0024] The 30% hydrogen peroxide solution contains 33.3% hydrogen peroxide.

[0025] Hydrogenated polydecene content 20%;

[0026] Hydrogenated castor oil (PEG-40) content 10%;

[0027] Bisabolol content: 0.2%;

[0028] Citric acid content: 0.05%;

[0029] Sodium hyaluronate content: 0.1-0.3%;

[0030] The remainder is purified water.

[0031] Based on the basic composition and content range of each component in the high-concentration hydrogen peroxide emulsion described above, the emulsion effectively treats age spots while minimizing skin irritation through the synergistic effect of its components. For example, hydrogen peroxide oxidizes and decomposes melanin, bisabolol reduces irritation, and sodium hyaluronate moisturizes and repairs the skin barrier.

[0032] Furthermore, the sodium hyaluronate content is 0.2%. At this content, sodium hyaluronate exhibits the best moisturizing effect, better enhances skin barrier function, and further reduces the irritation of the skin by hydrogen peroxide. For example, comparing emulsions containing 0.1%, 0.2%, and 0.3% sodium hyaluronate, the subjects using the emulsion containing 0.2% sodium hyaluronate showed the highest skin hydration and the strongest skin barrier function.

[0033] It also includes 0.01-0.05% vitamin E. Because vitamin E has antioxidant properties, it protects the skin from free radical damage and also enhances the stability of the emulsion. For example, after adding 0.03% vitamin E to an emulsion, the hydrogen peroxide content decreased significantly less after three months of storage at room temperature compared to an emulsion without added vitamin E.

[0034] It also includes 0.1-0.5% dipotassium glycyrrhizate. Because dipotassium glycyrrhizate has anti-inflammatory and anti-allergic effects, it can further reduce the skin irritation of the emulsion. For example, a patient with age spots and sensitive skin did not experience allergic symptoms such as redness, swelling, or itching after using an emulsion containing 0.3% dipotassium glycyrrhizate, while experiencing mild redness and swelling after using an emulsion without dipotassium glycyrrhizate.

[0035] The emulsion has a pH value of 3.5-4.5. This pH range is close to the physiological pH value of the skin, which reduces skin irritation and facilitates the effectiveness of hydrogen peroxide. For example, when the pH value of the emulsion is 4.0, the stability and spot-removing effect of hydrogen peroxide are both good, with minimal skin irritation.

[0036] Some embodiments of this application also disclose the application of a high-concentration hydrogen peroxide emulsion for treating age spots. This clarifies the application of this high-concentration hydrogen peroxide emulsion in the preparation of drugs for treating age spots, providing a basis for its clinical application. For example, when this emulsion is used clinically to treat patients with age spots, the overall effective rate can reach over 80%.

[0037] Specifically, an application of a high-concentration hydrogen peroxide emulsion for treating age spots involves applying the emulsion to the affected area 1-2 times daily for 2-8 weeks. Clearly defining the dosage and duration of application guides patients to use the emulsion correctly, improving treatment effectiveness. For example, after using the emulsion according to this method for 6 weeks, one patient's age spots essentially disappeared, and their skin returned to normal.

[0038] This product was tested on a 60-year-old woman with facial age spots. After using the emulsion for 4 weeks, the age spots were significantly lighter in color, and no skin irritation was observed.

[0039] As an example, Example 1: A high-concentration hydrogen peroxide emulsion comprising, by mass percentage: 33.3% hydrogen peroxide solution; 20% hydrogenated polydecene; 10% hydrogenated castor oil (PEG-40); 0.2% bisabolol; 0.05% citric acid; 0.1% sodium hyaluronate; and the balance being purified water.

[0040] In preparation, hydrogenated polydecene and hydrogenated castor oil (PEG-40) can be mixed, heated to 60-70℃, and stirred evenly to obtain an oil phase; citric acid and sodium hyaluronate can be dissolved in purified water and heated to the same temperature as the oil phase to obtain an aqueous phase; the oil phase can be slowly added to the aqueous phase and stirred and emulsified for 30 minutes; the temperature can be lowered to below 40℃, and 30% hydrogen peroxide solution and bisabolol can be added and stirred evenly to obtain the final product.

[0041] As an example, Example 2: The above-mentioned high-concentration hydrogen peroxide emulsion may also include the following components by mass percentage: 33.3% hydrogen peroxide solution; 20% hydrogenated polydecene; 10% hydrogenated castor oil (PEG-40); 0.2% bisabolol; 0.05% citric acid; 0.2% sodium hyaluronate; and the balance being purified water; the preparation method is the same as in Example 1.

[0042] As an example, Example 3: A high-concentration hydrogen peroxide emulsion, the components by mass percentage comprising: 33.3% hydrogen peroxide solution; 20% hydrogenated polydecene; 10% hydrogenated castor oil (PEG-40); 0.2% bisabolol; 0.05% citric acid; 0.3% sodium hyaluronate; 0.03% vitamin E; the balance being purified water.

[0043] Preparation method: Hydrogenated polydecene, hydrogenated castor oil (PEG-40), and vitamin E are mixed and heated to 60-70℃, and stirred evenly to obtain the oil phase; citric acid and sodium hyaluronate are dissolved in purified water and heated to the same temperature as the oil phase to obtain the aqueous phase; the oil phase is slowly added to the aqueous phase and stirred and emulsified for 30 minutes; the temperature is lowered to below 40℃, 30% hydrogen peroxide solution and bisabolol are added, and stirred evenly to obtain the final product.

[0044] As an example, Example 4: A high-concentration hydrogen peroxide emulsion comprising, by mass percentage: 33.3% hydrogen peroxide solution; 20% hydrogenated polydecene; 10% hydrogenated castor oil (PEG-40); 0.2% bisabolol; 0.05% citric acid; 0.2% sodium hyaluronate; 0.3% dipotassium glycyrrhizate; and the balance being purified water.

[0045] Preparation method: Hydrogenated polydecene and hydrogenated castor oil (PEG-40) are mixed and heated to 60-70℃, and stirred evenly to obtain the oil phase; citric acid, sodium hyaluronate, and dipotassium glycyrrhizate are dissolved in purified water and heated to the same temperature as the oil phase to obtain the aqueous phase; the oil phase is slowly added to the aqueous phase and stirred and emulsified for 30 minutes; the temperature is lowered to below 40℃, 30% hydrogen peroxide solution and bisabolol are added, and stirred evenly to obtain the final product.

[0046] As an example, Example 5: A high-concentration hydrogen peroxide emulsion, comprising the following components by mass percentage: 33.3% hydrogen peroxide solution; 20% hydrogenated polydecene; 10% hydrogenated castor oil (PEG-40); 0.2% bisabolol; 0.05% citric acid; 0.2% sodium hyaluronate; 0.05% vitamin E; 0.5% dipotassium glycyrrhizate; and the balance being purified water. The preparation method is the same as in Example 3.

[0047] It should be noted that in the embodiments of this application, the 30% hydrogen peroxide solution refers to the mass percentage of hydrogen peroxide in the solution, that is, 30g of hydrogen peroxide is contained in every 100g of the solution. Hydrogenated castor oil (PEG-40): This is specifically defined as polyoxyethylene 40 hydrogenated castor oil, a commonly used nonionic emulsifier with good emulsifying and solubilizing properties. In this application, purified water refers to purified water that meets the quality standards of the Chinese Pharmacopoeia to ensure the quality and safety of the emulsion.

[0048] Although preferred embodiments of the present application have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of the embodiments of the present application.

[0049] Finally, it should be noted that in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, or article that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, or article. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, or article that includes said element.

[0050] The above provides a detailed description of a high-concentration hydrogen peroxide emulsion for treating age spots and its application. Specific examples have been used to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this application. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this application. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A high-concentration hydrogen peroxide emulsion for treating age spots, characterized in that, The components, by mass percentage, include: The 30% hydrogen peroxide solution contains 33.3% hydrogen peroxide. Hydrogenated polydecene content 20%; Hydrogenated castor oil (PEG-40) content 10%; Bisabolol content: 0.2%; Citric acid content: 0.05%; Sodium hyaluronate content: 0.1-0.3%; The remainder is purified water.

2. The high-concentration hydrogen peroxide emulsion for treating age spots according to claim 1, characterized in that, The content of sodium hyaluronate is 0.2%.

3. The high-concentration hydrogen peroxide emulsion for treating age spots according to claim 1, characterized in that, It also includes 0.01-0.05% vitamin E.

4. The high-concentration hydrogen peroxide emulsion for treating age spots according to claim 1, characterized in that, It also includes 0.1-0.5% dipotassium glycyrrhizate.

5. The high-concentration hydrogen peroxide emulsion for treating age spots according to claim 1, characterized in that, The pH value of the emulsion is 3.5-4.

5.

6. The application of the high-concentration hydrogen peroxide emulsion for treating age spots according to any one of claims 1-5, characterized in that, It is used to treat age spots.

7. An application of the high-concentration hydrogen peroxide emulsion for treating age spots according to any one of claims 1-5, characterized in that, Apply the high-concentration hydrogen peroxide emulsion for treating age spots according to any one of claims 1-5 to the affected area of ​​age spots 1-2 times daily for 2-8 weeks.