The invention discloses a traditional Chinese medicine compound composition having a therapeutic effect on atrial fibrillation and a preparation method thereof, which comprises the following Chinese medicine decoction pieces in parts by mass: 10-20 parts of broiled silkworm, 10-20 parts of whole scorpion, and 5 parts of amber powder ~10 parts, 10-20 parts of rehmannia root, 20-30 parts of ginseng, 10-20 parts of sophora flavescens, 10-20 parts of salvia miltiorrhiza, 5-10 parts of coptis, 20-30 parts of broiled turtle shell, 5-10 parts of cinnamon, Comfrey 10-20 parts. The present invention is aimed at the basic pathogenesis of atrial fibrillation, heart and kidney yin deficiency, internal movement of deficiency wind, internal blazing of heart fire, fighting between wind and fire, consumption of qi and yin, and occurrence of palpitations, tachycardia, and irregular pulse. Established the treatment principle of clearing heart and cooling blood, nourishing yin and dispelling wind, and the provided Chinese medicine compound has the effect of clearing heart and cooling blood, nourishing yin and dispelling wind. Clinical studies have confirmed that the Chinese medicine compound composition can significantly reduce the number of recurrences in patients with paroxysmal atrial fibrillation It can improve the clinical symptoms of atrial fibrillation such as palpitations, chest tightness, dizziness, dry mouth, bitter mouth, upset, hot hands and feet, spontaneous sweating or night sweats.