The invention discloses a
traditional Chinese medicine formula for treating
idiopathic pulmonary fibrosis and a preparation method of the
traditional Chinese medicine formula, the
traditional Chinese medicine formula consists of twelve
raw material medicines in specific parts by weight: radix glehniae,
radix ophiopogonis,
astragalus membranaceus,
codonopsis pilosula, selfheal,
oyster, processed
pinellia ternate, edible tulip, seaweed, concha meretricis seu cyclinae, rhizoma sparganii and
curcuma zedoary. The composition can effectively inhibit
fibroblast proliferation and activation and reduce
extracellular matrix
secretion, and can play an anti-
fibrosis role by inhibiting TNF-alpha
inflammatory factors and NF-kappa B
signal pathways,
clinical tests show that the composition can significantly improve clinical symptoms of patients and
delay lung function decline, and is good in safety and suitable for clinical application. The invention also provides a preparation method of the composition, various dosage forms such as decoction, granules, freeze-dried
powder and the like can be prepared, the preparation process is simple and convenient, the composition is suitable for industrial production, and a safe and effective new traditional Chinese
medicine treatment choice is provided for
idiopathic pulmonary fibrosis.