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Oral percarbonateamide oxygen-supply agent and preparation thereof

A technology of percarbamide and oxygen supply, which is applied in the direction of amide active ingredients, respiratory diseases, drug combination, etc. It can solve the problems of stomach damage, unsuitable for direct oral administration, etc., and achieve the effect of improving palpitation, high utilization rate, and easy to carry

Inactive Publication Date: 2009-06-10
张玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the way of oral administration is extremely convenient, percarbamide compounds are not suitable for direct oral administration because they are acidic, and direct oral administration will cause local damage to the stomach.
[0003] Thus up to now, there is no percarbamide oxygenation agent of oral dosage form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of oral oxygen tablets:

[0029] Take medicinal percarbamide 100g, deacetylated chitin (chitin) 1-5g, 6-10% starch slurry in an appropriate amount;

[0030] Percarbamide was dried at 35°C for 24 hours, ground and passed through an 80-mesh sieve, mixed with crushed chitin, and then added with starch slurry to make a soft material;

[0031] The obtained soft material is passed through a 18-mesh sieve to make wet granules, dried at 35°C, then passed through an 18-mesh sieve for sizing, weighing, and tableting.

[0032] Each tablet contains 0.5g of percarbamide, and you can take 4 tablets per hour when using it, and use it continuously if necessary.

Embodiment 2

[0034] Preparation of oral oxygen granules:

[0035] Take medicinal percarbamide 100g, deacetylated chitin (chitin) 1-5g, dextrin 3-8g;

[0036] The percarbamide was dried at 35°C for 24 hours, and the dried percarbamide, dextrin and chitin were respectively passed through a 100-mesh sieve, and the percarbamide and auxiliary materials were mixed evenly to make soft In the process of mixing and grinding, do not use too much force and too long time, so as to avoid the decomposition of percarbamide caused by the temperature rise, usually it should not exceed 40°C.

[0037] The obtained soft material is passed through a 16-mesh sieve to make granules, dried at 35°C, and packed in bags. 2g per bag, one bag per serving, mixed with warm water.

Embodiment 3

[0039] Preparation of oral oxygen powder:

[0040] Take medicinal percarbamide 100g, deacetylated chitin (chitin) 1-5g, dextrin 3-8g;

[0041] Grind and mix chitin and dextrin evenly, then add percarbamide, grind and mix together, and then disperse into bags.

[0042] One sachet per 2g, take one sachet with warm water.

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PUM

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Abstract

An orally taken percarbonamide as the oxygen donor in the form of tablet, particles or powder for the patients of pneumonectasis, pneumocardial disease, respiration failure, asthma, etc contains the medicinal percarbonamide and deacetyl chitin proportionally.

Description

Technical field: [0001] The invention relates to an oxygen donor in oral dosage form and a preparation method thereof. Background technique: [0002] At present, percarbamide is only in the form of injection for oxygen supply to the human body, and the way of oxygen supply by injection is generally only used in first aid. It is not suitable for health care oxygen supply and general hypoxia, and the injection of oxygen at the same time will cause local pain. Although the oral mode is extremely convenient, percarbamide compounds are acidic, and direct oral administration can cause local damage to the stomach, so it is not suitable for direct oral administration. [0003] Thus up to now, there is no percarbamide oxygen donor of oral dosage form. Invention content: [0004] The present invention provides an oral percarbamide oxygen-donating agent and a preparation method of the oxygen-donating agent in order to avoid the disadvantages of the above-mentioned prior art. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/16A61P11/00
Inventor 张玲
Owner 张玲
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