Medicine for treating coronary heart disease as well as preparation method and application thereof

Abstract

The invention relates to a medicine for treating coronary heart disease and application thereof. Comprising the following raw materials in parts by weight: 5-15 parts of pericarpium trichosanthis, 5-15 parts of radix salviae miltiorrhizae, 10-20 parts of herba epimedii, 5-15 parts of folium ginkgo, 10-20 parts of rhizoma corydalis, 5-15 parts of ramulus cinnamomi, 5-15 parts of radix puerariae, 5-15 parts of rhizoma chuanxiong, 5-15 parts of lignum dalbergiae odoriferae, 2-6 parts of flos caryophylli, 5-15 parts of radix aucklandiae and 2-6 parts of long pepper. The composition can be used for reducing myocardial oxygen consumption, improving myocardial blood supply, promoting formation of collateral circulation of a myocardial infarction region, relieving angina attack symptoms of patients with coronary heart diseases and improving long-term prognosis effects and life quality.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for treating coronary heart disease and application thereof. Background Art

[0002] Coronary heart disease is called "chest pain" in traditional Chinese medicine. Chest pain is caused by improper diet, emotional disorder, invasion of cold evil, old age and physical weakness, which lead to dysfunction of heart, liver, spleen and kidney, resulting in deficiency of qi, blood, yin and yang. It is a disease that is caused by the blockage of heart pulse by pathological products such as deficiency of vital energy, phlegm, blood stasis, qi stagnation and cold coagulation, and is clinically manifested by tightness and pain in the tanzhong or left chest.

[0003] At present, most of the treatments for coronary heart disease in Western medicine are symptomatic treatments. The basic method is to use antihypertensive drugs for high blood pressure, lipid-lowering drugs for high blood lipids, and hypoglycemic drugs for high blood sugar, combined with aspirin to prevent platelet aggregation and thrombotic plaque formation and nitroglycerin for the treatment of angina pectoris. Although it can relieve the patient's symptoms in a short period of time, the long-term treatment effect is not good. For severe cases, interventional treatment is adopted, namely stent implantation (commonly known as stent) and surgical coronary artery bypass grafting (commonly known as bypass surgery). Stent implantation and bypass surgery are not only expensive, but also bring great pain to patients, and the quality of life of patients after recovery is not high.

[0004] Traditional Chinese medicine basically uses compound Danshen dripping pills, Xuefu Zhuyu decoction, Guwei Xiebai Banxia decoction, Shengmai powder combined with ginseng nourishing decoction, Zuoguiyin, etc. However, each has its own advantages and disadvantages, so it is important to develop a new drug for the treatment of coronary heart disease. Summary of the invention

[0005] The purpose of the present invention is to provide a medicine for treating coronary heart disease and its application. The medicine has a unique formula, synergistic synergy between the formulas and significant effect.

[0006] The technical solution of the present invention:

[0007] A medicine for treating coronary heart disease comprises the following raw materials in parts by weight: 5-15 parts of Trichosanthes peel, 5-15 parts of Salvia miltiorrhiza, 10-20 parts of Epimedium, 5-15 parts of Ginkgo biloba leaves, 10-20 parts of Corydalis yanhusuo, 5-15 parts of cinnamon twigs, 5-15 parts of Pueraria root, 5-15 parts of Chuanxiong, 5-15 parts of Dalbergia odorifera, 2-6 parts of cloves, 5-15 parts of costusroot, and 2-6 parts of Piper longum.

[0008] Beneficial effects of the present invention:

[0009] 1. The present application prescription can reduce myocardial oxygen consumption, improve myocardial blood supply, promote the formation of collateral circulation in the myocardial infarction area, alleviate the symptoms of angina pectoris in patients with coronary heart disease, and improve the long-term prognosis and quality of life by using the composition. The inventor summarized and sorted out the prescription in his long-term clinical work, in which Trichosanthes peel and Salvia miltiorrhiza are the main drugs, Corydalis yanhusuo, Cinnamon twig and Chuanxiong are the ministerial drugs, Epimedium, Pueraria root and Ginkgo leaf are the adjuvant drugs, and Dalbergia odorifera, Clove, Aucklandia lappa and Piper longifolia are the guiding drugs.

[0010] 2. In the prescription of this application

[0011] Main drug: Trichosanthes peel can dissipate phlegm, widen the chest and dissipate stagnation, relieve blood stasis and dissipate stagnation, and can treat chest tightness. It can be used for symptoms of fullness and tightness caused by poor myocardial blood supply, improve myocardial ischemia, and relieve angina pectoris. Salvia miltiorrhiza is a drug that can promote blood circulation and remove blood stasis, promote blood circulation and relieve swelling. It enters the heart meridian and can promote blood circulation and remove blood stasis, promote qi and relieve pain, and treat angina pectoris caused by coronary heart disease. Tanshinone and vitamin E have the effects of calming the nerves, dilating coronary arteries, increasing blood flow, and anti-arrhythmic effects.

[0012] Ministerial drugs: Chuanxiong and Yuanhu, after the drugs relieve vascular spasm, play the role of promoting blood circulation and removing blood stasis, and dredge blood vessels. Yuanhu enters the liver meridian, spleen meridian and heart meridian, can promote blood circulation, promote qi and relieve pain. Danshen and Yuanhu can increase the effect of promoting qi and relieving pain, and effectively improve chest pain, chest tightness, chest pain, angina pectoris, coronary heart disease, etc. caused by qi stagnation and blood stasis. Treat various pains caused by qi and blood stagnation. Guizhi warms the blood vessels, warms the meridians and promotes yang to relieve chest pain. Chuanxiong can promote blood circulation, enhance vascular elasticity, relieve vascular spasm, and help improve problems such as poor blood circulation and meridian obstruction. It can promote blood circulation and promote qi, treat chest pain, contain ferulic acid, can inhibit nerve centers, have sedative, analgesic and anticonvulsant effects, excite the medullary respiratory center and vasomotor center, directly dilate peripheral blood vessels, increase coronary artery flow, and improve myocardial ischemia and hypoxia.

[0013] Adjuvants: Clove, Piper longum, and Aucklandia lappa relieve vascular spasms. Ginkgo biloba can dilate blood vessels, improve blood supply, and relieve vascular spasms, thereby alleviating pain symptoms. Aucklandia lappa promotes qi circulation and relieves pain, and strengthens the stomach and helps digestion. Epimedium belongs to the liver and kidney meridians, and can dilate peripheral blood vessels, dispel wind and dampness, and relieve spasms.

[0014] Envoy: Clove: warms the middle and lowers the benefit, warms the kidney and helps the yang, has a stimulating aroma, and improves myocardial spasm. Piper: warms the middle and dispels cold, relieves spasms and relieves pain. Pueraria root: treats coronary heart disease, angina pectoris, and dredges blood vessels.

[0015] 3. The drug in this application can be taken orally and applied externally. The safety, reliability and effectiveness of traditional Chinese medicine in treating coronary heart disease are superior to stenting and bypass surgery for heart disease, and cardiac defibrillation and ablation. The cure rate is 90% and the effectiveness rate reaches 98%. DETAILED DESCRIPTION

[0016] The following describes the embodiments of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.

[0017] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.

[0018] When the embodiment gives a numerical range, it should be understood that, unless otherwise specified in the present invention, the two endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those of ordinary skill in the art to which the present invention belongs.

[0019] It is worth noting that the raw materials used in the present invention are all common commercially available products, so their sources are not specifically limited.

[0020] Western medical theory believes that coronary heart disease is caused by atherosclerotic lesions in the coronary arteries, which cause vascular stenosis or obstruction, resulting in myocardial ischemia, hypoxia or necrosis. Traditional Chinese medicine believes that the effects of the six evils, seven emotions, diet, work and rest, etc., cause dysfunction of the internal organs, which then lead to chest pain, heart pain, true heart pain, and heart disease. The pathogenesis can be classified as "root deficiency and superficial excess". "Root deficiency" refers to the deficiency of qi and blood, yin and yang of the heart, and "substantial excess" refers to qi stagnation and blood stasis, phlegm turbidity and cold coagulation, and heat accumulation, which block the heart meridian and cause pain. It has been found that due to long-term labor, positional restrictions and various bad eating habits such as excessive smoking and drinking, cold invasion, and overwork, the costal cartilage, sternum, aseptic inflammation and various pains radiate to the heart, causing coronary artery contraction, spasm, and insufficient blood supply to cause pain, angina pectoris, heart tightness, shortness of breath, and weakness in the limbs, and coronary heart disease and angina pectoris caused by phlegm and blood stasis and meridian qi stagnation and blood stasis coronary artery spasm. The research results provide new ideas, new perspectives, and new solutions for the traditional Chinese medicine treatment of coronary heart disease, and provide a favorable scientific basis for the treatment and prevention of coronary heart disease. The inventor uses the Chinese medicine for oral and external application of this application to treat patients with coronary heart disease and angina pectoris and has been effectively treated, with an effective rate of 98%.

[0021] Under the leadership of Song Lingchun, an old Chinese medicine doctor at Lingchun Chinese Medicine Hospital in Lishu County, the inventors have developed the drug of this application after years of research and development, using new theories and combining traditional Chinese medicine dialectical treatment. It can effectively treat patients with coronary heart disease, make the replacement blood vessels start to work, regenerate capillaries, make blood vessels thicker, replace blood vessels with blood stasis, restore the original myocardial function, restore the circulation of the limbs, remove the substances that block blood vessels-free radicals, improve myocardial ischemia, achieve pain relief, no suffocation, no shortness of breath, and restore the normal operation of the heart. In traditional Chinese medicine, traditional Chinese medicines such as Trichosanthes peel, Salvia miltiorrhiza, Epimedium, Ginkgo biloba, Corydalis, Cinnamon twig, Pueraria root, Chuanxiong, Dalbergia odorifera, Clove, Aucklandia lappa, Piper longipi are selected as raw materials, and modern research on traditional Chinese medicine has played an advanced prescription that uses the past for the present and the foreign for the Chinese. It can achieve the following effects: a. Soften the coronary arteries; b. Clear the blockages in arteriosclerosis; c. Relieve the spasms of various arteriosclerosis, restore the blood circulation of the myocardium, and achieve the treatment of coronary heart disease and angina pectoris, with an efficacy of 98%.

[0022] Gualou peel: sweet and cold in nature. Enters the lung and stomach meridians. It has the effects of clearing heat and resolving phlegm, widening the chest and promoting qi. "Zhongyao Zhi" says: "It can clear phlegm and relieve liver depression. It can treat cough caused by phlegm heat and pain in the chest and ribs." Modern pharmacological studies have shown that the chemical components contained in Gualou peel have a significant protective effect on acute myocardial ischemia and myocardial ischemia reperfusion caused by the posterior pituitary in rats, improve the ability to tolerate hypoxia, lower blood pressure, expand the coronary artery, and have lipid-lowering, blood sugar-lowering, antibacterial and expectorant effects. It can be used for chest obstruction, chest congestion, phlegm-heat cough, chest tightness and rib pain, etc.

[0023] Danshen: Also known as purple danshen, blood ginseng, Dahongpao, red root, etc., it is the dried root and rhizome of the Lamiaceae plant Danshen. It is dug in spring and autumn, removed from mud and sand, and dried. It enters the heart and liver meridians. It tastes bitter and is slightly cold in nature. It has the effects of promoting blood circulation and removing blood stasis, relieving pain from menstruation, clearing the heart and eliminating restlessness, cooling blood and eliminating carbuncle. It is used for chest pain, abdominal pain, accumulation of masses, heat arthralgia, restlessness and insomnia, irregular menstruation, dysmenorrhea, amenorrhea, and sores and swelling.

[0024] Epimedium: Epimedium has the effects of tonifying kidney yang, strengthening tendons and bones, and removing rheumatism. Epimedium is also called Xianlingpi. The nature and flavor of epimedium are pungent, sweet and warm. It is often used in combination with Chinese herbal medicines such as Cistanche deserticola, Eucommia ulmoides, and Morinda officinalis to treat impotence and spermatorrhea, tendon weakness, rheumatic pain, numbness and cramps caused by kidney yang deficiency. It is a good medicine for treating kidney yang deficiency and impotence and spermatorrhea.

[0025] Ginkgo biloba: Ginkgo biloba can dilate blood vessels, improve blood supply, relieve vascular spasms, and thus reduce pain symptoms. Chuanxiong can promote blood circulation, enhance vascular elasticity, relieve vascular spasms, and help improve problems such as poor blood circulation and meridian obstruction.

[0026] Yuanhu: Yuanhu enters the liver meridian, spleen meridian and heart meridian, can promote blood circulation, promote qi and relieve pain. Salvia miltiorrhiza combined with Yuanhu can increase the effect of promoting qi and relieving pain, and effectively improve chest pain, chest tightness, chest pain, angina pectoris, coronary heart disease, etc. caused by qi stagnation and blood stasis.

[0027] Cinnamon twig: Cinnamon twig is pungent, sweet and warm. It enters the heart, lung and bladder meridians. It has the effects of inducing sweating and relieving exterior symptoms, warming the meridians and promoting yang, dispelling cold and relieving pain, and assisting yang and transforming qi. It can be used for wind-cold exterior symptoms, for symptoms of fever, covering up cold and sweating. In addition, it can also be used for palpitations, chest pain, it can warm the meridians and promote heart yang, dredge the collaterals and relieve pain. Thirdly, because it enters the bladder meridian, it has the effects of assisting yang and transforming qi and diuresis. Fourthly, it has the effects of dispelling cold and relieving pain, and is used for dysmenorrhea and joint pain.

[0028] Pueraria root: Pueraria root has many pharmacological effects, such as antipyretic, coronary artery dilation, anti-myocardial ischemia, improvement of cardiac function, improvement of cerebral circulation, lowering blood pressure, inhibiting platelet aggregation, lowering blood sugar, lowering blood lipids, anti-oxidation, anti-tumor, and liver protection.

[0029] Chuanxiong: Chuanxiong is pungent in taste and warm in nature. It can enter the liver, gallbladder, and pericardium meridians. It has the effects and functions of promoting blood circulation and qi, dispelling wind and relieving pain, nourishing blood and regulating menstruation, dilating blood vessels, regulating menstruation and activating collaterals, etc.

[0030] Dianxiang: Dianxiang is pungent and warm in nature. It has the effects of promoting blood circulation and dispersing blood stasis, stopping bleeding and relieving pain, lowering qi, and eliminating filth. Treatment suggestions: It is recommended to treat various symptoms of blood stasis and bleeding, as well as pain caused by blood stasis and qi stagnation.

[0031] Clove: Clove, a Chinese medicine name, is the dried flower buds of the Myrtaceae plant clove. Clove is slightly pestle-shaped, with a spherical corolla and petals that are clasped in a shingle-like pattern. They are brown to brownish yellow in color. Inside the petals are stamens and styles. After crushing, many yellow granular anthers can be seen. Clove is pungent and warm in nature. It enters the spleen, stomach, lung, and kidney meridians and has the effects of warming the middle and relieving adverse symptoms, and tonifying the kidney and supporting yang.

[0032] Costus root: Costus root is bitter and warm in nature and enters the spleen, stomach, large intestine, gallbladder and triple burner meridians. It can promote qi and relieve pain, invigorate the spleen and help digestion. It is mainly used for spleen and stomach qi stagnation syndrome, dysentery, tenesmus, abdominal pain, flank pain, jaundice, hernia pain, and chest pain caused by qi stagnation and blood stasis. Costus root is a very commonly used qi-promoting and analgesic drug. While relieving pain, costus root also has a very obvious effect of relieving swelling. Therefore, it is mainly used for various pains caused by qi stagnation.

[0033] Piper: Piper is a traditional Chinese medicine that is an analgesic and stomachic medicine. It is spicy and hot in nature and non-toxic. It is often used clinically to treat abdominal pain, vomiting, diarrhea, coronary heart disease, angina pectoris, neuralgia and toothache caused by stomach cold.

[0034] Example 1

[0035] A medicine for treating coronary heart disease comprises the following raw materials in parts by weight: 10 parts of Trichosanthes peel, 10 parts of Salvia miltiorrhiza, 15 parts of Epimedium, 10 parts of Ginkgo biloba leaves, 15 parts of Corydalis yanhusuo, 10 parts of cinnamon twigs, 10 parts of Pueraria root, 10 parts of Chuanxiong, 10 parts of Dalbergia odorifera, 3 parts of cloves, 10 parts of costusroot, and 3 parts of Piper longum.

[0036] The preparation method of the medicine is as follows: the above raw materials are mixed together and crushed into 200 meshes, and then canned into capsules, each capsule weighing 0.5 grams.

[0037] Dosage: 2-2.5g at a time, twice a day.

[0038] Example 2

[0039] A medicine for treating coronary heart disease comprises the following raw materials in parts by weight: 15 parts of Trichosanthes peel, 15 parts of Salvia miltiorrhiza, 20 parts of Epimedium, 15 parts of Ginkgo biloba leaves, 20 parts of Corydalis yanhusuo, 15 parts of cinnamon twigs, 14 parts of Pueraria root, 15 parts of Chuanxiong, 15 parts of Dalbergia odorifera, 6 parts of cloves, 15 parts of costusroot, and 6 parts of Piper longum.

[0040] The preparation method of the medicine is as follows: the above raw materials are mixed together and crushed into 200 meshes, and then canned into capsules, each capsule weighing 0.5 grams.

[0041] Dosage: 2-2.5g at a time, twice a day.

[0042] Example 3

[0043] A medicine for treating coronary heart disease comprises the following raw materials in parts by weight: 5 parts of Trichosanthes peel, 5 parts of Salvia miltiorrhiza, 10 parts of Epimedium, 5 parts of Ginkgo biloba leaves, 10 parts of Corydalis yanhusuo, 5 parts of cinnamon twigs, 5 parts of Pueraria root, 5 parts of Chuanxiong, 5 parts of Dalbergia odorifera, 2 parts of cloves, 5 parts of costusroot, and 2 parts of Piper longum.

[0044] The preparation method of the medicine is as follows: the above raw materials are mixed together and crushed into 200 meshes, and then canned into capsules, each capsule weighing 0.5 grams.

[0045] Dosage: 2-2.5g at a time, twice a day.

[0046] Example 4 Clinical Study

[0047] Clinical analysis data of the Chinese medicine composition of Example 1 of the present invention 100 patients with coronary heart disease from Lishu County Lingchun Chinese Medicine Hospital (formerly known as Lishu County Huichun Chinese Medicine Hospital) were selected for observation and divided into a treatment group and a control group according to a 1:1 random method, with 50 cases in the treatment group and an average age of about 60 years old; and 50 cases in the control group and an average age of about 61 years old. There was no significant difference between the two groups in terms of age, gender and course of disease.

[0048] Diagnostic criteria:

[0049] Western medicine diagnostic criteria: based on the diagnostic criteria for coronary heart disease in the "Nomenclature and Diagnostic Criteria for Ischemic Heart Disease" developed by the International Society of Cardiology and the World Health Organization's Joint Task Force on Clinical Nomenclature Standardization.

[0050] Diagnostic criteria of TCM:

[0051] 1. Chest tightness and pain, even pain in the left shoulder, back, throat, stomach, inner side of left upper arm, etc., usually lasts from a few seconds to tens of minutes, and can be relieved after rest or medication. It is recurrent, often accompanied by palpitations, shortness of breath, sweating, and even panting and inability to lie down.

[0052] 2. Sudden onset, intermittent onset, recurring. In severe cases, there may be severe chest pain, persistent pain, sweating, cold limbs, pale complexion, bluish lips and nails, scattered or weak pulse, and other dangerous symptoms, which may lead to sudden death.

[0053] 3. More common in middle-aged and older people, often triggered by overwork, depression, anger, overeating or climate change. There are also cases where there is no obvious cause or the disease occurs during rest.

[0054] Treatment:

[0055] The control group was given Compound Danshen Dropping Pills, orally or sublingually, 10 pills at a time, 3 times a day.

[0056] The treatment group was given the formula medicine of Example 1 of the present application, 2-2.5g at a time, twice a day. At the same time, massage the chest Tanzhong acupoint once a day, and then stir the medicinal vaseline oil of Example 1 of the present application into a paste, apply it externally at the Tanzhong acupoint, once a day. Press the chest Tanzhong acupoint and apply the medicine externally at the Tanzhong acupoint to pressurize the chest cavity, promote blood stasis to circulate, open the closed blood vessels to circulate blood, start the blood circulation of the tasting blood vessels, increase blood circulation in the lateral limbs, restore the blood supply to the myocardium, and restore myocardial ischemia and hypoxia. Angina pectoris, heart suffocation, palpitations, shortness of breath and arrhythmia are relieved. Most of the spasms in blood vessels are functional reasons. In general, such as catching a cold, staying up late due to fatigue, and the stimulation of mental tension are the main factors causing it. First, maintain a good mood and then cooperate with the above treatment. The coronary arteries can self-regulate contraction and relaxation, and have strong purification capabilities. When the above three methods (oral medication, external application and chest massage) are used to treat the increased cardiovascular metabolism level, the metabolite adenosine can strongly dilate the coronary arteries to increase coronary blood flow, as well as neural and hormonal effects. It can also regulate vascular contraction and relaxation to relieve spasms. Once the heart has problems, oral Chinese medicine, acupoint massage, and external application of Chinese medicine can be used as auxiliary treatments to increase the vitality of the heart.

[0057] Efficacy criteria: 1) Cured: The symptoms in the diagnostic criteria disappear, and the five criteria of coronary heart disease instrument examination (including the five criteria that can be detected by the instrument, 1. Electrocardiogram, 2. Cardiac B-ultrasound, 3. Treadmill exercise electrocardiogram, 4. Coronary artery CTA, 5. Coronary angiography. The above five criteria are judged according to the current hospital regulations.) return to normal, the left ventricular blood intake fraction is normal at 50-70%, and the B-type sodium acid peptide is around 450; 2) Significantly effective: The symptoms in the diagnostic criteria basically disappear, and the five criteria of coronary heart disease instrument examination are generally normal; 3) Effective: The symptoms in the diagnostic criteria are alleviated, and the five criteria of coronary heart disease instrument examination are generally normal, and the electrocardiogram shows myocardial ischemia, ST segment changes, and T wave inversion; 4) Ineffective: The symptoms in the diagnostic criteria do not disappear, and the five criteria of coronary heart disease instrument examination do not improve, the left ventricular blood intake fraction is lower than 50%, and the B-type sodium acid peptide is higher than 450.

[0058] Experimental results: Comparative evaluation of the effects of the treatment group and the control group

[0059] Group Number of cases get well Significant effect efficient invalid Total effective rate% Treatment Group 50 cases 43 cases 4 cases 2 cases 1 case 98％ Control group 50 cases 37 cases 3 cases 2 cases 8 cases 84％

[0060] Case 1

[0061] Hu, male, 55 years old, from the fifth team of Xingshan Village, Lishu Town, Lishu County, complained on August 7, 2018: discomfort in the precordial area for more than 2 years, and the pain worsened after activities. Current medical history: The patient had discomfort in the precordial area 2 days ago, which was often induced by cold and exercise. Taking Jiuxin Pills and infusion treatment was ineffective, so Hu went to Siping Central Hospital, a tertiary hospital, for coronary CT, which showed 85% stenosis of the right coronary artery. At that time, he was preparing to implant a stent, but found that the blood pressure rose to 200 / 100, but did not put it in, and was discharged later. The next day, he came to Lishu Lingchun Chinese Medicine Hospital. After the patient moved, he induced pain in the precordial area, accompanied by air pressure and spontaneous sweating, which lasted 1-2 minutes each time and had attacks every day. Taking Jiuxin Pills was ineffective. Today, he has had 4-5 attacks of precordial pain. He took nitroglycerin to relieve it and then went to the hospital. The symptoms are: chest tightness, shortness of breath, colic, triggered by activity, fear of coldness in the chest and back, transient pain in the head, urination 1-2 times at night, normal bowel movements, 3-4 hours of sleep per night, frequent drooling, dark tongue with thin white coating, yellow and greasy in the middle, and slippery pulse. Diagnosis: chest pain with Gualou Xiebaizi decoction syndrome, Western medicine diagnosis: coronary artery atherosclerotic heart disease, stable angina pectoris. Treatment prescription (Gualou Xiebaizi Decoction with modifications), Gualou Pi 15g, Danshen 15g, Epimedium 15g, Ginkgo Leaf 15g, Yuanhu 15g, Cinnamon Twig 15g, Pueraria lobata 15g, Chuanxiong 15g, Dalbergia odorifera 15g, Clove 5g, Aucklandia 15g, Piper 5g as raw materials, take 2.5g orally, twice a day, take with warm water in the morning and evening, take 14 doses, massage the chest Tanzhong point 14 times, take 2.5g of this medicine and mix it with Vaseline and apply it on the chest Tanzhong point. Follow-up: All symptoms were alleviated, and after taking 14 more doses, the patient was cured, the precordial area no longer had colic, shortness of breath, heart no longer felt stuffy, the limbs were strong, no sweating, and the sleep was very good. All symptoms disappeared.

[0062] Case 2

[0063] Wu Moumou, male, August 2019, an employee of a bureau in Gongzhuling City, suffered from coronary heart disease angina pectoris, cerebral infarction, dizziness, and depression. He was treated in Changchun TCM Class III Hospital and other hospitals for seven years without recovery. Later, he came to this hospital. Dr. Song massaged the patient's chest area Tanzhong acupoint, and then stirred the medicinal vaseline oil of Example 2 of this application (15 parts of Trichosanthes peel, 15 parts of Salvia miltiorrhiza, 20 parts of Epimedium, 15 parts of Ginkgo biloba leaves, 20 parts of Corydalis, 15 parts of Cinnamon twigs, 14 parts of Pueraria root, 15 parts of Chuanxiong, 15 parts of Dalbergia odorifera, 6 parts of Cloves, 15 parts of Aucklandia lappa, 6 parts of Piper longum) into a paste, applied externally at the Tanzhong acupoint, massage and external application of Chinese medicine once a day. And cooperate with oral administration of the formula medicine of Example 2 of this application, 2-2.5g at a time, twice a day. After taking 14 doses of medicine, he came for a follow-up visit, and the last treatment was completely symptom-free for two months, and he recovered. Two-year follow-up showed that the patient had recovered well.

[0064] Case 3

[0065] Guo Moumou, male, 65 years old, April 1, 2023, Guojiadian, Lishu County, came to the hospital for treatment and reported dizziness, headache, angina pectoris, palpitations, bradycardia. Dr. Song massaged the patient's chest area Tanzhong acupoint, and then stirred the vaseline oil of the prescription medicine of Example 2 of this application (15 parts of Trichosanthes peel, 15 parts of Salvia miltiorrhiza, 20 parts of Epimedium, 15 parts of Ginkgo biloba leaves, 20 parts of Corydalis, 15 parts of Cinnamon twigs, 14 parts of Pueraria root, 15 parts of Chuanxiong, 15 parts of Dalbergia odorifera, 6 parts of Cloves, 15 parts of Aucklandia lappa, 6 parts of Piper longum) into a paste, applied externally on the chest Tanzhong acupoint massage, and then applied the Chinese medicine externally once a day. And cooperate with oral administration of the prescription medicine of Example 2 of this application, 2-2.5g at a time, twice a day. After taking 14 doses of medicine, come for follow-up, and recover in one month after the final treatment, and follow up after half a year to recover well.

[0066] Comparison table of TCM treatment and Western medicine stent bypass treatment for coronary heart disease

[0067]

[0068] Because the mortality rate is higher in stenting and bypass treatment, the disability rate is higher, the poverty rate is the highest, the cure rate is low, and the effectiveness rate is low. Even if the life can be saved after stenting and bypass treatment, the quality of life will be much worse than before. So try to use conservative treatment. The treatment of coronary heart disease cannot be treated by stenting because of more than 75% blockage of unilateral coronary artery angiography. The blockage of coronary artery is caused by plaque and coronary artery spasm. There are seven invisible symptoms of coronary heart disease (1. Chest tightness: squeezing pain in the chest, which is very unbearable and feels like being crushed to death; 2. Shortness of breath: It feels like a stone is pressing on the chest and it is difficult to exhale, and you feel like you are suffocating to death; 3. Severe colic in the precordial area, the pain is like a knife cutting and radiates to the back, shoulders, teeth and stomach, etc. It hurts like hell, and you feel like you are going to die from pain; 4. Upset: The feeling of being about to die, life... 5. Palpitations: Feeling like the heart is about to jump out of the chest, feeling like death, fear of cold, fear of heat; 6. Heartache: Feeling like dying, covering the chest with hands, feeling restless when standing, fear of cold, fear of heat; 7. Heart heat, chest heat, chest fever, unbearable fever, sweating, fear of cold, fear of heat, numbness, like fire in the chest, limbs paralyzed, anxiety, chest tightness, shortness of breath, people are called heart attack, insomnia, palpitations, cold hands and feet, nervousness, irritability. ) is the main factor causing coronary artery spasm. To relieve coronary artery spasm, the blockage is not 75%, and stents and bypass surgery should not be placed. Even if the coronary artery is 90% blocked, there is no need to put in a stent or bypass. First, the spasm must be relieved. Secondly, the blood vessels are flesh, not metal, and can retract and transport. Furthermore, the heart arteries are congenital, and some compensatory blood vessels and closed blood vessels can be opened by pressing the chest and taking Chinese medicine internally and externally to start blood supply. Finally, blood is liquid, and the heart is equivalent to a pump. Only a small gap is needed to start blood supply and resuscitate the heart. Therefore, even if the artery is 90% blocked, there is no need to put in a stent or bypass. It can be cured with Chinese medicine techniques and Chinese medicine.

[0069] Case 4

[0070] Mr. Wang, male, 77 years old, came to our hospital complaining of chest pain, which occasionally occurred during sleep. The attacks began to occur frequently one week ago. He came to our hospital for treatment on July 20, 2020. The patient complained of severe stuffiness and irritability with pain in the precordial area. Chest squeezing pain accompanied by fatigue, shortness of breath, and constipation occurred during slight exercise. He was originally diagnosed with myocardial infarction in Beijing Fuwai Hospital. He had three stent placements with a total of four stents. His condition worsened, so he called Beijing Fuwai Hospital and asked him to prepare 400,000 to go to Fuwai Hospital for bypass surgery. Due to the epidemic, he could not go to Fuwai Hospital, so he came to Lingchun Hospital for treatment. Traditional Chinese medicine diagnosed him with chest pain, true heart pain, dry mouth, red tongue, purple lips, dark red tongue, white greasy tongue coating, and deep and knotted pulse, which met the diagnostic criteria of coronary heart disease angina pectoris combined with arrhythmia and phlegm blocking the blood vessels. Prescription: 15g of Trichosanthes peel, 15g of Salvia miltiorrhiza, 15g of Epimedium, 15g of Ginkgo biloba, 20g of Corydalis, 15g of Cinnamon twig, 15g of Pueraria root, 15g of Chuanxiong, 15g of Dalbergia odorifera, 5g of Clove, 15g of Aucklandia lappa, 5g of Piper longum, 14 doses of decoction, external administration with chest massage. Follow-up on August 15, 2020: The patient reported that his chest pain, chest tightness, and squeezing pain in the chest were relieved, his bowel movements were normal, his dry mouth, dark red tongue, and purple lips were relieved, and his pulse was intermittent. Prescription: 15g of Trichosanthes peel, 15g of Salvia miltiorrhiza, 15g of Epimedium, 15g of Ginkgo biloba, 20g of Corydalis, 15g of Cinnamon twig, 15g of Pueraria root, 15g of Chuanxiong, 15g of Dalbergia odorifera, 5g of Clove, 15g of Aucklandia lappa, 5g of Piper longifolia, 14 doses, decocted in water, massaged at the chest Tanzhong point, stirred into a paste with the prescribed medicinal vaseline oil, and applied externally at the chest Tanzhong point. On September 20, the patient reported that the chest tightness, shortness of breath, and pain in the precordial area had disappeared, and the limbs were strong. The above prescription was taken for another 21 doses, massaged at the chest Tanzhong point, stirred into a paste with the prescribed medicinal vaseline oil, and applied externally at the chest Tanzhong point. Follow-up after half a year showed that the condition was stable and there was no recurrence.

[0071] Case 5

[0072] Chen Moumou, male, 80 years old, from Sandagangzi Village, Shuanghe Township, Lishu County, complained of chest pain, irritability, and precordial tightness. He came to Lishu Lingchun Traditional Chinese Medicine Clinic for medical treatment on May 7, 2021 due to frequent attacks a week ago. The patient reported that he had chest tightness, irritability, irritability, weakness in the limbs, spontaneous sweating, precordial pain during exercise, shortness of breath and loose stools. He went to Jilin University First Hospital for CT angiography to diagnose angina pectoris. The left circumflex coronary artery was stenotic by 75%. Jilin University First Hospital wanted to treat with coronary stents, but he disagreed. Later, he came to Lishu Lingchun Traditional Chinese Medicine Hospital, where Chinese medicine diagnosed chest pain, repeated heart pain, dry and bitter mouth, dark purple tongue, thin white fur, and slippery pulse, which met the diagnostic criteria for unstable angina and blood stasis. Prescription: 10 parts of Trichosanthes peel, 10 parts of Salvia miltiorrhiza, 15 parts of Epimedium, 10 parts of Ginkgo biloba leaves, 15 parts of Corydalis, 10 parts of Cinnamon twig, 10 parts of Pueraria root, 10 parts of Chuanxiong, 10 parts of Dalbergia odorifera, 3 parts of Clove, 10 parts of Aucklandia lappa, 3 parts of Piper longum, 14 doses, decocted in water. Massage the chest Tanzhong point, stir the prescription medicinal vaseline oil into a paste, and apply it to the chest Tanzhong point. On May 25, 2021, he went to the hospital for a follow-up visit. He said that his chest was not so painful, not so stuffy, his limbs were strong, his bowel movements were normal, his mouth was not dry, his tongue was dark red, his lips were not purple, and his pulse was slippery and rapid. He continued to take 10 parts of Trichosanthes peel, 10 parts of Salvia miltiorrhiza, 15 parts of Epimedium, 10 parts of Ginkgo biloba, 15 parts of Corydalis, 10 parts of Cinnamon twig, 10 parts of Pueraria root, 10 parts of Chuanxiong, 10 parts of Dalbergia odorifera, 3 parts of Cloves, 10 parts of Aucklandia lappa, and 3 parts of Piper longipi. He took 21 doses of decoction. He massaged the chest Tanzhong acupoint, stirred the prescription medicinal vaseline oil into a paste, and applied it to the chest Tanzhong acupoint. On June 10, 2021, he went to the hospital for a third visit. He said that the symptoms of chest tightness, shortness of breath, weakness in the limbs, dry mouth and bitter mouth, irritability, and chest pain disappeared. There were slight petechiae on the tongue, the tongue coating was slightly yellow and greasy, and the pulse was slippery. Prescription: 15g of Trichosanthes peel, 15g of Salvia miltiorrhiza, 15g of Epimedium, 15g of Ginkgo biloba leaf, 20g of Corydalis yanhusuo, 15g of cinnamon twig, 15g of Pueraria root, 15g of Chuanxiong, 15g of Dalbergia odorifera, 5g of Clove, 15g of Aucklandia lappa, 5g of Piper longifolia, 14 doses, taken with water, massaged on the chest Tanzhong point, stirred into a paste with the prescribed medicinal vaseline oil, and applied externally on the chest Tanzhong point. No recurrence was found in the follow-up for the second half of the year.

[0073] Case 6

[0074] Li Xianzhong, male, 62 years old, from Beishan, Guojiadian Town, suffered from coronary heart disease, angina pectoris, upset, heart palpitations, and a fever that felt like he was going to die. He took a taxi to the intensive care unit (ICU) of Siping Central Hospital for emergency treatment and then had a stent placed ten days later. Due to his poor family background and lack of money, he refused treatment and later went to Lingchun Chinese Medicine Hospital to find Dr. Song Lingchun for treatment. His condition improved significantly at that time and he was cured without a single injection. He took 2.5 grams of this medicine and mixed it with vaseline and applied it externally on the chest Tanzhong point. After taking 10 doses of this medicine orally, he got much better, could sleep peacefully, had more energy, and was no longer upset. After more than two months of treatment, he was cured, saving him two or three hundred thousand yuan, and he did not suffer any pain and recovered safely.

[0075] Case 7

[0076] Wang Moumou, female, 48 years old, from Jiujia Village, Shengli Township, Lishu County, suffered from coronary heart disease, angina pectoris, dizziness, angina pectoris, chest tightness and shortness of breath, palpitations, upset, and weakness in the four limbs. She was hospitalized three or four times a year, and three heart stents were placed. She was often treated in the First Hospital of Jilin Medical University, Siping Central Hospital, and Lishu County Hospital, but she could not be cured. Later, she went to Lingchun Chinese Medicine Hospital of Lishu County to find Dr. Song Lingchun and was hospitalized for treatment. Dr. Song massaged the patient's chest area Tanzhong acupoint, and then stirred the prescription medicine of Example 1 of the present application (5 parts of Trichosanthes peel, 5 parts of Salvia miltiorrhiza, 10 parts of Epimedium, 5 parts of Ginkgo leaf, 10 parts of Corydalis, 5 parts of Cinnamon twig, 5 parts of Pueraria root, 5 parts of Ligusticum chuanxiong, 5 parts of Dalbergia odorifera, 2 parts of Cloves, 5 parts of Aucklandia lappa, and 2 parts of Piper longum) into a paste with vaseline oil, applied externally on the Tanzhong acupoint, and massage and external application of Chinese medicine were once a day. The patient was treated with oral administration of the drug of Example 1 of the present application, 2-2.5 g at a time, twice a day. With the use of traditional Chinese medicine techniques, oral administration of Chinese medicine, external application of Chinese medicine and chest massage, the patient recovered in three months, with an ejection fraction of 50%, B-type sodium acid peptide of 450, symptoms disappeared, and coronary artery vessels were normal.

[0077] The present invention has conducted a large number of experiments on the selection of formula raw materials and the ratio relationship during the research and development of this traditional Chinese medicine preparation, and successfully invented the above-mentioned formula and preparation process. The weight ratio is very important. The more or less of each component will have a certain impact on the overall therapeutic effect, and the process flow will also have a certain impact on the efficacy and stability of the drug quality.

Claims

1. A drug for treating coronary heart disease, characterized in that: The invention comprises the following raw materials in parts by weight: 5-15 parts of Trichosanthes peel, 5-15 parts of Salvia miltiorrhiza, 10-20 parts of Epimedium, 5-15 parts of Ginkgo biloba leaves, 10-20 parts of Corydalis yanhusuo, 5-15 parts of cinnamon twigs, 5-15 parts of Pueraria root, 5-15 parts of Chuanxiong, 5-15 parts of Dalbergia odorifera, 2-6 parts of cloves, 5-15 parts of costusroot and 2-6 parts of Piper longum.

2. A drug for treating coronary heart disease according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 10 parts of Trichosanthes peel, 10 parts of Salvia miltiorrhiza, 15 parts of Epimedium, 10 parts of Ginkgo biloba leaves, 15 parts of Corydalis yanhusuo, 10 parts of cinnamon twigs, 10 parts of Pueraria root, 10 parts of Chuanxiong rhizome, 10 parts of Dalbergia odorifera, 3 parts of cloves, 10 parts of costusroot and 3 parts of Piper longum.

3. Use of the drug for treating coronary heart disease according to claim 1 in treating coronary heart disease.

4. A drug for treating coronary heart disease according to claim 1, characterized in that: The preparation method of the medicine is as follows: the above raw materials are mixed together and crushed to 200 meshes, and canned into capsules, each capsule weighing 0.5 grams.

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