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44 results about "Hypotensive Drugs" patented technology
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In cardiovascular drug: Drugs affecting the blood vessels Hypotensive drugs, particularly nitroglycerine tablets and calcium channel blockers, are often used to relieve angina pectoris.
Autonomous drug delivery system
An autonomous drug delivery system advantageously utilizes physiological monitor outputs so as to automatically give a bolus of a rescue drug or other necessary medication when certain criteria and confidence levels are met. An emergency button is provided to manually trigger administration of the rescue drug. The rescue drug may be an opioid antagonist in response to an analgesia overdose, a hypotensive drug to avert an excessive drop in blood pressure or an anti-arrhythmia drug to suppress abnormal heartbeats, to name a few.
Owner:MASIMO CORP
Cornel kernel water extract and application thereof
InactiveCN103110685ASimple stepsEasy to operateFood preparationCardiovascular disorderThoracic aortaActive component
The invention discloses a cornel kernel water extract and application of the cornel kernel water extract in preparing a thoracic aorta ring diastole composite and a hypotensive composite, and belongs to the technical field of medicines. The extraction method of the cornel kernel water extract comprises the following steps of: taking dried cornel kernels; smashing into powder of 20-100 meshes; adding water to the kernel powder, and then uniformly mixing; standing at normal temperature for 20-28 hours, and then heating to boil for 20-50 minutes; and filtering to obtain filter liquor, and then concentrating the filter liquor at 40-60 DEG C. The extraction method disclosed by the invention can be used for preparing the cornel kernel extract by adopting an water extraction method and has the advantages of simple step and easiness in operation. The cornel kernel water extract obtained by adopting the extraction method is proved through experiments to play a role of isolated vascular ring diastole, can be used as the active component contained in arterial diastole drug and food or health-care products and can also be used as the active component contained in hypotensive drug and food or health-care products.
Owner:HENAN UNIV OF SCI & TECH
Medicament composition of amlodipine and simvastatin as well as preparation method and application thereof
InactiveCN101485659AImprove the inconvenience of taking separatelyImprove complianceOrganic active ingredientsMetabolism disorderDyslipidemiaTreatment effect
The invention discloses a pharmaceutical composition of amlodipine and simvastatin, which belongs to the technical field of medicine. The pharmaceutical composition is prepared by combining the amlodipine and the simvastatin according to the weight ratio of 1: 1.5-16, and pharmaceutical excipients can also be added to prepare a steady preparation form. A compound medicine of the invention can be taken at any time (before and after dinner), improve the inconvenience that a hypotensor and a lipid-lowering medicine need to be taken respectively, and increase the compliance of patients. On the other hand, the pharmaceutical composition can remarkably strengthen the effect of blood pressure reduction when not decreasing the effect of blood lipid reduction, and can reduce the dosage of drug use; and a complex prescription formed by the amlodipine and the simvastatin can remarkably reduce the toxic effect when the two medicines are used singly, and improves the safety and tolerance. The pharmaceutical composition can be used as a novel medicine for treating mixed hypertension and hyperlipidemia.
Owner:NAT INST OF PHARMA R & D CO LTD
Medicament for treating hypertension
InactiveCN101301381AImprove chest tightnessImprove autoimmune functionCardiovascular disorderMolluscs material medical ingredientsSalvia miltiorrhizaSide effect
The invention provides a medicine for treating hypertension, belonging to the Chinese traditional medicine field. The finished medicine comprises the following effective components by mass: 20 grams of mother-of-pearl, 25 grams of abalone shell, 50 grams of tuber fleeceflower root, 15 grams of chrysanthemum, 30 grams of salvia miltiorrhiza, 15 grams of achyranthes, 30 grams of selfheal, 15 grams of cortex moutan, 30 grams of fructus aristolochiae and 15 grams of uncaria. The medicine can relax vessels, promote blood circulation and remove blood stasis and regulate blood lipid and completely resolve the possibility of the recrudescence of the cure hypertension, and the total effective rate is 100 percent and the cure rate is 96.2 percent. Regardless of the age, length of medical history and existence or non-existence of complication, the medicine can achieve the effective treatment during a treatment period, so that the medicine overcomes defects existing in conventional single hypotensive drugs, overcomes side effects of Western medicine, improves the self immunity capability of human bodies, particularly inhibits the complication and achieves an aim of the treatment focusing on relieving both the secondary and primary symptoms.
Owner:韩振
Potassium-free sodium-reducing granulated edible salt and preparation method thereof
InactiveCN110506923AReduce sodium chloride contentFood ingredient as taste affecting agentFlavorHypotensive drug
The invention provides potassium-free sodium-reducing granulated edible salt. The potassium-free sodium-reducing granulated edible salt comprises the following components in percentage by weight: 50-75% of sodium chloride, 1-30% of yeast extract and the balance of auxiliary materials, wherein the sum of the weight percentages of the components is 100%. The potassium-free sodium-reducing granulatededible salt is designed according to the principle that saltiness and freshness are synergistic and salt is reduced but flavor is not reduced; under the condition that potassium chloride is not added, the purpose of reducing the salt by more than 25% can be achieved; the potassium-free sodium-reducing granulated edible salt is different from common sodium-reducing salt added with the potassium chloride in the market; due to the fact that the potassium chloride is not added, the sodium-reducing salt is also suitable for hypertension patients who take hypotensive drugs, and is more widely available than the common sodium-reducing salt. Through a granulating process, the sodium-reducing salt is more attractive in appearance and more convenient to use; and meanwhile, an anti-caking agent doesnot need to be added.
Owner:ENG TECH INST CO LTD OF CNSIC
Red rice products and applications thereof for preparing hypotensor
InactiveCN101333500AIncrease added valueHigh in gamma-aminobutyric acidFungiFungi medical ingredientsYeastBiotechnology
The invention relates to a red yeast product as well as an application thereof in preparing hypotensive drugs; and the red yeast product is prepared by the following processes: adopting early rice and monascus strains to make red yeast by fermentation, evenly mixing red yeast wine lees added with red yeast and rice pericarps by adding water, drying the mixture after the fermentation for 40 to 200 hours, crushing the mixture and then disinfecting and sterilizing the mixture to make the red yeast product, wherein, the red yeast wine lees, the rice pericarps and the red yeast have the weight ratio of 1.0-2.0:0.5-1.5:0.08-0.15; and the weight ratio of the three materials and water is 100:75-150. The invention utilizes the red yeast wine lees with rather low Gamma-aminobutyric acid content to make the red yeast product with rather high Gamma-aminobutyric acid content, and increases the added value of red yeast wine lees; and the red yeast product has an unexpected effect to the treatment and prevention of hypertension, and also has the auxiliary blood pressure lowering function.
Owner:义乌市丹溪酒业有限公司
Peptide having angiotensin converting enzyme inhibitory effect
InactiveUS7022676B2Preventing the deterioration by bacterial pollutionInhibitionAngiotensinsTetrapeptide ingredientsChemical synthesisAngiotensin-converting enzyme
A peptide Met-Lys-Pro, which is obtained by chemical synthesis ot hydrolysis of casein, is used as the active ingredient of angiotensin converting enzyme inhibitors or hypotensive drugs.
Owner:MORINAGA MILK IND CO LTD
Health-care tea and preparation method thereof
The invention relates to a health-care tea and a preparation method thereof. The health-care tea comprises the following raw materials in parts by weight: 10-20 parts of radix puerariae, 10-20 parts of dogbane leaf, 15-30 parts of hawthorn, and 10-20 parts of schisandra chinensis. The preparation method of the health-care tea comprises the following steps: weighing all raw materials in parts by weight; crushing the weighed raw materials, and sieving; and sterilizing the sieved raw materials, and bagging according to 3-5g per bag. The health-care tea achieves the functions of clearing the heat and calming the liver, invigorating the blood circulation and dispersing stagnation, engendering liquid and allaying thirst, and reducing blood pressure without toxic and side effects, can be drunk for a long time, and patients with mild hypertention can not eat hypotensive drugs to achieve the purpose of stabilizing the blood pressure.
Owner:朱克兰
Method for detecting various angiotensin converting enzyme inhibitor type hypotensive drugs in urine samples
InactiveCN109799305AThe detection method is simpleHigh precisionComponent separationAngiotensin-converting enzymeSpectrograph
The invention discloses a method for detecting various angiotensin converting enzyme inhibitor type hypotensive drugs in urine samples. The method is characterized in that the angiotensin converting enzyme inhibitor type hypotensive drugs in urine are detected by means of liquid chromatograph-mass spectrograph joint use. The method includes steps of urine sample pretreatment, liquid chromatograph-mass spectrograph parameter optimization and urine sample detection. The defect that a detection method in the prior art fails to simultaneously detect the various angiotensin converting enzyme inhibitor type hypotensive drugs in the urine samples is overcome, and the simple and convenience detection method is provided for detecting various angiotensin converting enzyme inhibitor type hypotensivedrugs in the urine samples. The detection method is convenient and simple in operation and high in accuracy, and whether the various angiotensin converting enzyme inhibitor type hypotensive drugs exist in urine or not can be judged simultaneously.
Owner:苏州旭辉检测有限公司
A method for detecting hypoglycemic and hypotensive drugs in blood by ultra-high performance liquid chromatography-mass spectrometry
ActiveCN104133006BMeet the requirements of actual testingThe test result is accurateComponent separationRetention timeBlood sugar
The invention provides a method for detecting 31 common blood pressure-lowering and blood sugar-lowering drugs in blood by an ultra high performance liquid-mass spectrometry, and is characterized in that the method comprises the following steps: (1) confirmation of detected target compounds; (2) sample processing: processing a sample by an organic solvent protein-deposition method; (3) primary screening detection: carrying out primary screening detection by a multiple reaction monitoring (MRM) mode of the ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS) in different periods of time; (4) reexamining of the sample which is positive by the primary screening detection in the step (3): after treating and concentrating the sample which is positive by the screening detection, carrying out UPLC-MS / MS detection; and optionally, (5) reexamining of the sample which is positive by the reexamining detection in the step (4): reexamining by a high performance liquid chromatography-high resolution time-of-flight tandem mass spectrometry (HPLC-QTOF). According to a fact that the drugs have different retention time in the set detection conditions, a method for sectional detection is creatively completed. The required time for totally completing the detection of 31 drugs can be within 11 minutes.
Owner:中国民用航空局民用航空医学中心
Red rice products and applications thereof for preparing hypotensor
The invention relates to a red yeast product as well as an application thereof in preparing hypotensive drugs; and the red yeast product is prepared by the following processes: adopting early rice and monascus strains to make red yeast by fermentation, evenly mixing red yeast wine lees added with red yeast and rice pericarps by adding water, drying the mixture after the fermentation for 40 to 200hours, crushing the mixture and then disinfecting and sterilizing the mixture to make the red yeast product, wherein, the red yeast wine lees, the rice pericarps and the red yeast have the weight ratio of 1.0-2.0:0.5-1.5:0.08-0.15; and the weight ratio of the three materials and water is 100:75-150. The invention utilizes the red yeast wine lees with rather low Gamma-aminobutyric acid content to make the red yeast product with rather high Gamma-aminobutyric acid content, and increases the added value of red yeast wine lees; and the red yeast product has an unexpected effect to the treatment and prevention of hypertension, and also has the auxiliary blood pressure lowering function.
Owner:义乌市丹溪酒业有限公司
Hypotensive drug pillow
InactiveCN104873047AEasy to useNo side effectsPillowsAnthropod material medical ingredientsChrysanthemum FlowerPharmaceutical drug
The invention belongs to a drug pillow, and particularly relates to a hypotensive drug pillow. The hypotensive drug pillow comprises a pillow core and a pillow sleeve; the pillow core fills with traditional Chinese medicine prepared by crushing and mixing; the traditional Chinese medicine contains the following raw materials in part by weight: 2-5 parts of radix puerariae, 2-5 parts of wild chrysanthemum flower, 2-5 parts of buckwheat hull, 1-3 parts of mint, 1-3 parts of semen cassiae, 1-3 parts of prunella spike, 1-3 parts of gastrodia elata, and 1-3 parts of silkworm excrement. The hypotensive drug pillow is convenient to use, safe and reliable, free from toxic and side effects, and obvious in hypotensive effect.
Owner:ANHUI XIAZHEN GRP
Novel substitutional tea capable of reducing blood sugar, blood pressure and blood fat and preparation method thereof
PendingCN112956571AImprove mental stateImprove absorption and utilizationTea substituesNutritionInonotus obliquus
The invention discloses novel substitutional tea capable of reducing blood sugar, blood pressure and blood fat and a preparation method thereof. The novel substitutional tea is prepared from the following components in parts by weight: 30-70 parts of inonotus obliquus, 25-65 parts of folium mori, 10-20 parts of cyclocarya paliurus and 10-50 parts of folium cortex eucommiae. According to the novel substitutional tea capable of reducing blood sugar, blood pressure and blood fat and the preparation method thereof, a nutritional supplement is made into a substitutional tea form, so that the absorption and utilization degree can be enhanced, and some nutritional ingredients necessary for a human body can be supplemented in the tea drinking process of people; and through reasonable compatibility of all the components, a traditional Chinese medicine composition has the effects of reducing blood pressure, blood sugar and blood fat, dispelling the effects of alcohol, coordinating intestines and stomach and resisting oxidation, reduces adverse effects of bad living habits on body health of people, is convenient, has no side effect, can be drunk by both the old and the young, is low in cost, and solves the problems that a traditional blood sugar and blood pressure reducing medicine is large in side effect, strong in medicine resistance, more in medicine amount and more difficult to drink, the more the medicine is, the higher the blood sugar and the blood pressure are, the blood sugar and the blood pressure cannot be effectively and radically treated, complications are easily caused in the later period, and the cost is high.
Owner:伊彦龙
A kind of antihypertensive health care product and preparation method thereof
InactiveCN103907931BIncrease vitalityRelieve painNatural extract food ingredientsFood ingredient functionsLiver and kidneyBud
Owner:熊文花
Pressure-reduction pillow
InactiveCN104510244AGood antihypertensive effectReduce dosagePillowsCardiovascular disorderCyathula officinalisApocynum venetum
The invention discloses a pressure-reduction pillow and relates to a health-care product. The pillow comprises a pillow skin (1) and a pillow core (2). A pressure-reduction interlayer (3) is arranged between the pillow skin (1) and the pillow core (2) and comprises a sealed thin cloth layer and internal pressure-reduction medicine powder. The pressure-reduction medicine powder comprises efficacy raw materials of, by mass, 250 to 400 semen cassia, 100 to 300 of chrysanthemums, 150 to 300 of spica prunellaes, 80 to 120 of yerbadetajo herbs, 60 to 100 of radix cyathulae, 40 to 150 of cinnamons, 50 to 100 of apocynums and 50 to 100 of eucommia ulmoides. By means of the pillow, the pillow serves as the carrier, the pressure-reduction medicine is disposed between the pillow core and the pillow skin in an interlayer mode, a patient can receive the traditional Chinese medicine adjusting efficacy by lying on the pillow, the pillow is damage-free to the body, Western medicine taking pains of patients are reduced, damage to bodies by Western medicine is reduced, the pillow is convenient to use, and the pressure reduction effect is apparent.
Owner:尹燕斌
Hypertension drug-food nano-element drink
InactiveCN104906305AHeavy metal active ingredientsInanimate material medical ingredientsLiver and kidneyAdditive ingredient
The present invention discloses a hypertension drug-food nano-element drink, and belongs to the technical field of production and formulation of health drinks, the hypertension drug-food nano-element drink comprises food therapy hypotensive drug-food elements with both excellent drug and food propertes and water, the food therapy hypotensive drug-food elements have the effects of resisting liver-kidney yin-deficiency hypertension, nourishing blood and tonifying qi, disinfecting, and reducing blood pressure in spring, resisting hypertension caused by excessive liver-fire in summer, nourishing and suppressing Yang, diuresis and reducing blood pressure in autumn, and conditioning liver and kidney, activating blood and reducing blood pressure in winter. Now people's mental stress is large, life is irregular, air and environment are polluted, nutrients are unbalanced, toxic and harmful elements such as lead and cadmium accumulate in the body, necessary elemental zinc, selenium, germanium and magnesium are disorder or in deficiency, so that arterial pressure rise-caused heart, brain, kidney, blood vessel and other viscera functional or organic change systemic disease are caused, by use of typically traditional Chinese medicine proved recipe and diet therapy food active ingredients, and modern nano extraction technology, safe and effective supplement of the body nutrients can be achieved, heavy metal can be resisted, immunity is enhanced, and the hypertension drug-food nano-element drink can disinfect, reduce blood pressure, and prevent complications.
Owner:NANTONG SNAKEBITE THERAPY INST
Health maintenance chocolate and application thereof
InactiveCN105613896AAdd flavorHigh nutritional value for health careCocoaFood ingredient functionsNutritive valuesDark chocolate
The invention belongs to the fields of health food and medicines and provides a health maintenance chocolate prepared from raw materials such as honey and red dates. The health maintenance chocolate comprises 40-70wt% of cocoa mass, 5-10wt% of honey, 5-20wt% of red date powder, 10-20wt% of soybean flour and 10-20wt% of radix puerariae powder. According to the health maintenance chocolate, saccharose is not used, but honey and red dates are creatively used as main sweetening agents, so that not only can the bitterness of black chocolate be removed, but also the flavor of the health maintenance chocolate is enhanced; the honey with efficacies of nourishing, moistening dryness, whitening skin and lubricating the intestines is utilized as a main sugar source, so that the nutritional value of the health maintenance chocolate is greatly enhanced; according to clinical verifications, after a patient with hypertension takes the health maintenance chocolate for 1-3 months, the blood pressure value of the patient is reduced to a normal value, thereby indicating that the health maintenance chocolate provided by the invention has an effect of treating hypertension and is capable of preventing the liver of the patient taking hypotensive drugs for a long term from being damaged.
Owner:潘维新
Medicament for treating hypertension
InactiveCN101301381BImprove chest tightnessImprove autoimmune functionCardiovascular disorderMolluscs material medical ingredientsSalvia miltiorrhizaSide effect
Owner:韩振
SNP loci for predicting efficacy of high blood pressure individualized drug and detection kit
The invention provides SNP loci for predicting the efficacy of a high blood pressure individualized drug and a detection kit. The invention discloses the application of a reagent for detecting the genotype of SNP loci on CYP2C19 and CPY3A5 in preparation of a kit predicating the blood pressure-lowering efficacy of irbesartan, and the SNP loci are 681 G>A (rs4244285) on CYP2C19, 636 G>A (rs4986893)on CYP2C19 and 189-237 G>A (rs776746) on CPY3A5. The invention also provides the corresponding kit and SNP locus combination.
Owner:NINGBO AJCORE BIOSCIENCES INC
Hypotensive drug urapidil hydrochloride composition water injection
InactiveCN105106112AImprove stabilityImprove solubilityOrganic active ingredientsOrganic chemistryChlorideNuclear chemistry
The invention discloses a hypotensive drug urapidil hydrochloride composition water injection, and belongs to the technical field of medicines. The composition consists of urapidil hydrochloride and calcium chloride; urapidil hydrochloride is crystal; an X-ray powder diffraction diagram obtained by measurement by using Cu-Ka rays is represented in figure 1. The new crystal form of the urapidil hydrochloride provided by the invention is different from a crystal form structure in the prior art; a test shows that compared with the prior art, the hypotensive drug urapidil hydrochloride composition water injection has the advantages that the compound with the new crystal form is high in stability, the content of an impurity I is extremely low, and the total content of impurities is also controlled within a lower range; furthermore, with the prolonging of the storage time, the change of the content is smaller. Meanwhile, the dissolving property and the flowability of the urapidil hydrochloride crystal compound in water are obviously improved when compared with the prior art; the water injection prepared from the compound of the new crystal form is simple in constituent, high in stability and very suitable for clinical application.
Owner:杨献美
Matsutake polypeptide and matsutake extract, and application thereof
InactiveCN104974225ARich Screening LibrarySignificant application valuePeptide/protein ingredientsPeptide preparation methodsDrugHypotensive drug
The invention discloses a matsutake polypeptide and a matsutake extract, and application thereof. The polypeptide disclosed by the invention is derived from matsutake and named matsutake polypeptide, which is disclosed as Sequence 1 in the sequence table. The matsutake extract containing the matsutake polypeptide also belongs to the protection range of the invention. The preparation method of the matsutake extract comprises the following steps: (1) adding matsutake sporophores into water, homogenizing, and extracting; and (2) after finishing the step (1), centrifuging and collecting the supernatant. The polypeptide disclosed by the invention is derived from food, thereby enriching the hypotensive drug screening library and providing theoretical references for further development of matsutake. The matsutake polypeptide and matsutake extract have significant application value for treating hypertension.
Owner:CHINA AGRI UNIV
Method for detecting various angiotensin II receptor blocker type hypotensive drugs in urine samples
InactiveCN109799304AOvercome the defect that simultaneous detection of multiple sartan drugs in urine samples cannot be achievedThe detection method is simpleComponent separationSpectrographAngiotensin II Receptor Blockers
The invention discloses a method for detecting various angiotensin II receptor blocker type hypotensive drugs in urine samples. The method is characterized in that the angiotensin II receptor blockertype hypotensive drugs in urine are detected by means of liquid chromatograph-mass spectrograph joint use. The method includes steps of urine sample pretreatment, liquid chromatograph-mass spectrograph parameter optimization and urine sample detection. The defect that a detection method in the prior art fails to simultaneously detect the various angiotensin II receptor blocker type hypotensive drugs in the urine samples is overcome, and the simple and convenience detection method is provided for detecting various angiotensin II receptor blocker type hypotensive drugs in the urine samples. Thedetection method is convenient and simple in operation and high in accuracy, and whether the various angiotensin II receptor blocker type hypotensive drugs exist in urine or not can be judged simultaneously.
Owner:苏州旭辉检测有限公司
Health care product for assisting in treating hypertension
InactiveCN102793788AReduce cholesterolRestore elasticityFood preparationCardiovascular disorderRed yeast riceCassia
The invention discloses a health care product for assisting in treating hypertension. The health care product is prepared from the following raw materials in parts by weight: 2-6 parts of red yeast rice, 3-12 parts of cortex eucommiae, 4-16 parts of dogbane leaf, 2-8 parts of cassia occidentalis, 3-14 parts of lotus plumule and 4-10 parts of pepper. The health care product for assisting in treating hypertension provided by the invention can be used for reducing impurities such as cholesterol, triglyceride and the like on the inner walls of blood vessels, extending blood vessels, enhancing the permeability of blood vessels and assisting in lowering blood pressure, has a better curative effect, is safe for using, and has a wide application range.
Owner:SUZHOU GULI BIOTECH
Summer heat clearing and blood pressure reducing health green tea
InactiveCN104431069AReduce dosageLittle side effectsPre-extraction tea treatmentSide effectToxic material
The invention relates to the technical field of health beverages and discloses summer heat clearing and blood pressure reducing health green tea. The summer heat clearing and blood pressure reducing health green tea is prepared from the following raw materials in parts by weight: 30-45 parts of green tea, 15-18 parts of chrysanthemum flowers, 15-20 parts of fructus schizandrae, 15-20 parts of dried sophora flowers, 13-17 parts of arabian jasmine flowers, 15-25 parts of fructus crataegi, 15-25 parts of dried lotus leaves, 10-15 parts of rock sugar and 60-120 parts of water. The summer heat clearing and blood pressure reducing health green tea disclosed by the invention has the effects of clearing away heat, promoting diuresis to eliminate dampness and clearing away toxic materials, can be used for reducing and stabilizing blood pressure after being drunk for a long time and can also be used for enhancing the immunity, reducing dosage of hypotensive drugs and reducing side effects caused to the human body after taking of drugs for a long time. The summer heat clearing and blood pressure reducing health green tea disclosed by the invention is good in taste, low in cost, simple in manufacturing method, free of side effects, capable of clearing away heat and fire, safe, effective, simple in method and applicable to popular taste.
Owner:GUANGDE HUIBAI TEA PROFESSIONAL COOP
Traditional Chinese medicine formula for relieving hypertension
PendingCN111150796ABlood pressure controlLower blood pressurePill deliveryConiferophyta medical ingredientsFormularyRadix Ophiopogonis
The invention discloses a traditional Chinese medicine formula for relieving hypertension and relates to the technical field of traditional Chinese medicine formulae. The traditional Chinese medicineformula is characterized by consisting of the following raw materials in parts by weight: 20 parts of American ginseng, 10 parts of pine needles, 10 parts of radix codonopsis pilosula, 10 parts of radix ophiopogonis and 5 parts of Chinese magnoliavine fruits. The traditional Chinese medicine formula has the beneficial effects that the traditional Chinese medicine formula is adopted, respective effects of the traditional Chinese medicine components are utilized and matched with one another, and blood pressure of a patient suffering from hypertension can be effectively controlled; the medicine can be taken by the patient for a long time, is good in security and free of toxic or side effect; and for a patient suffering from sudden blood pressure increase, a hypotensive drug can be additionally taken to reduce the blood pressure rapidly, and the medicine can be taken to keep the blood pressure stable in long-term treatment, the blood pressure can be kept at a normal level, and complications caused by unstable blood pressure can be retarded.
Owner:李红光
Traditional Chinese medicine capable of conditioning internal organs, clearing intestines and removing toxins and preparation method of traditional Chinese medicine
The invention discloses a traditional Chinese medicine capable of conditioning internal organs, clearing intestines and removing toxins and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from rhizoma polygonati, radix glehniae, herba cistanche, semen cassia, selfheal spikes, radix bupleuri, cortex phellodendri, radix ophiopogonis, rhizoma polygoni cuspidati, rhizoma dioscoreae colletii and smilax china. The traditional Chinese medicine can treat various heart diseases, cyst, calculus, hypertension, hyperlipidemia and diabetes, and patients suffering from three highs are not required to take medicines, insulin or hypotensive drugs after taking the traditional Chinese medicine. Besides, the traditional Chinese medicine can also be usedfor treating andrology and gynecology diseases, dizziness, ostealgia, insomnia, gastric acid, incipience of hemiplegia, polyp and virus infection and has significant effects.
Owner:白霞
The preparation method of dihydropyridine compound
InactiveCN103242221BRaw materials are easy to getEasy to operateOrganic chemistryBulk chemical productionDihydropyridineBiochemical engineering
The invention discloses a preparation method of a dihydropyridine compound (IV), comprising the following steps: using a compound VII and a compound VIII as initial raw materials and carrying out a cyclization reaction in a solvent to prepare an intermediate IX; and (2) putting the compound IX in a solvent and removing protective groups to prepare the compound IV. The protective groups used in the invention are common, the raw materials are easily available, and poisonous and harmful substances are not generated after the protective groups are removed. In addition, the operation is simple, a reagent used for removing the protective groups is cheap and easily available, the operation is convenient, the post-treatment is simple, costs are low, environmental pollution is little, and the preparation method is suitable for industrial production. The preparation method provided by the invention has advantages of high yield, stable product quality, low cost and simple operation, and is suitable for industrial preparation of a hypotensive drug Cleviprex key intermediate. An equation is shown in the specification.
Owner:SHANGHAI INST OF PHARMA IND CO LTD
Method for discriminating individualized verapamil medication by mass spectrometry through primer composition
InactiveCN111172264AQuality Medical ServicesPromoting the process of rational drug useMicrobiological testing/measurementMultiplexDrug metabolism
The invention provides a method for discriminating individualized verapamil medication by mass spectrometry through a primer composition. The method comprises the following steps: respectively designing multiple amplification primers and extension primers according to eight to-be-detected target SNP loci; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, simultaneously and respectively carrying out amplification and single-base extension reaction on the eight target SNP loci by using a plurality of sets of primers; andcarrying out time-of-flight mass spectrometry analysis on a product after the single base extension reaction, identifying genotypes of SNP related to different drug metabolism according to products ofextension primers with different molecular weights represented by a mass spectrum peak, and guiding the medication of hypotensive drug verapamil. The method can simultaneously detect eight SNP loci related to metabolism of the hypotensive drug verapamil, and has the advantages of low cost, no need of probe synthesis, short time consumption, simple and convenient result analysis and extremely wideapplication field.
Owner:BIOYONG TECH
Application of salvianolic acid G to preparation of drug resistant to hypertensive myocardial fibrosis
InactiveCN109091476AReduce depositionImprove ejection fractionOrganic active ingredientsCardiovascular disorderHypertension medicationsSide effect
The invention discloses an application of salvianolic acid G or a pharmacologically acceptable salt of salvianolic acid G to preparation of a drug and / or a healthcare product resistant to hypertensionand / or heart disease. After verification, salvianolic acid G can reduce deposition of collagen in myocardia and increase EF (ejection fraction) and FS (fractional shortening) of the heart while reducing blood pressure, thereby being capable of effectively improving heart structure and function damage caused by hypertension. The adverse factors of single function way, severe side effects and the like of an existing hypotensive drug are expected to be solved, and basis is provided for further development of interventional mechanism of salvianolic acid G for hypertensive myocardial fibrosis.
Owner:SOUTHERN MEDICAL UNIVERSITY
Hypotensive drug urapidil hydrochloride composition freeze-dried powder injection
InactiveCN105193746AImprove stabilityImprove solubilityPowder deliveryOrganic active ingredientsMedicineBiology
The invention discloses a hypotensive drug urapidil hydrochloride composition freeze-dried powder injection and belongs to the technical field of medicine. The composition comprises urapidil hydrochloride and an excipient. The excipient is trehalose, and the urapidil hydrochloride is a novel crystal form compound. The X-ray powder diffraction pattern obtained through Cu-K alpha ray measurement is shown in the picture 1 and is different from urapidil hydrochloride reported in the prior art. Tests prove that compared with the prior art, the solubility and mobility in water of the novel crystal form compound are obviously improved, and the freeze-dried powder injection prepared through the novel crystal form compound is good in stability, good in stability after being combined with a solvent, extremely low in insoluble particle content, and quite suitable for clinic application.
Owner:QINGDAO HUAZHICAO PHARMA CO LTD
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