The invention provides a detection product for differentiating enalapril individualized medication types. An extension primer which has different molecular weights at different single nucleotide polymorphism (SNP) sites is utilized, so that through matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MassArray matrix-assisted laser desorption ionisation-time-of-flight massspectrometry, MALDI-TOF MS), a plurality of sites can be detected at the same time, and finally the detection product for differentiating enalapril individualized medication types is obtained. A preparation method of the detection product comprises the steps of according to a plurality of objective SNP sites to be detected, respectively designing a multiplex amplification primer and an extensionprimer; compounding a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, performing amplification and a single-base extension reaction onthe objective SNP sites at the same time with multiple sets of primers; and performing time-of-flight mass spectrometric analysis on products after the single-base extension reaction, identifying thegenotypes of different drug metabolism relevant SNPs according to products of different molecular weight extension primers represented by mass spectrum peaks, and guiding the medication of the hypertension reducing medicine namely the enalapril. The detection product disclosed by the invention can detect 6 enalapril drug metabolism pertinent SNP sites at the same time, and has the advantages of being low in cost, free from synthetized probes, short in time consumption, simple and convenient in result analysis, and extremely broad in application field.