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Cornel kernel water extract and application thereof

A technology of dogwood fruit stone and water extract, which is applied in the field of medicine and can solve problems such as cumbersome steps and untapped needs

Inactive Publication Date: 2013-05-22
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method uses a variety of organic solvents for extraction, and the steps are cumbersome
Moreover, there are few reports on the medicinal efficacy of the active ingredients in the fruit stone of Cornus officinalis, and its value in the field of medicine has yet to be explored.

Method used

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  • Cornel kernel water extract and application thereof
  • Cornel kernel water extract and application thereof
  • Cornel kernel water extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In this example, the dogwood fruit cores are dried by the following method: take the dogwood fruit cores, dry them with hot air at 60° C. for 10 hours, and carry out microwave drying. The microwave frequency is 2400 MHz, the microwave power is 10 KW, and the microwave time is 30 minutes.

[0023] The preparation method of the cornus officinale water extract in this example is as follows: take the dried Cornus officinalis, crush it to 20 mesh powder, add water to the fruit stone powder according to the weight ratio of the fruit stone powder to water as 1:5, and mix evenly Finally, let stand at room temperature for 28 hours, heat and boil for 50 minutes, filter to obtain the filtrate, and then concentrate the filtrate with a rotary evaporator at a temperature of 40°C to obtain the water extract of Cornus officinalis.

Embodiment 2

[0025] In this example, the dogwood fruit stones are dried by the following method: take dogwood fruit stones, dry them with hot air at 80° C. for 8 hours, and carry out microwave drying. The microwave frequency is 2450 MHz, the microwave power is 15 KW, and the microwave time is 20 minutes.

[0026] The preparation method of the water extract of Cornus officinalis in this example is as follows: take the dried Cornus officinalis, grind it to 60 mesh powder, add water to the fruit stone powder according to the weight ratio of fruit stone powder and water as 1:4, and mix evenly After that, let stand at room temperature for 24 hours, heat and boil for 35 minutes, filter to obtain the filtrate, and then concentrate the filtrate with a rotary evaporator at a temperature of 50°C to obtain the water extract of Cornus officinalis.

Embodiment 3

[0028] In this example, the dogwood fruit stones are dried by the following method: take dogwood fruit stones, dry them with hot air at 100° C. for 5 hours, and carry out microwave drying. The microwave frequency is 2500 MHz, the microwave power is 10 KW, and the microwave time is 30 minutes.

[0029] The preparation method of the cornus officinalis water extract in this example is as follows: take the dried cornus officinalis, crush it to 100 mesh powder, add water to the fruit stone powder according to the weight ratio of the fruit stone powder to water as 1:3, and mix evenly Finally, let stand at room temperature for 20 hours, heat and boil for 20 minutes, filter to obtain the filtrate, and then concentrate the filtrate with a rotary evaporator at a temperature of 60°C to obtain the water extract of Cornus officinalis.

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PUM

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Abstract

The invention discloses a cornel kernel water extract and application of the cornel kernel water extract in preparing a thoracic aorta ring diastole composite and a hypotensive composite, and belongs to the technical field of medicines. The extraction method of the cornel kernel water extract comprises the following steps of: taking dried cornel kernels; smashing into powder of 20-100 meshes; adding water to the kernel powder, and then uniformly mixing; standing at normal temperature for 20-28 hours, and then heating to boil for 20-50 minutes; and filtering to obtain filter liquor, and then concentrating the filter liquor at 40-60 DEG C. The extraction method disclosed by the invention can be used for preparing the cornel kernel extract by adopting an water extraction method and has the advantages of simple step and easiness in operation. The cornel kernel water extract obtained by adopting the extraction method is proved through experiments to play a role of isolated vascular ring diastole, can be used as the active component contained in arterial diastole drug and food or health-care products and can also be used as the active component contained in hypotensive drug and food or health-care products.

Description

technical field [0001] The invention relates to a cornus officinalis water extract and the application of the water extract in preparing a composition for relaxing thoracic aorta rings and a composition for lowering blood pressure, and belongs to the technical field of medicine. Background technique [0002] Cornus officinalis Sieb.et Zucc. is the dried and mature pulp of Cornus officinalis, a plant of the genus Cornus in the family Cornaceae. Cornus officinale pulp contains a variety of active ingredients, such as amino acids, vitamins, trace elements, malic acid, ursolic acid, etc., and also contains tannins such as dogwood tannins 1, 2, 3, tannins A, B, C, D, E, F, G, clove tannin, roadside green tannin D, etc., as well as gallic acid, polyphenolic glycoside compounds and glycoside components, glycoside components such as cornel schizoside, morolosin, etc. These active ingredients have various functions such as regulating the body's immunity, anti-oxidation, anti-tumor, ...

Claims

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Application Information

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IPC IPC(8): A61K36/40A61P9/08A61P9/12A23L1/29A61K131/00A23L33/00
Inventor 路西明杜景霞胡志红李艳冯建芳宋向东沈志明
Owner HENAN UNIV OF SCI & TECH
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