The invention belongs to the field of
medicine, and particularly relates to a
urapidil sustained release preparation and a preparation method thereof. The
urapidil sustained release preparation consists of a
medicine-containing small
pill, an isolation
coating layer and a sustained release
coating layer, wherein the
medicine-containing small
pill comprises a blank pellet, a main medicine layer anda
solvent; the main medicine layer comprises 20 to 40 parts of
urapidil, 7 to 15 parts of a bonding agent, 30 to 40 parts of a
diluent and 3 to 10 parts of an anti-sticking agent through being metered in parts by
mass; the isolation
coating layer comprises an isolation coating material, talcum
powder and a
solvent; and the sustained release coating layer comprises 70 to 85 parts of a sustained release coating material, 0 to 8 parts of
triethyl citrate, 6 to 15 parts of talcum
powder and a
solvent through being metered in parts by
mass. The invention develops a novel urapidil sustained releasepreparation
recipe, and has the advantages of high product stability and no burst release phenomenon; meanwhile, the continuous uniform and sustained medicine release of the medicine can be ensured;and in addition, the urapidil sustained release preparation has the characteristics of simple preparation process and high efficiency.