Anti-hypertension urapidil medicine compound

A technology of urapidil and anti-hypertension, applied in the field of medicine, can solve the problems of patients with toxicity, affect the quality of drugs, and poor stability, and achieve the effect of improving fluidity, improving drug efficacy, and good stability

A technology of urapidil and anti-hypertension, applied in the field of medicine, can solve the problems of patients with toxicity, affect the quality of drugs, and poor stability, and achieve the effect of improving fluidity, improving drug efficacy, and good stability

CN105111152AInactive Publication Date: 2015-12-02QINGDAO HUAZHICAO PHARMA CO LTD
5 Cites 0 Cited by

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-hypertension urapidil medicine compound
  • Anti-hypertension urapidil medicine compound
  • Anti-hypertension urapidil medicine compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Preparation of urapidil crystal compound

[0023] (1) Add the crude urapidil to a mixed solution of chloroform and propanol whose volume is 4 times the weight of urapidil, the volume ratio of chloroform and propanol is 3:1, heat up to 30°C, and stir until completely dissolved;

[0024] (2) In a sound field with a frequency of 30KHz and an output power of 45W, add a mixed solution of ether, acetone, and cyclohexane whose volume is 8 times the weight of urapidil while stirring, and the volume ratio of ether, acetone, and cyclohexane It is 4:1:1, the stirring speed is 150 rpm, and the adding speed is 100 ml / min;

[0025] (3) After adding the mixed solution of ether, acetone, and cyclohexane, under a sound field with a frequency of 25KHz and an output power of 40W, cool down to -10°C at 10°C / hour, grow crystals for 2 hours, wash, and dry in vacuum , to obtain urapidil compound.

[0026] The X-ray powder diffraction pattern obtained by measuring the compound...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an anti-hypertension urapidil medicine compound, and belongs to the technical field of medicine. X-ray powder diffraction patterns of the anti-hypertension urapidil medicine compound measured by Cu-Ka rays are shown as a figure 1. Compared with the prior art, the anti-hypertension urapidil medicine compound has the advantages that the anti-hypertension urapidil medicine compound which is a urapidil crystal-form compound is good in stability and rarely contains impurities I, and the total impurity content of the anti-hypertension urapidil medicine compound is within a narrow range under the control and rarely changes along with extension of the storage time; the solubility and the flowability of the urapidil crystal-form compound in water are obviously improved, accordingly, the anti-hypertension urapidil medicine compound brings convenience for preparing preparations, and the efficacy of the anti-hypertension urapidil medicine compound can be greatly improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an antihypertensive drug urapidil compound. Background technique [0002] Hypertension is a kind of common disease, frequently-occurring disease. With the improvement of people's living standards, the number of hypertensive patients is increasing day by day, especially the number of hypertensive crisis and severe hypertensive patients is constantly increasing, but there are few safe and effective injection drugs clinically used for this type of disease. High blood pressure affects work and life, and high blood pressure is the most important risk factor for coronary heart disease and cerebrovascular disease. 50% of myocardial infarction patients are hypertensive patients, and 76% of stroke patients have a history of hypertension. Therefore, the risk of high blood pressure is sudden death or disability. Hypertensive patients should learn how to take care of life and early treat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
02 Dec 2015
Publication
CN105111152A
IPC
C07D239/545
CPC
C07D239/545
Inventors
刘学键