Urapidil large volume injection, its preparation method and application
A technology of urapidil and injection, applied in the field of urapidil injection, can solve the problems of inconvenience in clinical use, unqualified heat source, influence on curative effect, etc., and achieve the effect of convenient medication
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Embodiment 1
[0058] Weigh 9.0g of sodium chloride, add 100ml of water for injection, add 0.1% activated carbon, boil for 15 minutes, filter while hot; take another 0.5g of urapidil, add 100ml of water for injection, adjust the pH value to 2.5 with 1mol / L hydrochloric acid solution , heated and stirred to make the solution pass through the charcoal layer of filtered sodium chloride solution, mix the filtrate with sodium chloride solution, add water for injection to 800ml, mix well, adjust the pH value to 5.0 with 0.1mol / L sodium hydroxide solution, add water for injection To 1000ml, mix well, measure the content of intermediates, filter with a microporous membrane after passing the test, potting, sterilize at 115°C for 30 minutes, light inspection, and pack in glass bottles, each independent packaging specification is 100ml / bottle. .
Embodiment 2
[0060] Weigh 50g of glucose, add 100ml of water for injection, add 0.1% activated carbon, boil for 15 minutes, and filter while hot; take another 0.5g of urapidil, add 100ml of water for injection, adjust the pH value to 2.0 with 1mol / L hydrochloric acid solution, heat and stir to make The solution passes through the charcoal layer of the glucose solution, the filtrate is mixed with the glucose solution, add water for injection to 800ml, mix well, adjust the pH value to 4.6 with 0.1mol / L sodium hydroxide solution, add water for injection to 1000ml, mix well, and measure the middle After passing the test, filter it with a microporous membrane, seal it, sterilize it at 115°C for 30 minutes, inspect it with light, and pack it in a glass bottle. The specification of each independent package is 100ml / bottle.
Embodiment 3
[0062] Weigh 30g of dextran, add 100ml of water for injection, add 0.1% activated carbon, boil for 15 minutes, and filter while hot; take another 0.6g of urapidil, add 100ml of water for injection, adjust the pH value to 2.3 with 1mol / L hydrochloric acid solution, heat and stir to make The solution passes through the charcoal layer of the filtered dextran solution, mix the filtrate with the dextran solution, add water for injection to 800ml, mix well, adjust the pH value to 5.4 with 0.1mol / L sodium hydroxide solution, add water for injection to 1000ml, mix well, and measure the middle After passing the test, filter it with a microporous membrane, seal it, sterilize it at 115°C for 30 minutes, inspect it with light, and pack it in a glass bottle. The specification of each independent package is 50ml / bottle.
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