Urapidil large volume injection, its preparation method and application

Abstract

The invention provides a Urapidil large volume injection, its preparation method and use in making medicament for treating hypertension, wherein the preparation comprises Urapidil, isotonic conditioning agent, pH regulator and water for injection, wherein the isotonic conditioning agent is selected from sodium chloride, glucose, dextran, mannitol or sorbierite, the pH regulator is selected from hydrochloric acid and sodium hydroxide.

Description

technical field

[0001] The present invention relates to a kind of urapidil injection, its preparation method and its application, in particular to a kind of urapidil large-capacity injection, its preparation method and its application in the preparation of medicine for treating hypertension. Background technique

[0002] Urapidil, a uracil derivative substituted by phenylpiperazine, is a highly selective α-receptor blocker with dual mechanisms of action both peripheral and central. Mainly by activating 5-hydroxytryptamine receptors, reducing the sympathetic feedback regulation of the medullary cardiovascular control center to reduce blood pressure, without common reflex tachycardia; the peripheral effect is mainly to block post-synaptic α 1 Receptors, which reduce peripheral resistance and dilate blood vessels. Urapidil can expand the arteries and veins in a balanced manner, and can be used clinically for various types of hypertension. Its intravenous administration is use...