Method for preparing hydrochloride urapidil

A technology of uradil hydrochloride and uradil, applied in the direction of organic chemistry, can solve the problems of unqualified product content, pH, clarity, difficult pH control, etc., and achieve the effect of simple method, easy operation and stable quality
CN101200451AInactive Publication Date: 2008-06-18YAOPHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YAOPHARMA CO LTD
Publication Date
2008-06-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method of the urapidil hydrochloride. The method comprises the following procedures, the urapidil is dissolved in the alcohols or / and the ketones solvent, the organic solution of the hydrogen chloride is slowly added after the heating dissolution for controlling pH at the range of 2.0 to 4.0, then the mixture is crystallized by decreasing the temperature into the range of 20 to 70 DEG C, and the urapidil hydrochloride is filtrated and dried by the decompression drying. The content is not lower than 99.5 percent, the clarity and the pH meet the purity requirement of the raw material used in the injection. The invention has the advantages of simple method, stable quality, easy operation and being suitable for the industrial production.
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Description

technical field

[0001] The invention relates to a preparation method of urapidil hydrochloride. Background technique

[0002] The chemical name of urapidil hydrochloride is 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4 (1H, 3H) pyridildione hydrochloride, the English name is Urapidil Hydrochloride, and the English chemical name is 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3 -Dimethy1-2,4(1H,3H)-pyrimi dinedione Hydrochloride, its chemical structural formula:

[0003]

[0004] The trade names of urapidil hydrochloride are Urapil, Ebrantil, and Lixidine, which are uracils substituted by oxazosin. This product has both peripheral and central hypotensive effects. Peripheral mainly blocks the post-synaptic α1 receptors, causing vasodilation to significantly reduce peripheral resistance. At the same time, it also has a weak presynaptic α2 blocking effect, blocking the vasoconstrictive effect of catecholamines (different from the perip...

Claims

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