Method for purifying urapidil with counter solvent recrystallization method

An anti-solvent recrystallization and urapidil technology, applied in the direction of organic chemistry, can solve the problems of low yield and long crystallization time, and achieve the effect of high yield, rapid precipitation and easy control of conditions
CN102267951BInactive Publication Date: 2013-05-01HENAN FUREN MEDICAL TECH DEV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HENAN FUREN MEDICAL TECH DEV
Publication Date
2013-05-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for purifying urapidil, in particular to a method for purifying urapidil with a counter solvent recrystallization method, belonging to the field of purification of compounds. The method is implemented by the following steps of: adding urapidil of which the purity is over 96 percent into an organic solvent; heating and dissolving; performing suction filtration; pouring the filtrate into a counter solvent; standing; performing suction filtration under reduced pressure; and performing vacuum drying to obtain the urapidil. The method has the advantages of simpleness in operation, short time needed for precipitating a product, higher yield of the obtained urapidil than that of the prior art, and purity of over 99.82 percent (HPLC (High Performance Liquid Chromatography)); and the method is extremely suitable for industrial production.
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Description

technical field

[0001] The invention relates to a method for purifying uradil, in particular to a method for purifying uradil by using an anti-solvent recrystallization method, and belongs to the field of compound purification. Background technique

[0002] Urapidil (Urapidil) is uracil substituted by benzoxinazole, its chemical name is 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]-propyl]-amino] -1, 3-Dimethyl-2, 4(1H, 3H)-pyrimidinedione, the English name is 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1 ,3-dimethyl-2, 4(1H, 3H)-pyrimidinedione, the structural formula is:

[0003]

[0004] The trade names of urapidil hydrochloride are Ningding, Ebrantil and Lixidine. Its mechanism of action is 1 Receptor blockers and weaker β-receptor blockers have both peripheral and central hypotensive effects. Peripheral Major Blockade Alpha 1 receptor, and excitatory central 5-HT 1A Receptors, thereby reducing the sympathetic feedback regulation of the medullary cardiova...

Claims

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