Urapidil fructose injection and preparation method thereof
A technology of urapidil fructose and injection, applied in the field of medicine, can solve the problems of aggravating the symptoms of diabetic patients, unqualified heat source, blood sugar fluctuation, etc., and achieve the effect of avoiding infection and pollution
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0025] Investigate the relationship between pH value and solubility, prepare aqueous solutions with different pH values through phosphate buffer solution, and conduct tests according to the solubility test method of Part II of the Chinese Pharmacopoeia 2005 edition to investigate the solubility of urapidil. The results are shown in Table 1:
[0026] Table 1 The relationship between pH value and solubility
[0027]
[0028] Obviously, the lower the pH value, the greater the solubility, and when the pH value = 6.8, the solubility decreased significantly.
[0029] Secondly, to investigate the influence of different pH values on the stability of urapidil, by preparing urapidil fructose solutions with different pH values, filling them in ampoules, heating them at 100°C for 6 hours, and measuring the content and activity of urapidil by HPLC method. Uradil related substances, the results are shown in Table 2.
[0030] The influence of table 2 different pH values on ...
Embodiment 2
[0034] Formula: fructose 50g; urapidil 0.1g; 1mol / l hydrochloric acid solution and 0.1mol / l sodium hydroxide solution; activated carbon 1g; water for injection about 1000ml.
[0035] Weigh 50g of fructose, add 100ml of water for injection, add 1g of activated carbon, boil for 15 minutes, and filter while hot;
[0036] In addition, weigh 0.1 g of Urapidil, add 100 ml of water for injection, adjust the pH value to 3.3 with a hydrochloric acid solution with a concentration of 1 mol / l, heat and stir to make the solution pass through the carbon layer of the fructose solution, mix the filtrate with the fructose solution, and add water for injection to 70% of the total amount, mix well, adjust the pH value to 4.5 with 0.1mol / l sodium hydroxide solution, add water for injection to 1000ml, mix well;
[0037] Determination of the content of intermediates, fine filtration and potting after passing the test;
[0038] Sterilize at 115°C for 30 minutes and check with light.
Embodiment 3
[0040] Formula: fructose 100g; urapidil 0.32g; 2mol / l hydrochloric acid solution and 0.2mol / l sodium hydroxide solution; activated carbon 1.1g; water for injection about 1000ml.
[0041] Weigh 100g of fructose, add 100ml of water for injection, add 1.1g of activated carbon, boil for 20 minutes, and filter while hot;
[0042] Weigh 3.2g of urapidil, add 100ml of water for injection, adjust the pH value to 3.5 with a hydrochloric acid solution with a concentration of 2mol / l, heat and stir to make the solution pass through the carbon layer of the fructose solution, mix the filtrate with the fructose solution, and add water for injection to 80% of the total amount, mix well, adjust the pH value to 4.6 with 0.2mol / l sodium hydroxide solution, add water for injection to 1000ml, mix well;
[0043] Determination of the content of intermediates, fine filtration and potting after passing the test;
[0044] Sterilize at 115°C for 30 minutes and check with light.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com