Medicine urapidil composition for treating senile hypertensive crisis
A technology of urapidil and a composition is applied in the field of drug urapidil composition for treating hypertensive crisis in the elderly, can solve the problems of poor stability, difficult storage, toxicity of patients, etc., and achieves good stability and insoluble particles. Low content and improved flowability
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Embodiment 1
[0025] Example 1: Preparation of urapidil crystals
[0026] (1) Grind the crude product of urapidil, pass through a 90-mesh sieve, and add it to a mixed solution of N-methylacetamide and ethanol whose volume is 10 times the weight of uradil. The volume ratio is 1:3, and the temperature is raised to 30°C while stirring; the stirring speed is 180 rpm; add activated carbon, stir for 50 minutes and then sterile filter;
[0027] (2) Add distilled water while stirring, and lower the temperature to -15°C at the same time; the stirring speed is 240 rpm; the volume of distilled water is 7 times the weight of urapidil, and the adding speed is 95 ml / min; the cooling rate is 10°C / min. Hour;
[0028] (3) After adding the mixed solvent, the obtained crystals were left to stand for crystallization; filtered, washed, and vacuum-dried for 6 hours to obtain the urapidil compound.
[0029] The X-ray powder diffraction pattern obtained by measuring the obtained urapidil crystal using Cu-Kα ra...
Embodiment 2
[0030] Example 2: Preparation of urapidil composition
[0031] The composition is: 1 part by weight of urapidil crystal prepared by the present invention, and 0.001 part by weight of anhydrous sodium carbonate.
[0032] The preparation method is:
[0033] (1) Weigh urapidil crystals and anhydrous sodium carbonate in proportion and mix them thoroughly;
[0034] (2) Dispense into sterilized vials and stopper them.
Embodiment 3
[0035] Example 3: Preparation of urapidil composition
[0036] The composition is: 1 part by weight of urapidil crystal prepared by the present invention, and 0.0015 part by weight of anhydrous sodium carbonate.
[0037] The preparation method is:
[0038] (1) Weigh urapidil crystals and anhydrous sodium carbonate in proportion and mix them thoroughly;
[0039] (2) Dispense into sterilized vials and stopper them.
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