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Application of salvianolic acid G to preparation of drug resistant to hypertensive myocardial fibrosis

A technique for myocardial fibrosis and anti-hypertension, applied in the field of biomedicine, can solve the problems of repeated side effects of drug withdrawal, single way of reducing blood pressure with western medicine, etc., so as to improve cardiac structure and functional damage, increase cardiac ejection fraction and shorten the short axis. rate effect

Inactive Publication Date: 2018-12-28
SOUTHERN MEDICAL UNIVERSITY
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Problems solved by technology

[0005] The purpose of the present invention is to provide the application of salvianolic acid G in the preparation of antihypertensive myocardial fibrosis drugs, so as to solve the problems of single antihypertensive way of western medicine, repeated drug withdrawal and large side effects, etc., to lower blood pressure and improve myocardial fiber for active ingredients of traditional Chinese medicine. provide a basis for

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  • Application of salvianolic acid G to preparation of drug resistant to hypertensive myocardial fibrosis
  • Application of salvianolic acid G to preparation of drug resistant to hypertensive myocardial fibrosis
  • Application of salvianolic acid G to preparation of drug resistant to hypertensive myocardial fibrosis

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Embodiment Construction

[0022] The present invention will be further described below in conjunction with specific tests. It should be understood that the following tests are only used to illustrate the present invention and are not intended to limit the protection scope of the present invention.

[0023] 1. Preparation of drug solution:

[0024] Preparation of salvianolic acid G solution: Precisely weigh 250mg, 500mg, 1000mg of pure salvianolic acid G (purchased from Shanghai Lianshuo Biotechnology Co., Ltd., item number SY231561), add 0.9% normal saline to dissolve and make to volume to 100mL to obtain 2.5mg / mL, 5mg / mL, and 10mg / mL solutions, and store them in a refrigerator at 4°C in the dark for later use.

[0025] Configuration of valsartan solution: ready-to-use, use a mortar to grind valsartan tablets into powder, accurately weigh 150mg, add 0.9% normal saline to dissolve and dilute to 100mL to obtain 1.5mg / mL of valsartan solution, protected from light and stored in a refrigerator at 4°C.

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Abstract

The invention discloses an application of salvianolic acid G or a pharmacologically acceptable salt of salvianolic acid G to preparation of a drug and / or a healthcare product resistant to hypertensionand / or heart disease. After verification, salvianolic acid G can reduce deposition of collagen in myocardia and increase EF (ejection fraction) and FS (fractional shortening) of the heart while reducing blood pressure, thereby being capable of effectively improving heart structure and function damage caused by hypertension. The adverse factors of single function way, severe side effects and the like of an existing hypotensive drug are expected to be solved, and basis is provided for further development of interventional mechanism of salvianolic acid G for hypertensive myocardial fibrosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of salvianolic acid G in the preparation of antihypertensive myocardial fibrosis drugs. Background technique [0002] Myocardial fibrosis refers to the excessive deposition of collagen fibers in the myocardial interstitium or the collagen volume fraction is significantly higher than normal. A large number of basic and clinical data have confirmed that myocardial stiffness increases in the process of hypertension, restricts myocardial activity, reduces ventricular compliance, and affects myocardial systolic and diastolic functions, which is an important cause of heart failure. In recent years, studies have found that the above-mentioned manifestations are closely related to the excessive deposition of myocardial fiber collagen, that is, myocardial fibrosis. Therefore, research on inhibiting and reversing myocardial fibrosis is of great significance...

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Application Information

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IPC IPC(8): A61K31/335A61P9/12A61P9/00
CPCA61K31/335A61P9/00A61P9/12
Inventor 张国华吕琳吴少瑜陈凯黄裕刘馨庄宇鑫全东令马韵词
Owner SOUTHERN MEDICAL UNIVERSITY
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