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Quick acting and heart resurrecting oral disintegrating tablet and its preparation process

The technology of orally disintegrating tablet and Xinkou is applied in the field of Suxiao Jiuxin orally disintegrating tablet and its preparation, which can solve the problems of unstable efficacy and content of Suxiao Jiuxin pill, coma, inconvenience for severe patients to take, easy sublimation of borneol, etc., so as to improve the bioavailability It is convenient for first aid and prevention, and the effect of relieving chest tightness

Inactive Publication Date: 2005-03-16
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the above situation, in order to solve the problem that borneol is easy to sublimate, resulting in unstable content of Suxiao Jiuxin Pill, and inconvenient administration for coma and severe patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] · Selection and pretreatment of medicinal ingredients

[0046] Take 1 kg of Ligusticum chuanxiong and 10 liters of ethanol into a reaction tank, heat back to reheat, extract for 10 hours, concentrate under reduced pressure, recover ethanol and volatile oil, and combine the volatile oil and concentrate. Take 10 g of the above-mentioned volatile oil and add it into 50 g of ethanol solution containing 6% Eudragit E-100 to obtain an oil phase. Take another 1000ml of water, add 30g of polyethylene glycol to disperse, and form a water phase; under the condition of stirring the water phase, drop the organic phase into the water phase at a constant speed, and obtain the medicinal Ligusticum chuanxiong package through cross-linking and solidification. Drug microcapsules; then use excess water 1000ml to extract the organic solvent, and then filter and dry to obtain the easy-flowing coated Ligusticum chuanxiong drug-loaded microcapsules that can release the medicinal ingredients. ...

Embodiment 2

[0064] The selection and pretreatment of medicinal ingredients and the preparation of tablets are the same as in Example 1.

[0065] Tablet formulation (by weight) components are:

[0066] Medicinal ingredients Chuanxiong 4.40g

[0067] Drug-loaded borneol 5.60g

[0068] Microcrystalline Cellulose 19.0g

[0069] Mannitol 14.4g

[0070] Sodium carboxymethyl starch 15.0g

[0071] Mint 0.25g

[0072] Stevioside 0.05g

[0073] Magnesium stearate 0.65g

[0074] Micronized silica gel 0.65g

[0075] A total of 1000 pieces were made

[0076] Production: the specific preparation method is:

[0077] Grind the stevioside, peppermint, Ligusticum chuanxiong and borneol separately, mix them evenly, and pass through an 80-mesh sieve. Separately pass sodium carboxymethyl starch, microcrystalline cellulose, mannitol, micropowder silica gel, and magnesium stearate through an 80-mesh sieve according to the prescription amount, mix them evenly, and then mix ...

Embodiment 3

[0079] The selection and pretreatment of medicinal ingredients and the preparation of tablets are the same as in Example 1.

[0080] The formula (by weight) components are:

[0081] Medicinal ingredients Chuanxiong 4.40g

[0082] Drug-loaded borneol 5.60g

[0083] Microcrystalline Cellulose 21.00g

[0084] Mannitol 15.60g

[0085] Cross-linked polyvinylpyrrolidone 12.00g

[0086] Stevioside 0.05g

[0087] Mint 0.25g

[0088] Magnesium stearate 0.55g

[0089] Micronized silica gel 0.55g

[0090] A total of 1000 pieces were made

[0091] The specific preparation method is:

[0092] Grind stevioside, Ligusticum chuanxiong and borneol separately, pass through an 80-mesh sieve, weigh according to the prescription amount, and mix evenly. In addition, cross-linked polyvinylpyrrolidone, microcrystalline cellulose, mannitol, micropowder silica gel, and magnesium stearate were respectively passed through an 80-mesh sieve, weighed according to...

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Abstract

The invention discloses a quick acting and heart resurrecting oral disintegrating tablet and its preparation process, wherein coating process is employed to prepare solid microcapsule or microsphere or dispersion from borneo camphor, which consists of mixing with Ligusticum wallichii1, flavoring agent, bulking agent, crumbling agent, lubricating agent, flow aid, sieving and pelleting.

Description

technical field [0001] The invention belongs to an orally disintegrating Chinese patent medicine preparation and a preparation method thereof, and relates to a quick-acting heart-relief orally disintegrating tablet containing borneol drug-loaded microcapsules or solid dispersion drug-loaded particles to stabilize the drug effect content and a preparation method thereof; Quick-acting Jiuxin orally disintegrating tablet for increasing coronary blood flow, relieving angina pectoris, mainly treating coronary heart disease, chest tightness, suffocation, precordial pain, easy to take, and quick onset for indications, and its preparation method. Background technique [0002] Suxiao Jiuxin Pill is a classic Chinese patent medicine with sedative, analgesic and anti-myocardial ischemia effects. It is used for the treatment of coronary heart disease, chest tightness, suffocation, precordial pain and other diseases. However, traditional pills often have shortcomings such as incomplete ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P9/10
Inventor 张韻慧晋兴华吴亚男李志耕
Owner TIANJIN UNIV
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