Traditional Chinese medicine combined extract and application thereof in preparing medicine for treating coronary heart disease

An extract and coronary heart disease technology, applied in the field of traditional Chinese medicine preparation, can solve the problems of low therapeutic effect and unsatisfactory therapeutic effect, and achieve the effects of reducing lipid peroxidation damage, aerobic free radical scavenging, and reducing LPO content

Inactive Publication Date: 2016-04-06
杨美娟
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the existing Chinese medicine for the treatment of coronary heart disease still has shortcomings such as unsatisfactory therapeutic effect, especially for hypertensive tube venereal disease, its therapeutic effect is lower, therefore, the inventor of the medicine of the present invention summarizes through long-term clinical practice, researches A drug with ideal effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The traditional Chinese medicine combination extract is prepared from the following traditional Chinese medicines in parts by weight: 30 parts of Snakewort, 18 parts of tung tree leaves, 23 parts of Daphne root, and 19 parts of saffron.

Embodiment 2

[0020] The traditional Chinese medicine combination extract is prepared from the following traditional Chinese medicines in parts by weight: 35 parts of Snake Grass, 16.5 parts of tung tree leaves, 24.5 parts of daphne root, and 18 parts of saffron.

Embodiment 3

[0022] The traditional Chinese medicine combination extract is prepared from the following traditional Chinese medicines in parts by weight: 40 parts of Snakewort, 15 parts of tung tree leaves, 26 parts of Daphne root, and 17 parts of saffron.

[0023] The preparation method of Chinese medicine combination extract in the above-mentioned each embodiment, preparation steps are as follows:

[0024] (1) Grinding the raw materials separately, passing through a 100-120 mesh sieve, using supercritical carbon dioxide extraction technology, the extraction temperature is 55°C, the extraction pressure is controlled at 7MPa, the extraction time is 3h, and the extracted volatile oil is collected to obtain extract A, which is set aside;

[0025] (2) The extract A obtained in step (1) is used as a solvent with a concentration of 94% ethanol, and is extracted by warm soaking at 75 ° C. The number of extractions is 3 times, and the extraction time is 3 hours each time. 10 times, filter, collec...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a traditional Chinese medicine combined extract and application thereof in preparing medicines for treating coronary heart disease. The traditional Chinese medicine combined extract is prepared from oldenlandia diffusa, aleurites fordii hemsl, daphne odora thunb. and saffron crocus by processing the raw materials through a supercritical CO2 extraction technology by taking ethanol as a solvent and collecting extracted volatile oil, concentrating and drying, adding a mixed liquid of chloroform and n-butyl alcohol, standing by at low temperature and dialyzing by virtue of a dialysis membrane after layering, decomposing, concentrating and processing dialysis liquid, collecting activity main peaks after purifying by virtue of a chromatographic column, combining and processing, so that the traditional Chinese medicine combined extract is obtained. The invention also discloses application of the traditional Chinese medicine combined extract, as a pharmaceutical composition with active ingredients pharmaceutically accepted as additives, in preparing medicines for treating the coronary heart disease and coronary heart disease complicated with hypertension disease. The medicine disclosed by the invention has a significant effect on improving such symptoms as chest tightness, chest pain and the like in patients with the coronary heart disease complicated with hypertension disease; and the medicine can effectively control the occurrence of angina, increase SOD (superoxide dismutase) activity and reduce (LPO) lipid peroxidation content, and the medicine can effectively relieve lipid peroxidization injury.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicines, in particular to a combined extract of traditional Chinese medicines and its application in the preparation of medicines for treating coronary heart disease. Background technique [0002] Coronary heart disease (coronary arteriosclerotic heart disease) is a global public health concern. At least half of the millions of people who die from heart disease in the United States are coronary heart disease, and there has been a clear increase in my country in the past ten years, and the number of cases is increasing every year. Epidemiological survey data have confirmed that hypertension complicated with coronary heart disease is 2-4 times higher than normal blood pressure patients with coronary heart disease, and about 3-5% of hypertensive patients are complicated with coronary heart disease, and the level of increased blood pressure is linearly related to the incid...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P9/10A61P9/12
CPCA61K36/748A61K36/47A61K36/83A61K36/88A61K2236/37A61K2236/50A61K2236/53A61K2236/55A61K2300/00
Inventor 杨美娟
Owner 杨美娟
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap