Traditional Chinese medicine combined extract and application thereof in preparing medicine for treating coronary heart disease

Abstract

The invention discloses a traditional Chinese medicine combined extract and application thereof in preparing medicines for treating coronary heart disease. The traditional Chinese medicine combined extract is prepared from oldenlandia diffusa, aleurites fordii hemsl, daphne odora thunb. and saffron crocus by processing the raw materials through a supercritical CO2 extraction technology by taking ethanol as a solvent and collecting extracted volatile oil, concentrating and drying, adding a mixed liquid of chloroform and n-butyl alcohol, standing by at low temperature and dialyzing by virtue of a dialysis membrane after layering, decomposing, concentrating and processing dialysis liquid, collecting activity main peaks after purifying by virtue of a chromatographic column, combining and processing, so that the traditional Chinese medicine combined extract is obtained. The invention also discloses application of the traditional Chinese medicine combined extract, as a pharmaceutical composition with active ingredients pharmaceutically accepted as additives, in preparing medicines for treating the coronary heart disease and coronary heart disease complicated with hypertension disease. The medicine disclosed by the invention has a significant effect on improving such symptoms as chest tightness, chest pain and the like in patients with the coronary heart disease complicated with hypertension disease; and the medicine can effectively control the occurrence of angina, increase SOD (superoxide dismutase) activity and reduce (LPO) lipid peroxidation content, and the medicine can effectively relieve lipid peroxidization injury.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicines, in particular to a combined extract of traditional Chinese medicines and its application in the preparation of medicines for treating coronary heart disease. Background technique [0002] Coronary heart disease (coronary arteriosclerotic heart disease) is a global public health concern. At least half of the millions of people who die from heart disease in the United States are coronary heart disease, and there has been a clear increase in my country in the past ten years, and the number of cases is increasing every year. Epidemiological survey data have confirmed that hypertension complicated with coronary heart disease is 2-4 times higher than normal blood pressure patients with coronary heart disease, and about 3-5% of hypertensive patients are complicated with coronary heart disease, and the level of increased blood pressure is linearly related to the incid...

AI Technical Summary

Problems solved by technology

But the existing Chinese medicine for the treatment of coronary heart disease still has shortcomings such as unsatisfactory therapeutic effect, especially for hypertensive tube venereal disease, its therapeutic effect is lower, therefore, the inventor of the medicine of the present invention summarizes through long-term clinical practice, researches A drug with ideal effect