Polyacid compound for resisting penicillin streptococcus pneumoniae (PRSP) and its preparing method

Abstract

The present invention belongs to the field of chemically synthesized medicine and its preparation process. The medicine of the present invention is synthesized with amantadine, moroxydine, 5-Fu (5-Fc), isoniazid and other clinical medicine and polyoxometallate, and through self-assembling. The said polyoxometallate includes heteropoly acid salts of Keggin type with chemical expression XM12O40n-, Dowson type X2M18O62n- and of chemical expression LnW10O36n-. The combined use of said medicines and polyoxometallate has obvious curative effect on intractable streptococcus pneumoniae infection.

Description

technical field

[0001] The invention belongs to chemically synthesized drugs and a preparation method thereof, in particular to polyacid antibacterial drugs capable of inhibiting penicillin-resistant Streptococcus pneumoniae (PRSP) and a preparation method thereof. Background technique

[0002] Streptococcus pneumoniae belongs to Gram-positive bacteria and is one of the most important pathogens of severe invasive infections (such as meningitis, sepsis, acute otitis media, sepsis, pneumonia) and upper respiratory tract infections. Globally, 4 to 6 million people die each year from this bacterial infection. It was once considered that penicillin was a routine sensitive drug for Streptococcus pneumoniae. Since the first reports of penicillin-resistant Streptococcus pneumoniae (PRSP, penicilline-resistant streptococcuspneumoniae) infection in Australia and South Africa in the 1960s and 1970s, PRSP infection has There have been reports all over the world, and surveys have shown ...