The invention discloses a formula of Metapenaeus ensis disease-resistant feed. The Metapenaeus ensis disease-resistant feed is prepared from 10-20 parts by weight of corn powder, 3-4 parts by weight of soybean polypeptide, 1-2 parts by weight of calcium hydrogen phosphate, 0.5-1.4 parts by weight of stone flour, 0.01-0.1 parts by weight of lysine with a concentration of 98%, 4-6 parts by weight of cottonseed meal, 12-14 parts by weight of purslane, 10-15 parts by weight of wheat bran, 2-3 parts by weight of lotus leaves, 13-27 parts by weight of bean dregs, 1-2 parts by weight of bitter orange, 1-2 parts by weight of ligusticum wallichii, 1-2 parts by weight of fish oil, 10-15 parts by weight of peanut meal, 1-3 parts by weight of zinc, 1-3 parts by weight of iodine, 1-3 parts by weight of VC, 3-8 parts by weight of brewer yeast, 12-15 parts by weight of dried orange peel, 1-3 parts by weight of seaweed meal, 0.5-1 part by weight of garlic powder, 1-2 parts by weight of roses, 0.1-0.4 parts by weight of table salt, 10-15 parts by weight of radix pulsatillae, 1-5 parts by weight of threonine, 1-2 parts by weight of isatis root, 1-2 parts by weight of grosvenor momordica fruits and 1-2 parts by weight of bighead atractylodes rhizome. Compared with the existing feed, the Metapenaeus ensis disease-resistant feed utilizes combination of coarse grains and extract, utilizes traditional Chinese medicines with effects of clearing fire, has a scientific formula, is suitable for Metapenaeus ensis growth and development, has virus resistance, reduces Metapenaeus ensis mortality by 25% and improves a yield by 62%.