Application of metapenaeus ensis in preparation of angiotensin converting enzyme (ACE) inhibitors

A new prawn and angiotensin technology, applied in application, food preparation, food science, etc., can solve the problems of no ACE inhibitors or blood pressure-lowering drugs found

Inactive Publication Date: 2012-08-22
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, no patents have been found on the preparation of ACE inhibitors or antihypertensive drugs using Penaeus penaeus

Method used

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  • Application of metapenaeus ensis in preparation of angiotensin converting enzyme (ACE) inhibitors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-14

[0031] Examples 1-14 , Preparation of Penaeus clovenae polypeptide hydrolyzate

[0032] Take the cooked prawns, remove the shell and head, take the shrimp meat, smash it into powder with a grinder, and collect the powder.

[0033] Prepare simulated gastric juice and simulated intestinal juice as follows:

[0034] Simulated gastric juice: take 1.0g NaCl, 1.6g pepsin, 3.5ml concentrated hydrochloric acid, and dilute to 500ml with double distilled water.

[0035] Simulated intestinal juice: Take 6.8gKH 2 PO 4 Dissolve in 250ml of double-distilled water, mix and shake, add 190ml of 0.2mol / L NaOH and 400ml of double-distilled water, add trypsin (0.2519g), mix well, adjust the pH value to 7.5±0.1 with 0.2mol / L NaOH, and dilute to 1000ml.

[0036] As shown in Table 2, different protease hydrolysis, simulated gastric juice hydrolysis and simulated gastrointestinal juice hydrolysis were carried out to the obtained Penaeus lanceolata meal, specifically as follows:

[0037] Hydroly...

Embodiment 15-28

[0044] Examples 15-28 , Determination of ACE inhibitory activity

[0045] Take the hydrolyzed solution of minced meat of Penaeus lanceolata in Examples 1-14 respectively, after diluting it five times, take the in vitro simulation assay method to measure the ACE inhibitory activity, and the results are shown in the following table 3:

[0046] Table 3. ACE inhibitory activity

[0047] Example

ACE inhibition rate (%)

1

96.3

2

94.9

3

95.7

4

95.0

5

95.4

6

90.5

7

91.4

8

92.4

9

86.9

10

77.9

11

77.5

12

89.6

13

90.6

[0048] 14

76.6

[0049] From the results in Table 3, it can be seen that for different reaction times, Penaeus lanceolata can release hypotensive peptides starting from 0.17 hours, and the longer the reaction time, the higher the ACE ...

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Abstract

The invention discloses application of metapenaeus ensis in preparation of angiotensin converting enzyme (ACE) inhibitors. Preferably, metapenaeus ensis is the product obtained after meat paste of metapenaeus ensis is hydrolyzed by simulated gastric fluid, simulated gastrointestinal fluid and protease. The invention presents a new approach to development and utilization of metapenaeus ensis and the metapenaeus ensis has certain application prospect.

Description

technical field [0001] The invention belongs to the field of food, and in particular relates to the application of Penaeus penaeus for the preparation of angiotensin converting enzyme (Angiotensin Converting Enzyme, ACE) inhibitors. Background technique [0002] Penaeus ensis (English: Metapenaeus ensis, Latin synonym: Penaeus monoceros, Penaeus mastersis, Penaeus incisipes, Metapenaeus monoceros), commonly known as base shrimp, sand shrimp, is a medium-sized seawater shrimp, in Fujian, Taiwan, Guangdong, Hainan, my country Provinces and other sea areas are distributed. In recent years, the aquaculture development in Shanghai, Fujian, Guangdong and other provinces has been rapid, especially by utilizing the characteristics of the shrimp's ability to tolerate low salinity, freshwater aquaculture experiments have been carried out and initial success has been achieved. [0003] The nutritional value of Penaeus lanceolata is relatively high, and the main nutritional components a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L1/33A23L33/00A23L17/40
Inventor 谢静莉方明王波杜磊李鹏吴燕玲李莹束雯婷张旭晟邓高静
Owner EAST CHINA UNIV OF SCI & TECH
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