403 results about "Mosaic virus" patented technology

The invention provides an application of an AC2 gene and the like in improving the expression quantity of GFP (Green Fluorescent Protein) and / or inhibiting degradation of an mRNA (Messenger Ribonucleic Acid) attenuated substrate taking the GFP as a reporter gene. Researches find that AC2 has an mRNA decay inhibition function, can inhibit degradation of a nonsense-mediated mRNA decay substrate taking GFP as a reporter gene and degradation of an endogenous nonsense-mediated mRNA decay substrate of arabidopsis thaliana, can improve the expression quantity of mRNA of AT1G0106020, RPS6, SMG7, AT5G35490, AT5G64430, AT1G36730 and the like, can reduce the expression quantity of AT1G72450 and AT2G400, has interaction with Dcp1 and Dcp2, and can be used for inhibiting the expression quantity of mRNA of AT1G0106020, RPS6, SMG7, AT5G35490, AT5G6430, AT1G36730 and the like. The growth ability of the yeast in an auxotroph culture medium can be improved, the expression level of Dcp1 can be reduced, and a research result lays a foundation for clarification of AC2 functions.

The invention discloses application of a small molecule compound in prevention and treatment of plant RNA virus infection, and belongs to the technical field of biology. According to the invention, 2 '-amino-2'-deoxyguanosine (ADG) is used as a unique antiviral active component to be applied to prevention and treatment of plant RNA viruses for the first time, and broad-spectrum inhibition of various plant RNA viruses such as turnip mosaic virus (TuMV), tomato mosaic virus (ToMV) and tobacco mosaic virus (TMV) can be realized only by a low concentration of 250 [mu] M and a simple exogenous spraying mode; and after spraying, the normal growth of plants is not influenced, the risk of phytotoxicity is thoroughly avoided, the safety, high efficiency and broad spectrum of plant RNA virus prevention and control are remarkably improved, and important practical application significance is achieved for guaranteeing the yield and quality of crops in agricultural production and promoting agricultural green transformation.

The invention discloses an application of a soybean nucleolus GTP binding protein gene GmNSN1 in soybean resistance to soybean mosaic virus diseases. The invention relates to an application of a soybean nucleolus GTP binding protein gene GmNSN1 as shown in SEQ ID NO.1 and SEQ ID NO.2 in genetic engineering modification of soybean mosaic virus resistance. The soybean nucleolus GTP binding protein gene GmNSN1 can negatively regulate and control the resistance of soybeans to diseased soybean mosaic virus diseases, and the antiviral response of the soybeans can be activated due to function deficiency of the soybean nucleolus GTP binding protein gene GmNSN1. The gene is knocked out through a CRISPR / Cas9 gene editing technology, so that the resistance of soybeans to the soybean mosaic virus disease can be remarkably improved.

The invention discloses an application of a soybean GmCLO1 coding gene in regulating the resistance of soybeans to soybean mosaic virus diseases. The invention discloses application of the soybean GmCLO1 gene as shown in SEQ ID NO.1 in genetic engineering modification of soybean mosaic virus resistance. Overexpression of the gene can significantly improve the resistance of soybeans to soybean mosaic virus diseases, and gene editing knockout of the gene can significantly reduce the resistance of soybeans to soybean mosaic virus diseases. The soybean coding gene GmCLO1 disclosed by the invention can be transformed into soybeans through genetic engineering, and the resistance of the soybeans to the soybean mosaic virus diseases is finally regulated and controlled.

The invention discloses an application of a soybean ARGONAUTE family gene GmAGO5 in soybean resistance to soybean mosaic virus diseases. The invention also discloses application of the soybean ARGONAUTE family gene GmAGO5 as shown in SEQ ID NO.1 and SEQ ID NO.2 in genetic engineering modification of soybean mosaic virus resistance. The soybean ARGONAUTE family gene GmAGO5 can negatively regulate and control the resistance of soybeans to diseased soybean mosaic virus diseases, and the antiviral response of the soybeans can be activated due to function deficiency of the soybean ARGONAUTE family gene GmAGO5. The gene is knocked out through a CRISPR / Cas9 gene editing technology, so that the resistance of soybeans to the soybean mosaic virus disease can be remarkably improved.

The invention discloses a pCAMBIA1300-mini RNA3-BC-NLPPya vector as well as a construction method and application of the pCAMBIA1300-mini RNA3-BC-NLPPya vector in high cucumber mosaic virus resistance, the vector is characterized in that mini RNA3-BC-NLPPya is constructed to a pCAMBIA1300 vector skeleton, and the gene sequences of mini RNA3-BC and NLPPya are as shown in SEQ ID NO: 2 and SEQ ID NO: 5. The invention finds that the miniRNA3-BC-NLPPya can efficiently inhibit the infection of the CMV and effectively weaken the harm caused by the CMV, does not need to apply any medicine, is an efficient and green disease-resistant technology, and can provide a new strategy for preventing and controlling the cucumber mosaic virus and similar viruses thereof.

The invention belongs to the technical field of analytical chemistry detection, and particularly relates to a construction method and application of a tobacco mosaic virus molecular imprinting sensor based on MIL-101 (Fe). The construction method comprises the following steps: by taking a tobacco mosaic virus TMV as a template virus, preparing a molecularly imprinted polymer MIPs with a TMV specific recognition cavity on the surface of MIL-101 (Fe) through a free radical polymerization reaction; the template virus is removed in the preparation process of the molecularly imprinted polymer MIPs, and a TMV specific recognition cavity of the molecularly imprinted polymer MIPs contains MIL-101 (Fe); the molecularly imprinted polymer MIPs is the tobacco mosaic virus molecularly imprinted sensor based on MIL-101 (Fe). Hydrochloric acid is introduced, so that the TMV specific recognition cavity structure of the molecularly imprinted polymer MIPs is cracked to release Fe < 3 + >, then potassium thiocyanate is added, and the Fe < 3 + > and KSCN are subjected to a complexation reaction to generate a red complex. And the complexation reaction of Fe < 3 + > and KSCN is used as a signal probe, the rapid semi-quantitative visual detection of the target virus TMV by naked eyes is realized, and quantitative detection and analysis are carried out through an ultraviolet spectrophotometer.

The invention provides an application of a TGBp1 gene, or a TGBp1 gene coding protein, or a recombinant vector or host bacteria containing a TGBp1 gene coding region in down-regulation of the MeGRXC3 expression level. Researches find that TGBp1 and MeGRXC3 interact with each other, so that the growth ability of yeast in an SD / -Leu / -Trp / -His / -Ade auxotroph culture medium can be improved, the expression of MeGRXC3 can be down-regulated, the active oxygen content of tobacco leaves for co-expression of TGBp1 and MeGRXC3 is improved, and the growth ability of the yeast in the SD / -Leu / -Trp / -His / -Ade auxotroph culture medium is improved. Research results lay a theoretical foundation for breeding of common cassava mosaic virus disease resistance.

The invention discloses a strain of disease-resistant and growth-promoting pseudomonas avenae LC40 and application thereof, and relates to the technical field of microorganisms, the pseudomonas avenae is specifically pseudomonas avenae LC40, the pseudomonas avenae LC40 is preserved in China General Microbiological Culture Collection Center (CGMCC) on December 2, 2024, and the preservation number is CGMCC No.32869. The invention further discloses a method for preparing the disease-resistant and growth-promoting pseudomonas avenae LC40. The bacterial strain can be used for inhibiting tobacco mosaic virus (TMV), tomato brown fruit ruffle virus (ToBRFV), rice blast germ (Magnaporthe oryzae) and alternaria tenuissima (Alternaria tenuissima), and the bacterial strain can be used for inhibiting the tobacco mosaic virus (TMV), the tomato brown fruit ruffle virus (ToBRFV), the rice blast germ (Magnaporthe oryzae (Magnaporthe oryzae (Magnaporthe oryzae (Magnaporthe oryzae) and the allium tenuissima (Alternaria tenuissima). The Pseudomonas Asian LC40 provided by the invention has phosphorus solubilizing capacity and can secrete auxin compounds IAA, and field test results show that the LC40 strain has the effects of promoting growth and increasing yield of tomatoes. The pseudomonas Asian LC40 strain can effectively prevent and control plant diseases and promote crop growth, so that the yield and quality of crops are improved, and the pseudomonas Asian LC40 strain shows good application prospects of disease prevention and growth promotion.

The invention provides an application of an AC2 gene, or an AC2 gene coding protein, or a recombinant vector or host bacteria containing an AC2 gene coding region in reducing the expression level of AtSGS3, and / or reducing the expression level of MeSGS3, and / or reducing an SGS3 / RDR6 compound. Researches find that SLCMV AC2 interacts with AtSGS3 and MeSGS3, the growth ability of yeast in an SD / -Ade / -His / -Leu / -Trp auxotroph culture medium and an SD / -Ade / -His / -Leu / -Trp auxotroph culture medium added with 3-AT can be improved, expression of AtSGS3 and MeSGS3 can be down-regulated, an SGS3 / RDR6 compound can be reduced, and a research result lays a foundation for clarification of a molecular mechanism of SLCMV AC2 regulation and control of host RNA silencing.

The invention discloses a CRISPR (clustered regularly interspaced short palindromic repeats) / Cas-based kit for isothermal rapid visual detection of tomato mosaic virus and a detection method of the CRISPR / Cas-based kit. The invention belongs to the technical field of plant quarantine, and particularly relates to a CRISPR / Cas-based kit for isothermal rapid visual detection of tomato mosaic virus and a detection method thereof. The composition for identifying the tomato mosaic virus comprises crRNA specific to nucleic acid to be detected, an RT-RPA primer pair, Cas12 protein and a fluorescent reporter probe, the RT-RPA primer pair is composed of a primer ToMV-F and a primer ToMV-R, and the fluorescent reporter probe is a single-chain RNA with one end connected with a fluorophore and the other end connected with a quenching group. According to the present invention, the rapid, accurate and visual detection of the to-be-detected sample can be achieved, the advantages of good specificity, high sensitivity, convenient operation, high detection efficiency and the like are provided, and the basic requirements of field and port detection can be met.

The invention relates to a heterocyclic pyrimidinedione compound and application thereof in preparation of pesticides and medicines, in particular to the heterocyclic pyrimidinedione compound and application thereof in preparation of herbicides and plant virus resisting agents, and application in preparation of medicines for resisting fungal infection, especially candida auricula infection. The compound provided by the invention has good inhibition effect on KARI enzymes from different sources. Under the dosage of 100g / mu, the weeding effect of the compound provided by the invention on rape during stem and leaf treatment can reach 100%. The compound disclosed by the invention has a good inhibition effect on a candida auricula 12766 strain, and the minimum inhibition concentration (MIC) value of the compound can reach 0.31 mg / L when a YNB culture medium is used. The in-vivo passivation effect of the compound on the tobacco mosaic virus TMV under the concentration of 500 mg / L can reach 64.2%.

The invention discloses a sugarcane streak mosaic virus infectious cloning vector as well as a construction method and application thereof, and belongs to the technical field of biology. The recombinant plasmid provided by the invention contains a whole genome of the SCSMV, and the nucleotide sequence of the whole genome is the 771 to 10583 nucleotides of SEQ ID No. 1. The recombinant plasmid disclosed by the invention is obtained by taking a pCB301 vector as a skeleton and then inserting the skeleton into a whole genome of SCSMV, and the recombinant agrobacterium tumefaciens (pCB301-SCSMV infectious clone) prepared by the recombinant plasmid can successfully infect nicotiana benthamiana and has efficient infection ability; the infectious clone of the recombinant expression plasmid prepared from the recombinant plasmid can successfully infect nicotiana benthamiana, has efficient infection ability and can express foreign proteins.

The invention belongs to the technical field of biology, and particularly relates to an anti-soybean mosaic virus molecular marker primer group, a kit and application of the anti-soybean mosaic virus molecular marker primer group, the anti-soybean mosaic virus molecular marker primer group comprises a primer group designed based on an RSC3K genome sequence; the RSC3K genome sequence is formed by the following steps: two alleles LOC100526921 and LOC100812666 of a susceptible variety are respectively subjected to a segment of deletion, and then are recombined to form the RSC3K genome sequence. The product obtained by amplification of the molecular marker primer group shows a codominant result, no contrast is needed, the cost is low, genotype detection can be carried out on a breeding material in a short time and with high throughput, and time and energy are saved.

Provided herein is a novel, multimodal in situ vaccination approach to treat cancer by combining ablation with administration of the naturally occurring plant virus or virus-like particle (VLP) nanoparticles such as cowpea mosaic virus (CPMV), a plant virus-based immunoadjuvant.

The invention provides a coumarin derivative containing oxadiazole (thiadiazole) thioether and a preparation method and application thereof, the structural general formula of the coumarin derivative containing oxadiazole (thiadiazole) thioether is shown as I, and the structural general formula of the coumarin derivative containing thiadiazole thioether is shown as II, the synthesis route of the coumarin derivative containing oxadiazole (thiadiazole) thioether is simple and practical, the preparation raw materials are easy to obtain, the cost is low, and the prepared compound has a good control effect on plant viruses including tobacco mosaic virus, cucumber mosaic virus, potato Y virus, southern rice black-streaked dwarf virus or rice stripe virus. According to the invention, a favorable lead compound is provided for the creation of a natural bionic antiviral agent; # imgabs0 #

The invention discloses an anti-soybean mosaic virus nano medicament and a preparation method thereof. The anti-soybean mosaic virus nano medicament is synthesized from a xinjunan solution, SPc powder and a solvent, wherein the weight ratio of the SPc powder to the xinjunan solution is 1: (0.5-3.0); the solvent is clear water, purified water and deionized water. The invention relates to a self-assembled nano antiviral pesticide based on SPc and a broad-spectrum bactericide / antiviral agent xinjunan, which is used for preventing and treating SMV in the field. The SPc is self-assembled with the xinjunan through hydrogen bonds and Van der Waals force, the particle size of the xinjunan is remarkably reduced, the contact angle of the xinjunan on soybean leaf surfaces is reduced, the leaf surface retention is improved, and excellent wettability and adhesion performance are shown. Besides, the nano-agent obviously inhibits accumulation of viruses in soybean plants, so that the maturing rate of soybean fruits is increased, the mottle rate of seed coats is reduced, and the field control effect on SMV is greatly enhanced.

The invention relates to the technical field of gene engineering, in particular to application of a Glyma. 16G210600 gene to improvement of resistance of plants to mosaic viruses. According to the application of the Glyma. 16G210600 gene in improving the resistance of plants to mosaic viruses, the nucleotide sequence of the Glyma. 16G210600 gene is as shown in SEQ ID NO: 1. The soybean gene Glyma. 16G210600 is screened from a soybean genome in a homologous comparison manner, and molecular biology and genetic engineering technical means prove that the over-expression of the soybean gene Glyma. 16G210600 can improve the resistance of tobacco to viruses such as tobacco mosaic virus (TMV), soybean mosaic virus (SMV), cabbage leaf roll virus (CaLCuV) and barley stripe mosaic virus (BSMV).

The invention belongs to the technical field of plant biology, and particularly relates to wheat stem rot related protein TaNDR1 and application thereof. According to the invention, a gene with a non-microspecies specific disease resistance function is cloned from wheat and is named as TaNDR1. According to the invention, a barley stripe mosaic virus induced vector for silencing the TaNDR1 gene in wheat is constructed, the expression of the TaNDR1 gene is reduced, a silent TaNDR1 wheat plant is obtained, and after the silent TaNDR1 wheat is inoculated with stem rot pathogen, the stem rot resistance of the wheat is obviously reduced. Therefore, after the expression quantity of the TaNDR1 in the susceptible wheat plant is increased, the stem rot resistance of the susceptible wheat plant can be obviously improved, so that the gene can be used for cultivating the stem rot resistant wheat.

The invention provides an application of a phosphatidylinositol monophosphate 5-kinase gene BnPIP5K9 of rape in regulating and controlling the oil content of the rape. The genetic basis of the oil content of rape seeds is analyzed on the basis of multiple omics, and it is found that the expression quantity of the phosphatidylinositol monophosphate 5-kinase gene BnPIP5K9 in rape is significantly positively correlated with the oil content; the gene BnPIP5K9 is subjected to gene overexpression and knockout to create a mutant for functional verification by further utilizing a tobacco mosaic virus double-35S promoter and a CRISPR / Cas9 gene editing technology, the result shows that the oil content of rape seeds can be remarkably increased by 2.16-2.77% by overexpression of the gene, in addition, rape germplasm resources with gene BnPIP5K9 function deficiency can be obtained through the CRISPR / Cas9 technology, and the rape seed quality is improved. A new theory and a new gene resource are provided for high-oil breeding and oil improvement of the rape, and the method has extremely high application value and potential.

The invention relates to the field of biotechnology and biological breeding, and particularly relates to a method for constructing a single-chain guide RNA (sgRNA) vector for delivering CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) by utilizing a cucumber mosaic virus (CMV), carrying out site-specific editing on a target gene in a Cas9 transgenic plant, causing site-specific mutagenesis of plant genome DNA (Deoxyribose Nucleic Acid) by the vector to be inherited to a progeny, and not carrying the CMV in the progeny. The invention discloses a construction method of a vector pCB301R3-sgPDS and an application of the vector pCB301R3-sgPDS. The pCB301R3-sgPDS is a genetic gene editing vector based on mediation of a cucumber mosaic virus. According to the invention, sgRNA is delivered through CMV for the first time, so that fixed-point editing and seed transmission of plant target genes are efficiently realized in crops.

The invention discloses an efficient broad-spectrum biocontrol bacterium pseudomonas FM36 and application thereof. The wheat pseudomonas is a strain FM36, is classified and named as Pseudomonas siliginis, is preserved in the China General Microbiological Culture Collection Center (CGMCC), and has a preservation number of CGMCC NO.32868. The invention further discloses a preparation method of the high-efficiency broad-spectrum biocontrol bacterium pseudomonas FM36. The invention further discloses an application of the high-efficiency broad-spectrum biocontrol bacterium pseudomonas FM36, and the application of the high-efficiency broad-spectrum biocontrol bacterium pseudomonas FM36. The invention further provides application of the wheat pseudomonas FM36 strain in promoting tomato growth and preventing and treating plant viruses and pathogenic fungi. The wheat pseudomonas provided by the invention has a promoting effect on the growth and yield increase of tomatoes, and has obvious antagonism and obvious antagonism on pathogenic fungi such as tobacco mosaic virus (TMV), chilli vein mottle virus (ChiVMV), rhizoctonia solani, Magnaporthe oryzae, alternaria tenuissima, colletotrichum sp.sp.cubense, fusarium oxysporum f.sp.cubense and the like, and the wheat pseudomonas has an obvious antagonism effect on pathogenic fungi such as the tobacco mosaic virus (TMV), the chilli vein mottle virus (ChiVMV), the rhizoctonia solani, the Magnaporthe oryzae, the alternaria tenuissima, the colletotrichum sp.sp.cubense and the like.

The invention belongs to the technical field of plant biology, and particularly relates to application of TaC2H2 protein in wheat stem rot resistance. According to the invention, a barley stripe mosaic virus inducible vector for silencing the TaC2H2 gene in wheat is constructed, the expression of the TaC2H2 gene is reduced, a silent TaC2H2 wheat plant is obtained, and the stem rot resistance of the silent TaC2H2 wheat is obviously reduced after the silent TaC2H2 wheat is inoculated with stem rot pathogens. Therefore, the TaC2H2 gene plays a positive role in wheat stem rot resistance regulation and control, so that the gene can be used for cultivating stem rot resistant wheat.

The present invention relates to a plant comprising a modified Tom2a gene, the wildtype of which comprises SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5, or SEQ ID No. 6, or comprises another homologous sequence having at least 70% sequence identity to SEQ ID No. 1, which modified gene leads to increased resistance to a Tobamovirus. The modification in the Tom2a gene leads to a modified Tom2a protein that has a deletion, a substitution, or an insertion of at least one amino acid when compared to SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11, or SEQ ID No. 12, or compared to another homologous sequence having at least 70% sequence similarity to SEQ ID No. 7. The plant is preferably a plant of the family Cucurbitaceae or Solanaceae. The invention further relates to a modified Tom2a gene encoding a Tom2a protein comprising a deletion, a substitution, or an insertion of at least one amino acid when compared to SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11, or SEQ ID No. 12, or compared to another homologous sequence having at least 70% sequence similarity to SEQ ID No. 7.

The invention provides an application of a CP gene, or a protein encoded by the CP gene, or a recombinant vector or host bacteria containing a CP gene coding region in down-regulation of the MeGRXC3 expression level. Researches find that CP and MeGRXC3 interact with each other, so that the growth ability of yeast in an SD / -Leu / -Trp / -His / -Ade auxotrophic culture medium can be improved, cell autophagy can be activated, the expression of MeGRXC3 can be down-regulated, and the active oxygen content of plant tissues co-expressed with MeGRXC3 can be increased. Research results lay a theoretical foundation for breeding of common cassava mosaic virus disease resistance.

The invention discloses an application of a soybean GmPT1 coding gene in resisting soybean mosaic virus diseases. The invention discloses application of the soybean inorganic phosphate transporter gene GmPT1 as shown in SEQ ID NO.1 and SEQ ID NO.2 in genetic engineering modification of soybean mosaic virus resistance. The over-expression of the gene can significantly improve the resistance of soybeans to soybean mosaic virus diseases. The soybean inorganic phosphate transporter gene GmPT1 disclosed by the invention can be transformed into soybeans through genetic engineering, and the resistance of the soybeans to soybean mosaic virus diseases is finally regulated and controlled.

The invention belongs to the technical field of viral nucleic acid molecular diagnosis, and particularly relates to a kit for detecting cucumber green mottle mosaic virus based on enzyme-mediated dual-amplification nucleic acid amplification, a detection method and application. The detection system comprises a primer pair DNA upstream primer (SEQ ID NO.2) and a DNA downstream primer (SEQ ID NO.3) for amplifying a coat protein gene of the cucumber green mottle mosaic virus, and a probe (RNA primer (SEQ ID NO.1)) for detecting a CP gene, a nucleic acid amplification group enzyme system, a signal amplification group enzyme system, a nucleic acid scavenging enzyme, an activating enzyme NTP, a buffer solution and a freeze-drying protective agent, wherein the system is prepared into pre-subpackaged freeze-dried balls. The kit provided by the invention can realize RNA detection of aM concentration, and can realize early screening of cucumber green mottle mosaic virus due to high detection sensitivity.

The invention belongs to the technical field of biosensors, and provides a tobacco mosaic virus (TMV) dual-mode biosensor as well as a preparation method and application thereof. The biosensor is composed of a dual-mode luminescent material Co / Ce-TCBPE (at) Ru (dcbpy) 32-COOH, a lateral flow chromatography LFIA flexible electrode, a TMV antibody Ab1, a TMV antibody Ab1 and a self-assembled micro electrochemical luminescence (ECL) sensor, and through qualitative and quantitative dual-signal output of vision and ECL detection, the TMV detection sensitivity and accuracy are remarkably improved. The detection range of the sensor is 0.1 pg / mL-100 ng / mL, the detection limit reaches 48.9 fg / mL, and the sensor has the advantages of simplicity and convenience in operation, quick response, high stability, dual signal guarantee and the like, is suitable for quick visual detection of plant diseases, and has a wide application prospect in agricultural detection.

The invention relates to the technical field of biotechnology and crop disease prevention and control, in particular to application of PABP protein coded by solanaceae plants to prevention and control of tobacco mosaic virus viruses. The invention finds that the PABP protein (taking NbPABP as an example) encoded by solanaceae plants and the encoding gene thereof play an important role in infection and proliferation of the pepper mild mottle virus PMMoV, are susceptible genes of PMMoV encoded by host plants, can be used for preventing and treating pepper mild mottle virus diseases caused by PMMoV, and can be used for molecular breeding for resisting / resisting PMMoV and the like. Valuable protein is provided for antiviral infection of plants, particularly, the antiviral level of solanaceous plants can be improved, production safety of solanaceous vegetables is guaranteed and promoted, and the protein has wide application prospects in the fields of antiviral breeding of plants and the like.

The invention relates to a benzoxazole derivative containing a dithioacetal unit as well as a preparation method and application of the benzoxazole derivative. The compound disclosed by the invention has excellent antiviral activity on cucumber green mottle mosaic virus and the like, and can be used for medicines or medicaments for preventing and treating plant virus diseases such as cucumber green mottle mosaic disease and the like. The structure and the preparation process are simple, and the production cost is low; the benzoxazole derivative containing the dithioacetal unit comprises a benzoxazole compound with the dithioacetal unit, or a stereoisomer of the benzoxazole compound, or a salt of the benzoxazole compound or a solvate of the benzoxazole compound. Structural formula of benzoxazole compound with dithioacetal unit is as follows: # imgabs0 #